Modulating effects of flavonoids an food mutagens in human blood and sperm samples in the comet assay

Teratogenesis Carcinogenesis and Mutagenesis

Volumn 17, Issue 2, 1997, Pages 45-58

  Anderson, Diana ^a,d   Basaran, Nurşen ^b   Dobrzyńska, Malgorzata M ^c   Basaran, Ahmet A ^b   Yu, Tian Wei ^a  

^a BIBRA International ^*  (United Kingdom)

^b HACETTEPE UNIVERSITY   (Turkey)

^c NATIONAL INSTITUTE OF HYGIENE   (Poland)

^d BIBRA INTERNATIONAL   (United Kingdom)

Author keywords

IQ; Kaempferol; Kaempferol 3 rutinoside; Myricetin; Quercetin; Rutin; Silymarin; Trp

Indexed keywords

2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; 3 AMINO 1 METHYL 5H PYRIDO[4,3 B]INDOLE; ANTIMUTAGENIC AGENT; KAEMPFEROL; MUTAGENIC AGENT; MYRICETIN; QUERCETIN; RUTOSIDE; SILYMARIN;

ARTICLE; CONTROLLED STUDY; FOOD; HUMAN; HUMAN CELL; LYMPHOCYTE; MUTAGENICITY; PRIORITY JOURNAL; SPERM;

ADULT; DRUG INTERACTIONS; FEMALE; FLAVONOIDS; FOOD CONTAMINATION; HUMANS; LYMPHOCYTES; MALE; MUTAGENICITY TESTS; MUTAGENS; PLANT EXTRACTS; SPERMATOZOA;

EID: 0030748115     PISSN: 02703211     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6866(1997)17:2<45::AID-TCM1>3.0.CO;2-E     Document Type: Article

References (35)

1. Mitscher LA, Telikepalli H, McGhee E, Shankel DM: Natural antimutagenic agents. Mutat Res 350:143-152, 1996.
2. Ames BN: Dietary carcinogens and anticarcinogens. Science 24:1256-1262, 1983.
3. Clarke CH, Shankel DM: Antimutagenesis in microbial systems. Bacteriol Rev 39:33-35, 1975.
4. DeFlora S (ed): Role and mechanisms of inhibitors in prevention of mutation and cancer. Mutat Res 202:277-449, 1988.
5. DeFlora S, Bronzetti G, Sobels FH: Preface: Assessment of antimutagenicity and anticarcinogenicity. Mutat Res 276:153-155, 1992.
6. DeFlora S, Ramel C: Mechanisms of inhibitors of mutagenesis and carcinogenesis. Classification and overview. Mutat Res 202:285-306, 1988.
7. Ferguson LR: Antimutagens as cancer chemopreventive agents in the diet. Mutat Res 307:395-410, 1994.
8. Hartman PE, Shankel DM: Antimutagens and anticarcinogens: A survey of putative interceptor molecules. Environ Mol Mutagen 15:145-182, 1990.
9. Wattenberg LW: Chemoprevention of cancer. Cancer Res 45:1-8, 1985.
10. Edenharder R, Vonpetersdorff, Rauscher R: Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and other heterocyclic amine mutagens from cooked food. Mutat Res 287:261-274, 1993.
11. 2, in vitro, is diminished by silymarin. Skin Pharmacol 8:279-291, 1995.
12. Pietrangelo A, Borella F, Casalgrandi G, Montosi G, Cecarelli D, Gallesi D, Giovannini F, Gasparetto A, Masini A: Antioxidant activity of silybin in vivo during long-term iron overload in rats. Gastroenterology 109:1941-1949, 1995.
13. Manach C, Regerat F, Texier O, Agullo G, Demigne C, Remesy C: Bioavailability metabolism and physiological impact of 4-oxo-flavonoids. Nutr Res 3:517-544, 1996.
14. Sahu SC, Gray CG: Interaction of flavonoids, trace metals and oxygen nuclear kDNA damage and lipid peroxidation induced by myricetin. Cancer Lett 70:73-79, 1993.
15. Anderson D, Dobrzyńska MM. Yu T-W: Modulating effects of silymarin and myricetin on food mutagens and doxorubicin in assays with different genetic endpoints. J Environ Pathol Toxicol Oncol (in press).
16. MacGregor J, Lurd L: Mutagenicity of plant flavonoids: Structural requirements for mutagenic activity in Salmonella typhimurium. Mutat Res 54:297-309, 1978.
17. Brown JP: A review of the genetic effects of naturally occurring flavonoids, anthroquinones and related compounds. Mutat Res 75:243-277, 1980.
18. Mitscher LA, Telikepalli H, McGhee E, Shankel DM: Natural antimutagenic agents. Mutat Res 350:143-152, 1996.
19. Rowland I, Anderson D: Mutagens in cooked foods. BNF Nutr Bull 14:182-190, 1989.
20. Anderson D, Yu T-W, Phillips BJ, Schmezer P: The effect of various antioxidants and other modifying agents on oxygen radical generated DNA damage in human lymphocytes in the Comet assay. Mutat Res 307:261-271, 1994.
21. Pool-Zobel BL, Klein RG, Liegibil VM, Kuchenmeister F, Weber S, Schmezer P: Systemic genotoxic effects of tobacco related nitrosamines following oral and inhalation administration of Sprague-Dawley rats. Clin Invest 70:299-306, 1992.
22. Pool-Zobel BL, Guigas C, Klein R, Neudecker CH, Renner HW, Schmezer P: Assessment of genotoxic effects by lindane. Food Chem Toxicol 4:271-283, 1993.
23. Singh NP, McCoy MT, Tice RR, Schneider EL: A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191, 1988.
24. Hughes CM, Lewis SEM, McKelvey-Martin VJ, Thompson W: A comparison of baseline and induced DNA damage in human spermatozoa from fertile and infertile men, using a modified Comet assay. Mol Hum Reprod 2:613-619, 1996.
25. Singh NP, Danner DB, Tice RR, McCoy MT, Collins GD, Schneider EL: Abundant alkali sensitive sites in DNA of human and mouse sperm. Exp Cell Res 184:461-470, 1989.
26. VanLoon AAWM DenBoer PJ, Van der Schans GP, Mackenbach O, Grootegoed JA, Baan RA, Lohman PHM: Immunochemical detection of DNA damage induction and repair at different cellular stages of spermatogenesis of the hamster after in vitro or in vivo exposure to ionising radiation. Exp Cell Res 193:303-309, 1991.
27. VanLoon AAWM, Sonneveld E, Hooger-brugge J, Van der Schans GP, Grootegoed JA, Lohman PHM, Baan RA: Induction and repair of single strand breaks and DNA base damage at different cellular stages of spermatogenesis of the hamster upon in vitro exposure to ionising radiation. Mutat Res 294:139-148, 1993.
28. Anderson D, Dhawan A, Yu TW, Plewa M: An investigation of bone marrow and testicular cells in vivo using the Comet assay. Mutat Res 370:159-174, 1996.
29. Sidney R, Grimes JR: Nuclear proteins in spermatogenesis. Comp Biochem Physiol 83:495-500, 1986.
30. Sega GA, Sluder AE, McCoy LS, Owens JG, Generoso EE: The use of alkaline elution procedures to measure DNA damage in spermatogenic stages of mice exposed to methanesulfonate. Mutat Res 159:55-63, 1986.
31. Sega GA, Generoso E: Measurement of DNA breakage in specific germ cell stages of male mice exposed to acrylamide using an alkaline elution procedure. Mutat Res 242:79-87, 1990.
32. Sega GA: Molecular dosimetry of chemical mutagens: Measurement of molecular dose and DNA repair in mammalian germ cells. Mutat Res 38:317-326, 1976.
33. Ashwood-Smith MJ, Edwards RG: DNA repair by oocytes. Mol Hum Reprod 2:46-51, 1996.
34. Aitken J, Fisher H: Reactive oxygen species generation and human spermatozoa: The balance of benefit and risk. BioEssays 16:259-267, 1994.
35. Genesca A, Barrios L, Miro R, Cabalin MR, Benet J, Fuster C, Bonfill X, Egozcue J: Lymphocyte and sperm chromosome studies in cancer-treated men. Hum Genet 84:353-355, 1990.