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Volumn 40, Issue 6, 2014, Pages 701-715

A systematic review of salvage therapy to patients with metastatic colorectal cancer previously treated with fluorouracil, oxaliplatin and irinotecan +/- targeted therapy

Author keywords

Chemotherapy; Colorectal cancer; Refractory; Salvage therapy; Targeted therapy

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; BIRINAPANT; BRIVANIB; CAPECITABINE; CARBOPLATIN; CETUXIMAB; CYCLOPHOSPHAMIDE; ERLOTINIB; EVEROLIMUS; FLUOROURACIL; GEMCITABINE; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; HISTONE DEACETYLASE INHIBITOR; IRINOTECAN; LINIFANIB; MITOMYCIN; N (6,7 DIHYDRO 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL) 2,2 DIMETHYL N' (2,2,3,3,3 PENTAFLUOROPROPYL)PROPANEDIAMIDE; OXALIPLATIN; PANITUMUMAB; PANOBINOSTAT; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; RALTITREXED; REGORAFENIB; SUNITINIB; TEMSIROLIMUS; THALIDOMIDE; UFT; UNINDEXED DRUG;

EID: 84899945019     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2014.02.006     Document Type: Review
Times cited : (64)

References (139)
  • 1
    • 78049332872 scopus 로고    scopus 로고
    • Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors
    • Haggar F.A., Boushey R.P. Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clin Colon Rectal Surg 2009, 22:191-197.
    • (2009) Clin Colon Rectal Surg , vol.22 , pp. 191-197
    • Haggar, F.A.1    Boushey, R.P.2
  • 2
    • 0030888321 scopus 로고    scopus 로고
    • Oxaliplatin with high-dose leucovorin and 5-fluorouracil 48-hour continuous infusion in pretreated metastatic colorectal cancer
    • de Gramont A., Vignoud J., Tournigand C., Louvet C., Andre T., Varette C., et al. Oxaliplatin with high-dose leucovorin and 5-fluorouracil 48-hour continuous infusion in pretreated metastatic colorectal cancer. Eur J Cancer 1997, 33:214-219.
    • (1997) Eur J Cancer , vol.33 , pp. 214-219
    • de Gramont, A.1    Vignoud, J.2    Tournigand, C.3    Louvet, C.4    Andre, T.5    Varette, C.6
  • 3
    • 0037531121 scopus 로고    scopus 로고
    • Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: interim results of a phase III trial
    • Rothenberg M.L., Oza A.M., Bigelow R.H., Berlin J.D., Marshall J.L., Ramanathan R.K., et al. Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: interim results of a phase III trial. J Clin Oncol 2003, 21:2059-2069.
    • (2003) J Clin Oncol , vol.21 , pp. 2059-2069
    • Rothenberg, M.L.1    Oza, A.M.2    Bigelow, R.H.3    Berlin, J.D.4    Marshall, J.L.5    Ramanathan, R.K.6
  • 4
    • 84870812342 scopus 로고    scopus 로고
    • Prognostic and predictive biomarkers for epidermal growth factor receptor-targeted therapy in colorectal cancer: beyond KRAS mutations
    • Custodio A., Feliu J. Prognostic and predictive biomarkers for epidermal growth factor receptor-targeted therapy in colorectal cancer: beyond KRAS mutations. Crit Rev Oncol Hematol 2013, 85:45-81.
    • (2013) Crit Rev Oncol Hematol , vol.85 , pp. 45-81
    • Custodio, A.1    Feliu, J.2
  • 5
    • 84899992093 scopus 로고    scopus 로고
    • Overall survival (OS) analysis from PRIME: randomized phase III study of panitumumab (pmab) with FOLFOX4 for first-line metastatic colorectal cancer (mCRC)
    • Douillard J.-Y., Siena S., Tabernero J., Burkes R.L., Barugel M.E., Humblet Y., et al. Overall survival (OS) analysis from PRIME: randomized phase III study of panitumumab (pmab) with FOLFOX4 for first-line metastatic colorectal cancer (mCRC). ASCO Meet Abstr 2013, 31:3620.
    • (2013) ASCO Meet Abstr , vol.31 , pp. 3620
    • Douillard, J.-Y.1    Siena, S.2    Tabernero, J.3    Burkes, R.L.4    Barugel, M.E.5    Humblet, Y.6
  • 6
    • 84877094311 scopus 로고    scopus 로고
    • Bevacizumab in colorectal cancer: current and future directions
    • Yeung Y., Tebbutt N.C. Bevacizumab in colorectal cancer: current and future directions. Expert Rev Anticancer Ther 2012, 12:1263-1273.
    • (2012) Expert Rev Anticancer Ther , vol.12 , pp. 1263-1273
    • Yeung, Y.1    Tebbutt, N.C.2
  • 7
    • 84867047384 scopus 로고    scopus 로고
    • Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
    • Van Cutsem E., Tabernero J., Lakomy R., Prenen H., Prausova J., Macarulla T., et al. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol 2012, 30:3499-3506.
    • (2012) J Clin Oncol , vol.30 , pp. 3499-3506
    • Van Cutsem, E.1    Tabernero, J.2    Lakomy, R.3    Prenen, H.4    Prausova, J.5    Macarulla, T.6
  • 8
    • 84872921660 scopus 로고    scopus 로고
    • Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
    • Grothey A., Van Cutsem E., Sobrero A., Siena S., Falcone A., Ychou M., et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2013, 381:303-312.
    • (2013) Lancet , vol.381 , pp. 303-312
    • Grothey, A.1    Van Cutsem, E.2    Sobrero, A.3    Siena, S.4    Falcone, A.5    Ychou, M.6
  • 9
    • 84861198824 scopus 로고    scopus 로고
    • Biologic therapies in the metastatic colorectal cancer treatment continuum-applying current evidence to clinical practice
    • Peeters M., Price T. Biologic therapies in the metastatic colorectal cancer treatment continuum-applying current evidence to clinical practice. Cancer Treat Rev 2012, 38:397-406.
    • (2012) Cancer Treat Rev , vol.38 , pp. 397-406
    • Peeters, M.1    Price, T.2
  • 10
    • 34447277453 scopus 로고    scopus 로고
    • Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial
    • Koopman M., Antonini N.F., Douma J., Wals J., Honkoop A.H., Erdkamp F.L., et al. Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial. Lancet 2007, 370:135-142.
    • (2007) Lancet , vol.370 , pp. 135-142
    • Koopman, M.1    Antonini, N.F.2    Douma, J.3    Wals, J.4    Honkoop, A.H.5    Erdkamp, F.L.6
  • 11
    • 34447255724 scopus 로고    scopus 로고
    • Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial
    • Seymour M.T., Maughan T.S., Ledermann J.A., Topham C., James R., Gwyther S.J., et al. Different strategies of sequential and combination chemotherapy for patients with poor prognosis advanced colorectal cancer (MRC FOCUS): a randomised controlled trial. Lancet 2007, 370:143-152.
    • (2007) Lancet , vol.370 , pp. 143-152
    • Seymour, M.T.1    Maughan, T.S.2    Ledermann, J.A.3    Topham, C.4    James, R.5    Gwyther, S.J.6
  • 12
    • 80053384385 scopus 로고    scopus 로고
    • Sequential versus combination chemotherapy for the treatment of advanced colorectal cancer (FFCD 2000-05): an open-label, randomised, phase 3 trial
    • Ducreux M., Malka D., Mendiboure J., Etienne P.L., Texereau P., Auby D., et al. Sequential versus combination chemotherapy for the treatment of advanced colorectal cancer (FFCD 2000-05): an open-label, randomised, phase 3 trial. Lancet Oncol 2011, 12:1032-1044.
    • (2011) Lancet Oncol , vol.12 , pp. 1032-1044
    • Ducreux, M.1    Malka, D.2    Mendiboure, J.3    Etienne, P.L.4    Texereau, P.5    Auby, D.6
  • 13
    • 79955555659 scopus 로고    scopus 로고
    • Targeting the phosphatidylinositol 3-kinase signaling pathway in breast cancer
    • Hernandez-Aya L.F., Gonzalez-Angulo A.M. Targeting the phosphatidylinositol 3-kinase signaling pathway in breast cancer. Oncologist 2011, 16:404-414.
    • (2011) Oncologist , vol.16 , pp. 404-414
    • Hernandez-Aya, L.F.1    Gonzalez-Angulo, A.M.2
  • 16
    • 33749533138 scopus 로고    scopus 로고
    • Chemotherapy with mitomycin C and capecitabine in patients with advanced colorectal cancer pretreated with irinotecan and oxaliplatin
    • Rimassa L., Gullo G., Carnaghi C., Abbadessa G., Zuradelli M., Tronconi M.C., et al. Chemotherapy with mitomycin C and capecitabine in patients with advanced colorectal cancer pretreated with irinotecan and oxaliplatin. Tumori 2006, 92:285-289.
    • (2006) Tumori , vol.92 , pp. 285-289
    • Rimassa, L.1    Gullo, G.2    Carnaghi, C.3    Abbadessa, G.4    Zuradelli, M.5    Tronconi, M.C.6
  • 17
    • 33845264169 scopus 로고    scopus 로고
    • Capecitabine and mitomycin C may be an effective treatment option for third-line chemotherapy in advanced colorectal cancer
    • Scartozzi M., Falcone A., Pucci F., Braconi C., Pierantoni C., Cavanna L., et al. Capecitabine and mitomycin C may be an effective treatment option for third-line chemotherapy in advanced colorectal cancer. Tumori 2006, 92:384-388.
    • (2006) Tumori , vol.92 , pp. 384-388
    • Scartozzi, M.1    Falcone, A.2    Pucci, F.3    Braconi, C.4    Pierantoni, C.5    Cavanna, L.6
  • 18
    • 84862815695 scopus 로고    scopus 로고
    • A multicenter, multinational analysis of mitomycin C in refractory metastatic colorectal cancer
    • Ferrarotto R., Machado K., Mak M.P., Shah N., Takahashi T.K., Costa F.P., et al. A multicenter, multinational analysis of mitomycin C in refractory metastatic colorectal cancer. Eur J Cancer 2012, 48:820-826.
    • (2012) Eur J Cancer , vol.48 , pp. 820-826
    • Ferrarotto, R.1    Machado, K.2    Mak, M.P.3    Shah, N.4    Takahashi, T.K.5    Costa, F.P.6
  • 19
    • 34548357027 scopus 로고    scopus 로고
    • UFT/leucovorin and mitomycin C as salvage treatment in patients with advanced colorectal cancer - a retrospective analysis
    • Vormittag L., Kornek G.V., Gruhsmann B., Lenauer A., Foger A., Depisch D., et al. UFT/leucovorin and mitomycin C as salvage treatment in patients with advanced colorectal cancer - a retrospective analysis. Anticancer Drugs 2007, 18:709-712.
    • (2007) Anticancer Drugs , vol.18 , pp. 709-712
    • Vormittag, L.1    Kornek, G.V.2    Gruhsmann, B.3    Lenauer, A.4    Foger, A.5    Depisch, D.6
  • 20
    • 79954507349 scopus 로고    scopus 로고
    • Mitomycin-C in combination with fluoropyrimidines in the treatment of metastatic colorectal cancer after oxaliplatin and irinotecan failure
    • Alkis N., Demirci U., Benekli M., Yilmaz U., Isikdogan A., Sevinc A., et al. Mitomycin-C in combination with fluoropyrimidines in the treatment of metastatic colorectal cancer after oxaliplatin and irinotecan failure. J BUON 2011, 16:80-83.
    • (2011) J BUON , vol.16 , pp. 80-83
    • Alkis, N.1    Demirci, U.2    Benekli, M.3    Yilmaz, U.4    Isikdogan, A.5    Sevinc, A.6
  • 21
    • 21344437927 scopus 로고    scopus 로고
    • Capecitabine as third line therapy in patients with advanced colorectal cancer
    • Gubanski M., Naucler G., Almerud A., Lidestahl A., Lind P.A. Capecitabine as third line therapy in patients with advanced colorectal cancer. Acta Oncol 2005, 44:236-239.
    • (2005) Acta Oncol , vol.44 , pp. 236-239
    • Gubanski, M.1    Naucler, G.2    Almerud, A.3    Lidestahl, A.4    Lind, P.A.5
  • 22
    • 84899992466 scopus 로고    scopus 로고
    • Capecitabine monotherapy and the clinical significance of neutrophil-lymphocyte ratio versus platelet-lymphocyte ratio in patients with metastatic colorectal cancer
    • Lee S., Kwon H.-C., Kim S.-H., Oh S.Y., Lee J.H., Yoon H.-H., et al. Capecitabine monotherapy and the clinical significance of neutrophil-lymphocyte ratio versus platelet-lymphocyte ratio in patients with metastatic colorectal cancer. ASCO Meet Abstr 2012, 30:660.
    • (2012) ASCO Meet Abstr , vol.30 , pp. 660
    • Lee, S.1    Kwon, H.-C.2    Kim, S.-H.3    Oh, S.Y.4    Lee, J.H.5    Yoon, H.-H.6
  • 23
    • 65549152765 scopus 로고    scopus 로고
    • Retrospective analysis of S-1 monotherapy in patients with metastatic colorectal cancer after failure to fluoropyrimidine and irinotecan or to fluoropyrimidine, irinotecan and oxaliplatin
    • Yasui H., Yoshino T., Boku N., Onozawa Y., Hironaka S., Fukutomi A., et al. Retrospective analysis of S-1 monotherapy in patients with metastatic colorectal cancer after failure to fluoropyrimidine and irinotecan or to fluoropyrimidine, irinotecan and oxaliplatin. Jpn J Clin Oncol 2009, 39:315-320.
    • (2009) Jpn J Clin Oncol , vol.39 , pp. 315-320
    • Yasui, H.1    Yoshino, T.2    Boku, N.3    Onozawa, Y.4    Hironaka, S.5    Fukutomi, A.6
  • 24
    • 84655176666 scopus 로고    scopus 로고
    • Salvage S-1 monotherapy in metastatic colorectal cancer patients who failed irinotecan-based or oxaliplatin-based chemotherapy
    • Lee D.J., Lee J., Lee H.Y., Lim T., Lee S.J., Yi S.Y., et al. Salvage S-1 monotherapy in metastatic colorectal cancer patients who failed irinotecan-based or oxaliplatin-based chemotherapy. Med Oncol 2011, 28(Suppl. 1):S291-S294.
    • (2011) Med Oncol , vol.28 , Issue.SUPPL. 1
    • Lee, D.J.1    Lee, J.2    Lee, H.Y.3    Lim, T.4    Lee, S.J.5    Yi, S.Y.6
  • 25
    • 84899929108 scopus 로고    scopus 로고
    • Effectiveness of gemcitabine and capecitabine in advanced colorectal cancer patients: a retrospective analysis
    • Salgado M., Reboredo M., Medina A., Quintero G., Pellon M.L., Romero Reinoso C., et al. Effectiveness of gemcitabine and capecitabine in advanced colorectal cancer patients: a retrospective analysis. ASCO Meet Abstr 2012, 30:649.
    • (2012) ASCO Meet Abstr , vol.30 , pp. 649
    • Salgado, M.1    Reboredo, M.2    Medina, A.3    Quintero, G.4    Pellon, M.L.5    Romero Reinoso, C.6
  • 27
    • 84899936807 scopus 로고    scopus 로고
    • Carboplatin plus fluorouracil (CF) as salvage treatment after failure of standard chemotherapy in patients with metastatic colorectal cancer
    • Kim S. Carboplatin plus fluorouracil (CF) as salvage treatment after failure of standard chemotherapy in patients with metastatic colorectal cancer. Ann Oncol 2013, 24:iv102-iv103.
    • (2013) Ann Oncol , vol.24
    • Kim, S.1
  • 28
    • 23944505197 scopus 로고    scopus 로고
    • Continuous infusion of oxaliplatin plus chronomodulated capecitabine in 5-fluorouracil- and irinotecan-resistant advanced colorectal cancer patients
    • Santini D., Vincenzi B., La Cesa A., Caricato M., Schiavon G., Spalletta B., et al. Continuous infusion of oxaliplatin plus chronomodulated capecitabine in 5-fluorouracil- and irinotecan-resistant advanced colorectal cancer patients. Oncology 2005, 69:27-34.
    • (2005) Oncology , vol.69 , pp. 27-34
    • Santini, D.1    Vincenzi, B.2    La Cesa, A.3    Caricato, M.4    Schiavon, G.5    Spalletta, B.6
  • 29
    • 84872948810 scopus 로고    scopus 로고
    • Rechallenge with oxaliplatin and fluoropyrimidine for metastatic colorectal carcinoma after prior therapy
    • Townsend A.R., Bishnoi S., Broadbridge V., Beeke C., Karapetis C.S., Jain K., et al. Rechallenge with oxaliplatin and fluoropyrimidine for metastatic colorectal carcinoma after prior therapy. Am J Clin Oncol 2013, 36:49-52.
    • (2013) Am J Clin Oncol , vol.36 , pp. 49-52
    • Townsend, A.R.1    Bishnoi, S.2    Broadbridge, V.3    Beeke, C.4    Karapetis, C.S.5    Jain, K.6
  • 30
    • 21244501662 scopus 로고    scopus 로고
    • Mitomycin-C and capecitabine as third-line chemotherapy in patients with advanced colorectal cancer: a phase II study
    • Lim D.H., Park Y.S., Park B.B., Ji S.H., Lee J., Park K.W., et al. Mitomycin-C and capecitabine as third-line chemotherapy in patients with advanced colorectal cancer: a phase II study. Cancer Chemother Pharmacol 2005, 56:10-14.
    • (2005) Cancer Chemother Pharmacol , vol.56 , pp. 10-14
    • Lim, D.H.1    Park, Y.S.2    Park, B.B.3    Ji, S.H.4    Lee, J.5    Park, K.W.6
  • 31
    • 84866248992 scopus 로고    scopus 로고
    • Uracil-tegafur/leucovorin and mitomycin C salvage therapy in patients with advanced colorectal cancer: a phase II study
    • Francois E., Smith D., Dahan L., Michel C., Perrier H., Mari V., et al. Uracil-tegafur/leucovorin and mitomycin C salvage therapy in patients with advanced colorectal cancer: a phase II study. J Chemother 2012, 24:207-211.
    • (2012) J Chemother , vol.24 , pp. 207-211
    • Francois, E.1    Smith, D.2    Dahan, L.3    Michel, C.4    Perrier, H.5    Mari, V.6
  • 32
    • 77954398798 scopus 로고    scopus 로고
    • UFT/leucovorin as salvage treatment in patients with advanced colorectal cancer
    • Michalaki V., Gennatas S., Gennatas C., Mitomycin C. UFT/leucovorin as salvage treatment in patients with advanced colorectal cancer. J BUON 2010, 15:270-273.
    • (2010) J BUON , vol.15 , pp. 270-273
    • Michalaki, V.1    Gennatas, S.2    Gennatas, C.3    Mitomycin, C.4
  • 33
    • 0042123510 scopus 로고    scopus 로고
    • Raltitrexed and mitomycin-C as third-line chemotherapy for colorectal cancer after combination regimens including 5-fluorouracil, irinotecan and oxaliplatin: a phase II study
    • Rosati G., Rossi A., Germano D., Reggiardo G., Manzione L. Raltitrexed and mitomycin-C as third-line chemotherapy for colorectal cancer after combination regimens including 5-fluorouracil, irinotecan and oxaliplatin: a phase II study. Anticancer Res 2003, 23:2981-2985.
    • (2003) Anticancer Res , vol.23 , pp. 2981-2985
    • Rosati, G.1    Rossi, A.2    Germano, D.3    Reggiardo, G.4    Manzione, L.5
  • 34
    • 33645802020 scopus 로고    scopus 로고
    • Salvage treatment with single-agent capecitabine in patients with heavily pretreated advanced colorectal cancer
    • Ardavanis A.S., Ioannidis G.N., Orphanos G.S., Rigatos G.A. Salvage treatment with single-agent capecitabine in patients with heavily pretreated advanced colorectal cancer. Anticancer Res 2006, 26:1669-1672.
    • (2006) Anticancer Res , vol.26 , pp. 1669-1672
    • Ardavanis, A.S.1    Ioannidis, G.N.2    Orphanos, G.S.3    Rigatos, G.A.4
  • 35
    • 84899971652 scopus 로고    scopus 로고
    • Metronomic capecitabine (cape) and cyclophosphamide (CTX) for refractory metastatic colorectal cancer (mCRC): results of a phase II trial
    • Marmorino F., Cremolini C., Loupakis F., Salvatore L., Schirripa M., Antoniotti C., et al. Metronomic capecitabine (cape) and cyclophosphamide (CTX) for refractory metastatic colorectal cancer (mCRC): results of a phase II trial. ASCO Meeting Abstracts 2013, 31:e14577.
    • (2013) ASCO Meeting Abstracts , vol.31
    • Marmorino, F.1    Cremolini, C.2    Loupakis, F.3    Salvatore, L.4    Schirripa, M.5    Antoniotti, C.6
  • 36
    • 33845666953 scopus 로고    scopus 로고
    • A phase II trial of S-1 monotherapy in metastatic colorectal cancer after failure of irinotecan- and oxaliplatin-containing regimens
    • Jeung H.C., Rha S.Y., Cho B.C., Yoo N.C., Roh J.K., Roh W.J., et al. A phase II trial of S-1 monotherapy in metastatic colorectal cancer after failure of irinotecan- and oxaliplatin-containing regimens. Br J Cancer 2006, 95:1637-1641.
    • (2006) Br J Cancer , vol.95 , pp. 1637-1641
    • Jeung, H.C.1    Rha, S.Y.2    Cho, B.C.3    Yoo, N.C.4    Roh, J.K.5    Roh, W.J.6
  • 37
    • 84899926743 scopus 로고    scopus 로고
    • A phase II trial of salvage treatment with gemcitabine and S-1 combination in heavily pretreated patients with metastatic colorectal cancer
    • Sym S.J., Hong J., Ahn H.K., Park J., Cho E.K., Lee J.H., et al. A phase II trial of salvage treatment with gemcitabine and S-1 combination in heavily pretreated patients with metastatic colorectal cancer. ASCO Meet Abstr 2013, 31:3595.
    • (2013) ASCO Meet Abstr , vol.31 , pp. 3595
    • Sym, S.J.1    Hong, J.2    Ahn, H.K.3    Park, J.4    Cho, E.K.5    Lee, J.H.6
  • 38
    • 55749105396 scopus 로고    scopus 로고
    • Gemcitabine and protracted 5-fluorouracil infusion as third-line chemotherapy in refractory colorectal cancer patients
    • Bitossi R., Sculli C.M., Tampellini M., Alabiso I., Brizzi M.P., Ferrero A., et al. Gemcitabine and protracted 5-fluorouracil infusion as third-line chemotherapy in refractory colorectal cancer patients. Anticancer Res 2008, 28:3055-3060.
    • (2008) Anticancer Res , vol.28 , pp. 3055-3060
    • Bitossi, R.1    Sculli, C.M.2    Tampellini, M.3    Alabiso, I.4    Brizzi, M.P.5    Ferrero, A.6
  • 39
    • 84899917603 scopus 로고    scopus 로고
    • Phase II clinical activity and tolerability of the SMAC-mimetic birinapant (TL32711) plus irinotecan in irinotecan-relapsed/refractory metastatic colorectal cancer
    • Senzer N.N., LoRusso P., Martin L.P., Schilder R.J., Amaravadi R.K., Papadopoulos K.P., et al. Phase II clinical activity and tolerability of the SMAC-mimetic birinapant (TL32711) plus irinotecan in irinotecan-relapsed/refractory metastatic colorectal cancer. ASCO Meet Abstr 2013, 31:3621.
    • (2013) ASCO Meet Abstr , vol.31 , pp. 3621
    • Senzer, N.N.1    LoRusso, P.2    Martin, L.P.3    Schilder, R.J.4    Amaravadi, R.K.5    Papadopoulos, K.P.6
  • 40
    • 84866925889 scopus 로고    scopus 로고
    • TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial
    • Yoshino T., Mizunuma N., Yamazaki K., Nishina T., Komatsu Y., Baba H., et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol 2012, 13:993-1001.
    • (2012) Lancet Oncol , vol.13 , pp. 993-1001
    • Yoshino, T.1    Mizunuma, N.2    Yamazaki, K.3    Nishina, T.4    Komatsu, Y.5    Baba, H.6
  • 41
    • 2542450966 scopus 로고    scopus 로고
    • A novel antimetabolite, TAS-102 retains its effect on FU-related resistant cancer cells
    • Emura T., Murakami Y., Nakagawa F., Fukushima M., Kitazato K. A novel antimetabolite, TAS-102 retains its effect on FU-related resistant cancer cells. Int J Mol Med 2004, 13:545-549.
    • (2004) Int J Mol Med , vol.13 , pp. 545-549
    • Emura, T.1    Murakami, Y.2    Nakagawa, F.3    Fukushima, M.4    Kitazato, K.5
  • 42
    • 78651098415 scopus 로고    scopus 로고
    • Hepatic arterial infusion of 5-fluorouracil for patients with liver metastases from colorectal cancer refractory to standard systemic chemotherapy: a multicenter, retrospective analysis
    • Nishiofuku H., Tanaka T., Aramaki T., Boku N., Inaba Y., Sato Y., et al. Hepatic arterial infusion of 5-fluorouracil for patients with liver metastases from colorectal cancer refractory to standard systemic chemotherapy: a multicenter, retrospective analysis. Clin Colorectal Cancer 2010, 9:305-310.
    • (2010) Clin Colorectal Cancer , vol.9 , pp. 305-310
    • Nishiofuku, H.1    Tanaka, T.2    Aramaki, T.3    Boku, N.4    Inaba, Y.5    Sato, Y.6
  • 43
    • 77953544989 scopus 로고    scopus 로고
    • Raltitrexed and oxaliplatin hepatic arterial infusion for advanced colorectal cancer: a retrospective study
    • Khouri C., Guiu B., Cercueil J.P., Chauffert B., Ladoire S., Ghiringhelli F. Raltitrexed and oxaliplatin hepatic arterial infusion for advanced colorectal cancer: a retrospective study. Anticancer Drugs 2010, 21:656-661.
    • (2010) Anticancer Drugs , vol.21 , pp. 656-661
    • Khouri, C.1    Guiu, B.2    Cercueil, J.P.3    Chauffert, B.4    Ladoire, S.5    Ghiringhelli, F.6
  • 44
    • 70350513653 scopus 로고    scopus 로고
    • Rescue chemotherapy using multidrug chronomodulated hepatic arterial infusion for patients with heavily pretreated metastatic colorectal cancer
    • Bouchahda M., Adam R., Giacchetti S., Castaing D., Brezault-Bonnet C., Hauteville D., et al. Rescue chemotherapy using multidrug chronomodulated hepatic arterial infusion for patients with heavily pretreated metastatic colorectal cancer. Cancer 2009, 115:4990-4999.
    • (2009) Cancer , vol.115 , pp. 4990-4999
    • Bouchahda, M.1    Adam, R.2    Giacchetti, S.3    Castaing, D.4    Brezault-Bonnet, C.5    Hauteville, D.6
  • 45
    • 60649099351 scopus 로고    scopus 로고
    • Salvage therapy for liver-dominant colorectal metastatic adenocarcinoma: comparison between transcatheter arterial chemoembolization versus yttrium-90 radioembolization
    • Hong K., McBride J.D., Georgiades C.S., Reyes D.K., Herman J.M., Kamel I.R., et al. Salvage therapy for liver-dominant colorectal metastatic adenocarcinoma: comparison between transcatheter arterial chemoembolization versus yttrium-90 radioembolization. J Vasc Interv Radiol 2009, 20:360-367.
    • (2009) J Vasc Interv Radiol , vol.20 , pp. 360-367
    • Hong, K.1    McBride, J.D.2    Georgiades, C.S.3    Reyes, D.K.4    Herman, J.M.5    Kamel, I.R.6
  • 46
    • 84899940364 scopus 로고    scopus 로고
    • Hepatic artery infusion (HAI) of irinotecan, 5-fluorouracil, and oxaliplatin plus intravenous cetuximab (Cet) (Optiliv) after failure on one versus two or three chemotherapy protocols in patients (pts) with unresectable liver metastases from wt KRAS colorectal cancer (LM-CRC) (European phase II clinical trial NCT00852228)
    • Ducreux M., Innominato P.F., Hebbar M., Smith D.M., Lepere C., Focan C.N.J., et al. Hepatic artery infusion (HAI) of irinotecan, 5-fluorouracil, and oxaliplatin plus intravenous cetuximab (Cet) (Optiliv) after failure on one versus two or three chemotherapy protocols in patients (pts) with unresectable liver metastases from wt KRAS colorectal cancer (LM-CRC) (European phase II clinical trial NCT00852228). ASCO Meet Abstr 2013, 31:3599.
    • (2013) ASCO Meet Abstr , vol.31 , pp. 3599
    • Ducreux, M.1    Innominato, P.F.2    Hebbar, M.3    Smith, D.M.4    Lepere, C.5    Focan, C.N.J.6
  • 47
    • 78651356885 scopus 로고    scopus 로고
    • Hepatic intra-arterial injection of drug-eluting bead, irinotecan (DEBIRI) in unresectable colorectal liver metastases refractory to systemic chemotherapy: results of multi-institutional study
    • Martin R.C., Joshi J., Robbins K., Tomalty D., Bosnjakovik P., Derner M., et al. Hepatic intra-arterial injection of drug-eluting bead, irinotecan (DEBIRI) in unresectable colorectal liver metastases refractory to systemic chemotherapy: results of multi-institutional study. Ann Surg Oncol 2011, 18:192-198.
    • (2011) Ann Surg Oncol , vol.18 , pp. 192-198
    • Martin, R.C.1    Joshi, J.2    Robbins, K.3    Tomalty, D.4    Bosnjakovik, P.5    Derner, M.6
  • 48
    • 65549152542 scopus 로고    scopus 로고
    • Bevacizumab plus FOLFIRI or FOLFOX as third-line or later treatment in patients with metastatic colorectal cancer after failure of 5-fluorouracil, irinotecan, and oxaliplatin: a retrospective analysis
    • Kang B.W., Kim T.W., Lee J.L., Ryu M.H., Chang H.M., Yu C.S., et al. Bevacizumab plus FOLFIRI or FOLFOX as third-line or later treatment in patients with metastatic colorectal cancer after failure of 5-fluorouracil, irinotecan, and oxaliplatin: a retrospective analysis. Med Oncol 2009, 26:32-37.
    • (2009) Med Oncol , vol.26 , pp. 32-37
    • Kang, B.W.1    Kim, T.W.2    Lee, J.L.3    Ryu, M.H.4    Chang, H.M.5    Yu, C.S.6
  • 49
    • 84873808521 scopus 로고    scopus 로고
    • Bevacizumab plus chemotherapy as salvage treatment in chemorefractory patients with metastatic colorectal cancer
    • Geva R., Vecchione L., Tejpar S., Piessevaux H., Van Cutsem E., Prenen H. Bevacizumab plus chemotherapy as salvage treatment in chemorefractory patients with metastatic colorectal cancer. Onco Targets Ther 2013, 6:53-58.
    • (2013) Onco Targets Ther , vol.6 , pp. 53-58
    • Geva, R.1    Vecchione, L.2    Tejpar, S.3    Piessevaux, H.4    Van Cutsem, E.5    Prenen, H.6
  • 50
    • 79953751240 scopus 로고    scopus 로고
    • Retrospective cohort study on the safety and efficacy of bevacizumab with chemotherapy for metastatic colorectal cancer patients: the HGCSG0801 study
    • Sogabe S., Komatsu Y., Yuki S., Kusumi T., Hatanaka K., Nakamura M., et al. Retrospective cohort study on the safety and efficacy of bevacizumab with chemotherapy for metastatic colorectal cancer patients: the HGCSG0801 study. Jpn J Clin Oncol 2011, 41:490-497.
    • (2011) Jpn J Clin Oncol , vol.41 , pp. 490-497
    • Sogabe, S.1    Komatsu, Y.2    Yuki, S.3    Kusumi, T.4    Hatanaka, K.5    Nakamura, M.6
  • 51
    • 84856409609 scopus 로고    scopus 로고
    • Capecitabine and bevacizumab in heavily pre-treated patients with advanced colorectal cancer
    • Larsen F.O., Boisen M.K., Fromm A.L., Jensen B.V. Capecitabine and bevacizumab in heavily pre-treated patients with advanced colorectal cancer. Acta Oncol 2012, 51:231-233.
    • (2012) Acta Oncol , vol.51 , pp. 231-233
    • Larsen, F.O.1    Boisen, M.K.2    Fromm, A.L.3    Jensen, B.V.4
  • 52
    • 33746833739 scopus 로고    scopus 로고
    • Phase II multicenter trial of bevacizumab plus fluorouracil and leucovorin in patients with advanced refractory colorectal cancer: an NCI Treatment Referral Center Trial TRC-0301
    • Chen H.X., Mooney M., Boron M., Vena D., Mosby K., Grochow L., et al. Phase II multicenter trial of bevacizumab plus fluorouracil and leucovorin in patients with advanced refractory colorectal cancer: an NCI Treatment Referral Center Trial TRC-0301. J Clin Oncol 2006, 24:3354-3360.
    • (2006) J Clin Oncol , vol.24 , pp. 3354-3360
    • Chen, H.X.1    Mooney, M.2    Boron, M.3    Vena, D.4    Mosby, K.5    Grochow, L.6
  • 53
    • 70350103864 scopus 로고    scopus 로고
    • Bevacizumab in association with de Gramont 5-fluorouracil/folinic acid in patients with oxaliplatin-, irinotecan-, and cetuximab-refractory colorectal cancer: a single-center phase 2 trial
    • Vincenzi B., Santini D., Russo A., Spoto C., Venditti O., Gasparro S., et al. Bevacizumab in association with de Gramont 5-fluorouracil/folinic acid in patients with oxaliplatin-, irinotecan-, and cetuximab-refractory colorectal cancer: a single-center phase 2 trial. Cancer 2009, 115:4849-4856.
    • (2009) Cancer , vol.115 , pp. 4849-4856
    • Vincenzi, B.1    Santini, D.2    Russo, A.3    Spoto, C.4    Venditti, O.5    Gasparro, S.6
  • 54
    • 84899935144 scopus 로고    scopus 로고
    • A phase II study on third-line chemotherapy combined bevacizumab with S-1 for metastatic colorectal cancer with mutated KRAS: SAVIOR study
    • Takagane A., Miyake Y., Kobayashi K., Nagata N., Sato A., Ogata Y., et al. A phase II study on third-line chemotherapy combined bevacizumab with S-1 for metastatic colorectal cancer with mutated KRAS: SAVIOR study. ASCO Meet Abstr 2013, 31:552.
    • (2013) ASCO Meet Abstr , vol.31 , pp. 552
    • Takagane, A.1    Miyake, Y.2    Kobayashi, K.3    Nagata, N.4    Sato, A.5    Ogata, Y.6
  • 55
    • 84868527016 scopus 로고    scopus 로고
    • Phase II clinical and pharmacokinetic study of aflibercept in patients with previously treated metastatic colorectal cancer
    • Tang P.A., Cohen S.J., Kollmannsberger C., Bjarnason G., Virik K., MacKenzie M.J., et al. Phase II clinical and pharmacokinetic study of aflibercept in patients with previously treated metastatic colorectal cancer. Clin Cancer Res 2012, 18:6023-6031.
    • (2012) Clin Cancer Res , vol.18 , pp. 6023-6031
    • Tang, P.A.1    Cohen, S.J.2    Kollmannsberger, C.3    Bjarnason, G.4    Virik, K.5    MacKenzie, M.J.6
  • 56
    • 36048992408 scopus 로고    scopus 로고
    • Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy
    • Saltz L.B., Rosen L.S., Marshall J.L., Belt R.J., Hurwitz H.I., Eckhardt S.G., et al. Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy. J Clin Oncol 2007, 25:4793-4799.
    • (2007) J Clin Oncol , vol.25 , pp. 4793-4799
    • Saltz, L.B.1    Rosen, L.S.2    Marshall, J.L.3    Belt, R.J.4    Hurwitz, H.I.5    Eckhardt, S.G.6
  • 57
    • 84899927386 scopus 로고    scopus 로고
    • Phase II study of linifanib in KRAS mutated metastatic refractory colorectal cancer
    • Chan E., Ayers G.D., Goff L., McClanahan P., Holloway M., Ciomber K., et al. Phase II study of linifanib in KRAS mutated metastatic refractory colorectal cancer. Eur J Cancer 2013, 49:S549.
    • (2013) Eur J Cancer , vol.49
    • Chan, E.1    Ayers, G.D.2    Goff, L.3    McClanahan, P.4    Holloway, M.5    Ciomber, K.6
  • 58
    • 33644852628 scopus 로고    scopus 로고
    • The combination of capecitabine and thalidomide in previously treated, refractory metastatic colorectal cancer
    • McCollum A.D., Wu B., Clark J.W., Kulke M.H., Enzinger P.C., Ryan D.P., et al. The combination of capecitabine and thalidomide in previously treated, refractory metastatic colorectal cancer. Am J Clin Oncol 2006, 29:40-44.
    • (2006) Am J Clin Oncol , vol.29 , pp. 40-44
    • McCollum, A.D.1    Wu, B.2    Clark, J.W.3    Kulke, M.H.4    Enzinger, P.C.5    Ryan, D.P.6
  • 60
    • 84876089340 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and irinotecan plus either sunitinib or placebo in metastatic colorectal cancer: a randomized Phase III Trial
    • Carrato A., Swieboda-Sadlej A., Staszewska-Skurczynska M., Lim R., Roman L., Shparyk Y., et al. Fluorouracil, leucovorin, and irinotecan plus either sunitinib or placebo in metastatic colorectal cancer: a randomized Phase III Trial. J Clin Oncol 2013, 31:1341-1347.
    • (2013) J Clin Oncol , vol.31 , pp. 1341-1347
    • Carrato, A.1    Swieboda-Sadlej, A.2    Staszewska-Skurczynska, M.3    Lim, R.4    Roman, L.5    Shparyk, Y.6
  • 61
    • 84859300222 scopus 로고    scopus 로고
    • A Japanese post-marketing surveillance of cetuximab (Erbitux(R)) in patients with metastatic colorectal cancer
    • Ishiguro M., Watanabe T., Yamaguchi K., Satoh T., Ito H., Seriu T., et al. A Japanese post-marketing surveillance of cetuximab (Erbitux(R)) in patients with metastatic colorectal cancer. Jpn J Clin Oncol 2012, 42:287-294.
    • (2012) Jpn J Clin Oncol , vol.42 , pp. 287-294
    • Ishiguro, M.1    Watanabe, T.2    Yamaguchi, K.3    Satoh, T.4    Ito, H.5    Seriu, T.6
  • 62
    • 33646143224 scopus 로고    scopus 로고
    • Efficacy and safety of cetuximab/irinotecan in chemotherapy-refractory metastatic colorectal adenocarcinomas: a clinical practice setting, multicenter experience
    • Gebbia V., Del Prete S., Borsellino N., Ferrau F., Tralongo P., Verderame F., et al. Efficacy and safety of cetuximab/irinotecan in chemotherapy-refractory metastatic colorectal adenocarcinomas: a clinical practice setting, multicenter experience. Clin Colorectal Cancer 2006, 5:422-428.
    • (2006) Clin Colorectal Cancer , vol.5 , pp. 422-428
    • Gebbia, V.1    Del Prete, S.2    Borsellino, N.3    Ferrau, F.4    Tralongo, P.5    Verderame, F.6
  • 63
    • 34249722420 scopus 로고    scopus 로고
    • Cetuximab and irinotecan as third line therapy in patients with advanced colorectal cancer after failure of irinotecan, oxaliplatin and 5-fluorouracil
    • Pfeiffer P., Nielsen D., Yilmaz M., Iversen A., Vejlo C., Jensen B.V. Cetuximab and irinotecan as third line therapy in patients with advanced colorectal cancer after failure of irinotecan, oxaliplatin and 5-fluorouracil. Acta Oncol 2007, 46:697-701.
    • (2007) Acta Oncol , vol.46 , pp. 697-701
    • Pfeiffer, P.1    Nielsen, D.2    Yilmaz, M.3    Iversen, A.4    Vejlo, C.5    Jensen, B.V.6
  • 64
    • 35649023295 scopus 로고    scopus 로고
    • Hepatic resection after rescue cetuximab treatment for colorectal liver metastases previously refractory to conventional systemic therapy
    • Adam R., Aloia T., Levi F., Wicherts D.A., de Haas R.J., Paule B., et al. Hepatic resection after rescue cetuximab treatment for colorectal liver metastases previously refractory to conventional systemic therapy. J Clin Oncol 2007, 25:4593-4602.
    • (2007) J Clin Oncol , vol.25 , pp. 4593-4602
    • Adam, R.1    Aloia, T.2    Levi, F.3    Wicherts, D.A.4    de Haas, R.J.5    Paule, B.6
  • 65
    • 44849083804 scopus 로고    scopus 로고
    • Biweekly cetuximab and irinotecan as third-line therapy in patients with advanced colorectal cancer after failure to irinotecan, oxaliplatin and 5-fluorouracil
    • Pfeiffer P., Nielsen D., Bjerregaard J., Qvortrup C., Yilmaz M., Jensen B. Biweekly cetuximab and irinotecan as third-line therapy in patients with advanced colorectal cancer after failure to irinotecan, oxaliplatin and 5-fluorouracil. Ann Oncol 2008, 19:1141-1145.
    • (2008) Ann Oncol , vol.19 , pp. 1141-1145
    • Pfeiffer, P.1    Nielsen, D.2    Bjerregaard, J.3    Qvortrup, C.4    Yilmaz, M.5    Jensen, B.6
  • 66
    • 84655164982 scopus 로고    scopus 로고
    • Feasibility of cetuximab given with a simplified schedule every 2 weeks in advanced colorectal cancer: a multicenter, retrospective analysis
    • Bouchahda M., Macarulla T., Liedo G., Levi F., Elez M.E., Paule B., et al. Feasibility of cetuximab given with a simplified schedule every 2 weeks in advanced colorectal cancer: a multicenter, retrospective analysis. Med Oncol 2011, 28(Suppl 1):S253-S258.
    • (2011) Med Oncol , vol.28 , Issue.SUPPL 1
    • Bouchahda, M.1    Macarulla, T.2    Liedo, G.3    Levi, F.4    Elez, M.E.5    Paule, B.6
  • 67
    • 79953782046 scopus 로고    scopus 로고
    • Cetuximab and circadian chronomodulated chemotherapy as salvage treatment for metastatic colorectal cancer (mCRC): safety, efficacy and improved secondary surgical resectability
    • Levi F., Karaboue A., Gorden L., Innominato P.F., Saffroy R., Giacchetti S., et al. Cetuximab and circadian chronomodulated chemotherapy as salvage treatment for metastatic colorectal cancer (mCRC): safety, efficacy and improved secondary surgical resectability. Cancer Chemother Pharmacol 2011, 67:339-348.
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 339-348
    • Levi, F.1    Karaboue, A.2    Gorden, L.3    Innominato, P.F.4    Saffroy, R.5    Giacchetti, S.6
  • 68
    • 84899926565 scopus 로고    scopus 로고
    • Cetuximab beyond progression in KRAS wild-type metastatic colorectal cancer
    • Lam K., Lee V., Choi C., Sze H., Kwok R., Shum B., et al. Cetuximab beyond progression in KRAS wild-type metastatic colorectal cancer. Ann Oncol 2013, 24:iv108.
    • (2013) Ann Oncol , vol.24
    • Lam, K.1    Lee, V.2    Choi, C.3    Sze, H.4    Kwok, R.5    Shum, B.6
  • 69
    • 78651081207 scopus 로고    scopus 로고
    • Safety and efficacy of panitumumab therapy after progression with cetuximab: experience at two institutions
    • Saif M.W., Kaley K., Chu E., Copur M.S. Safety and efficacy of panitumumab therapy after progression with cetuximab: experience at two institutions. Clin Colorectal Cancer 2010, 9:315-318.
    • (2010) Clin Colorectal Cancer , vol.9 , pp. 315-318
    • Saif, M.W.1    Kaley, K.2    Chu, E.3    Copur, M.S.4
  • 70
    • 77952239903 scopus 로고    scopus 로고
    • Safety and efficacy of panitumumab following cetuximab: retrospective review of the Memorial Sloan-Kettering experience
    • Power D.G., Shah M.A., Asmis T.R., Garcia J.J., Kemeny N.E. Safety and efficacy of panitumumab following cetuximab: retrospective review of the Memorial Sloan-Kettering experience. Invest New Drugs 2010, 28:353-360.
    • (2010) Invest New Drugs , vol.28 , pp. 353-360
    • Power, D.G.1    Shah, M.A.2    Asmis, T.R.3    Garcia, J.J.4    Kemeny, N.E.5
  • 71
    • 84874409955 scopus 로고    scopus 로고
    • Safety and efficacy of panitumumab therapy after metastatic colorectal cancer progression with cetuximab: experience at a single Japanese institution
    • Sonoda H., Mekata E., Shimizu T., Endo Y., Tani T. Safety and efficacy of panitumumab therapy after metastatic colorectal cancer progression with cetuximab: experience at a single Japanese institution. Oncol Lett 2013, 5:1331-1334.
    • (2013) Oncol Lett , vol.5 , pp. 1331-1334
    • Sonoda, H.1    Mekata, E.2    Shimizu, T.3    Endo, Y.4    Tani, T.5
  • 72
    • 84899978013 scopus 로고    scopus 로고
    • Retrospective cohort study on the safety and efficacy of panitumumab for patients with metastatic colorectal cancer: the HGCSG1002 study-analysis of after cetuximab refractory
    • Kobayashi Y., Fukushima H., Sasaki T., Yuki S., Okuda H., Kusumi T., et al. Retrospective cohort study on the safety and efficacy of panitumumab for patients with metastatic colorectal cancer: the HGCSG1002 study-analysis of after cetuximab refractory. ASCO Meet Abstr 2013, 31:541.
    • (2013) ASCO Meet Abstr , vol.31 , pp. 541
    • Kobayashi, Y.1    Fukushima, H.2    Sasaki, T.3    Yuki, S.4    Okuda, H.5    Kusumi, T.6
  • 73
    • 84899916546 scopus 로고    scopus 로고
    • Does panitumumab have a clinical benefit in cetuximab-refractory KRAS wild-type metastatic colorectal cancer?
    • Watanabe T., Shinozaki E., Kijima S., Ohhara Y., Kuboki Y., Takagi K., et al. Does panitumumab have a clinical benefit in cetuximab-refractory KRAS wild-type metastatic colorectal cancer?. ASCO Meet Abstr 2012, 30:654.
    • (2012) ASCO Meet Abstr , vol.30 , pp. 654
    • Watanabe, T.1    Shinozaki, E.2    Kijima, S.3    Ohhara, Y.4    Kuboki, Y.5    Takagi, K.6
  • 74
    • 84984675875 scopus 로고    scopus 로고
    • PANERB study: which category of patients, suffering from metastatic colorectal cancer, can benefit from panitumumab treatment after cetuximab-based regimen failure?
    • Metges J., Ramée J., Dupuis O., Deguiral P., Boucher E., Cojocarasu O., et al. PANERB study: which category of patients, suffering from metastatic colorectal cancer, can benefit from panitumumab treatment after cetuximab-based regimen failure?. Ann Oncol 2012, 23:ix196.
    • (2012) Ann Oncol , vol.23
    • Metges, J.1    Ramée, J.2    Dupuis, O.3    Deguiral, P.4    Boucher, E.5    Cojocarasu, O.6
  • 75
    • 56749182272 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan in heavily pretreated metastatic colorectal cancer progressing on irinotecan: MABEL Study
    • Wilke H., Glynne-Jones R., Thaler J., Adenis A., Preusser P., Aguilar E.A., et al. Cetuximab plus irinotecan in heavily pretreated metastatic colorectal cancer progressing on irinotecan: MABEL Study. J Clin Oncol 2008, 26:5335-5343.
    • (2008) J Clin Oncol , vol.26 , pp. 5335-5343
    • Wilke, H.1    Glynne-Jones, R.2    Thaler, J.3    Adenis, A.4    Preusser, P.5    Aguilar, E.A.6
  • 76
    • 79953121335 scopus 로고    scopus 로고
    • EGFR related mutational status and association to clinical outcome of third-line cetuximab-irinotecan in metastatic colorectal cancer
    • Spindler K.L., Pallisgaard N., Lindebjerg J., Frifeldt S.K., Jakobsen A. EGFR related mutational status and association to clinical outcome of third-line cetuximab-irinotecan in metastatic colorectal cancer. BMC Cancer 2011, 11:107.
    • (2011) BMC Cancer , vol.11 , pp. 107
    • Spindler, K.L.1    Pallisgaard, N.2    Lindebjerg, J.3    Frifeldt, S.K.4    Jakobsen, A.5
  • 77
    • 77952253032 scopus 로고    scopus 로고
    • Cetuximab given every 2 weeks plus irinotecan is an active and safe option for previously treated patients with metastatic colorectal cancer
    • Roca J.M., Alonso V., Pericay C., Escudero P., Salud A., Losa F., et al. Cetuximab given every 2 weeks plus irinotecan is an active and safe option for previously treated patients with metastatic colorectal cancer. Chemotherapy 2010, 56:142-146.
    • (2010) Chemotherapy , vol.56 , pp. 142-146
    • Roca, J.M.1    Alonso, V.2    Pericay, C.3    Escudero, P.4    Salud, A.5    Losa, F.6
  • 78
    • 33750615769 scopus 로고    scopus 로고
    • Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines
    • Lenz H.J., Van Cutsem E., Khambata-Ford S., Mayer R.J., Gold P., Stella P., et al. Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines. J Clin Oncol 2006, 24:4914-4921.
    • (2006) J Clin Oncol , vol.24 , pp. 4914-4921
    • Lenz, H.J.1    Van Cutsem, E.2    Khambata-Ford, S.3    Mayer, R.J.4    Gold, P.5    Stella, P.6
  • 79
    • 49149097899 scopus 로고    scopus 로고
    • A phase II study of cetuximab/irinotecan in patients with heavily pretreated metastatic colorectal cancer: predictive value of early specific toxicities
    • Gamucci T., Nelli F., Cianci G., Grassi G., Moscetti L., Sperduti I., et al. A phase II study of cetuximab/irinotecan in patients with heavily pretreated metastatic colorectal cancer: predictive value of early specific toxicities. Clin Colorectal Cancer 2008, 7:273-279.
    • (2008) Clin Colorectal Cancer , vol.7 , pp. 273-279
    • Gamucci, T.1    Nelli, F.2    Cianci, G.3    Grassi, G.4    Moscetti, L.5    Sperduti, I.6
  • 80
    • 84882753525 scopus 로고    scopus 로고
    • Cetuximab every second week with irinotecan in patients with metastatic colorectal cancer refractory to 5-FU, oxaliplatin, and irinotecan: KRAS mutation status and efficacy
    • Jensen B.V., Schou J.V., Johannesen H.H., Christensen I.J., Nielsen D., Johansen J.S., et al. Cetuximab every second week with irinotecan in patients with metastatic colorectal cancer refractory to 5-FU, oxaliplatin, and irinotecan: KRAS mutation status and efficacy. ASCO Meet Abstr 2010, 28:3573.
    • (2010) ASCO Meet Abstr , vol.28 , pp. 3573
    • Jensen, B.V.1    Schou, J.V.2    Johannesen, H.H.3    Christensen, I.J.4    Nielsen, D.5    Johansen, J.S.6
  • 81
    • 84865553918 scopus 로고    scopus 로고
    • Cetuximab rechallenge in metastatic colorectal cancer patients: how to come away from acquired resistance?
    • Santini D., Vincenzi B., Addeo R., Garufi C., Masi G., Scartozzi M., et al. Cetuximab rechallenge in metastatic colorectal cancer patients: how to come away from acquired resistance?. Ann Oncol 2012, 23:2313-2318.
    • (2012) Ann Oncol , vol.23 , pp. 2313-2318
    • Santini, D.1    Vincenzi, B.2    Addeo, R.3    Garufi, C.4    Masi, G.5    Scartozzi, M.6
  • 82
    • 84865092896 scopus 로고    scopus 로고
    • Intrapatient cetuximab dose escalation in metastatic colorectal cancer according to the grade of early skin reactions: the randomized EVEREST study
    • Van Cutsem E., Tejpar S., Vanbeckevoort D., Peeters M., Humblet Y., Gelderblom H., et al. Intrapatient cetuximab dose escalation in metastatic colorectal cancer according to the grade of early skin reactions: the randomized EVEREST study. J Clin Oncol 2012, 30:2861-2868.
    • (2012) J Clin Oncol , vol.30 , pp. 2861-2868
    • Van Cutsem, E.1    Tejpar, S.2    Vanbeckevoort, D.3    Peeters, M.4    Humblet, Y.5    Gelderblom, H.6
  • 83
    • 38049044037 scopus 로고    scopus 로고
    • An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy
    • Van Cutsem E., Siena S., Humblet Y., Canon J.L., Maurel J., Bajetta E., et al. An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy. Ann Oncol 2008, 19:92-98.
    • (2008) Ann Oncol , vol.19 , pp. 92-98
    • Van Cutsem, E.1    Siena, S.2    Humblet, Y.3    Canon, J.L.4    Maurel, J.5    Bajetta, E.6
  • 84
    • 34548147248 scopus 로고    scopus 로고
    • Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer
    • Hecht J.R., Patnaik A., Berlin J., Venook A., Malik I., Tchekmedyian S., et al. Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer. Cancer 2007, 110:980-988.
    • (2007) Cancer , vol.110 , pp. 980-988
    • Hecht, J.R.1    Patnaik, A.2    Berlin, J.3    Venook, A.4    Malik, I.5    Tchekmedyian, S.6
  • 85
    • 84856239290 scopus 로고    scopus 로고
    • Panitumumab in patients with KRAS wild-type colorectal cancer after progression on cetuximab
    • Wadlow R.C., Hezel A.F., Abrams T.A., Blaszkowsky L.S., Fuchs C.S., Kulke M.H., et al. Panitumumab in patients with KRAS wild-type colorectal cancer after progression on cetuximab. Oncologist 2012, 17:14.
    • (2012) Oncologist , vol.17 , pp. 14
    • Wadlow, R.C.1    Hezel, A.F.2    Abrams, T.A.3    Blaszkowsky, L.S.4    Fuchs, C.S.5    Kulke, M.H.6
  • 86
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D., Humblet Y., Siena S., Khayat D., Bleiberg H., Santoro A., et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004, 351:337-345.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3    Khayat, D.4    Bleiberg, H.5    Santoro, A.6
  • 87
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • Van Cutsem E., Peeters M., Siena S., Humblet Y., Hendlisz A., Neyns B., et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007, 25:1658-1664.
    • (2007) J Clin Oncol , vol.25 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3    Humblet, Y.4    Hendlisz, A.5    Neyns, B.6
  • 88
    • 52749099497 scopus 로고    scopus 로고
    • Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
    • Linardou H., Dahabreh I.J., Kanaloupiti D., Siannis F., Bafaloukos D., Kosmidis P., et al. Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol 2008, 9:962-972.
    • (2008) Lancet Oncol , vol.9 , pp. 962-972
    • Linardou, H.1    Dahabreh, I.J.2    Kanaloupiti, D.3    Siannis, F.4    Bafaloukos, D.5    Kosmidis, P.6
  • 89
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
    • De Roock W., Claes B., Bernasconi D., De Schutter J., Biesmans B., Fountzilas G., et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010, 11:753-762.
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3    De Schutter, J.4    Biesmans, B.5    Fountzilas, G.6
  • 90
    • 84903183416 scopus 로고    scopus 로고
    • Effect of KRAS and NRAS mutations on treatment outcomes in patients with metastatic colorectal cancer (mCRC) treated first-line with cetuximab plus FOLFOX4: New results from the OPUS study
    • LBA444
    • Tejpar S., Lenz H.-J., Kohne C.-H., Heinemann V., Ciardiello F., Esser R., et al. Effect of KRAS and NRAS mutations on treatment outcomes in patients with metastatic colorectal cancer (mCRC) treated first-line with cetuximab plus FOLFOX4: New results from the OPUS study. ASCO Meet Abstr 2014, 32:LBA444.
    • (2014) ASCO Meet Abstr , vol.32
    • Tejpar, S.1    Lenz, H.-J.2    Kohne, C.-H.3    Heinemann, V.4    Ciardiello, F.5    Esser, R.6
  • 92
    • 64649092674 scopus 로고    scopus 로고
    • Health-related quality of life in patients with advanced colorectal cancer treated with cetuximab: overall and KRAS-specific results of the NCIC CTG and AGITG CO.17 trial
    • Au H.J., Karapetis C.S., O'Callaghan C.J., Tu D., Moore M.J., Zalcberg J.R., et al. Health-related quality of life in patients with advanced colorectal cancer treated with cetuximab: overall and KRAS-specific results of the NCIC CTG and AGITG CO.17 trial. J Clin Oncol 2009, 27:1822-1828.
    • (2009) J Clin Oncol , vol.27 , pp. 1822-1828
    • Au, H.J.1    Karapetis, C.S.2    O'Callaghan, C.J.3    Tu, D.4    Moore, M.J.5    Zalcberg, J.R.6
  • 93
    • 84883550748 scopus 로고    scopus 로고
    • Cardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: a systematic review of incidence, manifestations and predisposing factors
    • Polk A., Vaage-Nilsen M., Vistisen K., Nielsen D.L. Cardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: a systematic review of incidence, manifestations and predisposing factors. Cancer Treat Rev 2013, 39:974-984.
    • (2013) Cancer Treat Rev , vol.39 , pp. 974-984
    • Polk, A.1    Vaage-Nilsen, M.2    Vistisen, K.3    Nielsen, D.L.4
  • 94
    • 40349087139 scopus 로고    scopus 로고
    • Administration of cetuximab every 2 weeks in the treatment of metastatic colorectal cancer: an effective, more convenient alternative to weekly administration?
    • Tabernero J., Pfeiffer P., Cervantes A. Administration of cetuximab every 2 weeks in the treatment of metastatic colorectal cancer: an effective, more convenient alternative to weekly administration?. Oncologist 2008, 13:113-119.
    • (2008) Oncologist , vol.13 , pp. 113-119
    • Tabernero, J.1    Pfeiffer, P.2    Cervantes, A.3
  • 95
    • 84882798781 scopus 로고    scopus 로고
    • FOLFOX4 plus cetuximab administered weekly or every second week in the first-line treatment of patients with KRAS wild-type metastatic colorectal cancer: a randomized phase II CECOG study
    • Brodowicz T., Ciuleanu T.E., Radosavljevic D., Shacham-Shmueli E., Vrbanec D., Plate S., et al. FOLFOX4 plus cetuximab administered weekly or every second week in the first-line treatment of patients with KRAS wild-type metastatic colorectal cancer: a randomized phase II CECOG study. Ann Oncol 2013, 24:1769-1777.
    • (2013) Ann Oncol , vol.24 , pp. 1769-1777
    • Brodowicz, T.1    Ciuleanu, T.E.2    Radosavljevic, D.3    Shacham-Shmueli, E.4    Vrbanec, D.5    Plate, S.6
  • 96
    • 84873817509 scopus 로고    scopus 로고
    • Panitumumab combined with irinotecan for patients with KRAS wild-type metastatic colorectal cancer refractory to standard chemotherapy: a GERCOR efficacy, tolerance, and translational molecular study
    • Andre T., Blons H., Mabro M., Chibaudel B., Bachet J.B., Tournigand C., et al. Panitumumab combined with irinotecan for patients with KRAS wild-type metastatic colorectal cancer refractory to standard chemotherapy: a GERCOR efficacy, tolerance, and translational molecular study. Ann Oncol 2013, 24:412-419.
    • (2013) Ann Oncol , vol.24 , pp. 412-419
    • Andre, T.1    Blons, H.2    Mabro, M.3    Chibaudel, B.4    Bachet, J.B.5    Tournigand, C.6
  • 97
    • 84856717005 scopus 로고    scopus 로고
    • Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer
    • Montagut C., Dalmases A., Bellosillo B., Crespo M., Pairet S., Iglesias M., et al. Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer. Nat Med 2012, 18:221-223.
    • (2012) Nat Med , vol.18 , pp. 221-223
    • Montagut, C.1    Dalmases, A.2    Bellosillo, B.3    Crespo, M.4    Pairet, S.5    Iglesias, M.6
  • 98
    • 84862330247 scopus 로고    scopus 로고
    • Factors associated with the loss of response to infliximab in patients with Crohn's disease
    • Sono K., Yamada A., Yoshimatsu Y., Takada N., Suzuki Y. Factors associated with the loss of response to infliximab in patients with Crohn's disease. Cytokine 2012, 59:410-416.
    • (2012) Cytokine , vol.59 , pp. 410-416
    • Sono, K.1    Yamada, A.2    Yoshimatsu, Y.3    Takada, N.4    Suzuki, Y.5
  • 99
    • 79955632360 scopus 로고    scopus 로고
    • Bevacizumab in combination with cetuximab and irinotecan after failure of cetuximab and irinotecan in patients with metastatic colorectal cancer
    • Larsen F.O., Pfeiffer P., Nielsen D., Skougaard K., Qvortrup C., Vistisen K., et al. Bevacizumab in combination with cetuximab and irinotecan after failure of cetuximab and irinotecan in patients with metastatic colorectal cancer. Acta Oncol 2011, 50:574-577.
    • (2011) Acta Oncol , vol.50 , pp. 574-577
    • Larsen, F.O.1    Pfeiffer, P.2    Nielsen, D.3    Skougaard, K.4    Qvortrup, C.5    Vistisen, K.6
  • 100
    • 77954513403 scopus 로고    scopus 로고
    • Addition of sunitinib to cetuximab and irinotecan in patients with heavily pre-treated advanced colorectal cancer
    • Qvortrup C., Jensen B.V., Jorgensen T.L., Nielsen D., Bjerregaard J.K., Pfeiffer P. Addition of sunitinib to cetuximab and irinotecan in patients with heavily pre-treated advanced colorectal cancer. Acta Oncol 2010, 49:833-836.
    • (2010) Acta Oncol , vol.49 , pp. 833-836
    • Qvortrup, C.1    Jensen, B.V.2    Jorgensen, T.L.3    Nielsen, D.4    Bjerregaard, J.K.5    Pfeiffer, P.6
  • 101
    • 84862987061 scopus 로고    scopus 로고
    • Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer
    • Weickhardt A.J., Price T.J., Chong G., Gebski V., Pavlakis N., Johns T.G., et al. Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer. J Clin Oncol 2012, 30:1505-1512.
    • (2012) J Clin Oncol , vol.30 , pp. 1505-1512
    • Weickhardt, A.J.1    Price, T.J.2    Chong, G.3    Gebski, V.4    Pavlakis, N.5    Johns, T.G.6
  • 102
    • 80052197143 scopus 로고    scopus 로고
    • A phase II trial of bevacizumab plus everolimus for patients with refractory metastatic colorectal cancer
    • Altomare I., Bendell J.C., Bullock K.E., Uronis H.E., Morse M.A., Hsu S.D., et al. A phase II trial of bevacizumab plus everolimus for patients with refractory metastatic colorectal cancer. Oncologist 2011, 16:1131-1137.
    • (2011) Oncologist , vol.16 , pp. 1131-1137
    • Altomare, I.1    Bendell, J.C.2    Bullock, K.E.3    Uronis, H.E.4    Morse, M.A.5    Hsu, S.D.6
  • 103
    • 84877064638 scopus 로고    scopus 로고
    • Multicenter Phase II study of Tivozanib (AV-951) and Everolimus (RAD001) for patients with refractory, metastatic colorectal cancer
    • Wolpin B.M., Ng K., Zhu A.X., Abrams T., Enzinger P.C., McCleary N.J., et al. Multicenter Phase II study of Tivozanib (AV-951) and Everolimus (RAD001) for patients with refractory, metastatic colorectal cancer. Oncologist 2013, 18:377-378.
    • (2013) Oncologist , vol.18 , pp. 377-378
    • Wolpin, B.M.1    Ng, K.2    Zhu, A.X.3    Abrams, T.4    Enzinger, P.C.5    McCleary, N.J.6
  • 104
    • 35648941728 scopus 로고    scopus 로고
    • Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study
    • Saltz L.B., Lenz H.J., Kindler H.L., Hochster H.S., Wadler S., Hoff P.M., et al. Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study. J Clin Oncol 2007, 25:4557-4561.
    • (2007) J Clin Oncol , vol.25 , pp. 4557-4561
    • Saltz, L.B.1    Lenz, H.J.2    Kindler, H.L.3    Hochster, H.S.4    Wadler, S.5    Hoff, P.M.6
  • 105
    • 84883074556 scopus 로고    scopus 로고
    • Phase III randomized, placebo-controlled study of cetuximab plus brivanib alaninate versus cetuximab plus placebo in patients with metastatic, chemotherapy-refractory, wild-type K-RAS colorectal carcinoma: the NCIC clinical trials group and AGITG CO.20 trial
    • Siu L.L., Shapiro J.D., Jonker D.J., Karapetis C.S., Zalcberg J.R., Simes J., et al. Phase III randomized, placebo-controlled study of cetuximab plus brivanib alaninate versus cetuximab plus placebo in patients with metastatic, chemotherapy-refractory, wild-type K-RAS colorectal carcinoma: the NCIC clinical trials group and AGITG CO.20 trial. J Clin Oncol 2013, 31:2477-2484.
    • (2013) J Clin Oncol , vol.31 , pp. 2477-2484
    • Siu, L.L.1    Shapiro, J.D.2    Jonker, D.J.3    Karapetis, C.S.4    Zalcberg, J.R.5    Simes, J.6
  • 107
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht J.R., Mitchell E., Chidiac T., Scroggin C., Hagenstad C., Spigel D., et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 2009, 27:672-680.
    • (2009) J Clin Oncol , vol.27 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3    Scroggin, C.4    Hagenstad, C.5    Spigel, D.6
  • 108
    • 84866143308 scopus 로고    scopus 로고
    • Phase III randomized trial of cetuximab (CET) plus either brivanib alaninate (BRIV) or placebo in patients (pts) with metastatic (MET) chemotherapy refractory K-RAS wild-type (WT) colorectal carcinoma (CRC): The NCIC clinical trials group and AGITG CO.20 trial
    • Siu L.L., Shapiro J.D., Jonker D.J., Karapetis C.S., Zalcberg J.R., Simes J., et al. Phase III randomized trial of cetuximab (CET) plus either brivanib alaninate (BRIV) or placebo in patients (pts) with metastatic (MET) chemotherapy refractory K-RAS wild-type (WT) colorectal carcinoma (CRC): The NCIC clinical trials group and AGITG CO.20 trial. ASCO Meet Abstr 2012, 30:386.
    • (2012) ASCO Meet Abstr , vol.30 , pp. 386
    • Siu, L.L.1    Shapiro, J.D.2    Jonker, D.J.3    Karapetis, C.S.4    Zalcberg, J.R.5    Simes, J.6
  • 110
    • 84877350259 scopus 로고    scopus 로고
    • Phase II trial of temsirolimus alone and in combination with irinotecan for KRAS mutant metastatic colorectal cancer: outcome and results of KRAS mutational analysis in plasma
    • Spindler K.L., Sorensen M.M., Pallisgaard N., Andersen R.F., Havelund B.M., Ploen J., et al. Phase II trial of temsirolimus alone and in combination with irinotecan for KRAS mutant metastatic colorectal cancer: outcome and results of KRAS mutational analysis in plasma. Acta Oncol 2013, 52:963-970.
    • (2013) Acta Oncol , vol.52 , pp. 963-970
    • Spindler, K.L.1    Sorensen, M.M.2    Pallisgaard, N.3    Andersen, R.F.4    Havelund, B.M.5    Ploen, J.6
  • 111
    • 84880924013 scopus 로고    scopus 로고
    • Phase II trial of panobinostat (LBH589) in patients (pts) with refractory metastatic colorectal cancer (MCRC)
    • Gold P.J., Smith D.A., Iriarte D., Boatman B., Kaplan H.G. Phase II trial of panobinostat (LBH589) in patients (pts) with refractory metastatic colorectal cancer (MCRC). ASCO Meet Abstr 2012, 30:582.
    • (2012) ASCO Meet Abstr , vol.30 , pp. 582
    • Gold, P.J.1    Smith, D.A.2    Iriarte, D.3    Boatman, B.4    Kaplan, H.G.5
  • 113
    • 81755172138 scopus 로고    scopus 로고
    • Randomized placebo-controlled phase II trial of perifosine plus capecitabine as second- or third-line therapy in patients with metastatic colorectal cancer
    • Bendell J.C., Nemunaitis J., Vukelja S.J., Hagenstad C., Campos L.T., Hermann R.C., et al. Randomized placebo-controlled phase II trial of perifosine plus capecitabine as second- or third-line therapy in patients with metastatic colorectal cancer. J Clin Oncol 2011, 29:4394-4400.
    • (2011) J Clin Oncol , vol.29 , pp. 4394-4400
    • Bendell, J.C.1    Nemunaitis, J.2    Vukelja, S.J.3    Hagenstad, C.4    Campos, L.T.5    Hermann, R.C.6
  • 114
    • 84868691192 scopus 로고    scopus 로고
    • Results of the X-PECT study: A phase III randomized double-blind, placebo-controlled study of perifosine plus capecitabine (P-CAP) versus placebo plus capecitabine (CAP) in patients (pts) with refractory metastatic colorectal cancer (mCRC)
    • LBA3501
    • Bendell J.C., Ervin T.J., Senzer N.N., Richards D.A., Firdaus I., Lockhart A.C., et al. Results of the X-PECT study: A phase III randomized double-blind, placebo-controlled study of perifosine plus capecitabine (P-CAP) versus placebo plus capecitabine (CAP) in patients (pts) with refractory metastatic colorectal cancer (mCRC). ASCO Meet Abstr 2012, 30:LBA3501.
    • (2012) ASCO Meet Abstr , vol.30
    • Bendell, J.C.1    Ervin, T.J.2    Senzer, N.N.3    Richards, D.A.4    Firdaus, I.5    Lockhart, A.C.6
  • 115
    • 84873163534 scopus 로고    scopus 로고
    • Anticancer mechanisms and clinical application of alkylphospholipids
    • van Blitterswijk W.J., Verheij M. Anticancer mechanisms and clinical application of alkylphospholipids. Biochim Biophys Acta 2013, 1831:663-674.
    • (2013) Biochim Biophys Acta , vol.1831 , pp. 663-674
    • van Blitterswijk, W.J.1    Verheij, M.2
  • 116
    • 23844457178 scopus 로고    scopus 로고
    • Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo
    • Momota H., Nerio E., Holland E.C. Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res 2005, 65:7429-7435.
    • (2005) Cancer Res , vol.65 , pp. 7429-7435
    • Momota, H.1    Nerio, E.2    Holland, E.C.3
  • 117
    • 84883138328 scopus 로고    scopus 로고
    • FOLFIRI-Bevacizumab as first-line chemotherapy in 3500 patients with advanced colorectal cancer: a pooled analysis of 29 published trials
    • Petrelli F., Borgonovo K., Cabiddu M., Ghilardi M., Lonati V., Maspero F., et al. FOLFIRI-Bevacizumab as first-line chemotherapy in 3500 patients with advanced colorectal cancer: a pooled analysis of 29 published trials. Clin Colorectal Cancer 2013, 12:145-151.
    • (2013) Clin Colorectal Cancer , vol.12 , pp. 145-151
    • Petrelli, F.1    Borgonovo, K.2    Cabiddu, M.3    Ghilardi, M.4    Lonati, V.5    Maspero, F.6
  • 118
    • 84867122727 scopus 로고    scopus 로고
    • ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making
    • Schmoll H.J., Van Cutsem E., Stein A., Valentini V., Glimelius B., Haustermans K., et al. ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making. Ann Oncol 2012, 23:2479-2516.
    • (2012) Ann Oncol , vol.23 , pp. 2479-2516
    • Schmoll, H.J.1    Van Cutsem, E.2    Stein, A.3    Valentini, V.4    Glimelius, B.5    Haustermans, K.6
  • 119
    • 77954346705 scopus 로고    scopus 로고
    • Advanced colorectal cancer: ESMO clinical practice guidelines for treatment
    • Group EGW
    • Van Cutsem E., Nordlinger B., Cervantes A., Group EGW Advanced colorectal cancer: ESMO clinical practice guidelines for treatment. Ann Oncol 2010, 21(Suppl. 5):v93-v97.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 5
    • Van Cutsem, E.1    Nordlinger, B.2    Cervantes, A.3
  • 120
    • 2142703727 scopus 로고    scopus 로고
    • Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
    • Grothey A., Sargent D., Goldberg R.M., Schmoll H.J. Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 2004, 22:1209-1214.
    • (2004) J Clin Oncol , vol.22 , pp. 1209-1214
    • Grothey, A.1    Sargent, D.2    Goldberg, R.M.3    Schmoll, H.J.4
  • 122
    • 70549102293 scopus 로고    scopus 로고
    • Drug resistance associated with antiangiogenesis therapy
    • Eikesdal H.P., Kalluri R. Drug resistance associated with antiangiogenesis therapy. Semin Cancer Biol 2009, 19:310-317.
    • (2009) Semin Cancer Biol , vol.19 , pp. 310-317
    • Eikesdal, H.P.1    Kalluri, R.2
  • 123
    • 53749093040 scopus 로고    scopus 로고
    • Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100
    • Schneider B.P., Wang M., Radovich M., Sledge G.W., Badve S., Thor A., et al. Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. J Clin Oncol 2008, 26:4672-4678.
    • (2008) J Clin Oncol , vol.26 , pp. 4672-4678
    • Schneider, B.P.1    Wang, M.2    Radovich, M.3    Sledge, G.W.4    Badve, S.5    Thor, A.6
  • 124
    • 84875412193 scopus 로고    scopus 로고
    • Biomarker results from the AVADO phase 3 trial of first-line bevacizumab plus docetaxel for HER2-negative metastatic breast cancer
    • Miles D.W., de Haas S.L., Dirix L.Y., Romieu G., Chan A., Pivot X., et al. Biomarker results from the AVADO phase 3 trial of first-line bevacizumab plus docetaxel for HER2-negative metastatic breast cancer. Br J Cancer 2013, 108:1052-1060.
    • (2013) Br J Cancer , vol.108 , pp. 1052-1060
    • Miles, D.W.1    de Haas, S.L.2    Dirix, L.Y.3    Romieu, G.4    Chan, A.5    Pivot, X.6
  • 125
    • 84863897798 scopus 로고    scopus 로고
    • Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a biomarker evaluation from the AVAGAST randomized phase III trial
    • Van Cutsem E., de Haas S., Kang Y.K., Ohtsu A., Tebbutt N.C., Ming Xu, et al. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a biomarker evaluation from the AVAGAST randomized phase III trial. J Clin Oncol 2012, 30:2119-2127.
    • (2012) J Clin Oncol , vol.30 , pp. 2119-2127
    • Van Cutsem, E.1    de Haas, S.2    Kang, Y.K.3    Ohtsu, A.4    Tebbutt, N.C.5    Ming, X.6
  • 126
    • 84861656612 scopus 로고    scopus 로고
    • Does anti-EGFR therapy improve outcome in advanced colorectal cancer? A systematic review and meta-analysis
    • Vale C.L., Tierney J.F., Fisher D., Adams R.A., Kaplan R., Maughan T.S., et al. Does anti-EGFR therapy improve outcome in advanced colorectal cancer? A systematic review and meta-analysis. Cancer Treat Rev 2012, 38:618-625.
    • (2012) Cancer Treat Rev , vol.38 , pp. 618-625
    • Vale, C.L.1    Tierney, J.F.2    Fisher, D.3    Adams, R.A.4    Kaplan, R.5    Maughan, T.S.6
  • 127
  • 128
    • 84899972492 scopus 로고    scopus 로고
    • Panitumumab (Pmab) versus cetuximab (Cmab)/irinotecan (Iri) therapy among patients with KRAS wild-type (wt) metastatic colorectal cancer (MCRC)
    • Kennecke H.F., Chen L., Blanke C.D., Cheung W.Y., Schaff K., Speers C. Panitumumab (Pmab) versus cetuximab (Cmab)/irinotecan (Iri) therapy among patients with KRAS wild-type (wt) metastatic colorectal cancer (MCRC). ASCO Meet Abstr 2012, 30:640.
    • (2012) ASCO Meet Abstr , vol.30 , pp. 640
    • Kennecke, H.F.1    Chen, L.2    Blanke, C.D.3    Cheung, W.Y.4    Schaff, K.5    Speers, C.6
  • 129
    • 79959337678 scopus 로고    scopus 로고
    • Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial
    • Maughan T.S., Adams R.A., Smith C.G., Meade A.M., Seymour M.T., Wilson R.H., et al. Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet 2011, 377:2103-2114.
    • (2011) Lancet , vol.377 , pp. 2103-2114
    • Maughan, T.S.1    Adams, R.A.2    Smith, C.G.3    Meade, A.M.4    Seymour, M.T.5    Wilson, R.H.6
  • 130
    • 84899930660 scopus 로고    scopus 로고
    • First-line cetuximab with FOLFOX or FOLFIRI every 2 weeks in KRAS wild-type metastatic colorectal cancer: phase II APEC study
    • Cheng A.-L., Cornelio G., Shen L., Price T., Yang T.-S., Chung I.-J., et al. First-line cetuximab with FOLFOX or FOLFIRI every 2 weeks in KRAS wild-type metastatic colorectal cancer: phase II APEC study. Ann Oncol 2013, 24(Suppl. 4).
    • (2013) Ann Oncol , vol.24 , Issue.SUPPL. 4
    • Cheng, A.-L.1    Cornelio, G.2    Shen, L.3    Price, T.4    Yang, T.-S.5    Chung, I.-J.6
  • 131
    • 84861432557 scopus 로고    scopus 로고
    • Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: the NORDIC-VII study
    • Tveit K.M., Guren T., Glimelius B., Pfeiffer P., Sorbye H., Pyrhonen S., et al. Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: the NORDIC-VII study. J Clin Oncol 2012, 30:1755-1762.
    • (2012) J Clin Oncol , vol.30 , pp. 1755-1762
    • Tveit, K.M.1    Guren, T.2    Glimelius, B.3    Pfeiffer, P.4    Sorbye, H.5    Pyrhonen, S.6
  • 132
    • 84878794962 scopus 로고    scopus 로고
    • Role of targeted agents in metastatic colorectal cancer
    • Prenen H., Vecchione L., Van Cutsem E. Role of targeted agents in metastatic colorectal cancer. Target Oncol 2013, 8:83-96.
    • (2013) Target Oncol , vol.8 , pp. 83-96
    • Prenen, H.1    Vecchione, L.2    Van Cutsem, E.3
  • 133
    • 84883554603 scopus 로고    scopus 로고
    • Molecular markers to predict outcome to antiangiogenic therapies in colorectal cancer: Current evidence and future perspectives
    • Custodio A., Barriuso J., de Castro J., Martinez-Marin V., Moreno V., Rodriguez-Salas N., et al. Molecular markers to predict outcome to antiangiogenic therapies in colorectal cancer: Current evidence and future perspectives. Cancer Treat Rev 2013, 39:908-924.
    • (2013) Cancer Treat Rev , vol.39 , pp. 908-924
    • Custodio, A.1    Barriuso, J.2    de Castro, J.3    Martinez-Marin, V.4    Moreno, V.5    Rodriguez-Salas, N.6
  • 134
    • 84881543270 scopus 로고    scopus 로고
    • Promising biomarkers for predicting the outcomes of patients with KRAS wild-type metastatic colorectal cancer treated with anti-epidermal growth factor receptor monoclonal antibodies: A systematic review with meta-analysis
    • Yang Z.Y., Wu X.Y., Huang Y.F., Di M.Y., Zheng D.Y., Chen J.Z., et al. Promising biomarkers for predicting the outcomes of patients with KRAS wild-type metastatic colorectal cancer treated with anti-epidermal growth factor receptor monoclonal antibodies: A systematic review with meta-analysis. Int J Cancer 2013, 133:1914-1925.
    • (2013) Int J Cancer , vol.133 , pp. 1914-1925
    • Yang, Z.Y.1    Wu, X.Y.2    Huang, Y.F.3    Di, M.Y.4    Zheng, D.Y.5    Chen, J.Z.6
  • 135
    • 84862999938 scopus 로고    scopus 로고
    • Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
    • Misale S., Yaeger R., Hobor S., Scala E., Janakiraman M., Liska D., et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature 2012, 486:532-536.
    • (2012) Nature , vol.486 , pp. 532-536
    • Misale, S.1    Yaeger, R.2    Hobor, S.3    Scala, E.4    Janakiraman, M.5    Liska, D.6
  • 136
    • 84863000299 scopus 로고    scopus 로고
    • The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
    • Diaz L.A., Williams R.T., Wu J., Kinde I., Hecht J.R., Berlin J., et al. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 2012, 486:537-540.
    • (2012) Nature , vol.486 , pp. 537-540
    • Diaz, L.A.1    Williams, R.T.2    Wu, J.3    Kinde, I.4    Hecht, J.R.5    Berlin, J.6
  • 137
    • 84884343472 scopus 로고    scopus 로고
    • Proof-of-concept study of Sym004, an anti-EGFR monoclonal antibody (mAb) mixture, in patients (pts) with anti-EGFR mab-refractory KRAS wild-type (wt) metastatic colorectal cancer (mCRC)
    • Dienstmann R., Tabernero J., Van Cutsem E., Cervantes-Ruiperez A., Rosello Keranen S., Benavent Vinuales M., et al. Proof-of-concept study of Sym004, an anti-EGFR monoclonal antibody (mAb) mixture, in patients (pts) with anti-EGFR mab-refractory KRAS wild-type (wt) metastatic colorectal cancer (mCRC). ASCO Meet Abstr 2013, 31:3551.
    • (2013) ASCO Meet Abstr , vol.31 , pp. 3551
    • Dienstmann, R.1    Tabernero, J.2    Van Cutsem, E.3    Cervantes-Ruiperez, A.4    Rosello Keranen, S.5    Benavent Vinuales, M.6
  • 138
    • 84878794962 scopus 로고    scopus 로고
    • Role of targeted agents in metastatic colorectal cancer
    • Prenen H., Vecchione L., Van Cutsem E. Role of targeted agents in metastatic colorectal cancer. Target Oncol 2013, 8:83-96.
    • (2013) Target Oncol , vol.8 , pp. 83-96
    • Prenen, H.1    Vecchione, L.2    Van Cutsem, E.3
  • 139
    • 34249085905 scopus 로고    scopus 로고
    • Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria
    • Choi H., Charnsangavej C., Faria S.C., Macapinlac H.A., Burgess M.A., Patel S.R., et al. Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria. J Clin Oncol 2007, 25:1753-1759.
    • (2007) J Clin Oncol , vol.25 , pp. 1753-1759
    • Choi, H.1    Charnsangavej, C.2    Faria, S.C.3    Macapinlac, H.A.4    Burgess, M.A.5    Patel, S.R.6


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