메뉴 건너뛰기




Volumn 24, Issue 4, 2012, Pages 207-211

Uracil-tegafur/leucovorin and mitomycin C salvage therapy in patients with advanced colorectal cancer: A phase II study

Author keywords

Advanced colorectal cancer; Mitomycin C; Salvage; Third line chemotherapy; UFT

Indexed keywords

BEVACIZUMAB; CETUXIMAB; FLUOROPYRIMIDINE; FOLINIC ACID; IRINOTECAN; MITOMYCIN C; OXALIPLATIN; UFT;

EID: 84866248992     PISSN: 1120009X     EISSN: 19739478     Source Type: Journal    
DOI: 10.1179/1973947812Y.0000000021     Document Type: Article
Times cited : (6)

References (37)
  • 1
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
    • Douillard JY, Cunningham D, Roth AD, Navarro M, James RD, Karasek P, et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet. 2000;355(9209):1041-7.
    • (2000) Lancet , vol.355 , Issue.9209 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3    Navarro, M.4    James, R.D.5    Karasek, P.6
  • 2
    • 1842569206 scopus 로고    scopus 로고
    • A Randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • Goldberg RM, Sargent DJ, Morton RF, Fuchs CS, Ramanathan RK, Williamson SK, et al. A Randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 2004;22(1):23-30.
    • (2004) J Clin Oncol , vol.22 , Issue.1 , pp. 23-30
    • Goldberg, R.M.1    Sargent, D.J.2    Morton, R.F.3    Fuchs, C.S.4    Ramanathan, R.K.5    Williamson, S.K.6
  • 3
    • 0027461840 scopus 로고
    • Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer
    • Scheithauer W, Rosen H, Kornek GV, Sebesta C, Depisch D. Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer. Br Med J. 1993;306:752-6.
    • (1993) Br Med J , vol.306 , pp. 752-756
    • Scheithauer, W.1    Rosen, H.2    Kornek, G.V.3    Sebesta, C.4    Depisch, D.5
  • 4
    • 1342290189 scopus 로고    scopus 로고
    • FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
    • Tournigand C, André T, Achille E, Lledo G, Flesh M, Mery-Mignard D, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol. 2004;22(2):229-37.
    • (2004) J Clin Oncol , vol.22 , Issue.2 , pp. 229-237
    • Tournigand, C.1    André, T.2    Achille, E.3    Lledo, G.4    Flesh, M.5    Mery-Mignard, D.6
  • 5
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350(23):2335-42.
    • (2004) N Engl J Med , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 6
    • 81755172138 scopus 로고    scopus 로고
    • Randomized placebo-controlled phase II trial of perifosine plus capecitabine as second-or third-line therapy in patients with metastatic colorectal cancer
    • Bendell JC, Nemunaitis J, Vukelja SJ, Hagenstad C, Campos LT, Hermann RC, et al. Randomized placebo-controlled phase II trial of perifosine plus capecitabine as second-or third-line therapy in patients with metastatic colorectal cancer. J Clin Oncol. 2011;29(33):4394-400.
    • (2011) J Clin Oncol , vol.29 , Issue.33 , pp. 4394-4400
    • Bendell, J.C.1    Nemunaitis, J.2    Vukelja, S.J.3    Hagenstad, C.4    Campos, L.T.5    Hermann, R.C.6
  • 7
    • 84861057568 scopus 로고    scopus 로고
    • Results of a phase III randomized, double-blind, placebo-controlled, multicenter trial (CORRECT) of regorafe-nib plus best supportive care (BSC) versus placebo plus BSC in patients with metastatic colorectal cancer (mCRC) who have progressed after standard therapies
    • [Abstract (LBA385) 2012 Gastrointestinal Cancers Symposium]. 2012;30(Supplement nu4 (February 1 supplement))
    • Grothey A, Sobrero AF, Siena S, Falcone A, Ychou M, Lenz H-J, et al. Results of a phase III randomized, double-blind, placebo-controlled, multicenter trial (CORRECT) of regorafe-nib plus best supportive care (BSC) versus placebo plus BSC in patients with metastatic colorectal cancer (mCRC) who have progressed after standard therapies. J Clin Oncol. [Abstract (LBA385) 2012 Gastrointestinal Cancers Symposium]. 2012;30(Supplement nu4 (February 1 supplement)).
    • J Clin Oncol
    • Grothey, A.1    Sobrero, A.F.2    Siena, S.3    Falcone, A.4    Ychou, M.5    Lenz, H.-J.6
  • 9
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • van Cutsem E, Peeters M, Siena S, Humblet Y, Hendlisz A, Neyns B, et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol. 2007;25(13):1658-64.
    • (2007) J Clin Oncol , vol.25 , Issue.13 , pp. 1658-1664
    • van Cutsem, E.1    Peeters, M.2    Siena, S.3    Humblet, Y.4    Hendlisz, A.5    Neyns, B.6
  • 10
    • 33746587746 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor in colorectal cancer: Advances and controversies
    • Italiano A. Targeting the epidermal growth factor receptor in colorectal cancer: advances and controversies. Oncology. 2006;70:161-7.
    • (2006) Oncology , vol.70 , pp. 161-167
    • Italiano, A.1
  • 11
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado RG, Wolf M, Peeters M, van Cutsem E, Siena S, Freeman DJ, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol. 2008;26(10):1626-34.
    • (2008) J Clin Oncol , vol.26 , Issue.10 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3    van Cutsem, E.4    Siena, S.5    Freeman, D.J.6
  • 13
    • 64649092674 scopus 로고    scopus 로고
    • Health-related quality of life in patients with advanced colorectal cancer treated with cetuximab: Overall and KRAS-specific results of the NCIC CTG and AGITG CO.17 trial
    • Au H-J, Karapetis CS, O'Callaghan CJ, Tu D, Moore MJ, Zalcberg JR, et al. Health-related quality of life in patients with advanced colorectal cancer treated with cetuximab: overall and KRAS-specific results of the NCIC CTG and AGITG CO.17 trial. J Clin Oncol. 2009;27(11):1822-8.
    • (2009) J Clin Oncol , vol.27 , Issue.11 , pp. 1822-1828
    • Au, H.-J.1    Karapetis, C.S.2    O'Callaghan, C.J.3    Tu, D.4    Moore, M.J.5    Zalcberg, J.R.6
  • 14
    • 44249111440 scopus 로고    scopus 로고
    • EPIC: Phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
    • Sobrero AF, Maurel J, Fehrenbacher L, Scheithauer W, Abubakr YA, Lutz MP, et al. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J Clin Oncol. 2008;26(14):2311-9.
    • (2008) J Clin Oncol , vol.26 , Issue.14 , pp. 2311-2319
    • Sobrero, A.F.1    Maurel, J.2    Fehrenbacher, L.3    Scheithauer, W.4    Abubakr, Y.A.5    Lutz, M.P.6
  • 15
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • van Cutsem E, Kohne C-H, Hitre E, Zaluski J, Chang Chien CR, Makhson A, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med. 2009;360(14):1408-17.
    • (2009) N Engl J Med , vol.360 , Issue.14 , pp. 1408-1417
    • van Cutsem, E.1    Kohne, C.-H.2    Hitre, E.3    Zaluski, J.4    Chang, C.C.R.5    Makhson, A.6
  • 16
    • 79959337678 scopus 로고    scopus 로고
    • Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: Results of the randomised phase 3 MRC COIN trial
    • Maughan TS, Adams RA, Smith CG, Meade AM, Seymour MT, Wilson RH, et al. Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet. 2011;377(9783):2103-14.
    • (2011) Lancet , vol.377 , Issue.9783 , pp. 2103-2114
    • Maughan, T.S.1    Adams, R.A.2    Smith, C.G.3    Meade, A.M.4    Seymour, M.T.5    Wilson, R.H.6
  • 17
    • 84861432557 scopus 로고    scopus 로고
    • Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: The NORDIC-VII study
    • Tveit KM, Guren T, Glimelius B, Pfeiffer P, Sorbye H, Pyrhonen S, et al. Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: the NORDIC-VII study. J Clin Oncol. 2012;30(15):1755-62.
    • (2012) J Clin Oncol , vol.30 , Issue.15 , pp. 1755-1762
    • Tveit, K.M.1    Guren, T.2    Glimelius, B.3    Pfeiffer, P.4    Sorbye, H.5    Pyrhonen, S.6
  • 18
    • 0036159485 scopus 로고    scopus 로고
    • Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: A randomised crossover trial in advanced colorectal cancer
    • Borner MM, Schoffski P, de Wit R, Caponigro F, Comella G, Sulkes A, et al. Patient preference and pharmacokinetics of oral modulated UFT versus intravenous fluorouracil and leucovorin: a randomised crossover trial in advanced colorectal cancer. Eur J Cancer. 2002;38(3):349-58.
    • (2002) Eur J Cancer , vol.38 , Issue.3 , pp. 349-358
    • Borner, M.M.1    Schoffski, P.2    de Wit, R.3    Caponigro, F.4    Comella, G.5    Sulkes, A.6
  • 19
    • 0031691506 scopus 로고    scopus 로고
    • Comparison of 5-fluorouracil pharmacokinetics in patients receiving continuous 5-fluorouracil infusion and oral uracil plus N1-(2'-tetrahydrofuryl)-5-fluorouracil
    • Ho DH, Pazdur R, Covington W, Brown N, Huo YY, Lassere Y, et al. Comparison of 5-fluorouracil pharmacokinetics in patients receiving continuous 5-fluorouracil infusion and oral uracil plus N1-(2'-tetrahydrofuryl)-5-fluorouracil. Clin Cancer Res. 1998;4(9):2085-8.
    • (1998) Clin Cancer Res , vol.4 , Issue.9 , pp. 2085-2088
    • Ho, D.H.1    Pazdur, R.2    Covington, W.3    Brown, N.4    Huo, Y.Y.5    Lassere, Y.6
  • 20
    • 4344715339 scopus 로고    scopus 로고
    • Comparative pharmacology of oral fluoropyrimidines: A focus on pharmacokinetics, pharmacodynamics and pharmacomodulation
    • Milano G, Ferrero JM, Francois E. Comparative pharmacology of oral fluoropyrimidines: a focus on pharmacokinetics, pharmacodynamics and pharmacomodulation. Br J Cancer. 2004;91(4):613-7.
    • (2004) Br J Cancer , vol.91 , Issue.4 , pp. 613-617
    • Milano, G.1    Ferrero, J.M.2    Francois, E.3
  • 21
    • 0036727089 scopus 로고    scopus 로고
    • Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
    • Carmichael J, Popiela T, Radstone D, Falk S, Borner M, Oza A, et al. Randomized comparative study of tegafur/uracil and oral leucovorin versus parenteral fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 2002;20(17):3617-27.
    • (2002) J Clin Oncol , vol.20 , Issue.17 , pp. 3617-3627
    • Carmichael, J.1    Popiela, T.2    Radstone, D.3    Falk, S.4    Borner, M.5    Oza, A.6
  • 22
    • 0036731818 scopus 로고    scopus 로고
    • Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer
    • Douillard J-Y, Hoff PM, Skillings JR, Eisenberg P, Davidson N, Harper P, et al. Multicenter phase III study of uracil/tegafur and oral leucovorin versus fluorouracil and leucovorin in patients with previously untreated metastatic colorectal cancer. J Clin Oncol. 2002;20(17):3605-16.
    • (2002) J Clin Oncol , vol.20 , Issue.17 , pp. 3605-3616
    • Douillard, J.-Y.1    Hoff, P.M.2    Skillings, J.R.3    Eisenberg, P.4    Davidson, N.5    Harper, P.6
  • 23
    • 30644475407 scopus 로고    scopus 로고
    • A phase II study of oral uracil/ftorafur (UFT) plus leucovorin combined with oxaliplatin (TEGAFOX) as first-line treatment in patients with metastatic colorectal cancer
    • Bennouna J, Perrier H, Paillot B, Priou F, Jacob JH, Hebbar M, et al. A phase II study of oral uracil/ftorafur (UFT) plus leucovorin combined with oxaliplatin (TEGAFOX) as first-line treatment in patients with metastatic colorectal cancer. Br J Cancer. 2005;94(1):69-73.
    • (2005) Br J Cancer , vol.94 , Issue.1 , pp. 69-73
    • Bennouna, J.1    Perrier, H.2    Paillot, B.3    Priou, F.4    Jacob, J.H.5    Hebbar, M.6
  • 24
    • 34547589584 scopus 로고    scopus 로고
    • Phase II study of UFT with leucovorin and irinotecan (TEGAFIRI): First-line therapy for metastatic colorectal cancer
    • Delord JP, Bennouna J, Artru P, Perrier H, Husseini F, Desseigne F, et al. Phase II study of UFT with leucovorin and irinotecan (TEGAFIRI): first-line therapy for metastatic colorectal cancer. Br J Cancer. 2007;97(3):297-301.
    • (2007) Br J Cancer , vol.97 , Issue.3 , pp. 297-301
    • Delord, J.P.1    Bennouna, J.2    Artru, P.3    Perrier, H.4    Husseini, F.5    Desseigne, F.6
  • 25
    • 0014421328 scopus 로고
    • Mitomycin C therapy in advanced gastrointestinal cancer
    • Moertel CG, Reitemeier RJ, Hahn RG. Mitomycin C therapy in advanced gastrointestinal cancer. J Am Med Assoc. 1968;204:1045-8.
    • (1968) J Am Med Assoc , vol.204 , pp. 1045-1048
    • Moertel, C.G.1    Reitemeier, R.J.2    Hahn, R.G.3
  • 26
    • 0022624956 scopus 로고
    • Combination chemotherapy (5-fluorouracil, methyl-CCNU, mitomycin C) versus 5-fluorouracil alone for advanced previously untreated colorectal carcinoma. A phase III study of the Piedmont Oncology Association
    • Richards F, Case LD, White DR, Muss HB, Spurr CL, Jackson DV, et al. Combination chemotherapy (5-fluorouracil, methyl-CCNU, mitomycin C) versus 5-fluorouracil alone for advanced previously untreated colorectal carcinoma. A phase III study of the Piedmont Oncology Association. J Clin Oncol. 1986;4(4):565-70.
    • (1986) J Clin Oncol , vol.4 , Issue.4 , pp. 565-570
    • Richards, F.1    Case, L.D.2    White, D.R.3    Muss, H.B.4    Spurr, C.L.5    Jackson, D.V.6
  • 27
    • 9844229067 scopus 로고    scopus 로고
    • A prospective randomised trial of protracted venous infusion 5-fluorouracil with or without mitomycin C in advanced colorectal cancer
    • Ross P, Norman A, Cunningham D, Webb A, Iveson T, Padhani A, et al. A prospective randomised trial of protracted venous infusion 5-fluorouracil with or without mitomycin C in advanced colorectal cancer. Ann Oncol. 1997;8(10):995-1001.
    • (1997) Ann Oncol , vol.8 , Issue.10 , pp. 995-1001
    • Ross, P.1    Norman, A.2    Cunningham, D.3    Webb, A.4    Iveson, T.5    Padhani, A.6
  • 28
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 2000;92(3):205-16.
    • (2000) J Natl Cancer Inst , vol.92 , Issue.3 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3    Wanders, J.4    Kaplan, R.S.5    Rubinstein, L.6
  • 29
    • 0024536437 scopus 로고
    • Optimal two-stage designs for phase II clinical trials
    • Richard S. Optimal two-stage designs for phase II clinical trials. Controlled Clin Trials. 1989;10(1):1-10.
    • (1989) Controlled Clin Trials , vol.10 , Issue.1 , pp. 1-10
    • Richard, S.1
  • 30
    • 77954398798 scopus 로고    scopus 로고
    • Mitomycin C and UFT/leucovorin as salvage treatment in patients with advanced colorectal cancer
    • Michalaki V GS, Gennatas C. Mitomycin C and UFT/leucovorin as salvage treatment in patients with advanced colorectal cancer. J BUON. 2010;15(2):270-3.
    • (2010) J BUON , vol.15 , Issue.2 , pp. 270-273
    • Michalaki, V.G.S.1    Gennatas, C.2
  • 31
    • 34548357027 scopus 로고    scopus 로고
    • UFT/leucovorin and mitomycin C as salvage treatment in patients with advanced colorectal cancer - a retrospective analysis
    • Vormittag L, Kornek GV, Gruhsmann B, Lenauer A, Foger A, Depisch D, et al. UFT/leucovorin and mitomycin C as salvage treatment in patients with advanced colorectal cancer - a retrospective analysis. Anticancer Drugs 2007;18:709-12.
    • (2007) Anticancer Drugs , vol.18 , pp. 709-712
    • Vormittag, L.1    Kornek, G.V.2    Gruhsmann, B.3    Lenauer, A.4    Foger, A.5    Depisch, D.6
  • 33
    • 33845666953 scopus 로고    scopus 로고
    • A phase II trial of S-1 monotherapy in metastatic colorectal cancer after failure of irinotecan-and oxaliplatin-containing regimens
    • Jeung HC, Rha SY, Cho BC, Yoo NC, Roh JK, Roh WJ, et al. A phase II trial of S-1 monotherapy in metastatic colorectal cancer after failure of irinotecan-and oxaliplatin-containing regimens. Br J Cancer. 2006;95(12):1637-41.
    • (2006) Br J Cancer , vol.95 , Issue.12 , pp. 1637-1641
    • Jeung, H.C.1    Rha, S.Y.2    Cho, B.C.3    Yoo, N.C.4    Roh, J.K.5    Roh, W.J.6
  • 34
    • 0042123510 scopus 로고    scopus 로고
    • Raltitrexed and mitomycin-C as third-line chemotherapy for colorectal cancer after combination regimens including 5-fluorouracil, irinotecan and oxaliplatin: A phase II study
    • Rosati G, Rossi A, Germano D, Reggiardo G, Manzione L. Raltitrexed and mitomycin-C as third-line chemotherapy for colorectal cancer after combination regimens including 5-fluorouracil, irinotecan and oxaliplatin: a phase II study. Anticancer Res. 2003;23:2981-5.
    • (2003) Anticancer Res , vol.23 , pp. 2981-2985
    • Rosati, G.1    Rossi, A.2    Germano, D.3    Reggiardo, G.4    Manzione, L.5
  • 35
    • 26944454064 scopus 로고    scopus 로고
    • Capecitabine and mitomycin C as third-line therapy for patients with metastatic colorectal cancer resistant to fluorouracil and irinotecan
    • Chong G, Dickson JLB, Cunningham D, Norman AR, Rao S, Hill ME, et al. Capecitabine and mitomycin C as third-line therapy for patients with metastatic colorectal cancer resistant to fluorouracil and irinotecan. Br J Cancer. 2005;93(5):510-4.
    • (2005) Br J Cancer , vol.93 , Issue.5 , pp. 510-514
    • Chong, G.1    Dickson, J.L.B.2    Cunningham, D.3    Norman, A.R.4    Rao, S.5    Hill, M.E.6
  • 36
    • 84891742622 scopus 로고    scopus 로고
    • Hepatic artery infusion (HAI) of oxaliplatin (Ox) as third and fourth-line therapy for patients with hepatic metastases (M) from colorectal cancer (CRC) pretreated with systemic Ox
    • Gollasch H, Gebauer B, Sturm I, Thuss-Patience P, Pink D, Stroszczynski C, et al. Hepatic artery infusion (HAI) of oxaliplatin (Ox) as third and fourth-line therapy for patients with hepatic metastases (M) from colorectal cancer (CRC) pretreated with systemic Ox. ASCO Meet Abstr. 2004;22(14_suppl):3695.
    • (2004) ASCO Meet Abstr , vol.22 , Issue.14 SUPPL. , pp. 3695
    • Gollasch, H.1    Gebauer, B.2    Sturm, I.3    Thuss-Patience, P.4    Pink, D.5    Stroszczynski, C.6
  • 37
    • 2942596466 scopus 로고    scopus 로고
    • A phase II study of UFT and Leucovorin in combination with mitomycin C in patients with metastatic colorectal cancer
    • Gyldenkerne N, Glimelius B, Frodin JE, Kjaer M, Pfeiffer P, Hansen F, et al. A phase II study of UFT and Leucovorin in combination with mitomycin C in patients with metastatic colorectal cancer. Acta Oncol. 2004;43(3):276-9.
    • (2004) Acta Oncol , vol.43 , Issue.3 , pp. 276-279
    • Gyldenkerne, N.1    Glimelius, B.2    Frodin, J.E.3    Kjaer, M.4    Pfeiffer, P.5    Hansen, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.