Absolute levels and ratios of proinflammatory and anti-inflammatory cytokine production in vitro predict clinical immunity to Plasmodium falciparum malaria

Journal of Infectious Diseases

Volumn 185, Issue 7, 2002, Pages 971-979

  Dodoo, D ^a   Omer, F M ^b   Todd, J ^b   Akanmori, B D ^a   Koram, K A ^a   Riley, Eleanor M ^b  

^a University of Ghana   (Ghana)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; HEMOGLOBIN; INTERLEUKIN 10; INTERLEUKIN 12; PHYTOHEMAGGLUTININ; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ANEMIA; ARTICLE; CELLULAR IMMUNITY; CHILD; CYTOKINE PRODUCTION; FEVER; GHANA; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; IMMUNITY; INFECTION SENSITIVITY; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; NONHUMAN; PARASITEMIA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SCHIZONT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; BLOOD CELLS; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; CYTOKINES; FEMALE; HUMANS; IMMUNITY; INFANT; INFLAMMATION; LEUKOCYTES, MONONUCLEAR; MALARIA, FALCIPARUM; MALE; MIDDLE AGED; PARASITEMIA; PLASMODIUM FALCIPARUM; PREDICTIVE VALUE OF TESTS;

EID: 0036535062     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/339408     Document Type: Article

References (42)

1. Pathogenesis of malaria
2. Maintaining the immunological balance in parasitic infections: A role for TGFβ
3. Immunity to asexual blood stages of Plasmodium: Is resistance to acute malaria adaptive or innate?
4. A role for B cells in the development of T helper function in a malaria infection in mice
5. IL-12-induced protection against blood-stage Plasmodium chabaudi AS requires IFNγ and TNFα and occurs via a nitric oxide-dependent mechanism
6. Role of IFN-γ in lethal and nonlethal malaria in susceptible and resistant hosts
7. Early gamma interferon responses in lethal and nonlethal murine blood stage malaria
8. A Th1-associated increase in tumor necrosis factor alpha expression in the spleen correlates with resistance to blood-stage malaria in mice
9. The role of T cells in pathogenesis and protective immunity to murine malaria
10. Interferon-γ induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine
11. A pathogenic role of IL-12 in blood-stage murine malaria lethal strain Plasmodium berghei NK65 infection
12. The immune response to Plasmodium chabaudi malaria in interleukin-4-deficient mice
13. The time course of selected malarial infections in cytokine-deficient mice
14. Plasmodium chabaudi chabaudi: Differential susceptibility of gene-targeted mice deficient in IL-10 to an erythrocytic-stage infection
15. TGF beta production is inversely correlated with severity of murine malaria infection
16. Protective value of elevated levels of gamma interferon in serum against exoerythrocytic stages of Plasmodium falciparum
17. Cytokines in the pathogenesis of malaria: Levels of IL-1B, IL-4, IL-6, TNF-α and IFN-γ in plasma of healthy individuals and malaria patients in a holoendemic area
18. Serum cytokine profiles in experimental human malaria
19. Prediction of accelerated cure in Plasmodium falciparum malaria by the elevated capacity of tumour necrosis factor production
20. High plasma levels of nitrogen oxides are associated with severe disease and correlate with rapid parasitological and clinical cure in Plasmodium falciparum malaria
21. Tumor necrosis factor and disease severity in children with falciparum malaria
22. TNF concentration in fatal, non-fatal cerebral and uncomplicated Plasmodium falciparum malaria
23. Low concentrations of interleukin 10 in severe malarial anaemia compared with cerebral and uncomplicated malaria
24. A low interleukin-10 tumor necrosis factor-alpha ratio is associated with malaria anemia in children residing in a holoendemic malaria region in western Kenya
25. The prognostic and pathophysiologic role of pro- and antiinflammatory cytokines in severe malaria
26. Reduced interleukin-12 and transforming growth factor-β1 in severe childhood malaria: Relationship of cytokine balance with disease severity
27. Low interleukin-12 activity in severe Plasmodium falciparum malaria
28. Plasma interleukin-10: Tumor necrosis factor (TNF)-α ratio is associated with TNF promoter variants and predicts malarial complications
29. Immune responses to soluble exoantigens of Plasmodium falciparum may contribute to both pathogenesis and protection in clinical malaria: Evidence from a longitudinal, prospective study of semi-immune African children
30. Interferon-γ responses are associated with resistance to reinfection with Plasmodium falciparum in young African children
31. Malaria infection, morbidity and transmission in two ecological zones in Southern Ghana
32. Development of a whole blood assay to measure T cell responses to leprosy: A new tool for immunoepidemiological field studies of leprosy
33. Naive human αβT cells respond to membrane-associated components of malaria-infected erythrocytes by proliferation and production of IFN-γ
34. The statistical analysis of data from immunoepidemiological studies
35. Multiple significance tests: The Bonferroni method
36. + T cells in the Plasmodium yoelii model
37. Serum levels of interleukin 18 in patients with uncomplicated Plasmodium falciparum malaria
38. Decreased serum levels of TGF-beta in patients with acute Plasmodium falciparum malaria
39. Elevated serum levels of IL-10 and IFNγ in patients with acute Plasmodium falciparum malaria
40. Cytokine levels during mild and cerebral falciparum malaria in children living in a mesoendemic area
41. Variation in the TNFα promoter region associated with susceptibility to cerebral malaria
42. + T cells preferentially respond to live rather than killed malaria parasites