Leptin induces a proliferative response in breast cancer cells but not in normal breast cells

Nutrition and Cancer

Volumn 66, Issue 4, 2014, Pages 645-655

  Dubois, Virginie ^a,b   Jardé, Thierry ^a,b,c   Delort, Laetitia ^a,b   Billard, Hermine ^a,b   Bernard Gallon, Dominique ^d   Berger, Emmanuelle ^e   Geloen, Alain ^e   Vasson, Marie Paule ^a,b,f   Caldefie Chezet, Florence ^a,b,f  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b CRNH AUVERGNE   (France)

^c MONASH UNIVERSITY   (Australia)

^d CENTRE JEAN PERRIN   (France)

^e UNIVERSITÉ DE LYON   (France)

^f CLARA Région Lyon Auvergne Rhône Alpes ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; ESTROGEN RECEPTOR; LEPTIN; MESSENGER RNA; LEPTIN RECEPTOR;

APOPTOSIS; ARTICLE; AUTOREGULATION; BREAST CANCER; BREAST CARCINOGENESIS; BREAST CELL; CANCER CELL LINE; CELL CYCLE; CELL PROLIFERATION; CELL PROLIFERATION ASSAY; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MCF 7 CELL LINE; OBESITY; POSTMENOPAUSE; REVERSE TRANSCRIPTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; BLOOD; BREAST NEOPLASMS; CELL LINE; COMPLICATION; DRUG EFFECTS; FEMALE; FIBROCYSTIC BREAST DISEASE; GENETICS; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; FIBROCYSTIC BREAST DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; LEPTIN; MCF-7 CELLS; OBESITY; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION;

EID: 84899905028     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2014.894104     Document Type: Article

References (52)

1. Bergstrom A, Pisani P, Tenet V, Wolk A, and Adami HO: Overweight as an avoidable cause of cancer in Europe. Int J Cancer 91, 421-430, 2001.
2. Bianchini F, Kaaks R, and Vainio H: Overweight, obesity, and cancer risk. Lancet Oncol 3, 565-574, 2002.
3. Maccio A, Madeddu, and Mantovani G: Adipose tissue as target organ in the treatment of hormone-dependent breast cancer: new therapeutic perspectives. Obes Rev 10, 660-670, 2009.
4. Daling, JR,Malone KE,Doody DR, Johnson LG,GralowJR, et al.:Relation of body mass index to tumor markers and survival among young women with invasive ductal breast carcinoma. Cancer 92, 720-729, 2001.
5. Irigaray P, Newby JA, Lacomme S, and Belpomme D: Overweight/obesity and cancer genesis: more than a biological link. Biomed Pharmacother 61, 665-678, 2007.
6. Key TJ, Allen NE, Verkasalo PK, and Banks E: Energy balance and cancer: the role of sex hormones. Proc Nutr Soc, 60, 81-89, 2001.
7. Galic S, Oakhill JS, and Steinberg GR: Adipose tissue as an endocrine organ. Mol Cell Endocrinol 316, 129-139, 2010.
8. Somasundar P, McFadden DW, Hileman SM, and Vona-Davis L: Leptin is a growth factor in cancer. J Surg Res 116, 337-349, 2004.
9. Liuzzi A, Savia G, Tagliaferri M, Lucantoni R, Berselli ME, et al.: Serum leptin concentration in moderate and severe obesity: relationship with clinical, anthropometric and metabolic factors. Int J Obes Relat Metab Disord 23, 1066-1073, 1999.
10. Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, et al.: A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392, 398-401, 1998.
11. Hancke K, Grubeck D, Hauser N, Kreienberg R,Weiss JM, et al.:Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients. Breast Cancer Res Treat 119, 367-370, 2010.
12. Tessitore., Vizio B, Pesola D, Cecchini F, Mussa A, et al.: Adipocyte expression and circulating levels of leptin increase in both gynaecological and breast cancer patients. Int J Oncol 24, 1529-1535, 2004.
13. Hou, WK, Xu YX, Yu T, Zhang L, Zhang WW, et al.: Adipocytokines and breast cancer risk. Chin Med J (Engl) 120, 1592-1596, 2007.
14. Ozet A, Arpaci F, Yilmaz MI, Ayta H, Ozturk B, et al.: Effects of tamoxifen on the serum leptin level in patients with breast cancer. Jpn J Clin Oncol 31, 424-427, 2001.
15. Han CZ, Du LL, Jing JX, Zhao XW, Tian FG, et al.: Associations among lipids, leptin, and leptin receptor gene Gin223Arg polymorphisms and breast cancer in China. Biol Trace Elem Res 126, 38-48, 2008.
16. Carroll PA, Healy L, Lysaght J, Boyle T, Reynolds JV, et al.: Influence of the metabolic syndrome on leptin and leptin receptor in breast cancer. Mol Carcinog 50, 643-651, 2011.
17. Chen DC, Chung YF, Yeh YT, Chaung HC, Kuo FC, et al.: Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Cancer Lett 237, 109-114, 2006.
18. Jarde T, Caldefie-Chézet F, Damez M, Mishellany F, Penault-Llorca F, et al.: Leptin and leptin receptor involvement in cancer development: a study on human primary breast carcinoma. Oncol Rep 19, 905-911, 2008.
19. Jeong YJ, Bong JG, Park SH, Choi JH, and Oh HK: Expression of leptin, leptin receptor, adiponectin, and adiponectin receptor in ductal carcinoma in situ and invasive breast cancer. J Breast Cancer 14, 96-103, 2012.
20. Miyoshi Y, Funahashi T, Tanaka S, Taguchi T, Tamaki Y, et al., High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels. Int J Cancer 118, 1414-1419, 2006.
21. Cleary MP, Phillips FC, Getzin SC, Jacobson TL, Jacobson MK, et al.: Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors. Breast Cancer Res Treat 77, 205-215, 2003.
22. ClearyMP, Juneja SC, Phillips FC, Hu X, Grande JP, et al.: Leptin receptordeficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors. Exp Biol Med (Maywood) 229, 182-193, 2004.
23. Zheng Q, Dunlap SM, Zhu J, Downs-Kelly E, Rich J, et al.: Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival. Endocr Relat Cancer 18, 491-503, 2011.
24. Mauro L, Catalano S, Bossi G, Pellegrino M, Barone I, et al.: Evidences that leptin up-regulates E-cadherin expression in breast cancer: effects on tumor growth and progression. Cancer Res 67, 3412-3421, 2007.
25. Gonzalez RR, et al.: Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2). J Biol Chem 281, 26320-26328, 2006.
26. Gonzalez-Perez RR, Cherfils S, Escobar M, Yoo JH, Carino C, et al.: Leptin upregulates VEGF in breast cancer via canonic and non-canonical signalling pathways and NFkappaB/HIF-1alpha activation. Cell Signal 22, 1350-1362, 2010.
27. Dieudonne MN, Machinal-Quelin F, Serazin-Leroy V, Leneveu MC, Pecquery R, et al.: Leptin mediates a proliferative response in human MCF7 breast cancer cells. Biochem Biophys Res Commun 293, 622-628, 2002.
28. Soma D, Kitayama J, Yamashita H, Miyato H, Ishikawa M, et al.: Leptin augments proliferation of breast cancer cells via transactivation of HER2. J Surg Res 149, 9-14, 2008.
29. Yin N, Wang D, Zhang H, Yi X, Sun X, et al.: Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin. Cancer Res 64, 5870-5855, 2004.
30. Nkhata KJ, Ray A, Schuster TF, Grossmann ME, and Cleary MP: Effects of adiponectin and leptin co-treatment on human breast cancer cell growth. Oncol Rep 21, 1611-1619, 2009.
31. Fusco R, GalganiM, Procaccini C, Franco R, Pirozzi G, et al.: Cellular and molecular crosstalk between leptin receptor and estrogen receptor-{alpha} in breast cancer: molecular basis for a novel therapeutic setting. Endocr Relat Cancer 17, 373-382, 2010.
32. Ray A, Nkhata KJ, and ClearyMP: Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status. Int J Oncol 30, 1499-1509, 2007.
33. McCormack D, Schneider J, McDonald D, and McFadden D: The antiproliferative effects of pterostilbene on breast cancer in vitro are via inhibition of constitutive and leptin-induced Janus kinase/signal transducer and activator of transcription activation. Am J Surg 202, 541-544, 2011.
34. Otvos L Jr, Kovalszky I, Riolfi M, Ferla R, Olah J, et al.: Efficacity of leptin receptor antagonist peptide in a mousemodel of triple-negative breast cancer. Eur J Cancer 47, 1578-1584, 2011.
35. Catalano S, Marsico S, Giordano C, Mauro L, Rizza P, et al.: Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line. J Biol Chem 278, 28668-28676, 2003.
36. Catalano S,Mauro L, Marsico S, Giordano C, Rizza P, et al.: Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells. J Biol Chem 279, 19908-19915, 2004.
37. Debiton E, Madelmont JC, Legault J, and Barthomeuf C: Sanguinarineinduced apoptosis is associated with an early and severe cellular glutathione depletion. Cancer Chemother Pharmacol 51, 474-482, 2003.
38. Goncalves-Mendes N, Blanchon L, Meiniel A, Dastugue B, and Sapin V: Placental expression of SCO-spondin during mouse and human development. Gene Expr Patterns 4, 309-314, 2004.
39. Yang C, Yu B, Zhou D, and Chen S: Regulation of aromatase promoter activity in human breast tissue by nuclear receptors.Oncogene 21, 2854-2863, 2002.
40. Chen C, Chang YC, Liu CL, Chang KJ, and Guo IC: Leptin-induced growth of human ZR-75-1 breast cancer cells is associated with upregulation of cyclin D1 and c-Myc and down-regulation of tumor suppressor p53 and p21WAF1/CIP1. Breast Cancer Res Treat 98, 121-132, 2006.
41. Garofalo C, Sisci D, and Surmacz E: Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells. Clin Cancer Res 10, 6466-6475, 2004.
42. Caldefie-Chezet F., Damez M, de Latour M, Konska G, Mishellani F, et al.: Leptin: a proliferative factor for breast cancer? Study on human ductal carcinoma. Biochem Biophys Res Commun 334, 737-741, 2005.
43. Garofalo C, Koda M, Cascio S, Sulkowska M, Kanczuga-Koda L, et al.: Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res 12, 1447-1453, 2006.
44. Ishikawa M, Kitayama J, and Nagawa H: Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res 10, 4325-4331, 2004.
45. Jiang H, Yu J, Guo H, Song H, and Chen S: Upregulation of survivin by leptin/STAT3 signaling in MCF-7 cells. Biochem Biophys Res Commun 368, 1-5, 2008.
46. Jarde T, Caldefie-Chézet F, Goncalves-Mendes N, Mishellany F, Buechler C, et al., Involvement of adiponectin and leptin in breast cancer: clinical and in vitro studies. Endocr Relat Cancer 16, 1197-1210, 2009.
47. Okumura M, Yamamoto M, Sakuma H, Kojima T, Maruyama T, et al.: Leptin and high glucose stimulate cell proliferation inMCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression. Biochim Biophys Acta 1592, 107-116, 2002.
48. Saxena NK,Vertino PM, Anania FA, and Sharma D: Leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. J Biol Chem 282, 13316-13325, 2007.
49. Hu X, Juneja SC, Maihle NJ, and Cleary MP: Leptin-a growth factor in normal and malignant breast cells and for normal mammary gland development. J Natl Cancer Inst 94, 1704-1711, 2002.
50. Laud K, Gourdou I, Pessemesse L, Peyrat JP, and Djiane J: Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line. Mol Cell Endocrinol 188, 219-226, 2002.
51. Jarde T, Perrier S, Vasson MP and Caldefie-Chézet F: Molecular mechanisms of leptin and adiponectin in breast cancer. Eur J Cancer 47, 33-43, 2011.
52. Khandekar MJ, Cohen P, and Spiegelman, BM: Molecular mechanisms of cancer development in obesity. Nat Rev Cancer 11, 886-895, 2011.