Structure-activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 11, 2014, Pages 3021-3029

  Hayakawa, Nobuhiko ^a   Noguchi, Masatsugu ^a   Takeshita, Sen ^a   Eviryanti, Agung ^a   Seki, Yukie ^a   Nishio, Hikaru ^a   Yokoyama, Ryohei ^a   Noguchi, Misato ^a   Shuto, Manami ^a   Shima, Yoichiro ^a   Kuribayashi, Kanna ^a   Kageyama, Shunsuke ^a   Eda, Hiroyuki ^a   Suzuki, Manabu ^a   Hatta, Tomohisa ^b   Iemura, Shun Ichiro ^b   Natsume, Tohru ^b   Tanabe, Itsuya ^a   Nakagawa, Ryusuke ^a   Shiozaki, Makoto ^a   Sakurai, Kuniya ^a   Shoji, Masataka ^a   Andou, Ayatoshi ^a   Yamamoto, Takashi ^a   more..

^a AJINOMOTO CO INC   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

APY0201; IL 12 23; PIKfyve; Target identification

Indexed keywords

ANTIINFLAMMATORY AGENT; APY 0201; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 23; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PHOSPHATIDYLINOSITOL 3,5 BIPHOSPHATE; PHOSPHOTRANSFERASE INHIBITOR; PREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; APY0201; INTERLEUKIN 10; MOLECULAR LIBRARY; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CD4+ T LYMPHOCYTE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG RESPONSE; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; FEMALE; FIRST PASS EFFECT; HUMAN; HUMAN CELL; IMMUNOMODULATION; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN SYNTHESIS INHIBITION; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DEFICIENCY; DISEASE MODEL; DRUG DEVELOPMENT; DRUG EFFECTS; INFLAMMATION; KNOCKOUT MOUSE; MACROPHAGE; MOLECULAR LIBRARY; MONONUCLEAR CELL; PHARMACOLOGY; SCID MOUSE;

ANIMALS; CELL LINE; COLITIS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-23; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, SCID; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; PYRIMIDINES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899899120     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.03.036     Document Type: Article

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