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Volumn 16, Issue 18, 2008, Pages 8760-8764

Salicylanilides: Selective inhibitors of interleukin-12p40 production

Author keywords

Interleukin 12 (IL 12); Interleukin 12p40 (IL 12p40); Interleukin 23 (IL 23); Interleukin 6 (IL 6); Salicylanilide

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 23; INTERLEUKIN 6; SALICYLANILIDE DERIVATIVE;

EID: 51449089064     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.024     Document Type: Article
Times cited : (38)

References (21)
  • 12
    • 51449089931 scopus 로고    scopus 로고
    • note
    • Compounds 1 and 2 were not included among the original compounds that we evaluated for inhibition of IL-12p40 production.
  • 13
    • 51449105247 scopus 로고    scopus 로고
    • note
    • Inhibition of IL-12p40 production was also assessed using primary human dendritic cells however the human donor-to-donor cell variability of these primary cells and the difficulty posed by their routine collection made their use difficult thus a murine dentritic cell line was used for routine SAR development.
  • 14
    • 51449105032 scopus 로고    scopus 로고
    • note
    • A similar observation can be made by comparing compounds 13 and 8. One hypothesis for this effect would invoke subtle differences in interactions with different target proteins.
  • 15
    • 51449104551 scopus 로고    scopus 로고
    • note
    • TM 9.0, Advanced Chemistry Development, Inc., (ACD/Labs), Toronto, ON, Canada, www.acdlabs.com.
  • 16
    • 51449102354 scopus 로고    scopus 로고
    • note
    • Biochemical target identification, in order to understand the mechanism of action of these salicylanilides, will be reported elsewhere.
  • 17
    • 51449086455 scopus 로고    scopus 로고
    • Thomas, M. G.; Allanson, N. M. Brit. UK Pat. Appl. 2002, 13 pp.
    • Thomas, M. G.; Allanson, N. M. Brit. UK Pat. Appl. 2002, 13 pp.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.