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Compounds 1 and 2 were not included among the original compounds that we evaluated for inhibition of IL-12p40 production.
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13
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51449105247
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note
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Inhibition of IL-12p40 production was also assessed using primary human dendritic cells however the human donor-to-donor cell variability of these primary cells and the difficulty posed by their routine collection made their use difficult thus a murine dentritic cell line was used for routine SAR development.
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14
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51449105032
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note
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A similar observation can be made by comparing compounds 13 and 8. One hypothesis for this effect would invoke subtle differences in interactions with different target proteins.
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15
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51449104551
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note
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TM 9.0, Advanced Chemistry Development, Inc., (ACD/Labs), Toronto, ON, Canada, www.acdlabs.com.
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16
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51449102354
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note
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Biochemical target identification, in order to understand the mechanism of action of these salicylanilides, will be reported elsewhere.
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