13C-labelled microdialysis studies of cerebral metabolism in TBI patients

European Journal of Pharmaceutical Sciences

Volumn 57, Issue 1, 2014, Pages 87-97

  Carpenter, Keri L H ^a,b   Jalloh, Ibrahim ^a   Gallagher, Clare N ^a,c   Grice, Peter ^a   Howe, Duncan J ^a   Mason, Andrew ^a   Timofeev, Ivan ^a   Helmy, Adel ^a   Murphy, Michael P ^d   Menon, David K ^a,b   Kirkpatrick, Peter J ^a   Carpenter, T Adrian ^b   Sutherland, Garnette R ^c   Pickard, John D ^a,b   Hutchinson, Peter J ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CALGARY   (Canada)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Brain metabolism; Human; Microdialysis; NMR; Traumatic brain injury

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; CARBON 13; GLUCOSE; ISOTOPE; LACTIC ACID; PYRUVIC ACID; TRICARBOXYLIC ACID; BIOLOGICAL MARKER;

BRAIN METABOLISM; BRAIN TISSUE; ENERGY METABOLISM; ENERGY RESOURCE; EX VIVO STUDY; EXTRACELLULAR SPACE; FEEDING; GLYCOLYSIS; HUMAN; IN VIVO STUDY; MASS SPECTROMETRY; METABOLITE; MICRODIALYSIS; MOLECULE; MONITORING; NERVE CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATIVE PHOSPHORYLATION; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; REVIEW; TRAUMATIC BRAIN INJURY; BRAIN INJURY; CARBON NUCLEAR MAGNETIC RESONANCE; METABOLISM; METABOLOMICS; PREDICTIVE VALUE; PROCEDURES; PROGNOSIS;

BIOLOGICAL MARKERS; BRAIN INJURIES; CARBON-13 MAGNETIC RESONANCE SPECTROSCOPY; ENERGY METABOLISM; HUMANS; MASS SPECTROMETRY; METABOLOMICS; MICRODIALYSIS; PREDICTIVE VALUE OF TESTS; PROGNOSIS;

EID: 84899897308     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.12.012     Document Type: Review

References (43)

1. E.R. Andrew, A. Bradbury, and R.G. Eades Removal of dipolar broadening of nuclear magnetic resonance spectra of solids by specimen rotation Nature 183 1959 1802 1803
2. M.R. Antoniewicz Tandem mass spectrometry for measuring stable-isotope labeling Curr. Opin. Biotechnol. 24 2013 48 53
3. B.L. Bartnik, R.L. Sutton, M. Fukushima, N.G. Harris, D.A. Hovda, and S.M. Lee Upregulation of pentose phosphate pathway and preservation of tricarboxylic acid cycle flux after experimental brain injury J. Neurotrauma 22 2005 1052 1065 (Pubitemid 41532544)
4. 13C NMR study J. Neurotrauma 24 2007 1079 1092 (Pubitemid 47106283)
5. B.M. Bellander, E. Cantais, P. Enblad, P. Hutchinson, C.H. Nordstrom, C. Robertson, J. Sahuquillo, M. Smith, N. Stocchetti, U. Ungerstedt, A. Unterberg, and N.V. Olsen Consensus meeting on microdialysis in neurointensive care Intensive Care Med. 30 2004 2166 2169 (Pubitemid 40174251)
6. S.J. Bensinger, and H.R. Christofk New aspects of the Warburg effect in cancer cell biology Semin. Cell Dev. Biol. 23 2012 352 361
7. 13C magnetic resonance spectroscopy Magn. Reson. Med. 66 2011 505 519
8. 13C} MRS and fMRI Magn. Reson. Med. 45 2001 349 355 (Pubitemid 32173258)
9. 13C] NMR spectroscopy in vivo. A practical guide NMR Biomed. 24 2011 958 972
10. 2]glucose labeling study in humans J. Cereb. Blood Flow Metab. 27 2007 1593 1602 (Pubitemid 47301444)
11. 13C stable isotope-resolved metabolomics (SIRM) Mol. Cancer 8 2009 41
12. 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study Brain 132 2009 2839 2849
13. 13C]glutamate Magn. Reson. Med. 66 2011 18 23
14. 1H NMR spectroscopy NMR Biomed. 15 2002 375 384
15. 13C]glucose J. Neurochem. 63 1994 1377 1385
16. 13C-glucose and microdialysis Scand. J. Clin. Lab. Invest. 67 2007 155 164 (Pubitemid 46410605)
17. L. Hillered, P.M. Vespa, and D.A. Hovda Translational neurochemical research in acute human brain injury: the current status and potential future for cerebral microdialysis J. Neurotrauma 22 2005 3 41
18. L. Hillered, L. Persson, P. Nilsson, E. Ronne-Engstrom, and P. Enblad Continuous monitoring of cerebral metabolism in traumatic brain injury: a focus on cerebral microdialysis Curr. Opin. Crit. Care 12 2006 112 118
19. 13C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat Magn. Reson. Imaging 30 2012 1367 1372
20. P.J. Hutchinson, M.T. O'Connell, A. Seal, J. Nortje, I. Timofeev, P.G. Al-Rawi, J.P. Coles, T.D. Fryer, D.K. Menon, J.D. Pickard, and K.L. Carpenter A combined microdialysis and FDG-PET study of glucose metabolism in head injury Acta Neurochir. (Wien) 151 2009 51 61 (discussion 61)
21. I. Jalloh, A. Helmy, R.J. Shannon, C.N. Gallagher, D.K. Menon, K.L. Carpenter, and P.J. Hutchinson Lactate uptake by the injured human brain - evidence from an arterio-venous gradient and cerebral microdialysis study J. Neurotrauma 30 2013 2031 2037
22. T. Kaibara, G.R. Sutherland, F. Colbourne, and R.L. Tyson Hypothermia: depression of tricarboxylic acid cycle flux and evidence for pentose phosphate shunt upregulation J. Neurosurg. 90 1999 339 347 (Pubitemid 29068137)
23. 13C NMR J. Neurochem. 83 2002 682 695 (Pubitemid 35231822)
24. A.G. Kolias, M.R. Guilfoyle, A. Helmy, J. Allanson, and P.J. Hutchinson Traumatic brain injury in adults Pract. Neurol. 13 2013 228 235
25. 13C-enrichment measurement of extracellular glutamate in rat brain J. Neurosci. Methods 120 2002 179 192 (Pubitemid 35248167)
26. 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism J. Neurosci. 22 2002 1523 1531 (Pubitemid 35386271)
27. 2]glucose Am. J. Physiol. 274 1998 E843 E851
28. H.J. Marcus, K.L. Carpenter, S.J. Price, and P.J. Hutchinson In vivo assessment of high-grade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines J. Neurooncol. 97 2010 11 23
29. G.F. Mason, R. Gruetter, D.L. Rothman, K.L. Behar, R.G. Shulman, and E.J. Novotny Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR J. Cereb. Blood Flow Metab. 15 1995 12 25
30. D.K. Menon, J.P. Coles, A.K. Gupta, T.D. Fryer, P. Smielewski, D.A. Chatfield, F. Aigbirhio, J.N. Skepper, P.S. Minhas, P.J. Hutchinson, T.A. Carpenter, J.C. Clark, and J.D. Pickard Diffusion limited oxygen delivery following head injury Crit. Care Med. 32 2004 1384 1390 (Pubitemid 38738596)
31. 13C MRS examinations of the brain Magn. Reson. Med. 46 2001 39 48 (Pubitemid 32592137)
32. 13C]pyruvate Sci. Trans. Med. 5 2013 198ra108
33. O.E. Owen, S.C. Kalhan, and R.W. Hanson The key role of anaplerosis and cataplerosis for citric acid cycle function J. Biol. Chem. 277 2002 30409 30412 (Pubitemid 34970728)
34. M. Parkin, S. Hopwood, D.A. Jones, P. Hashemi, H. Landolt, M. Fabricius, M. Lauritzen, M.G. Boutelle, and A.J. Strong Dynamic changes in brain glucose and lactate in pericontusional areas of the human cerebral cortex, monitored with rapid sampling on-line microdialysis: relationship with depolarisation-like events J. Cereb. Blood Flow Metab. 25 2005 402 413 (Pubitemid 40315882)
35. L. Pellerin, and P.J. Magistretti Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization Proc. Natl. Acad. Sci. USA 91 1994 10625 10629 (Pubitemid 24329051)
36. L. Persson, and L. Hillered Chemical monitoring of neurosurgical intensive care patients using intracerebral microdialysis J. Neurosurg. 76 1992 72 80
37. L. Persson, J. Valtysson, P. Enblad, P.E. Warme, K. Cesarini, A. Lewen, and L. Hillered Neurochemical monitoring using intracerebral microdialysis in patients with subarachnoid hemorrhage J. Neurosurg. 84 1996 606 616 (Pubitemid 26104228)
38. S.G. Piccirillo, S. Dietz, B. Madhu, J. Griffiths, S.J. Price, V.P. Collins, and C. Watts Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin Br. J. Cancer 107 2012 462 468
39. C. Riganti, E. Gazzano, M. Polimeni, E. Aldieri, and D. Ghigo The pentose phosphate pathway: an antioxidant defense and a crossroad in tumor cell fate Free Radic. Biol. Med. 53 2012 421 436
40. 13C NMR spectroscopy NMR Biomed. 22 2009 266 271
41. I. Timofeev, K.L. Carpenter, J. Nortje, P.G. Al-Rawi, M.T. O'Connell, M. Czosnyka, P. Smielewski, J.D. Pickard, D.K. Menon, P.J. Kirkpatrick, A.K. Gupta, and P.J. Hutchinson Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients Brain 134 2011 484 494
42. 13C-Labeled substrates and the cerebral metabolic compartmentalization of acetate and lactate Brain Res. 992 2003 43 52 (Pubitemid 37356993)
43. O. Warburg On the origin of cancer cells Science 123 1956 309 314