Use of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat

Magnetic Resonance Imaging

Volumn 30, Issue 10, 2012, Pages 1367-1372

  Hu, Simon ^a   Yoshihara, Hikari A I ^a   Bok, Robert ^a   Zhou, Jenny ^b   Zhu, Minhua ^a   Kurhanewicz, John ^a   Vigneron, Daniel B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dichloroacetate (DCA); Dynamic nuclear polarization (DNP); Hyperpolarized carbon 13; Magnetic resonance spectroscopy; Pyruvate metabolism

Indexed keywords

ACETOACETIC ACID; ACETYL COENZYME A; ACETYLCARNITINE; BICARBONATE; CARBON 1 PYRUVATE C 13; CARBON 2 PYRUVATE C 13; DICHLOROACETIC ACID; GLUTAMIC ACID; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE; PYRUVIC ACID; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; ACETOACETIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; CARBON; PYRUVATE DEHYDROGENASE COMPLEX;

ANIMAL EXPERIMENT; ARTICLE; CARBON METABOLISM; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG MONITORING; ENZYME ACTIVATION; ENZYME METABOLISM; HYPERPOLARIZATION; IN VIVO STUDY; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SIGNAL NOISE RATIO; ANIMAL; BIOLOGICAL MODEL; CATALYSIS; CHEMISTRY; DRUG EFFECT; METABOLISM; METHODOLOGY; MITOCHONDRION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SPRAGUE DAWLEY RAT;

RATTUS;

ACETOACETATES; ACETYLCARNITINE; ANIMALS; ANTINEOPLASTIC AGENTS; CARBON ISOTOPES; CATALYSIS; DICHLOROACETIC ACID; GLUTAMIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MITOCHONDRIA; MODELS, BIOLOGICAL; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84868652584     PISSN: 0730725X     EISSN: 18735894     Source Type: Journal    
DOI: 10.1016/j.mri.2012.05.012     Document Type: Article

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