Huperzine a ameliorates cognitive deficits in streptozotocin-induced diabetic rats

International Journal of Molecular Sciences

Volumn 15, Issue 5, 2014, Pages 7667-7683

  Mao, Xiao Yuan ^a,b   Cao, Dan Feng ^c   Li, Xi ^a,b   Yin, Ji Ye ^a,b   Wang, Zhi Bin ^d   Zhang, Ying ^a,b   Mao, Chen Xue ^a,b   Zhou, Hong Hao ^a,b   Liu, Zhao Qian ^a,b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c INSTITUTE OF MEDICAL BIOLOGY   (China)

^d ZHENGZHOU UNIVERSITY   (China)

Author keywords

Apoptosis; Brain derived neurotrophic factor; Diabetes associated cognitive decline; Huperzine A; Inflammation; Oxidative stress

Indexed keywords

ACETYLCHOLINESTERASE; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CASPASE 3; CATALASE; CHOLINE ACETYLTRANSFERASE; GLUTATHIONE PEROXIDASE; HUPERZINE A; INTERLEUKIN 1BETA; INTERLEUKIN 6; MALONALDEHYDE; MESSENGER RNA; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; ALKALOID; BRAIN DERIVED NEUROTROPHIC FACTOR; CYTOKINE; GLUCOSE BLOOD LEVEL; NEUROPROTECTIVE AGENT; OXIDOREDUCTASE; SESQUITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL LOSS; COGNITIVE DEFECT; CONTROLLED STUDY; DIABETES ASSOCIATED COGNITIVE DECLINE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE BLOOD LEVEL; INFLAMMATION; LEARNING; MALE; MEMORY; MORRIS WATER MAZE TEST; NERVE CELL LESION; NEUROPROTECTION; NISSL STAINING; NONHUMAN; OXIDATIVE STRESS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANALYSIS; ANIMAL; CHEMISTRY; COGNITION DISORDERS; COMPLICATION; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; GENETICS; HIPPOCAMPUS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TOXICITY;

ALKALOIDS; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASPASE 3; COGNITION DISORDERS; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; MALE; MEMORY; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; OXIDOREDUCTASES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SESQUITERPENES; STREPTOZOCIN;

EID: 84899863687     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15057667     Document Type: Article

References (34)

1. Biessels, G.J.; Deary, I.J.; Ryan, C.M. Cognition and diabetes: A lifespan perspective. Lancet Neurol. 2008, 7, 184-190.
2. Wrighten, S.A.; Piroli, G.G.; Grillo, C.A.; Reagan, L.P.; A look inside the diabetic brain: Contributors to diabetes-induced brain aging. Biochim. Biophys. Acta 2009, 1792, 444-453.
3. Maiese, K.; Chong, Z.Z.; Shang, Y.C. Mechanistic insights into diabetes mellitus and oxidative stress. Curr. Med. Chem. 2007, 14, 1729-1738.
4. Mijnhout, G.S.; Scheltens, P.; Diamant, M.; Biessels, G.J.; Wessels, A.M.; Simsek, S.; Snoek, F.J.; Heine, R.J. Diabetic encephalopathy: A concept in need of a definition. Diabetologia 2006, 49, 1447-1448.
5. Kodl, C.T.; Seaquist, E.R. Cognitive dysfunction and diabetes mellitus. Endocr. Rev. 2008, 29, 494-511.
6. Wessels, A.M.; Scheltens, P.; Barkhof, F.; Heine, R.J. Hyperglycaemia as a determinant of cognitive decline in patients with type 1 diabetes. Eur. J. Pharmacol. 2008, 585, 88-96.
7. Ryan, C.M.; Geckle, M.O.; Orchard, T.J. Cognitive efficiency declines over time in adults with Type 1 diabetes: Effects of micro-and macrovascular complications. Diabetologia 2003, 46, 940-948.
8. Leibrock, J.; Lottspeich, F.; Hohn, A.; Hofer, M.; Hengerer, B.; Masiakowski, P.; Thoenen, H.; Barde, Y.A. Molecular cloning and expression of brain-derived neurotrophic factor. Nature 1989, 341, 149-152.
9. Xu, B.; Goulding, E.H.; Zang, K.; Cepoi, D.; Cone, R.D.; Jones, K.R.; Tecott, L.H.; Reichardt, L.F. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat. Neurosci. 2003, 6, 736-742.
10. Ono, M.; Ichihara, J.; Nonomura, T.; Itakura, Y.; Taiji, M.; Nakayama, C.; Noguchi, H Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice. Biochem. Biophys. Res. Commun. 1997, 238, 633-637.
11. Liu, J.; Feng, L.; Ma, D.; Zhang, M.; Gu, J.; Wang, S.; Fu, Q.; Song, Y.; Lan, Z.; Qu, R.; et al. Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. Neurosci. Lett. 2013, 549, 63-68.
12. Mohamed, A.K.; Bierhaus, A.; Schiekofer, S.; Tritschler, H.; Ziegler, R.; Nawroth, P.P. The role of oxidative stress and NF-kappaB activation in late diabetic complications. Biofactors 1999, 10, 157-167.
13. Liu, Y.W.; Zhu, X.; Li, W.; Lu, Q.; Wang, J.Y.; Wei, Y.Q.; Yin, X.X.; Ginsenoside Re attenuates diabetes-associated cognitive deficits in rats. Pharmacol. Biochem. Behav. 2012, 101, 93-98.
14. Fukui, K.; Onodera, K.; Shinkai, T.; Suzuki, S.; Urano, S. Impairment of learning and memory in rats caused by oxidative stress and aging, and changes in antioxidative defense systems. Ann. N. Y. Acad. Sci. 2001, 928, 168-175.
15. Baydas, G.; Donder, E.; Kiliboz, M.; Sonkaya, E.; Tuzcu, M.; Yasar, A.; Nedzvetskii, V.S. Neuroprotection by alpha-lipoic acid in streptozotocin-induced diabetes. Biochemistry 2004, 69, 1001-1005.
16. Deng, W.; Lu, H.; Teng, J. Carvacrol attenuates diabetes-associated cognitive deficits in rats. J. Mol. Neurosci. 2013, 51, 813-819.
17. Kuhad, A.; Bishnoi, M.; Tiwari, V.; Chopra, K. Suppression of NF-kappabeta signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits. Pharmacol. Biochem. Behav. 2009, 92, 251-259.
18. Zhou, J.; Zhang, H.Y.; Tang, X.C. Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci. Lett. 2001, 313, 137-140.
19. Wang, R.; Yan, H.; Tang, X.C. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta Pharmacol. Sin. 2006, 27, 1-26.
20. Wang, Z.F.; Tang, L.L.; Yan, H.; Wang, Y.J.; Tang, X.C. Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice. Pharmacol. Biochem. Behav. 2006, 83, 603-611.
21. Tang, L.L.; Wang, R.; Tang, X.C. Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production. Eur. J. Pharmacol. 2005, 519, 9-15.
22. Wang, C.Y.; Zheng, W.; Wang, T.; Xie, J.W.; Wang, S.L.; Zhao, B.L.; Teng, W.P.; Wang, Z.Y. Huperzine A activates Wnt/beta-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model. Neuropsychopharmacology 2011, 36, 1073-1089.
23. Forlenza, O.V.; Diniz, B.S.; Teixeira, A.L.; Ojopi, E.B.; Talib, L.L.; Mendonca, V.A.; Izzo, G.; Gattaz, W.F. Effect of brain-derived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment. World J. Biol. Psychiatry 2010, 11, 774-780.
24. Wu, W.; Wang, X.; Xiang, Q.; Meng, X.; Peng, Y.; Du, N.; Liu, Z.; Sun, Q.; Wang, C.; Liu, X. Astaxanthin alleviates brain aging in rats by attenuating oxidative stress and increasing BDNF levels. Food Funct. 2013, 5, 158-166.
25. Zhong, S.Z.; Ge, Q.H.; Qu, R.; Li, Q.; Ma, S.P. Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice. J. Neurol. Sci. 2009, 277, 58-64.
26. Cumiskey, D.; Butler, M.P.; Moynagh, P.N.; O'Connor, J. Evidence for a role for the group I metabotropic glutamate receptor in the inhibitory effect of tumor necrosis factor-alpha on long-term potentiation. Brain Res. 2007, 1136, 13-19.
27. Hayden, M.S.; Ghosh, S. Signaling to NF-kappaB. Genes Dev. 2004, 18, 2195-2224.
28. Kim, E.K.; Kwon, K.B.; Han, M.J.; Song, M.Y.; Lee, J.H.; Lv, N.; Ka, S.O.; Yeom, S.R.; Kwon, Y.D.; Ryu, D.G.; et al. Coptidis rhizoma extract protects against cytokine-induced death of pancreatic beta-cells through suppression of NF-kappaB activation. Exp. Mol. Med. 2007, 39, 149-159.
29. Wang, J.; Zhang, H.Y.; Tang, X.C. Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion. J. Neurosci. Res. 2010, 88, 807-815.
30. Perry, G.; Castellani, R.J.; Hirai, K.; Smith, M.A. Reactive oxygen species mediate cellular damage in Alzheimer disease. J. Alzheimers Dis. 1998, 1, 45-55.
31. Shi, Q.; Fu, J.; Ge, D.; He, Y.; Ran, J.; Liu, Z.; Wei, J.; Diao, T.; Lu, Y. Huperzine A ameliorates cognitive deficits and oxidative stress in the hippocampus of rats exposed to acute hypobaric hypoxia. Neurochem. Res. 2012, 37, 2042-2052.
32. Zhou, J.; Tang, X.C. Huperzine A attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons. FEBS Lett. 2002, 526, 21-25.
33. Kuhad, A.; Chopra, K. Effect of sesamol on diabetes-associated cognitive decline in rats. Exp. Brain Res. 2008, 185, 411-420.
34. Morris, R.G.; Garrud, P.; Rawlins, J.N.; O'Keefe, J. Place navigation impaired in rats with hippocampal lesions. Nature 1982, 297, 681-683.