메뉴 건너뛰기




Volumn 37, Issue 9, 2012, Pages 2042-2052

Huperzine A ameliorates cognitive deficits and oxidative stress in the hippocampus of rats exposed to acute hypobaric hypoxia

Author keywords

Acute hypobaric hypoxia; Apoptosis; Cognitive functions; Hippocampus; Huperzine A; Oxidative stress

Indexed keywords

CASPASE 3; GLUTATHIONE; HUPERZINE A; LACTATE DEHYDROGENASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

EID: 84866734428     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-012-0826-x     Document Type: Article
Times cited : (40)

References (43)
  • 1
    • 17644381575 scopus 로고    scopus 로고
    • Neuropsychological functioning associated with high-altitude exposure
    • Virues-Ortega J, Buela-Casal G, Garrido E et al (2004) Neuropsychological functioning associated with high-altitude exposure. Neuropsychol Rev 14:197-224
    • (2004) Neuropsychol Rev , vol.14 , pp. 197-224
    • Virues-Ortega, J.1    Buela-Casal, G.2    Garrido, E.3
  • 2
    • 0026847039 scopus 로고
    • Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans
    • Squire LR (1992) Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psychol Rev 99:195-231
    • (1992) Psychol Rev , vol.99 , pp. 195-231
    • Squire, L.R.1
  • 3
    • 0035746169 scopus 로고    scopus 로고
    • Frontiers of hypoxia research: Acute mountain sickness
    • Roach RC, Hackett PH (2001) Frontiers of hypoxia research: acute mountain sickness. J Exp Biol 204:3161-3170
    • (2001) J Exp Biol , vol.204 , pp. 3161-3170
    • Roach, R.C.1    Hackett, P.H.2
  • 4
    • 33751067747 scopus 로고    scopus 로고
    • Hypobaric hypoxia induces oxidative stress in rat brain
    • Maiti P, Singh SB, Sharma AK et al (2006) Hypobaric hypoxia induces oxidative stress in rat brain. Neurochem Int 49:709-716
    • (2006) Neurochem Int , vol.49 , pp. 709-716
    • Maiti, P.1    Singh, S.B.2    Sharma, A.K.3
  • 5
    • 56549118754 scopus 로고    scopus 로고
    • High altitude memory impairment is due to neuronal apoptosis in hippocampus, cortex and striatum
    • Maiti P, Singh SB, Mallick B et al (2008) High altitude memory impairment is due to neuronal apoptosis in hippocampus, cortex and striatum. J Chem Neuroanat 36:227-238
    • (2008) J Chem Neuroanat , vol.36 , pp. 227-238
    • Maiti, P.1    Singh, S.B.2    Mallick, B.3
  • 6
    • 84872215817 scopus 로고    scopus 로고
    • Acute hypobaric hypoxia stress induces cognitive impairment in rats
    • Shi QH, Fu JF, Ge D et al (2012) Acute hypobaric hypoxia stress induces cognitive impairment in rats. Xibei Guofang Yixue Zazhi 33:4-7
    • (2012) Xibei Guofang Yixue Zazhi , vol.33 , pp. 4-7
    • Shi, Q.H.1    Fu, J.F.2    Ge, D.3
  • 7
    • 0035876056 scopus 로고    scopus 로고
    • Huperzine a attenuates cognitive dysfunction and neuronal degeneration caused by betaamyloid protein-(1-40) in rat
    • Wang R, Zhang HY, Tang XC (2001) Huperzine a attenuates cognitive dysfunction and neuronal degeneration caused by betaamyloid protein-(1-40) in rat. Eur J Pharmacol 421:149-156
    • (2001) Eur J Pharmacol , vol.421 , pp. 149-156
    • Wang, R.1    Zhang, H.Y.2    Tang, X.C.3
  • 8
    • 0032557464 scopus 로고    scopus 로고
    • Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine a: Comparison with e2020 and tacrine
    • Wang T, Tang XC (1998) Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine a: comparison with e2020 and tacrine. Eur J Pharmacol 349:137-142
    • (1998) Eur J Pharmacol , vol.349 , pp. 137-142
    • Wang, T.1    Tang, X.C.2
  • 9
    • 0029112606 scopus 로고
    • Efficacy of tablet huperzine - A on memory, cognition, and behavior in Alzheimer's disease
    • Xu SS, Gao ZX, Weng Z et al (1995) Efficacy of tablet huperzine- a on memory, cognition, and behavior in alzheimer's disease. Zhongguo Yao Li Xue Bao 16:391-395
    • (1995) Zhongguo Yao Li Xue Bao , vol.16 , pp. 391-395
    • Xu, S.S.1    Gao, Z.X.2    Weng, Z.3
  • 10
    • 0004052706 scopus 로고    scopus 로고
    • Improving effects of huperzine a on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment
    • Ye JW, Cai JX, Wang LM et al (1999) Improving effects of huperzine a on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. J Pharmacol Exp Ther 288:814-819
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 814-819
    • Ye, J.W.1    Cai, J.X.2    Wang, L.M.3
  • 11
    • 0025763629 scopus 로고
    • Drug evaluation of huperzine a in the treatment of senile memory disorders
    • Zhang RW, Tang XC, Han YY et al (1991) drug evaluation of huperzine a in the treatment of senile memory disorders. Zhongguo Yao Li Xue Bao 12:250-252
    • (1991) Zhongguo Yao Li Xue Bao , vol.12 , pp. 250-252
    • Zhang, R.W.1    Tang, X.C.2    Han, Y.Y.3
  • 12
    • 76549112494 scopus 로고    scopus 로고
    • Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion
    • Wang J, Zhang HY, Tang XC (2010) Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion. J Neurosci Res 88:807-815
    • (2010) J Neurosci Res , vol.88 , pp. 807-815
    • Wang, J.1    Zhang, H.Y.2    Tang, X.C.3
  • 13
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11:47-60
    • (1984) J Neurosci Methods , vol.11 , pp. 47-60
    • Morris, R.1
  • 14
    • 0037072513 scopus 로고    scopus 로고
    • Huperzine a attenuates cognitive deficits and brain injury in neonatal rats after hypoxiaischemia
    • Wang LS, Zhou J, Shao XM et al (2002) Huperzine a attenuates cognitive deficits and brain injury in neonatal rats after hypoxiaischemia. Brain Res 949:162-170
    • (2002) Brain Res , vol.949 , pp. 162-170
    • Wang, L.S.1    Zhou, J.2    Shao, X.M.3
  • 15
    • 35548976159 scopus 로고    scopus 로고
    • N-acetyl cysteine supplementation prevents impairment of spatial working memory functions in rats following exposure to hypobaric hypoxia
    • Jayalakshmi K, Singh SB, Kalpana B et al (2007) N-acetyl cysteine supplementation prevents impairment of spatial working memory functions in rats following exposure to hypobaric hypoxia. Physiol Behav 92:643-650
    • (2007) Physiol Behav , vol.92 , pp. 643-650
    • Jayalakshmi, K.1    Singh, S.B.2    Kalpana, B.3
  • 16
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 17
    • 0021027358 scopus 로고
    • Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay
    • Cathcart R, Schwiers E, Ames BN (1983) Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. Anal Biochem 134:111-116
    • (1983) Anal Biochem , vol.134 , pp. 111-116
    • Cathcart, R.1    Schwiers, E.2    Ames, B.N.3
  • 18
    • 0020594423 scopus 로고
    • Plasma malonaldehyde levels during myocardial infarction
    • Dousset JC, Trouilh M, Foglietti MJ (1983) Plasma malonaldehyde levels during myocardial infarction. Clin Chim Acta 129:319-322
    • (1983) Clin Chim Acta , vol.129 , pp. 319-322
    • Dousset, J.C.1    Trouilh, M.2    Foglietti, M.J.3
  • 19
    • 0017064979 scopus 로고
    • A fluorometric method for determination of oxidized and reduced glutathione in tissues
    • Hissin PJ, Hilf R (1976) A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74:214-226
    • (1976) Anal Biochem , vol.74 , pp. 214-226
    • Hissin, P.J.1    Hilf, R.2
  • 20
    • 34547841506 scopus 로고    scopus 로고
    • Acetyl-l-carnitine ameliorates hypobaric hypoxic impairment and spatial memory deficits in rats
    • Barhwal K, Singh SB, Hota SK et al (2007) Acetyl-l-carnitine ameliorates hypobaric hypoxic impairment and spatial memory deficits in rats. Eur J Pharmacol 570:97-107
    • (2007) Eur J Pharmacol , vol.570 , pp. 97-107
    • Barhwal, K.1    Singh, S.B.2    Hota, S.K.3
  • 21
    • 0023894159 scopus 로고
    • Pharmacokinetics of huperzine a in rats and mice
    • Wang YE, Feng J, Lu WH et al (1988) Pharmacokinetics of huperzine a in rats and mice. Zhongguo Yao Li Xue Bao 9:193-196
    • (1988) Zhongguo Yao Li Xue Bao , vol.9 , pp. 193-196
    • Wang, Y.E.1    Feng, J.2    Lu, W.H.3
  • 22
    • 0003093544 scopus 로고    scopus 로고
    • Huperzine a improves cognitive deficits caused by chronic cerebral hypoperfusion in rats
    • Wang LM, Han YF, Tang XC (2000) Huperzine a improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Eur J Pharmacol 398:65-72
    • (2000) Eur J Pharmacol , vol.398 , pp. 65-72
    • Wang, L.M.1    Han, Y.F.2    Tang, X.C.3
  • 23
    • 0023776131 scopus 로고
    • Improving effect of huperzine a on discrimination performance in aged rats and adult rats with experimental cognitive impairment
    • Lu WH, Shou J, Tang XC (1988) Improving effect of huperzine a on discrimination performance in aged rats and adult rats with experimental cognitive impairment. Zhongguo Yao Li Xue Bao 9:11-15
    • (1988) Zhongguo Yao Li Xue Bao , vol.9 , pp. 11-15
    • Lu, W.H.1    Shou, J.2    Tang, X.C.3
  • 24
    • 0030896029 scopus 로고    scopus 로고
    • Huperzine a, a novel promising acetylcholinesterase inhibitor
    • Cheng DH, Ren H, Tang XC (1996) Huperzine a, a novel promising acetylcholinesterase inhibitor. NeuroReport 8:97-101
    • (1996) NeuroReport , vol.8 , pp. 97-101
    • Cheng, D.H.1    Ren, H.2    Tang, X.C.3
  • 25
    • 77956213429 scopus 로고    scopus 로고
    • Cholinesterase inhibitors ameliorate spatial learning deficits in rats following hypobaric hypoxia
    • Muthuraju S, Maiti P, Solanki P et al (2010) Cholinesterase inhibitors ameliorate spatial learning deficits in rats following hypobaric hypoxia. Exp Brain Res 203:583-592
    • (2010) Exp Brain Res , vol.203 , pp. 583-592
    • Muthuraju, S.1    Maiti, P.2    Solanki, P.3
  • 26
    • 0033945846 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress plays a key role in aging and apoptosis
    • Sastre J, Pallardo FV, Vina J (2000) Mitochondrial oxidative stress plays a key role in aging and apoptosis. IUBMB Life 49:427-435
    • (2000) IUBMB Life , vol.49 , pp. 427-435
    • Sastre, J.1    Pallardo, F.V.2    Vina, J.3
  • 27
    • 17044429015 scopus 로고    scopus 로고
    • Oxidative stress on mitochondrial antioxidant defense system in the aging process: Role of dl-alpha-lipoic acid and l-carnitine
    • Savitha S, Tamilselvan J, Anusuyadevi M et al (2005) Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of dl-alpha-lipoic acid and l-carnitine. Clin Chim Acta 355:173-180
    • (2005) Clin Chim Acta , vol.355 , pp. 173-180
    • Savitha, S.1    Tamilselvan, J.2    Anusuyadevi, M.3
  • 28
    • 0345529920 scopus 로고    scopus 로고
    • Nitric oxide produced in rat liver mitochondria causes oxidative stress and impairment of respiration after transient hypoxia
    • Schild L, Reinheckel T, Reiser M et al (2003) Nitric oxide produced in rat liver mitochondria causes oxidative stress and impairment of respiration after transient hypoxia. FASEB J 17:2194-2201
    • (2003) FASEB J , vol.17 , pp. 2194-2201
    • Schild, L.1    Reinheckel, T.2    Reiser, M.3
  • 29
    • 29544450082 scopus 로고    scopus 로고
    • Acute and severe hypobaric hypoxia increases oxidative stress and impairs mitochondrial function in mouse skeletal muscle
    • Magalhaes J, Ascensao A, Soares JM et al (2005) Acute and severe hypobaric hypoxia increases oxidative stress and impairs mitochondrial function in mouse skeletal muscle. J Appl Physiol 99:1247-1253
    • (2005) J Appl Physiol , vol.99 , pp. 1247-1253
    • Magalhaes, J.1    Ascensao, A.2    Soares, J.M.3
  • 30
    • 0027273677 scopus 로고
    • Evaluation of the concomitance of lipid peroxidation in experimental models of cerebral ischemia and stroke
    • Watson BD (1993) Evaluation of the concomitance of lipid peroxidation in experimental models of cerebral ischemia and stroke. Prog Brain Res 96:69-95
    • (1993) Prog Brain Res , vol.96 , pp. 69-95
    • Watson, B.D.1
  • 31
    • 4444310335 scopus 로고    scopus 로고
    • Nitric oxide synthase and intermittent hypoxia-induced spatial learning deficits in the rat
    • Li RC, Row BW, Kheirandish L et al (2004) Nitric oxide synthase and intermittent hypoxia-induced spatial learning deficits in the rat. Neurobiol Dis 17:44-53
    • (2004) Neurobiol Dis , vol.17 , pp. 44-53
    • Li, R.C.1    Row, B.W.2    Kheirandish, L.3
  • 32
    • 0036746892 scopus 로고    scopus 로고
    • Hypoxiainduced lipid peroxidation in rat brain and protective effect of carnitine and phosphocreatine
    • Rauchova H, Koudelova J, Drahota Z et al (2002) Hypoxiainduced lipid peroxidation in rat brain and protective effect of carnitine and phosphocreatine. Neurochem Res 27:899-904
    • (2002) Neurochem Res , vol.27 , pp. 899-904
    • Rauchova, H.1    Koudelova, J.2    Drahota, Z.3
  • 33
    • 33746524296 scopus 로고    scopus 로고
    • Activity of lactate dehydrogenase in serum and cerebral cortex of immature and mature rats after hypobaric hypoxia
    • Koudelova J, Rauchova H, Vokurkova M (2006) Activity of lactate dehydrogenase in serum and cerebral cortex of immature and mature rats after hypobaric hypoxia. Neurochem Res 31: 915-919
    • (2006) Neurochem Res , vol.31 , pp. 915-919
    • Koudelova, J.1    Rauchova, H.2    Vokurkova, M.3
  • 34
    • 0032239490 scopus 로고    scopus 로고
    • Effects of lecithinized sod on sequential change in sod activity after cerebral contusion in rats
    • Yunoki M, Kawauchi M, Ukita N et al (1998) Effects of lecithinized sod on sequential change in sod activity after cerebral contusion in rats. Acta Neurochir Suppl 71:142-145
    • (1998) Acta Neurochir Suppl , vol.71 , pp. 142-145
    • Yunoki, M.1    Kawauchi, M.2    Ukita, N.3
  • 35
    • 20944446415 scopus 로고    scopus 로고
    • Neuroprotective effects of huperzine a. A natural cholinesterase inhibitor for the treatment of alzheimer's disease
    • Wang R, Tang XC (2005) Neuroprotective effects of huperzine a. A natural cholinesterase inhibitor for the treatment of alzheimer's disease. Neurosignals 14:71-82
    • (2005) Neurosignals , vol.14 , pp. 71-82
    • Wang, R.1    Tang, X.C.2
  • 36
    • 0032229327 scopus 로고    scopus 로고
    • Reactive oxygen species mediate cellular damage in alzheimer disease
    • Perry G, Castellani RJ, Hirai K et al (1998) Reactive oxygen species mediate cellular damage in alzheimer disease. J Alzheimers Dis 1:45-55
    • (1998) J Alzheimers Dis , vol.1 , pp. 45-55
    • Perry, G.1    Castellani, R.J.2    Hirai, K.3
  • 37
    • 33846913199 scopus 로고    scopus 로고
    • Hypobaric hypoxia-induced dendritic atrophy of hippocampal neurons is associated with cognitive impairment in adult rats
    • Titus AD, Shankaranarayana Rao BS, Harsha HN et al (2007) Hypobaric hypoxia-induced dendritic atrophy of hippocampal neurons is associated with cognitive impairment in adult rats. Neuroscience 145:265-278
    • (2007) Neuroscience , vol.145 , pp. 265-278
    • Titus, A.D.1    Shankaranarayana Rao, B.S.2    Harsha, H.N.3
  • 38
    • 0142070823 scopus 로고    scopus 로고
    • Apoptosis in the adult striatum after transient forebrain ischemia and the effects of ischemic severity
    • Ruan YW, Ling GY, Zhang JL et al (2003) Apoptosis in the adult striatum after transient forebrain ischemia and the effects of ischemic severity. Brain Res 982:228-240
    • (2003) Brain Res , vol.982 , pp. 228-240
    • Ruan, Y.W.1    Ling, G.Y.2    Zhang, J.L.3
  • 39
    • 0038481271 scopus 로고    scopus 로고
    • Mitochondrial regulation of apoptosis
    • Mayer B, Oberbauer R (2003) Mitochondrial regulation of apoptosis. News Physiol Sci 18:89-94
    • (2003) News Physiol Sci , vol.18 , pp. 89-94
    • Mayer, B.1    Oberbauer, R.2
  • 41
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry NA, Lazebnik Y (1998) Caspases: enemies within. Science 281:1312-1316
    • (1998) Science , vol.281 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 42
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and datp-dependent formation of apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P, Nijhawan D, Budihardjo I et al (1997) Cytochrome c and datp-dependent formation of apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479-489
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3
  • 43
    • 0037189932 scopus 로고    scopus 로고
    • Huperzine a attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons
    • Zhou J, Tang XC (2002) Huperzine a attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons. FEBS Lett 526:21-25
    • (2002) FEBS Lett , vol.526 , pp. 21-25
    • Zhou, J.1    Tang, X.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.