Microneedles: An innovative approach to transdermal delivery- a review

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 6, Issue 4, 2014, Pages 18-25

  Akhtar, Nida ^a  

^a IFTM UNIVERSITY   (India)

Author keywords

Drug delivery; Enhanced; Needles; Permeation; Skin; Systemic circulation

Indexed keywords

CLINICAL PRACTICE; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG DOSAGE FORM; DRUG RELEASE; HOLLOW MICRONEEDLE; HUMAN; MEMBRANE TRANSPORT; MICRONEEDLE; PARTITION COEFFICIENT; PATIENT COMPLIANCE; REVIEW; SKIN; SOLID MICRONEEDLE; SYSTEMIC CIRCULATION; TRANSDERMAL DRUG ADMINISTRATION;

EID: 84899847338     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Review

References (72)

1. Dhamecha DL, Rathi AA, Saifee M, Lahoti SR, Dehghan MHG. Drug vehicle based approaches of penetration enhancement. Int J Pharm Pharma Sci 2009; 1(1): 24-46.
2. Ranade VV. Drug delivery systems: transdermal drug delivery. J Clin Pharmacol 1991; 31(5): 401-418.
3. Sharma N, Bharat PS, Mahajan U. Blooming pharma indystry with transdermal drug delivery system. Indo Global J Pharm Sci 2012; 2(3): 262-278.
4. Rani S, Saroha K, Syan N, Mathur P. Transdermal patches a successful tool in transdermal drug delivery system: an overview. Der Pharmacia Sinica 2011; 2(5): 17-29.
5. Anitha P, Ramkanth S, Sankari KU, Alagusundaram M, Gnanapraksah K, Devi PD, Prasanna R I. Ethosomes-a noninvasive vesicular carrier for transdermal drug delivery. Int J Rev Life Sci 2011; 1(1): 17-24.
6. Baheti SR, Wdher KJ, Umekar MJ. A recent approach towards transdermal drug delivery by physical and chemical techniques. Int Pharm Sci 2011; 1(1): 42-53.
7. Arunachalam A, Karthikeyan M, Kumar M, Prathap M, Sethuraman S, Kumar SA, Manidipa S. Transdermal drug delivery system: a review. Curr Pharm Res 2010; 1(1): 70-81.
8. Ehdaie B. Enhanced delivery of transdermal drugs through human skin with novel carriers. J Pharm Biomed Sci 2011; 1(8): 161-166.
9. Sivamani R K, Liepmann D, Maibach HI. Microneedles and transdermal applications. Exp Opin Drug Del 2007; 4(1): 19-25.
10. Kumar JA, Pullakandam N, Prabu SL, Gopal V. Transdermal drug delivery system: an overview. Int J Pharm Sci Rev Res 2010; 3(2): 49-54.
11. Akhtar NA, Pathak K. Preclinical and clinical aspects of antimicrobial drugs delivered via ethosomal carriers. Antiinfective Ag 2012; 10: 15-25.
12. Chandel AM, Patil V, Goyal R, Dhamija H, Parashar B. Ethosomes: a novel approach towards transdermal drug delivery. Int J Pharm Chem Sci 2012; 1(2): 563-569.
13. Prausnitz MR. Microneedles for transderml drug delivery. Adv Drug Del Rev 2004; 56: 581-587.
14. Prausnitz MR, Langer R. Transdermal Drug delivery. Nature Biotechnol 2008; 26: 1261-1268.
15. Patel D, Chaudhary SA, Parmar B, Bhura N. Transdermal drug delivery system: a review. Pharm Innov 2012; 1(4): 66-75.
16. Chen B, Wei J, Tay FEH, Wong YT, Iliescu C. Silicon micro needles array biodegradable tips for transdermal drug delivery. DTIP Mems Moems 2007; 1: 25-27.
17. Sheer A, Chauhan M. Ethosomes as vesicular carrier for enhanced transdermal delivery of ketoconazole-formulation and evaluation. IJPI's J Pharm Cosmetol 2011; 1(3): 1-14.
18. Alvarez-Figueroa M, Delgado-Charro M. Passive and iontophoretic transdermal penetration of methotrexate. Int J Pharm 2001; 212: 101-107.
19. Samnani A, Girhepunje K, Bhowmik M, Joshi A, Dubey B K. Design and evaluation of ultradeformable soft elastic nano vesicle ethosomes for dermal delivery. World's J Pharm Res 2012; 1(1): 106-119.
20. Girhepunje K, Pal R, Gevariya H, Behera A, Thirumoorthy N. Ethosomes: a novel vesicular carrier for enhanced dermal delivery of ciclopirox olamine. Der Pharmacia Lettre 2010; 2(1): 360-367.
21. Patel KN, Patel HK, Patel VA. Formulation and characterization of drug in adhesive transdermal patches of diclofenac acid. Int J Pharm Pharm Sci 2012; 4(1): 296-299.
22. Vanbever R, LeBoulenge E, Preat V. Transdermal delivery of fentanyl by electroporation. Pharm Res 1996; 13: 559-565.
23. Vanbever R, Lecouturier N, Preat V. Transdermal delivery of metoprolol by electroporation. Pharm Res 1994; 11: 1657-1662.
24. Shaik HR, Tirumoorthy N. Enhanced transdermal delivery of ketoconazole via ethosomes formulation and evaluation. World's J Pharm Pharm Sci 2012; 1(1): 238-249.
25. Banga AK, Prausnitz MR. Assessing the potential of skin electroporation for the delivery of protein-and gene-based drug. Trends Biotechnol 1998; 16: 408-412.
26. Barry BW, Southwell D, Woodford R. Optimization of bioavailability of topical steroid: penetration enhancers under occlusion. J Invest Dermatol 1984; 82: 49-52.
27. Saab ANN, Sloan KB, Neall HD, Villaneuva R. Effect of amino methyl(N-Mannich base) derivatization on the ability of S6 acetyloxy methyl-6-mercaptopurine prodrug to deliver 6-mercaptopurine through hairless mouse skin. J Pharm Sci 1990; 79: 1099-1104.
28. Byl NN. The use of ultrasound as an enhancer for transcutaneous drug delivery: phonophoresis. Phys Ther 1995; 75: 539-553.
29. Hui X, Anigbogu A, Singh P, Xiong G, Poblet N, Liu P, Maibach HI. Pharmacokinetic and local tissue disposition of [14C] sodium diclofenac following iontophoresis and systemic administration in rabbits. J Pharm Sci 2001; 90(9): 1269-1276.
30. Kanikannan JN, Singh J, Ramaro P. In vitro transdermal iontophoretic transport of timolol maleate: effect of age and species. J Controlled Rel 2001; 71(1): 99-105.
31. Nolan LMA, Corish J, Corrigan OI, Fitzpatrick D. Iontophoretic and chemical enhancement of drug delivery: Part-I: Across Artificial Membranes. Int J Pharm 2003; 257: 41-55.
32. Bendas ER, Tadros MI. Enhanced transdermal delivery of salbutamol sulphate via ethosomes. AAPS PharmSciTech 2007; 8: 1-15.
33. Prasanthi D, Lakhshmi PK. Vesicles: mechanism of transdermal permeation: a review. Asian J Pharm Clin Res 2012; 5: 18-25.
34. Thong H-Y, Zhai H, Maibach HI. Percutaneous penetration enhancers: an overview. Skin Pharmacol App Skin Physiol 2010; l: 184-196.
35. Katare OP, Raza K, Singh B, Dogra S. Novel drug delivery systems in topical treatment of psoriasis: rigors and vigors. Ind J Dermatol Venereol Leprol 2010; 76: 612-621.
36. Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. Ethosomesnovel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Controlled Rel 1999; 65: 403-418.
37. Keleb E, Sharma RK, Mosa EB, Aljahwi AAZ. Transdermal drug delivery system: design and evaluation. Int J Adv Pharm Sci 2010; 1: 210-211.
38. Saroha K, Nanda S, Rani S. Chemical penetration enhances: a novel approach in transdermal drug delivery system. Int J Curr Pharm Res 2011; 3(4): 5-9.
39. Kumar AV, Kulkarni PR, Raut RA. Microneedles: promising technique for transdermal drug delivery. Int J Pharm Bio Sci 2011; 2(1): 684-708.
40. Tabassum N, Sofi A, Khuroo T. Microneedle technology: a new drug delivery system. Int J Res Pharm Biomed Sci 2011; 2(1): 59-62.
41. Srinivas P, Shanthi CL, Sadanandam MS. Miconeedles patches in drug delivery: a review. Int J Pharm Tech 2010; 2(3): 329-344.
42. Vandervoort J, Ludig A. Microneedles for transdermal drug delivery: a minireview. Front Biosci 2008; 1(13): 1711-1715.
43. Gandhi K, Dahiya A, Monika, Kalra T, Singh K. Transdermal drug delivery-a review. Int J Res Pharm Sci 2012; 3(3): 379-388.
44. Morrow DIJ, McCarron PA, Woolfron AD, Donnelly RF. Innovative strategies for enhancing topical and trandermal drug delivery. Open Drug Del J 2007; 1: 36-59.
45. Kumar R, Philip A. Modified Transdermal Technologies: Breaking the barriers of drug permeation via the skin. Trop J Pharm Res 2007; 6(1): 633-644.
46. Chhabaria S, Namdeo A, Kheri R, Saraogi G, Singhai A. Current status and future innovations in transdermal drug delivery. Int J Pharm Sci Res 2012; 3(8): 2502-2509.
47. Yadav JD. Microneedles: promising technique for transdermal drug delivery. Int J Pharm BioSci 2011; 2(1): 684-708.
48. Paik SJ, Lim JM, Jung I, Park Y, Byun S, Chung S. A novel microneedle array integrated with a PDMS biochip for micro fluid system. Transducers Solid-State Sensors Actuators Microsys 2003; 2: 1446-1449.
49. Smith EW, Maibach HI. The textbook of Percutaneous Penetration Enhancers. 2nd ed; 2006.
50. Kapoor D, Patel M, Singhal M. Innovations in transdermal drug delivery system. Int Pharm Sci 2011; 1(1): 54-61.
51. Kocchar JS, Zou S, Chan SY, Kang L. Protein encapsulation in polymeric microneedles by photolithography. Int J Nanomed 2012; 7: 3143-3154.
52. Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery. Nature Rev Drug Discov 2004; 3: 115-124.
53. Kim Y-C, Park J-H, Prausnitz MR. Microneedles for drug and vaccine delivery. Adv Drug Del Rev 2012; 64: 1547-1568.
54. Bariya SH, Gohel MC, Mehta TA, OP Sharma. Microneedles: an emerging transdermal drug delivery system. J Pharm Pharmacol 2012; 64(1): 11-29.
55. Prausnitz MR, Mikszta JA, Cormier M, Andrianov AK. Microneedle-based vaccines. Curr Top Microbiol Immunol 2009; 333: 369-393.
56. McAllister DV, Allen MG, Prausnitz M R. Microfabricated microneedles for gene and drug delivery. Ann Rev Biomed Engg 2000; 2: 289-313.
57. Cormier M, Johnson B, Ameri M, Nyam K. Transdermal delivery of desmopressin using a coated micro needle array patch system. J Controlled Rel 2004; 97: 503-511.
58. Alarcon JB, Hartley AW, Harvey NG, Mikszta JA. Preclinical evaluation of microneedle technology for intradermal delivery of influenza vaccines. Clinc Vacc Immunol 2007; 14: 375-381.
59. Mortanto W, Davis SP, Holiday NR, Wang J, Gill HS, Prausnitz MR. Transdermal delivery of insulin using microneedles in vivo. Pharm Res 2004; 21(6): 945-952.
60. Duan D, Moeckly C, Gysbers J, Novak C, Prochnow G, Siebender K, Albers L, Hansen K. Enhanced delivery of topically-applied formulations following skin pre treatment with a hand-applied, plastic microneedle array. Curr Drug Del 2013; 8(5): 557-565.
61. Ghosh P, Pinninti RR, Hammell DC, Paudel KS, Stinchcomb AL. Development of a codrug approach for sustained drug delivery across microneedles-treatment skin. J Pharm Sci 2013; 102(5): 1458-1467.
62. Donnelly RF, Morrow DIJ, McCarron PA, Woolfson AD, Morrissey A, Juzenas P, Juzeniene A, Lani V, McCarthy HO, Moan J. Microneedle arrays permit enhanced intradermal delivery of a performed photosensitizer. Photochem Photobiol 2009; 85: 195-204.
63. Back C, Han M, Min J, Prausnitz MR, Park JH Local transdermal delivery of phenylephrine to the anal sphincter muscle using microneedles. J Controlled Rel 2011; 154: 138-147.
64. Qiu Y, Qin G, Zhang S, Wu Y, Xu B, Gao Y. Novel lyophilized hydrogel patches for convenient and effective administration of microneedle-mediated insulin delivery. Int J Pharm 2012; 437: 51-56.
65. Chen M-C, Ling M-H, Lai K-Y, Pramudityo E. Chitosan microneedle patches for sustained transdermal delivery of macromolecules. Biomacromol 2012; 13(12): 4022-4031.
66. Wermeling DP, Banks SL, Hudson DA, Gupta J, Prausnitz MR, Stinchcomb AL. Microneedles permit transdermal delivery of a skin-impermeant medication to humans. Proc Natl Acad Sci USA 2008; 105(6): 2058-2063.
67. Ito Y, Haguiwara E, Saeki A, Sugioka N, Takada K. Feasibility of microneedles for percutaneous absorption of insulin. Eur J Pharm Sci 2006; 29(1): 82-88.
68. Kommareddy S, Baudner BC, Oh S, Kwon S-Y, Singh M, O'Hagan DT. Dissolvable microneedle patches for the delivery of cell-culturederived influenza vaccine antigens. J Pharm Sci 2011; 1: 1-7.
69. Boonma A, Narayan RJ, Lee Y-S. Analytical modelling and evaluation of microneedles apparatus with deformable soft tissues for biomedical applications. Computer Aided Des Appl 2013; 10(1): 139-157.
70. Yuzhakov VV. Advanced delivery devices: The AdminPen™ Microneedle device for painless and convenient drug delivery technology. Drug Deliv Tech 2010; 10(4): 32-36.
71. Desale RS, Wagh KS, Akarte AM, Baviskar DT, Jain DK. Microneedles technology for advanced drug delivery: a review. Int J Pharm Tech Res 2012; 4(1): 181-189.
72. Lax R. Challenges for therapeutic peptides part 2: delivery systems. Innov Pharm Tech 2010; 43: 42-46.