Vesicles - mechanism of transdermal permeation: A review

Asian Journal of Pharmaceutical and Clinical Research

Volumn 5, Issue 1, 2012, Pages 18-25

  Prasanthi, D ^a   Lakshmi, P K ^a  

^a OSMANIA UNIVERSITY   (India)

Author keywords

Dermal; Ethosomes; Invasomes; Liposomes; Transdermal; Transferosomes

Indexed keywords

CORTICOSTEROID; CYCLOSPORIN A; DEXAMETHASONE; DICLOFENAC; DITHRANOL; DRUG CARRIER; ENOXACIN; ESTRADIOL; ETHOSOME; FLUOROURACIL; FUROSEMIDE; GALLIDERMIN; HYDROCORTISONE; INSULIN; INVASOME; KETOTIFEN; LEVONORGESTREL; LIDOCAINE; LIPOSOME; LOW MOLECULAR WEIGHT HEPARIN; MELATONIN; METHOTREXATE; MINOXIDIL; NIOSOME; RETINOIC ACID; TEMOPORFIN; TETRACAINE; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZIDOVUDINE;

DRUG ABSORPTION; DRUG ADMINISTRATION ROUTE; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG MECHANISM; DRUG PENETRATION; DRUG RELEASE; DRUG TISSUE LEVEL; DRUG TRANSPORT; DRUG UPTAKE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE PERMEABILITY; MEMBRANE STABILIZATION; MEMBRANE TRANSPORT; PHYSICAL CHEMISTRY; PROTEIN SECRETION; REVIEW; SKIN PENETRATION; SKIN PERMEABILITY; STRATUM CORNEUM; SYSTEMIC CIRCULATION; TRANSPORT VESICLE;

EID: 84856806729     PISSN: 09742441     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (83)

1. Vyas SP, Khar RK. Transdermal drug delivery. In: Vyas SP & Khar RK, ed. Controlled drug delivery-concepts and advances. New Delhi, India: Vallabh Prakashan, 2002, 411-447.
2. Yie W. Chein. Transdermal drug delivery & delivery systems. In: Yie W.Chein, ed. Novel drug delivery systems. New York: Marcel Dekker, 1992, 301-380.
3. Yie W. Chein. Transdermal controlled systemic medications. New York: Marcel Dekker, INC. 1987.
4. Brian Barry. Transdermal drug delivery. In: Michael E.Aulton,ed. Pharmaceutics-The science of dosage form design. New York: Churchill Livingstone, 2002, 499-533.
5. J. Hadgraft. Skin, the final frontier.Int. J.Pharm.2001;224:1-18.
6. Ashok K. Tiwary, Bharti Sapra and Subheet Jain. Innovations in Transdermal Drug Delivery:Formulations and Techniques.Recent Patents on Drug Delivery & Formulation. 2007;1:23-36.
7. Schreier H and Bouwstra J.A. Liposomes and niosomes as topical drug carriers: dermal and transdermal drug delivery. J.Controlled Release.1994; 30:1-15.
8. Bouwstra J.A, Honeywell-Nguyen P.L. Vesicles as a tool for transdermal and dermal delivery. Drug Discovery Today: Technologies.2005; 2(1): 67-74.
9. Vyas SP, Khar RK. Targeted and controlled drug delivery. New Delhi, India: CBS publisher and distributor. 2001.
10. Mezei M, Gulasekharam V. Liposomes-a selective drug delivery system for the topical route of administration. Lotion dosage form. Life Sci. 1980; 26: 1473-1477.
11. Wohlrab W, Lasch J. Penetration kinetics of liposomal hydrocortisone in human skin. Dermatologica. 1987; 174: 18-22.
12. Wohlrab W, Lasch J. The effect of liposomal incorporation of topically applied hydrocortisone on its serum concentration and urinary excretion. Dermatol. Monatsschr. 1989; 175: 348-352.
13. Kim M.K, Chung S.J, Lee M.H, Cho A.R, Shim C.K. Targeted and sustained delivery of hydrocortisone to normal and stratum corneum removed skin without enhanced skin absorption using a liposomal gel. J. Control. Release. 1997; 46: 243-251.
14. Fresta M, Puglisi G. Corticosteroid dermal delivery with skin-lipid liposomes. J. Control. Release. 1997; 44: 141-151.
15. Foldvari M, Gesztes A, Mezei M. Dermal drug delivery by liposome encapsulation: clinical and electron microscopic studies. J. Microencapsul. 1990; 7: 479-489.
16. Masini V, Bonte F, Meybeck A, Wepierre J. Cutaneous bioavailability in hairless rats of tretinoin in liposomes or gel. J. Pharm. Sci. 1993; 82: 17-21.
17. Egbaria K, Ramachandran C, Weiner N. Topical delivery of ciclosporin: evaluation of various formulations using in vitro diffusion studies in hairless mouse skin. Skin Pharmacol. 1990; 3: 21-28.
18. Bouwstra J.A, Honeywell-Nguyen P.L. Skin structure and mode of action of vesicles. Adv.Drug Deliv Rev.2002; 54:S41-S55.
19. Egbaria K, Ramachandran C, Weiner N. Topical application of liposomally entrapped cyclosporin evaluated by in vitro diffusion studies with human skin. Skin Pharmacol.1991; 4:21-28.
20. Kirjavainen M, Urtti A, Jaaskelainen I, Suhonen T.M, Paronen P, Valjakka-Koskela R et al. Interaction of liposomes with human skin in vitro -the influence of lipid composition and structure. Biochim.Biophys.Acta. 1996; 1304:179-189.
21. El Maghraby G.M, Barry B.W, Williams A.C. Can drug-bearing liposomes penetrate intact skin? J. Pharm. Pharmacol. 2006; 58;415-429.
22. Kirjavainen M, Monkkonen J, Saukkosaari M, Valjakka-Koskela R, Kiesvaara J,Urtti A. Phospholipids affect stratum corneum lipid bilayer fluidity and drug partitioning into the bilayers. J. Control. Release. 1999;58:207-214.
23. Zellmer S, Pfeil W, Lasch J. Interaction of phosphatidylcholine liposomes with the human stratum corneum. Biochim. Biophys. Acta. 1995;1237:176-182.
24. El Maghraby G.M, Barry B.W, Williams A.C. Liposomes and skin: From drug delivery to model membranes. Eur J Pharm. 2008;34: 203-222.
25. Ganesan M.G, Weiner N.D, Flynn G.L, Ho N.F.H. Influence of liposomal drug entrapment on percutaneous absorption. Int.J.Pharm.1984; 20: 139-154.
26. Kato A, Ishibashi Y, Miyake Y. Effect of egg yolk lecithin on transdermal delivery of bunazosin hydrochloride. J.Pharm.Pharmacol.1987; 39: 399-400.
27. Schaller M, Korting H.C. Interaction of liposomes with human skin: the role of the stratum corneum. Adv.DrugDeliv.Rev. 1996; 18:303-309.
28. Cevc G, Gebauer D, Stieber J, Schatzlein A, Blume G. Ultraflexible vesicles, Transferosomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin. Biochim.Biophys.Acta. 1998; 1368: 201-215.
29. Han I, Kim M, Kim J. Enhanced transfollicular delivery of adriamycin with a liposome and iontophoresis. Exp. Dermatol. 2004;13 (2): 86-92.
30. Paolino D. In vitro and in vivo evaluation of Bola-surfactant containing niosomes for transdermal delivery. Biomed. Microdevices. 2007; 9:421-433.
31. Azeem A. Non ionic surfactant vesicles as a carrier for transdermal delivery of frusemide.J. Dispers.Sci.Technol.2008; 29(5):723-730.
32. Ijeoma F. Uchegbu, Suresh P. Vyas. Non-ionic surfactant based vesicles (niosomes) in drug delivery. Int. J. Pharm. 1998;172:33-70.
33. Pankaj Karande, Samir Mitragotri. Enhancement of transdermal drug delivery via synergistic action of chemicals. Biochim. Biophys Acta. 2009; 1788: 2362-2373.
34. Heather A.E. Benson. Transdermal drug delivery: penetration enhancement techniques. Curr. Drug Delivery.2005;2:23-33.
35. Cevc G and Blume G. Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. Biochim. Biophys Acta.1992; 1104:226-232.
36. Cevc G, Schatzlein A, Richardsen H. Ultradeformable lipid vesicles can penetrate the skin and other semi-permeable barriers unfragmented. Evidence from double label CLSM experiments and direct size measurements. Biochim. Biophys Acta.2002; 1564:21-30.
37. Jain S, Sapre R, Tiwary A.K, Jain N.K. Proultraflexible lipid vesicles for effective transdermal delivery of levonorgestrel: development, characterisation and performance evaluation. AAPS PharmSciTech. 2005; 6: E513-E522.
38. Honeywell-Nguyen P.L, Arenja S, Bouwstra J.A. Skin penetration and mechanisms of action in the delivery of the D2-agonist rotigotine from surfactant-based elastic vesicle formulations. Pharm. Res. 2003; 20:1619-1625.
39. Honeywell-Nguyen P.L, Bouwstra J.A. The in vitro transport of pergolide from surfactant-based elastic vesicles through human skin: a suggested mechanism of action. J. Control.Release. 2003; 86: 145-156.
40. Cevc G and Blume G. New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, Transferosomes. Biochim. Biophys Acta. 2001; 1514:191-205.
41. El Maghraby G.M, Williams A.C, Barry B.W. Skin delivery of 5-flurouracil from ultradeformable and standard liposomes in-vitro. J. Pharm. Pharmacol.2001; 53(8): 1069-1077.
42. Planas M.E. Noninvasive percutaneous induction of topical analgesia by a new type of drug carrier, and prolongation of local pain insensitivity by anesthetic liposomes. Anesth. Analg. 1992; 75(4): 615-621.
43. Guo J.X. Lecithin vesicular carriers for transdermal delivery of cyclosporin A. Int. J. Pharm. 2000; 194(2): 201-207.
44. Cevc G. Transdermal drug delivery of insulin with ultradeformable carriers. Clin. Pharmacokinet. 2003; 42(5): 461-474.
45. Cevc G and Blume G. Biological activity and characteristics of triamcinolone acetonide formulated with the self regulating drug carriers, Transferosomes(R). Biochim. Biophys Acta,Biomembr. 2003;1614(2): 156-164.
46. Fesq H. Improved risk benefit ratio for topical triamcinolone acetonide in Transferosome (R) in comparison with equipotent cream and ointment: a randomized controlled trial. Br. J. Dermatol.2003;149(3): 611-619.
47. Cevc G and Blume G. Hydrocortisone and dexamethasone in very deformable drug carriers have increased biological potency, prolonged effect, and reduced therapeutic dosage. Biochim. Biophys Acta,Biomembr. 2004; 1663(1-2): 61-73.
48. Garg M. Ethinylestradiol loaded ultraflexible liposomes: pharmacokinetics and pharmacodynamics. J.Pharm. Pharmacol.2006; 58(4): 459-468.
49. Song Y.K, Kim C.K. Topical delivery of low-molecular-weight heparin with surface charged flexible liposomes. Biomaterials. 2006; 27(2): 271-280.
50. Trotta M. Deformable liposomes for dermal administration of methotrexate. Int. J. Pharm. 2004; 270(1-2): 119-125.
51. Trotta M. Elastic liposomes for skin delivery of dipotassium glycyrrhizinate. Int. J. Pharm. 2002; 241(2): 319-327.
52. Jain S, Tiwary A.K, Jain N.K. Sustained and targeted delivery of an anti-HIV agent using elastic liposomal formulation: mechanism of action. Curr. Drug Deliv. 2006;3: 157-166.
53. Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. Ethosomes-novel vesicular carriers for enhanced delivery: characterisation and skin penetration properties. J. Control. Release. 2000; 65: 403-418.
54. Touitou E, Godin B, Weiss C. Enhanced delivery of drugs into and across the skin by ethosomal carriers. Drug Dev. Res. 2000; 50: 406-415.
55. Foldvari M, Gesztes A, Mezei M, Cardinal L, Kowalczyk I, Behl M. Topical liposomal local anesthetics: design, optimization and evaluation of formulations. Drug Dev. Ind. Pharm. 1993; 19: 2499-2517.
56. Touitou E, Alkabes M, Dayan N. Ethosomes: novel lipid vesicular system for enhanced delivery. Pharm.Res. 1997; S14: 305-306.
57. Elsayed M.M, Abdallah O.Y, Naggar V.F, Khalafallah N.M. Deformable liposomes and ethosomes as carriers for skin delivery of ketotifen. Pharmazie. 2007; 62: 133-137.
58. Elsayed M.M, Abdallah O.Y, Naggar V.F, Khalafallah N.M. Lipid vesicles for skin delivery of drugs: Reviewing three decades of research. Int J. Pharm. 2007;332: 1-16.
59. Horwitz E, Pisanty S, Czerninski R, Helser M, Eliav E, Touitou E. A clinical evaluation of a novel liposomal carrier for acyclovir in the topical treatment of recurrent herpes labialis. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 1999; 87: 700-705.
60. Lodzki M, Godin B, Rakou L, Mechoulam R, Gallily R, Touitou E. Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model. J. Control. Release. 2003; 93: 377-387.
61. Godin B, Touitou E. Erythromycin ethosomal systems: physicochemical characterisation and enhanced antibacterial activity. Curr. Drug Deliv. 2005; 2: 269-275.
62. Paolino D, Lucania G, Mardente D, Alhaique F, Fresta M. Ethosomes for skin delivery of ammonium glycyrrhizinate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers. J. Control. Release. 2005; 106: 99-110.
63. Kirjavainen M, Urtti A, Valjakka-Koskela R, Kiesvaara J, Monkkonen J. Liposome-skin interactions and their effects on the skin permeation of drugs. Eur. J. Pharm. Sci. 1999; 7: 279-286.
64. Dayan N, Touitou E. Carriers for skin delivery of trihexyphenidyl HCL: ethosomes vs. Liposomes. Biomaterials. 2000; 21: 1879-1885.
65. Jain S, Umamaheshwari R, Bhadra D, Jain N. Ethosomes: a novel vesicular carrier for enhanced transdermal delivery of an anti HIV agent. Indian J. Pharm.Sci.2004; 66: 72-81.
66. Esposito E, Menegatti E, Cortesi R. Ethosomes and liposomes as topical vehicles for azelaic acid: a preformulation study. J.Cosmet. Sci. 2004; 55: 253-264.
67. Maria Manconi, Carla Caddeo, Chiara Sinico, Donatella Valenti, Maria Cristina Mostallino, Giovanni Biggio, Anna Maria Fadda. Ex vivo skin delivery of diclofenac by transcutol containing liposomes and suggested mechanism of vesicle-skin interaction. Eur. J. Pharm. Biopharm. 2011;(article in press).
68. Simona Mura, Maria Manconi, Chiara Sinico, Donatella Valenti, Anna Maria Fadda. Penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of Minoxidil. Int. J. Pharm. 2009;380: 72-79.
69. Nina Dragicevic-Curic, Dietrich Scheglmann, Volker Albrecht, Alfred Fahr. Temoporfin-loaded invasomes: Development, characterisation and in vitro skin penetration studies. J. Control. Release. 2008;127: 59-69.
70. Agarwal R, Katare O.P, Vyas S.P. Preparation and in-vitro evaluation of liposomal/niosomal delivery systems for antipsoriatic drug dithranol. Int. J. Pharm. 2001; 228: 43-52.
71. Jia-You Fang, Chi-Tzong Hong, Wen-Ta Chiu, Ying-Yue Wang. Effect of liposomes and niosomes on skin permeation of enoxacin. Int. J. Pharm. 2001; 219: 61-72.
72. Aranya Manosroi, Penpan Khanrin, Warangkana Lohcharoenkal, Rolf G.Werner, Friedrich Gotz, Worapaka Manosroi, Jiradej Manosroi. Transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes. Int. J. Pharm. 2010; 392: 304-310.
73. Donatella Paolino, Donato Cosco, Rita Muzzalupo, Elena Trapasso, Nevio Picci, Massimo Fresta. Innovative bola-surfactant niosomes as topical delivery systems of 5-fluorouracil for the treatment of skin cancer. Int. J.Pharm.2008; 353: 233-242.
74. Manosroi A, Jantrawut P, Manosroi J. Anti-inflammatory activity of gel containing novel elastic niosomes entrapped with diclofenac diethylammonium. Int. J. Pharm. 2008;360: 156-163.
75. Elsayed M.M.A, Abdallah O.Y, Naggar V.F, Khalafallah N.M. Deformable liposomes and ethosomes: Mechanism of enhanced skin delivery. Int. J. Pharm. 2006; 322: 60-66.
76. Sunil Manohar, Amit Rawat, Praveen K. Dubey, Prem N.Gupta, Kapil Khatri, Amit k. Goyal, Vyas S.P. Cationic transferosomes based topical genetic vaccine against hepatitis B. Int.J.Pharm. 2007; 340: 13-19.
77. Prem N.Gupta, Vivek Mishra, Amit Rawat, Praveen Dubey, Sunil Mahor, Suresh P. Vyas. Non-invasive vaccine delivery in transferosomes, niosomes and liposomes: a comparative study. Int. J.Pharm. 2005; 293: 73-82.
78. Ghada M. El Zaafarany, Gehanne A.S.Awa, Samar M.Holayel, Nahed D. Mortada. Role of edge activators and surface charge in developing ultradeformable vesicles with enhanced skin delivery. Int.J.Pharm. 2010; 397: 164-172.
79. Vaibhav Dubey, Dinesh Mishra, N.K. Jain. Melatonin loaded ethanolic liposomes: Physicochemical characterisation and enhanced transdermal delivery. Eur.J.Pharm. Biopharm.2007;67:398-405.
80. Subheet Jain, Ashok.k Tiwary, Bharti Sapra, Narendra K.Jain. Formulation and evaluation of ethosomes for transdermal delivery of lamivudine. AAPS Pharm SciTech.2007; 8: E1-E8.
81. Touitou E, Margarita Shumilov. Buspirone transdermal administration for menopausal syndromes, in vitro and in animal model studies. Int. J. Pharm. 2010;387:26-33.
82. Vaibhav Dubey, Dinesh Mishra, Manoj Nahar, Vikas Jain, Narendra Kumar Jain. Enhanced transdermal delivery of an anti-HIV agent via ethanolic liposomes. Nanomedicine. 2010;6: 590-596.
83. Yi-Ping Fang, Yi-Hung Tsai, Pao-Chu Wu, Yaw-Bin Huang. Comparison of 5-aminolevulinic acid - encapsulated liposome versus ethosome for skin delivery of photodynamic therapy. Int.J.Pharm. 2008; 356: 144-152.