Analytical modeling and evaluation of microneedles apparatus with deformable soft tissues for biomedical applications

Computer-Aided Design and Applications

Volumn 10, Issue 1, 2013, Pages 139-157

  Boonma, Apichart ^a   Narayan, Roger J ^b   Lee, Yuan Shin ^a  

^a North Carolina State University   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Biomedical device design; Geometry analysis; Soft tissue modeling

Indexed keywords

BIOMEDICAL APPLICATIONS; BIOMEDICAL DEVICES; DISTRIBUTED LOADS; GEOMETRIC DESIGN; GEOMETRY ANALYSIS; INSERTION FORCE; INSERTION PROCESS; LINEAR ELASTIC; MICRONEEDLES; NON-LINEAR FINITE ELEMENT MODEL; OPERATION STABILITY; SOFT TISSUE; SOFT TISSUE MODELING; TISSUE PENETRATIONS;

ANALYTICAL MODELS; DESIGN; FINITE ELEMENT METHOD; FRACTURE MECHANICS; GEOMETRY; MEDICAL APPLICATIONS; TISSUE;

NEEDLES;

EID: 84869463636     PISSN: 16864360     EISSN: None     Source Type: Journal    
DOI: 10.3722/cadaps.2013.139-157     Document Type: Article

References (17)

1. Kim, E.; Narayan, R.; and Lee, Y.-S.: Analytical Modeling And Excimer Laser Micromachining of Microchannel For Medical Devices Development, Proceedings of 2010 ASME International Mechanical Engineering Conference and Exhibition (IMECE), Vancouver, BC, Canada, November 12-18, 2010, (CD) Paper Number: IMECE2010-40985.
2. Park, J.-H.; Allen, M. G.; Prausnitz, M. R.: Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery. Journal of Controlled Release, no. 104, 2005, 51-66. DOI:10.1016/j.jconrel.2005.02.002.
3. Park, J.-H.; Yoon, Y.-L.; Choi, S.-O.; Prausnitz, M. R.; Allen, M. G.: Taper conical polymer microneedles fabricated using an integrated lens technique for transdermal drug delivery. IEEE Transactions on Biomedical Engineering, 54(5), 2007, 903-913. DOI: 10.1109/TBME.2006.889173.
4. Doran, C. F.; McCormack, B. A. O.; Macey, A.: A simplified model to determine the contribution of strain energy in the failure process of thin biological membranes during cutting. Strain, no. 40, 2004, 173-179. DOI: 10.1111/j.1475-1305.2004.tb01426.x
5. He, X.; Chen, Y.; Libo, T: Haptic Simulation of Flexible Needle Insertion. Proceedings of the 2007 IEEE International Conference on Robotics and Biomimetics, Sanya, China, 2007, 607-611. DOI:10.1109/ROBIO.2007.4522231.
6. Zahn, J. D.; Talbot, N. H.; Dorian, L.; Pisano, P.: Micro-fabricated polysilicon microneedles for minimally invasive biomedical devices, Biomed. Microdevices 2, 2000, 295-303. DOI: 10.1023/A:1009907306184.
7. Davis, S. P.; Landis, B. J.; Adams, Z. H.; Allen, M. G.; Prausnitz, M. R.: Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force. Journal of Biomech. 37, 2004, 1155-1163. DOI:10.1016/j.jbiomech.2003.12.010
8. Azar, T.; and Vincent, H.: Estimation of the fracture toughness of soft tissue from needle insertion. Proceeding of Biomedical Simulation, 4th International Symposium, ISBMS 2008, Lecture Notes in Computer Science. Springer Verlag, 2008, 166-175. DOI: 10.1007/978-3-540-70521-5_18
9. Lin, S. Y.; Narayan, R.; Lee, Y.-S.: Heterogeneous Deformable Modeling and Topology Modification for Surgical Cutting Simulation with Haptic Interfaces, Computer-Aided Design and Application, 5(6), 2008, 877-888. doi:10.3722/cadaps.2008.877-888.
10. Ko, K. W.; Kim, H.; Bae, S.; Kim, E.; Lee, Y.-S.: Determination of Spring Constant for Simulating Deformable Object under Compression, Journal of Key Engineering Materials, 417-418(2), 2010, 369-372. DOI: 10.4028/www.scientific.net/KEM.417-418.369.
11. Timoshenko, S. P.; Gere J. M.: Theory of Elastic Stability. McGRAW-Hill Book Company, INC., New York, 1961.
12. Odland, G: Structure of the skin, In Physiology, biochemistry and molecular biology of the skin, Oxford University Press, Oxford, 1991.
13. Conn, N.; Gould, N.; Toint, P.: Trust-Region Methods. MPS/SIAM Series on Optimization, SIAM and MPS 2000.
14. Pailler-Matteri, C.; Pavan, S.; Vargiolu, R.; Pirot, F.; Falson, F.; Zahouani, H.: Contribution of stratum corneum in determining biotriological properties of the human skin. Wear 263, 2007, 1038-1043. DOI:10.1016/j.wear.2007.01.128.
15. L'Etang, A.; Huang, Z.: FE simulation of laser generated surface acoustic wave propagation in skin. Ultrasonics 44, 2006, 1243-1247. DOI:10.1016/j.ultras.2006.05.077.
16. Geuzaine C.; Remacle J.-F.: Gmsh: a three dimensional finite element mesh generator with built-in pre-and post-processing facilities. 2010. www.geuz.org/gmsh/
17. Maurin, B.; Barbe, L.; Bayle, B.; Zanne, P.; Gangloff, J.; De Mathelin, M.; Gangi, A.; Soler, L.; Forgione, A.: In vivo study of forces during needle insertions. Proceeding of the medical robotics, navigation and visualisation scientific workshop 2004. DOI: 10.1142/9789812702678_0056.