Plasma metabolite profiles of Alzheimer's disease and mild cognitive impairment

Journal of Proteome Research

Volumn 13, Issue 5, 2014, Pages 2649-2658

  Wang, Gang ^a   Zhou, Yi ^a   Huang, Feng Jie ^b   Tang, Hui Dong ^a   Xu, Xu Hua ^a   Liu, Jia Jian ^b   Wang, Ying ^a   Deng, Yu Lei ^a   Ren, Ru Jing ^a   Xu, Wei ^a   Ma, Jian Fang ^a   Zhang, Yi Nan ^b   Zhao, Ai Hua ^b   Chen, Sheng Di ^a   Jia, Wei ^b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

Alzheimer's disease; amnestic mild cognitive impairment; biomarkers; metabolomics; plasma

Indexed keywords

2 AMINOADIPIC ACID; 2 BUTENEDIOIC ACID; 5,8 TETRADECADIENOIC ACID; 5,8,11,14,17 ICOSAPENTAENOIC ACID; ADRENIC ACID; AMINO ACID; ARACHIDONIC ACID; BIOLOGICAL MARKER; CERVONIC ACID; CHOLINESTERASE INHIBITOR; CYSTINE; CYTIDINE; DIMETHYLGLYCINE; DOCOSAHEXAENOIC ACID; ELAIDIC ACID; GLUTAMIC ACID; GLUTAMINE; HYPOXANTHINE; LINOLEIC ACID; MYRISTIC ACID; OLEIC ACID; PALMITIC ACID; PALMITOLEIC ACID; PENTADECANOIC ACID; PROLINE; PYROGLUTAMIC ACID; STEARIC ACID; SUCCINIC ACID; THYMINE; UNCLASSIFIED DRUG; URIDINE; SARCOSINE;

AGED; ALZHEIMER DISEASE; AMINO ACID METABOLISM; ARTICLE; BLOOD ANALYSIS; CARBOHYDRATE METABOLISM; CARBON METABOLISM; CITRIC ACID CYCLE; CONTROLLED STUDY; EARLY DIAGNOSIS; FATTY ACID METABOLISM; FEMALE; GLUTATHIONE METABOLISM; HUMAN; MAJOR CLINICAL STUDY; MALE; MASS FRAGMENTOGRAPHY; METABOLITE; METABOLOMICS; MILD COGNITIVE IMPAIRMENT; NUCLEIC ACID METABOLISM; PRIORITY JOURNAL; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANALOGS AND DERIVATIVES; BLOOD; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; MIDDLE AGED; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ARACHIDONIC ACID; BIOLOGICAL MARKERS; CHROMATOGRAPHY, LIQUID; CYTIDINE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTAMIC ACID; GLUTAMINE; HUMANS; MALE; MASS SPECTROMETRY; METABOLOMICS; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; REPRODUCIBILITY OF RESULTS; SARCOSINE; SENSITIVITY AND SPECIFICITY; THYMINE;

EID: 84899846964     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr5000895     Document Type: Article

References (45)

1. Ferreira, I. L.; Resende, R.; Ferreiro, E.; Rego, A. C.; Pereira, C. F. Multiple defects in energy metabolism in Alzheimer's disease Curr. Drug Targets 2010, 11, 1193-1206
2. Rojo, L. E.; Fernandez, J. A.; Maccioni, A. A.; Jimenez, J. M.; Maccioni, R. B. Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease Arch Med. Res. 2008, 39, 1-16
3. Kaddurah-Daouk, R.; Zhu, H.; Sharma, S.; Bogdanov, M.; Rozen, S. G.; Matson, W.; Oki, N. O.; Motsinger-Reif, A. A.; Churchill, E.; Lei, Z.; Appleby, D.; Kling, M. A.; Trojanowski, J. Q.; Doraiswamy, P. M.; Arnold, S. E. Alterations in metabolic pathways and networks in Alzheimer's disease Transl. Psychiatry 2013, 3, e244
4. Petersen, R. C. Early diagnosis of Alzheimer's disease: is MCI too late? Curr. Alzheimer Res. 2009, 6, 324-330
5. Sperling, R.; Johnson, K. Biomarkers of Alzheimer disease: current and future applications to diagnostic criteria Continuum 2013, 19, 325-338
6. Kester, M. I.; Scheffer, P. G.; Koel-Simmelink, M. J.; Twaalfhoven, H.; Verwey, N. A.; Veerhuis, R.; Twisk, J. W.; Bouwman, F. H.; Blankenstein, M. A.; Scheltens, P.; Teunissen, C.; van der Flier, W. M. Serial CSF sampling in Alzheimer's disease: specific versus non-specific markers Neurobiol. Aging 2012, 33, 1591-1598
7. Xu, X. H.; Huang, Y.; Wang, G.; Chen, S. D. Metabolomics: a novel approach to identify potential diagnostic biomarkers and pathogenesis in Alzheimer's disease Neurosci. Bull. 2012, 28, 641-648
8. Wang, J. H.; Byun, J.; Pennathur, S. Analytical approaches to metabolomics and applications to systems biology Semin. Nephrol. 2010, 30, 500-511
9. Dettmer, K.; Aronov, P. A.; Hammock, B. D. Mass spectrometry-based metabolomics Mass Spectrom. Rev. 2007, 26, 51-78
10. Tajima, Y.; Ishikawa, M.; Maekawa, K.; Murayama, M.; Senoo, Y.; Nishimaki-Mogami, T.; Nakanishi, H.; Ikeda, K.; Arita, M.; Taguchi, R.; Okuno, A.; Mikawa, R.; Niida, S.; Takikawa, O.; Saito, Y. Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease Lipids Health Dis 2013, 12 10.1186/1476-511X-12-68
11. Iuliano, L.; Pacelli, A.; Ciacciarelli, M.; Zerbinati, C.; Fagioli, S.; Piras, F.; Orfei, M. D.; Bossu, P.; Pazzelli, F.; Serviddio, G.; Caltagirone, C.; Spalletta, G. Plasma fatty acid lipidomics in amnestic mild cognitive impairment and Alzheimer's disease J. Alzheimers Dis. 2013, 36, 545-53
12. Cunnane, S. C.; Schneider, J. A.; Tangney, C.; Tremblay-Mercier, J.; Fortier, M.; Bennett, D. A.; Morris, M. C. Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease J. Alzheimers Dis. 2012, 29, 691-697
13. Gueli, M. C.; Taibi, G. Alzheimer's disease: amino acid levels and brain metabolic status Neurol. Sci. 2013, 34, 1575-1579
14. Tukiainen, T.; Tynkkynen, T.; Makinen, V. P.; Jylanki, P.; Kangas, A.; Hokkanen, J.; Vehtari, A.; Grohn, O.; Hallikainen, M.; Soininen, H.; Kivipelto, M.; Groop, P. H.; Kaski, K.; Laatikainen, R.; Soininen, P.; Pirttila, T.; Ala-Korpela, M. A multi-metabolite analysis of serum by 1H NMR spectroscopy: early systemic signs of Alzheimer's disease Biochem. Biophys. Res. Commun. 2008, 375, 356-361
15. Walter, A.; Korth, U.; Hilgert, M.; Hartmann, J.; Weichel, O.; Fassbender, K.; Schmitt, A.; Klein, J. Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients Neurobiol. Aging 2004, 25, 1299-1303
16. Kaddurah-Daouk, R.; Zhu, H.; Sharma, S.; Bogdanov, M.; Rozen, S. G.; Matson, W.; Oki, N. O.; Motsinger-Reif, A. A.; Churchill, E.; Lei, Z.; Appleby, D.; Kling, M. A.; Trojanowski, J. Q.; Doraiswamy, P. M.; Arnold, S. E. Alterations in metabolic pathways and networks in Alzheimer's disease Transl. Psychiatry 2013, 3 10.1038/tp.2013.18
17. Oresic, M.; Hyotylainen, T.; Herukka, S. K.; Sysi-Aho, M.; Mattila, I.; Seppanan-Laakso, T.; Julkunen, V.; Gopalacharyulu, P. V.; Hallikainen, M.; Koikkalainen, J.; Kivipelto, M.; Helisalmi, S.; Lotjonen, J.; Soininen, H. Metabolome in progression to Alzheimer's disease Transl. Psychiatry 2011, 1 10.1038/tp.2011.55
18. Greenberg, N.; Grassano, A.; Thambisetty, M.; Lovestone, S.; Legido-Quigley, C. A proposed metabolic strategy for monitoring disease progression in Alzheimer's disease Electrophoresis 2009, 30, 1235-1239
19. Trushina, E.; Dutta, T.; Persson, X. M.; Mielke, M. M.; Petersen, R. C. Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics PLoS One 2013, 8, e63644
20. Sato, Y.; Nakamura, T.; Aoshima, K.; Oda, Y. Quantitative and wide-ranging profiling of phospholipids in human plasma by two-dimensional liquid chromatography/mass spectrometry Anal. Chem. 2010, 82, 9858-9864
21. Sato, Y.; Suzuki, I.; Nakamura, T.; Bernier, F.; Aoshima, K.; Oda, Y. Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology J. Lipid Res. 2012, 53, 567-576
22. Han, X.; Rozen, S.; Boyle, S. H.; Hellegers, C.; Cheng, H.; Burke, J. R.; Welsh-Bohmer, K. A.; Doraiswamy, P. M.; Kaddurah-Daouk, R. Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics PLoS One 2011, 6, e21643
23. Tierney, M. C.; Fisher, R. H.; Lewis, A. J.; Zorzitto, M. L.; Snow, W. G.; Reid, D. W.; Nieuwstraten, P. The NINCDS-ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease: a clinicopathologic study of 57 cases Neurology 1988, 38, 359-364
24. Petersen, R. C.; Smith, G. E.; Waring, S. C.; Ivnik, R. J.; Tangalos, E. G.; Kokmen, E. Mild cognitive impairment: clinical characterization and outcome Arch Neurol 1999, 56, 303-308
25. Zivelin, A.; Rosenberg, N.; Peretz, H.; Amit, Y.; Kornbrot, N.; Seligsohn, U. Improved method for genotyping apolipoprotein E polymorphisms by a PCR-based assay simultaneously utilizing two distinct restriction enzymes Clin Chem. 1997, 43, 1657-1659
26. Qiu, Y.; Cai, G.; Su, M.; Chen, T.; Zheng, X.; Xu, Y.; Ni, Y.; Zhao, A.; Xu, L. X.; Cai, S.; Jia, W. Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS J. Proteome Res. 2009, 8, 4844-4850
27. Chouinard-Watkins, R.; Rioux-Perreault, C.; Fortier, M.; Tremblay-Mercier, J.; Zhang, Y.; Lawrence, P.; Vohl, M. C.; Perron, P.; Lorrain, D.; Brenna, J. T.; Cunnane, S. C.; Plourde, M. Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE epsilon4 allele Br. J. Nutr. 2013, 1-9
28. Yang, J.; Chen, T.; Sun, L.; Zhao, Z.; Qi, X.; Zhou, K.; Cao, Y.; Wang, X.; Qiu, Y.; Su, M.; Zhao, A.; Wang, P.; Yang, P.; Wu, J.; Feng, G.; He, L.; Jia, W.; Wan, C. Potential metabolite markers of schizophrenia Mol. Psychiatry 2013, 18, 67-78
29. Hooijmans, C. R.; Kiliaan, A. J. Fatty acids, lipid metabolism and Alzheimer pathology Eur. J. Pharmacol. 2008, 585, 176-196
30. Crupi, R.; Marino, A.; Cuzzocrea, S. n-3 Fatty Acids: Role in Neurogenesis and Neuroplasticity Curr. Med. Chem. 2013, 20, 2953-2963
31. Gu, Y.; Schupf, N.; Cosentino, S. A.; Luchsinger, J. A.; Scarmeas, N. Nutrient intake and plasma beta-amyloid Neurology 2012, 78, 1832-1840
32. Rapoport, S. I. Brain arachidonic and docosahexaenoic acid cascades are selectively altered by drugs, diet and disease Prostaglandins, Leukotrienes Essent. Fatty Acids 2008, 79, 153-156
33. Ronnemaa, E.; Zethelius, B.; Vessby, B.; Lannfelt, L.; Byberg, L.; Kilander, L. Serum fatty-acid composition and the risk of Alzheimer's disease: a longitudinal population-based study Eur. J. Clin Nutr 2012, 66, 885-890
34. Sun, X.; He, G.; Qing, H.; Zhou, W.; Dobie, F.; Cai, F.; Staufenbiel, M.; Huang, L. E.; Song, W. Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 18727-18732
35. Zhang, X.; Le, W. Pathological role of hypoxia in Alzheimer's disease Exp. Neurol. 2010, 223, 299-303
36. Carvalho, C.; Correia, S. C.; Santos, R. X.; Cardoso, S.; Moreira, P. I.; Clark, T. A.; Zhu, X.; Smith, M. A.; Perry, G. Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia J. Bioenerg. Biomembr. 2009, 41, 433-440
37. Garcia-Garcia, A.; Zavala-Flores, L.; Rodriguez-Rocha, H.; Franco, R. Thiol-redox signaling, dopaminergic cell death, and Parkinson's disease Antioxid. Redox Signaling 2012, 17, 1764-1784
38. Wang, J.; Xiong, S.; Xie, C.; Markesbery, W. R.; Lovell, M. A. Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease J. Neurochem. 2005, 93, 953-962
39. Albrecht, J.; Sonnewald, U.; Waagepetersen, H. S.; Schousboe, A. Glutamine in the central nervous system: function and dysfunction Front. Biosci. 2007, 12, 332-343
40. Lewerenz, J.; Hewett, S. J.; Huang, Y.; Lambros, M.; Gout, P. W.; Kalivas, P. W.; Massie, A.; Smolders, I.; Methner, A.; Pergande, M.; Smith, S. B.; Ganapathy, V.; Maher, P. The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities Antioxid. Redox Signaling 2013, 18, 522-555
41. Delwing, D.; Sanna, R. J.; Wofchuk, S.; Wyse, A. T. Proline promotes decrease in glutamate uptake in slices of cerebral cortex and hippocampus of rats Life Sci. 2007, 81, 1645-1650
42. Sell, D. R.; Strauch, C. M.; Shen, W.; Monnier, V. M. 2-aminoadipic acid is a marker of protein carbonyl oxidation in the aging human skin: effects of diabetes, renal failure and sepsis Biochem. J. 2007, 404, 269-277
43. Coppede, F.; Grossi, E.; Buscema, M.; Migliore, L. Application of artificial neural networks to investigate one-carbon metabolism in Alzheimer's disease and healthy matched individuals PLoS One 2013, 8, e74012
44. Midttun, O.; Kvalheim, G.; Ueland, P. M. High-throughput, low-volume, multianalyte quantification of plasma metabolites related to one-carbon metabolism using HPLC-MS/MS Anal. Bioanal. Chem. 2013, 405, 2009-2017
45. Trushina, E.; Mielke, M. M. Recent advances in the application of metabolomics to Alzheimer's Disease Biochim. Biophys. Acta 2013, 10.1016/j.bbadis.2013.06.014