Erlotinib promotes endoplasmic reticulum stress-mediated injury in the intestinal epithelium

Toxicology and Applied Pharmacology

Volumn 278, Issue 1, 2014, Pages 45-52

  Fan, Lu ^a   Hu, Lingna ^a   Yang, Baofang ^a   Fang, Xianying ^a   Gao, Zhe ^a   Li, Wanshuai ^a   Sun, Yang ^a   Shen, Yan ^a   Wu, Xuefeng ^a   Shu, Yongqian ^b   Gu, Yanhong ^b   Wu, Xudong ^a   Xu, Qiang ^a  

^a NANJING UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Diarrhea; E cadherin; ER stress; Erlotinib

Indexed keywords

BETA1 INTEGRIN; CCAAT ENHANCER BINDING PROTEIN; ERLOTINIB; INTERLEUKIN 17F; INTERLEUKIN 25; INTERLEUKIN 6; MESSENGER RNA; PROTEIN ZO1; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY; DIARRHEA; DOSE RESPONSE; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; MALE; MOUSE; NONHUMAN; TIGHT JUNCTION;

APOPTOSIS; DIARRHEA; E-CADHERIN; ER STRESS; ERLOTINIB;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CADHERINS; CELL LINE; DIARRHEA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM STRESS; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-17; INTERLEUKIN-6; INTERLEUKINS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED C57BL; PERMEABILITY; PROTEIN KINASE INHIBITORS; QUINAZOLINES; RATS; RNA INTERFERENCE; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION FACTOR CHOP; TRANSFECTION;

EID: 84899819944     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.04.015     Document Type: Article

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