Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cells

Steroids

Volumn 85, Issue , 2014, Pages 36-43

  Cechin, Sirlene R ^a   Buchwald, Peter ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

CD154; Corticosteroids; Hill equation; TNF; Transrepression

Indexed keywords

ALKALINE PHOSPHATASE PLACENTA ISOENZYME; BECLOMETASONE DIPROPIONATE; CD40 LIGAND; CLOBETASOL PROPIONATE; CYTOKINE; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LOTEPREDNOL ETABONATE; PREDNISOLONE; TRIAMCINOLONE ACETONIDE; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; TRANSCRIPTION FACTOR AP 1; TRIAMCINOLONE;

ARTICLE; CELL ASSAY; CELL TYPE; CONCENTRATION RESPONSE; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG POTENCY; EMBRYO; GENE CONSTRUCT; GENE REPRESSION; HEK293 CELL LINE; HUMAN; HUMAN CELL; IC 50; RECEPTOR AFFINITY; REPORTER GENE; SENSOR CELL; SIGMOID; TRANSCRIPTION INITIATION; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; PATHOLOGY; SIGNAL TRANSDUCTION;

ANTI-INFLAMMATORY AGENTS; CD40 LIGAND; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HUMANS; INFLAMMATION; NF-KAPPA B; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTIONAL ACTIVATION; TRIAMCINOLONE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84899819880     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2014.04.003     Document Type: Article

References (36)

1. B.P. Schimmer, and K.L. Parker Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones J.G. Hardman, L.E. Limbird, Goodman & Gilman's the pharmacological basis of therapeutics 1996 McGraw-Hill New York 1459 1485
2. P.J. Barnes Therapeutic strategies for allergic diseases Nature 402 Suppl. 1999 B31 B38
3. M.A. Avery, and J.R. Woolfrey Anti-inflammatory steroids D.J. Abraham, Burger's medicinal chemistry and drug discovery vol 3, cardiovascular agents and endocrines 6th ed. 2003 Wiley Hoboken, NJ 747 853
4. N. Bodor, and P. Buchwald Corticosteroid design for the treatment of asthma: structural insights and the therapeutic potential of soft corticosteroids Curr Pharm Des 12 2006 3241 3260 (Pubitemid 44375467)
5. S.M. Hollenberg, C. Weinberger, E.S. Ong, G. Cerelli, A. Oro, and R. Lebo et al. Primary structure and expression of a functional human glucocorticoid receptor cDNA Nature 318 1985 635 641 (Pubitemid 16172412)
6. J.N. Baraniuk Molecular actions of glucocorticoids: an introduction J Allergy Clin Immunol 97 1996 141 142 (Pubitemid 26049494)
7. P.J. Barnes Molecular mechanisms of corticosteroids in allergic diseases Allergy 56 2001 928 936
8. K.A. Smoak, and J.A. Cidlowski Mechanisms of glucocorticoid receptor signaling during inflammation Mech Ageing Dev 125 2004 697 706 (Pubitemid 39482400)
9. P.J. Barnes How corticosteroids control inflammation: Quintiles Prize Lecture 2005 Br J Pharmacol 148 2006 245 254 (Pubitemid 43804814)
10. R. Kumar, and E.B. Thompson The structure of the nuclear hormone receptors Steroids 64 1999 310 319 (Pubitemid 29284331)
11. N.Z. Lu, S.E. Wardell, K.L. Burnstein, D. Defranco, P.J. Fuller, and V. Giguere et al. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors Pharmacol Rev 58 2006 782 797 (Pubitemid 44833746)
12. P.J. Rohdewald Comparison of clinical efficacy of inhaled glucocorticoids Arzneim-Forsch/Drug Res 48 II 1998 789 796 (Pubitemid 28394104)
13. H. Derendorf, G. Hochhaus, B. Meibohm, H. Möllmann, and J. Barth Pharmacokinetics and pharmacodynamics of inhaled corticosteroids J Allergy Clin Immunol 101 1998 S440 S446
14. S. Rohatagi, V. Arya, K. Zech, R. Nave, G. Hochhaus, and K. Jensen et al. Population pharmacokinetics and pharmacodynamics of ciclesonide J Clin Pharmacol 43 2003 365 378 (Pubitemid 36372042)
15. D.E. Mager, N. Moledina, and W.J. Jusko Relative immunosuppressive potency of therapeutic corticosteroids measured by whole blood lymphocyte proliferation J Pharm Sci 92 2003 1521 1525 (Pubitemid 36792764)
16. P. Buchwald Glucocorticoid receptor binding: a biphasic dependence on molecular size as revealed by the bilinear LinBiExp model Steroids 73 2008 193 208
17. K. De Bosscher, and G. Haegeman Minireview: latest perspectives on antiinflammatory actions of glucocorticoids Mol Endocrinol 23 2009 281 291
18. K. De Bosscher, W. Vanden Berghe, and G. Haegeman The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression Endocr Rev 24 2003 488 522 (Pubitemid 37059110)
19. N.L. Dirks, S. Li, B. Huth, G. Hochhaus, C.R. Yates, and B. Meibohm Transrepression and transactivation potencies of inhaled glucocorticoids Pharmazie 63 2008 893 898
20. M. Salter, K. Biggadike, J.L. Matthews, M.R. West, M.V. Haase, and S.N. Farrow et al. Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease Am J Physiol Lung Cell Mol Physiol 293 2007 L660 L667
21. I. Uings, D. Needham, J. Matthews, M. Haase, R. Austin, and D. Angell et al. Discovery of GW870086: a potent anti-inflammatory steroid with a unique pharmacological profile Br J Pharmacol 169 2013 1389 1403
22. E. Margolles-Clark, O. Umland, N.S. Kenyon, C. Ricordi, and P. Buchwald Small molecule costimulatory blockade: organic dye inhibitors of the CD40-CD154 interaction J Mol Med 87 2009 1133 1143
23. L. Ganesan, and P. Buchwald The promiscuous protein binding ability of erythrosine B studied by metachromasy (metachromasia) J Mol Recognit 26 2013 181 189
24. T. Satoh, and M. Hosokawa Structure, function and regulation of carboxylesterases Chem Biol Interact 162 2006 195 211 (Pubitemid 44402409)
25. P. Buchwald Structure-metabolism relationships: steric effects and the enzymatic hydrolysis of carboxylic esters Mini-Rev Med Chem 1 2001 101 111
26. G. Zhou, G.K. Marathe, B. Willard, and T.M. McIntyre Intracellular erythrocyte platelet-activating factor acetylhydrolase I inactivates aspirin in blood J Biol Chem 286 2011 34820 34829
27. M.P. Mathew, E. Tan, S. Shah, R. Bhattacharya, M. Adam Meledeo, and J. Huang et al. Extracellular and intracellular esterase processing of SCFA-hexosamine analogs: implications for metabolic glycoengineering and drug delivery Bioorg Med Chem Lett 22 2012 6929 6933
28. L. Ganesan, E. Margolles-Clark, Y. Song, and P. Buchwald The food colorant erythrosine is a promiscuous protein-protein interaction inhibitor Biochem Pharmacol 81 2011 810 818
29. N. Auphan, J.A. DiDonato, C. Rosette, A. Helmberg, and M. Karin Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis Science 270 1995 286 290
30. R.M. Nissen, and K.R. Yamamoto The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain Genes Dev 14 2000 2314 2329
31. M.E. Wolff, J.D. Baxter, P.A. Kollman, D.L. Lee, I.D. Kuntz, and E. Bloom et al. Nature of steroid-glucocorticoid receptor interactions: thermodynamic analysis of the binding reaction Biochemistry 17 1978 3201 3208 (Pubitemid 8403162)
32. C.G. Wermuth Molecular variations based on isosteric replacements C.G. Wermuth, The practice of medicinal chemistry 1996 Academic Press London 203 237
33. R.K. Bledsoe, V.G. Montana, T.B. Stanley, C.J. Delves, C.J. Apolito, and D.D. McKee et al. Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition Cell 110 2002 93 105 (Pubitemid 34874609)
34. D.H. Jenkinson Classical approaches to the study of drug-receptor interactions J.C. Foreman, T. Johansen, Textbook of receptor pharmacology 2003 CRC Press Boca Raton, FL 3 80
35. T.P. Kenakin A pharmacology primer: theory, applications, and methods 2006 Academic Press San Diego, CA
36. N. Bodor, and P. Buchwald Retrometabolic drug design and targeting 2012 Wiley Hoboken, NJ