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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 22, 2012, Pages 6929-6933

Extracellular and intracellular esterase processing of SCFA-hexosamine analogs: Implications for metabolic glycoengineering and drug delivery

(8) Mathew, Mohit P a Tan, Elaine a Shah, Shivam a Bhattacharya, Rahul a Adam Meledeo, M a Huang, Jun a Espinoza, Freddy A a Yarema, Kevin J a

a Johns Hopkins University (United States)

Author keywords

Drug metabolism; Esterase; ManNAc analogs; Metabolic oligosaccharide engineering; Prodrugs

Indexed keywords

CARBOXYLESTERASE; CARBOXYLESTERASE 1; ESTERASE; HEXOSAMINE; SHORT CHAIN FATTY ACID; SIALIC ACID; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; BLOOD LEVEL; CELL CULTURE; DRUG DELIVERY SYSTEM; HYDROLYSIS; SIMULATION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CARBOXYLIC ESTER HYDROLASES; CELL LINE, TUMOR; DRUG CARRIERS; FATTY ACIDS, VOLATILE; HEXOSAMINES; HUMANS; HYDROLYSIS; MOLECULAR DOCKING SIMULATION; N-ACETYLNEURAMINIC ACID; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867877369 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.09.017 Document Type: Article

Times cited : (30)

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