메뉴 건너뛰기




Volumn 181, Issue 4, 2014, Pages 350-361

Development of a metabolomic radiation signature in urine from patients undergoing total body irradiation

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCARNITINE; BIOLOGICAL MARKER; CARNITINE DERIVATIVE; CREATININE; DECANOYLCARNITINE; FATTY ACID; HYPOXANTHINE; LYSINE DERIVATIVE; OCTANOYLCARNITINE; PURINE; TRIMETHYLLYSINE; UNCLASSIFIED DRUG; URIC ACID; XANTHINE;

EID: 84899817277     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR13567.1     Document Type: Article
Times cited : (72)

References (46)
  • 2
    • 79953004304 scopus 로고    scopus 로고
    • Radiation injury after a nuclear detonation: Medical consequences and the need for scarce resources allocation
    • Dicarlo AL, Maher C, Hick JL, Hanfling D, Dainiak N, Chao N et al. Radiation injury after a nuclear detonation: medical consequences and the need for scarce resources allocation. Disaster Med Public Health Prep 2011; 5 Suppl 1:S32-44.
    • (2011) Disaster Med Public Health Prep , vol.5 , Issue.SUPPL. 1
    • Dicarlo, A.L.1    Maher, C.2    Hick, J.L.3    Hanfling, D.4    Dainiak, N.5    Chao, N.6
  • 3
    • 77952003449 scopus 로고    scopus 로고
    • Radiation combined injury: Overview of NIAID research
    • Dicarlo AL, Ramakrishnan N, Hatchett RJ. Radiation combined injury: overview of NIAID research. Health Phys 2010; 98:863-7.
    • (2010) Health Phys , vol.98 , pp. 863-867
    • Dicarlo, A.L.1    Ramakrishnan, N.2    Hatchett, R.J.3
  • 4
    • 84856455614 scopus 로고    scopus 로고
    • Comparison of mouse urinary metabolic profiles after exposure to the inflammatory stressors gamma radiation and lipopolysaccharide
    • Laiakis EC, Hyduke DR, Fornace AJ. Comparison of mouse urinary metabolic profiles after exposure to the inflammatory stressors gamma radiation and lipopolysaccharide. Radiat Res 2012; 177:187-99.
    • (2012) Radiat Res , vol.177 , pp. 187-199
    • Laiakis, E.C.1    Hyduke, D.R.2    Fornace, A.J.3
  • 5
    • 20244382799 scopus 로고    scopus 로고
    • Medical management of the acute radiation syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group
    • Waselenko JK, Macvittie TJ, Blakely WF, Pesik N, Wiley AL, Dickerson WE et al. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med 2004; 140:1037-51.
    • (2004) Ann Intern Med , vol.140 , pp. 1037-1051
    • Waselenko, J.K.1    MacVittie, T.J.2    Blakely, W.F.3    Pesik, N.4    Wiley, A.L.5    Dickerson, W.E.6
  • 6
    • 0034658681 scopus 로고    scopus 로고
    • Electron spin resonance dosimetry of teeth of Goiania radiation accident victims
    • Rossi AM, Wafcheck CC, De Jesus EF, Pelegrini F. Electron spin resonance dosimetry of teeth of Goiania radiation accident victims. Appl Radiat Isot 2000; 52:1297-303.
    • (2000) Appl Radiat Isot , vol.52 , pp. 1297-1303
    • Rossi, A.M.1    Wafcheck, C.C.2    De Jesus, E.F.3    Pelegrini, F.4
  • 8
    • 84862999198 scopus 로고    scopus 로고
    • Current status of hematopoietic stem cell transplantation for acute radiation syndromes
    • Asano S. Current status of hematopoietic stem cell transplantation for acute radiation syndromes. Int J Hematol 2012; 95:227-31.
    • (2012) Int J Hematol , vol.95 , pp. 227-231
    • Asano, S.1
  • 9
    • 67650562145 scopus 로고    scopus 로고
    • Dealing with at-risk populations in radiological/nuclear emergencies
    • Wilkinson D. Dealing with at-risk populations in radiological/nuclear emergencies. Radiat Prot Dosimetry 2009; 134:136-42.
    • (2009) Radiat Prot Dosimetry , vol.134 , pp. 136-142
    • Wilkinson, D.1
  • 12
    • 0031444959 scopus 로고    scopus 로고
    • Effect of hormones on the variation of radiosensitivity in females as measured by induction of chromosomal aberrations
    • Roberts CJ, Morgan GR, Danford N. Effect of hormones on the variation of radiosensitivity in females as measured by induction of chromosomal aberrations. Environ Health Perspect 1997; 105 Suppl 6:1467-71.
    • (1997) Environ Health Perspect , vol.105 , Issue.SUPPL. 6 , pp. 1467-1471
    • Roberts, C.J.1    Morgan, G.R.2    Danford, N.3
  • 13
    • 79952139326 scopus 로고    scopus 로고
    • Prediction of in vivo radiation dose status in radiotherapy patients using ex vivo and in vivo gene expression signatures
    • Paul S, Barker CA, Turner HC, Mclane A, Wolden SL, Amundson SA. Prediction of in vivo radiation dose status in radiotherapy patients using ex vivo and in vivo gene expression signatures. Radiat Res 2011; 175:257-65.
    • (2011) Radiat Res , vol.175 , pp. 257-265
    • Paul, S.1    Barker, C.A.2    Turner, H.C.3    McLane, A.4    Wolden, S.L.5    Amundson, S.A.6
  • 16
    • 84888825288 scopus 로고    scopus 로고
    • Technological aspects
    • 360
    • Laiakis et al Technological aspects. Radiat Res 2011; 175:282-90.360
    • (2011) Radiat Res , vol.175 , pp. 282-290
    • Laiakis1
  • 17
    • 84867079107 scopus 로고    scopus 로고
    • Radiation metabolomics. Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by mass spectrometry-based metabolomics
    • Johnson CH, Patterson AD, Krausz KW, Kalinich JF, Tyburski JB, Kang DW et al. Radiation metabolomics. Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by mass spectrometry-based metabolomics. Radiat Res 2012; 178:328-40.
    • (2012) Radiat Res , Issue.178 , pp. 328-340
    • Johnson, C.H.1    Patterson, A.D.2    Krausz, K.W.3    Kalinich, J.F.4    Tyburski, J.B.5    Kang, D.W.6
  • 18
    • 70349310440 scopus 로고    scopus 로고
    • Radiation metabolomics. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm
    • Lanz C, Patterson AD, Slavik J, Krausz KW, Ledermann M, Gonzalez FJ et al. Radiation metabolomics. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm. Radiat Res 2009; 172:198-212.
    • (2009) Radiat Res , vol.172 , pp. 198-212
    • Lanz, C.1    Patterson, A.D.2    Slavik, J.3    Krausz, K.W.4    Ledermann, M.5    Gonzalez, F.J.6
  • 19
    • 75649142147 scopus 로고    scopus 로고
    • The urine proteome for radiation biodosimetry: Effect of total body vs. Local kidney irradiation
    • Sharma M, Halligan BD, Wakim BT, Savin VJ, Cohen EP, Moulder JE. The urine proteome for radiation biodosimetry: effect of total body vs. local kidney irradiation. Health Phys 2010; 98:186-95.
    • (2010) Health Phys , vol.98 , pp. 186-195
    • Sharma, M.1    Halligan, B.D.2    Wakim, B.T.3    Savin, V.J.4    Cohen, E.P.5    Moulder, J.E.6
  • 20
    • 46449100893 scopus 로고    scopus 로고
    • Radiation metabolomics. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice
    • Tyburski JB, Patterson AD, Krausz KW, Slavik J, Fornace AJJ, Gonzalez FJ et al. Radiation metabolomics. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice. Radiat Res 2008; 170:1-14.
    • (2008) Radiat Res , vol.170 , pp. 1-14
    • Tyburski, J.B.1    Patterson, A.D.2    Krausz, K.W.3    Slavik, J.4    Fornace, A.J.J.5    Gonzalez, F.J.6
  • 21
    • 67949095917 scopus 로고    scopus 로고
    • Radiation metabolomics. Dose-and timedependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice
    • Tyburski JB, Patterson AD, Krausz KW, Slavik J, Fornace AJJ, Gonzalez FJ et al. Radiation metabolomics. Dose-and timedependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice. Radiat Res 2009; 172:42-57.
    • (2009) Radiat Res , vol.172 , pp. 42-57
    • Tyburski, J.B.1    Patterson, A.D.2    Krausz, K.W.3    Slavik, J.4    Ajj, F.5    Gonzalez, F.J.6
  • 23
    • 38849104440 scopus 로고    scopus 로고
    • UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation
    • Patterson AD, Li H, Eichler GS, Krausz KW, Weinstein JN, Fornace AJJ et al. UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation. Anal Chem 2008; 80:665-74.
    • (2008) Anal Chem , vol.80 , pp. 665-674
    • Patterson, A.D.1    Li, H.2    Eichler, G.S.3    Krausz, K.W.4    Weinstein, J.N.5    Ajj, F.6
  • 24
    • 84891788820 scopus 로고    scopus 로고
    • MetaboLyzer: A novel statistical workflow for analyzing postprocessed LC-MS metabolomics data
    • Mak TD, Laiakis EC, Goudarzi M, Fornace AJJ. MetaboLyzer: A Novel Statistical Workflow for Analyzing Postprocessed LC-MS Metabolomics Data. Anal Chem 2014; 86:506-13.
    • (2014) Anal Chem , vol.86 , pp. 506-513
    • Mak, T.D.1    Laiakis, E.C.2    Goudarzi, M.3    Fornace, A.J.J.4
  • 25
    • 84899866097 scopus 로고    scopus 로고
    • Protecting U.S. Nuclear facilities from terrorist attack: Re-assessing the current
    • Kirkham L, Kuperman AJ. Protecting U.S. Nuclear Facilities From Terrorist Attack: Re-assessing the Current "Design Basis Threat" Approach. 2013. (http://blogs.utexas.edu/nppp/files/2013/08/NPPP-working-paper-1-2013-Aug- 15.pdf).
    • (2013) Design Basis Threat Approach
    • Kirkham, L.1    Kuperman, A.J.2
  • 26
    • 79955400689 scopus 로고    scopus 로고
    • Identification of urinary biomarkers from X-irradiated mice using NMR spectroscopy
    • Chen C, Brenner DJ, Brown TR. Identification of urinary biomarkers from X-irradiated mice using NMR spectroscopy. Radiat Res 2011; 175:622-30.
    • (2011) Radiat Res , vol.175 , pp. 622-630
    • Chen, C.1    Brenner, D.J.2    Brown, T.R.3
  • 27
    • 79953314279 scopus 로고    scopus 로고
    • Radiation metabolomics. UPLC-ESI-QTOFMSBased metabolomics for urinary biomarker discovery in gammairradiated rats
    • Johnson CH, Patterson AD, Krausz KW, Lanz C, Kang DW, Luecke H et al. Radiation metabolomics. UPLC-ESI-QTOFMSBased metabolomics for urinary biomarker discovery in gammairradiated rats. Radiat Res 2011; 175:473-84.
    • (2011) Radiat Res , vol.175 , pp. 473-484
    • Johnson, C.H.1    Patterson, A.D.2    Krausz, K.W.3    Lanz, C.4    Kang, D.W.5    Luecke, H.6
  • 28
    • 34548730771 scopus 로고    scopus 로고
    • Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles
    • Slupsky CM, Rankin KN, Wagner J, Fu H, Chang D, Weljie AM et al. Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles. Anal Chem 2007; 79:6995-7004.
    • (2007) Anal Chem , vol.79 , pp. 6995-7004
    • Slupsky, C.M.1    Rankin, K.N.2    Wagner, J.3    Fu, H.4    Chang, D.5    Weljie, A.M.6
  • 29
    • 77955655750 scopus 로고    scopus 로고
    • Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate
    • Waikar SS, Sabbisetti VS, Bonventre JV. Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate. Kidney Int 2010; 78:486-94.
    • (2010) Kidney Int , vol.78 , pp. 486-494
    • Waikar, S.S.1    Sabbisetti, V.S.2    Bonventre, J.V.3
  • 31
    • 84858077778 scopus 로고    scopus 로고
    • Carnitine derivatives: Clinical usefulness
    • Malaguarnera M. Carnitine derivatives: clinical usefulness. Curr Opin Gastroenterol 2012; 28:166-76.
    • (2012) Curr Opin Gastroenterol , vol.28 , pp. 166-176
    • Malaguarnera, M.1
  • 32
    • 4444315751 scopus 로고    scopus 로고
    • Carnitine: A nutritional, biosynthetic, and functional perspective
    • Steiber A, Kerner J, Hoppel CL. Carnitine: a nutritional, biosynthetic, and functional perspective. Mol Aspects Med 2004; 25:455-73.
    • (2004) Mol Aspects Med , vol.25 , pp. 455-473
    • Steiber, A.1    Kerner, J.2    Hoppel, C.L.3
  • 34
    • 67649158723 scopus 로고    scopus 로고
    • Determination of carnitine, its short chain acyl esters and metabolic precursors trimethyllysine and gamma-butyrobetaine by quasi-solid phase extraction and MS/MS detection
    • Hirche F, Fischer M, Keller J, Eder K. Determination of carnitine, its short chain acyl esters and metabolic precursors trimethyllysine and gamma-butyrobetaine by quasi-solid phase extraction and MS/MS detection. J Chromatogr B Analyt Technol Biomed Life Sci 2009; 877:2158-62.
    • (2009) J Chromatogr B Analyt Technol Biomed Life Sci , vol.877 , pp. 2158-2162
    • Hirche, F.1    Fischer, M.2    Keller, J.3    Eder, K.4
  • 35
    • 77953603769 scopus 로고    scopus 로고
    • Enzymology of the carnitine biosynthesis pathway
    • Strijbis K, Vaz FM, Distel B. Enzymology of the carnitine biosynthesis pathway. IUBMB Life 2010; 62:357-62.
    • (2010) IUBMB Life , vol.62 , pp. 357-362
    • Strijbis, K.1    Vaz, F.M.2    Distel, B.3
  • 36
    • 81455131665 scopus 로고    scopus 로고
    • A review of the logistic role of Lcarnitine in the management of radiation toxicity and radiotherapy side effects
    • Khan HA, Alhomida AS. A review of the logistic role of Lcarnitine in the management of radiation toxicity and radiotherapy side effects. J Appl Toxicol 2011; 31:707-13.
    • (2011) J Appl Toxicol , vol.31 , pp. 707-713
    • Khan, H.A.1    Alhomida, A.S.2
  • 37
    • 84872387402 scopus 로고    scopus 로고
    • Translating the basic knowledge of mitochondrial functions to metabolic therapy: Role of L-carnitine
    • Marcovina SM, Sirtori C, Peracino A, Gheorghiade M, Borum P, Remuzzi G et al. Translating the basic knowledge of mitochondrial functions to metabolic therapy: role of L-carnitine. Transl Res 2013; 161:73-84.
    • (2013) Transl Res , vol.161 , pp. 73-84
    • Marcovina, S.M.1    Sirtori, C.2    Peracino, A.3    Gheorghiade, M.4    Borum, P.5    Remuzzi, G.6
  • 39
    • 33746363249 scopus 로고    scopus 로고
    • Protective role of carnitine ester against radiationinduced oxidative stress in rats
    • Mansour HH. Protective role of carnitine ester against radiationinduced oxidative stress in rats. Pharmacol Res 2006; 54:165-71.
    • (2006) Pharmacol Res , vol.54 , pp. 165-171
    • Mansour, H.H.1
  • 40
    • 0037057759 scopus 로고    scopus 로고
    • A method for quantitative acylcarnitine profiling in human skin fibroblasts using unlabelled palmitic acid: Diagnosis of fatty acid oxidation disorders and differentiation between biochemical phenotypes of MCAD deficiency
    • Okun JG, Kolker S, Schulze A, Kohlmuller D, Olgemoller K, Lindner M et al. A method for quantitative acylcarnitine profiling in human skin fibroblasts using unlabelled palmitic acid: diagnosis of fatty acid oxidation disorders and differentiation between biochemical phenotypes of MCAD deficiency. Biochim Biophys Acta 2002; 1584:91-8.
    • (2002) Biochim Biophys Acta , vol.1584 , pp. 91-98
    • Okun, J.G.1    Kolker, S.2    Schulze, A.3    Kohlmuller, D.4    Olgemoller, K.5    Lindner, M.6
  • 41
    • 84870688466 scopus 로고    scopus 로고
    • Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans
    • Ichida K, Amaya Y, Okamoto K, Nishino T. Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans. Int J Mol Sci 2012; 13:15475-95.
    • (2012) Int J Mol Sci , vol.13 , pp. 15475-15495
    • Ichida, K.1    Amaya, Y.2    Okamoto, K.3    Nishino, T.4
  • 42
    • 0032827093 scopus 로고    scopus 로고
    • Effect of radiation on the xanthine oxidoreductase system in the liver of mice
    • Srivastava M, Kale RK. Effect of radiation on the xanthine oxidoreductase system in the liver of mice. Radiat Res 1999; 152:257-64.
    • (1999) Radiat Res , vol.152 , pp. 257-264
    • Srivastava, M.1    Kale, R.K.2
  • 43
    • 0041378062 scopus 로고    scopus 로고
    • Xanthine oxidoreductase is central to the evolution and function of the innate immune system
    • Vorbach C, Harrison R, Capecchi MR. Xanthine oxidoreductase is central to the evolution and function of the innate immune system. Trends Immunol 2003; 24:512-7.
    • (2003) Trends Immunol , vol.24 , pp. 512-517
    • Vorbach, C.1    Harrison, R.2    Capecchi, M.R.3
  • 44
    • 33846982585 scopus 로고    scopus 로고
    • Simultaneous determination of allantoin, hypoxanthine, xanthine, and uric acid in serum/plasma by CE
    • Causse E, Pradelles A, Dirat B, Negre-Salvayre A, Salvayre R, Couderc F. Simultaneous determination of allantoin, hypoxanthine, xanthine, and uric acid in serum/plasma by CE. Electrophoresis 2007; 28:381-7.
    • (2007) Electrophoresis , vol.28 , pp. 381-387
    • Causse, E.1    Pradelles, A.2    Dirat, B.3    Negre-Salvayre, A.4    Salvayre, R.5    Couderc, F.6
  • 45
    • 84862157080 scopus 로고    scopus 로고
    • Metabolomic response of human skin tissue to low dose ionizing radiation
    • Hu ZP, Kim YM, Sowa MB, Robinson RJ, Gao X, Metz TO et al. Metabolomic response of human skin tissue to low dose ionizing radiation. Mol Biosyst 2012; 8:1979-86.
    • (2012) Mol Biosyst , vol.8 , pp. 1979-1986
    • Hu, Z.P.1    Kim, Y.M.2    Sowa, M.B.3    Robinson, R.J.4    Gao, X.5    Metz, T.O.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.