Xanthine oxidoreductase is central to the evolution and function of the innate immune system

Trends in Immunology

Volumn 24, Issue 9, 2003, Pages 512-517

  Vorbach, Claudia ^a   Harrison, Roger ^b   Capecchi, Mario R ^c  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b University of Bath   (United Kingdom)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR; XANTHINE OXIDASE;

DETOXIFICATION; DOWNSTREAM PROCESSING; EPITHELIUM; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNITY; IN VIVO STUDY; MEDICAL LITERATURE; MOLECULAR EVOLUTION; MOLECULAR RECOGNITION; NONHUMAN; PHYSIOLOGY; REVIEW; SURFACE PROPERTY;

EID: 0041378062     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(03)00237-0     Document Type: Review

References (81)

1. Bray R.C. Molybdenum iron-sulfur flavin hydroxylases and related enzymes. Boyer P.D. The Enzymes. 1975;299-419 Academic Press.
2. Hille R., Nishino T. Flavoprotein structure and mechanism. 4. Xanthine oxidase and xanthine dehydrogenase. FASEB J. 9:1995;995-1003.
3. Ichida K., et al. Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria. J. Clin. Invest. 99:1997;2391-2397.
4. Vorbach C., et al. The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland. Genes Dev. 16:2002;3223-3235.
5. Harrison R. Structure and function of xanthine oxidoreductase: where are we now? Free Radic. Biol. Med. 33:2002;774-797.
6. Meneshian A., Bulkley G.B. The physiology of endothelial xanthine oxidase: from urate catabolism to reperfusion injury to inflammatory signal transduction. Microcirculation. 9:2002;161-175.
7. Squadrito G.L., et al. Reaction of uric acid with peroxynitrite and implications for the mechanism of neuroprotection by uric acid. Arch. Biochem. Biophys. 376:2000;333-337.
8. Sheehan D., et al. Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochem. J. 360:2001;1-16.
9. Gus'kov E.P., et al. Allantoin as a free-radical scavenger. Dokl. Biochem. Biophys. 383:2002;105-107.
10. Droge W. Free radicals in the physiological control of cell function. Physiol. Rev. 82:2002;47-95.
11. Beedham C. Molybdenum hydroxylases. Ionnides C. Enzyme Systems that Metabolise Drugs and Other Xenobiotics. 2002;147-187 John Wiley.
12. Garattini E., et al. Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology. Biochem. J. 372:2003;15-32.
13. Baeuerle P.A., Henkel T. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:1994;141-179.
14. Becker B.F. Towards the physiological function of uric acid. Free Radic. Biol. Med. 14:1993;615-631.
15. Christen S., et al. Marked elevation in cortical urate and xanthine oxidoreductase activity in experimental bacterial meningitis. Brain Res. 900:2001;244-251.
16. Nagler R.M., et al. Characterization of the differentiated antioxidant profile of human saliva. Free Radic. Biol. Med. 32:2002;268-277.
17. Babior B.M., et al. Biological defense mechanisms. Evidence for the participation of superoxide in bacterial killing by xanthine oxidase. J. Lab. Clin. Med. 85:1975;235-244.
18. Rosen G.M., et al. Free radicals and phagocytic cells. FASEB J. 9:1995;200-209.
19. Hancock J.T., et al. Antimicrobial properties of milk: dependence on presence of xanthine oxidase and nitrite. Antimicrob. Agents Chemother. 46:2002;3308-3310.
20. Granger D.N., et al. Superoxide radicals in feline intestinal ischemia. Gastroenterology. 81:1981;22-29.
21. Anderson R.S. Reactive oxygen species and antimicrobial defenses of invertebrates: a bivalve model. Adv. Exp. Med. Biol. 484:2001;131-139.
22. Godber B.L., et al. Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase. J. Biol. Chem. 275:2000;7757-7763.
23. Brunelli L., et al. The comparative toxicity of nitric oxide and peroxynitrite to Escherichia coli. Arch. Biochem. Biophys. 316:1995;327-334.
24. Nappi A.J., Vass E. Cytotoxic reactions associated with insect immunity. Adv. Exp. Med. Biol. 484:2001;329-348.
25. Taibi G., et al. Xanthine oxidase catalyzes the synthesis of retinoic acid. J. Enzyme Inhib. 16:2001;275-285.
26. Jarasch E.D., et al. Localization of xanthine oxidase in mammary-gland epithelium and capillary endothelium. Cell. 25:1981;67-82.
27. Kooij A., et al. High levels of xanthine oxidoreductase in rat endothelial, epithelial and connective tissue cells. A relation between localization and function? Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 62:1992;143-150.
28. Kurosaki M., et al. Tissue- and cell-specific expression of mouse xanthine oxidoreductase gene in vivo: regulation by bacterial lipopolysaccharide. Biochem. J. 306:1995;225-234.
29. Linder N., et al. Cellular expression of xanthine oxidoreductase protein in normal human tissues. Lab. Invest. 79:1999;967-974.
30. Peden D.B., et al. Uric acid is a major antioxidant in human nasal airway secretions. Proc. Natl. Acad. Sci. U. S. A. 87:1990;7638-7642.
31. Kastenbauer S., et al. Experimental meningitis in the rat: protection by uric acid at human physiological blood concentrations. Eur. J. Pharmacol. 425:2001;149-152.
32. Becker B.F., et al. Uric acid as radical scavenger and antioxidant in the heart. Pflugers Arch. 415:1989;127-135.
33. Partridge C.A., et al. Pulmonary microvascular endothelial cells constitutively release xanthine oxidase. Arch. Biochem. Biophys. 294:1992;184-187.
34. Vickers S., et al. Immunoaffinity localization of the enzyme xanthine oxidase on the outside surface of the endothelial cell plasma membrane. Surgery. 124:1998;551-560.
35. Rouquette M., et al. Xanthine oxidoreductase is asymmetrically localised on the outer surface of human endothelial and epithelial cells in culture. FEBS Lett. 426:1998;397-401.
36. Collins R.A., et al. Histochemical localization and possible antibacterial role of xanthine oxidase in the bovine mammary gland. J. Dairy Res. 55:1988;25-32.
37. Stevens C.R., et al. Antibacterial properties of xanthine oxidase in human milk. Lancet. 356:2000;829-830.
38. Van Den Munckhof R.J., et al. Ultrastructural localization of xanthine oxidase activity in the digestive tract of the rat. Histochem. J. 27:1995;897-905.
39. Morita Y., et al. Identification of xanthine dehydrogenase/xanthine oxidase as a rat paneth cell zinc-binding protein. Biochim. Biophys. Acta. 1540:2001;43-49.
40. Kurose I., Granger D.N. Evidence implicating xanthine oxidase and neutrophils in reperfusion-induced microvascular dysfunction. Ann. N. Y. Acad. Sci. 723:1994;158-179.
41. Granger D.N., Kubes P. The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion. J. Leukoc. Biol. 55:1994;662-675.
42. Takano M., et al. Rapid upregulation of endothelial P-selectin expression via reactive oxygen species generation. Am. J. Physiol. Heart Circ. Physiol. 283:2002;H2054-H2061.
43. Kopp E.B., Medzhitov R. The Toll-receptor family and control of innate immunity. Curr. Opin. Immunol. 11:1999;13-18.
44. Silverman N., Maniatis T. NF-κB signaling pathways in mammalian and insect innate immunity. Genes Dev. 15:2001;2321-2342.
45. Zhang G., Ghosh S. Toll-like receptor-mediated NF-κB activation: a phylogenetically conserved paradigm in innate immunity. J. Clin. Invest. 107:2001;13-19.
46. Xu P., et al. Molecular cloning and characterization of the human xanthine dehydrogenase gene (XDH). Genomics. 34:1996;173-180.
47. Hassoun P.M., et al. Upregulation of xanthine oxidase by lipopolysaccharide, interleukin-1, and hypoxia. Role in acute lung injury. Am. J. Respir. Crit. Care Med. 158:1998;299-305.
48. Meyer M., et al. Regulation of the transcription factors NF-κB and AP-1 by redox changes. Chem. Biol. Interact. 91:1994;91-100.
49. Forman H.J., et al. Redox signaling. Mol. Cell. Biochem. 234:2002;49-62.
50. Matsui N., et al. Xanthine oxidase-derived reactive oxygen species activate nuclear factor-κB during hepatic ischemia in rats. Jpn. J. Pharmacol. 84:2000;363-366.
51. Natarajan R., et al. Nitric oxide suppresses IL-8 transcription by inhibiting c-Jun N-terminal kinase-induced AP-1 activation. Exp. Cell Res. 266:2001;203-212.
52. Bungener W. Influence of allopurinol on the multiplication of rodent malaria parasites. Tropenmed. Parasitol. 25:1974;309-312.
53. Wang J., et al. Serum xanthine oxidase: origin, regulation, and contribution to control of trypanosome parasitemia. Antioxid. Redox Signal. 4:2002;161-178.
54. Kooij A., et al. Conversion of xanthine dehydrogenase into xanthine oxidase in rat liver and plasma at the onset of reperfusion after ischemia. Hepatology. 19:1994;1488-1495.
55. Turnage R.H., et al. Complement activation by the hydroxyl radical during intestinal reperfusion. Shock. 2:1994;445-450.
56. Tanhehco E.J., et al. Free radicals upregulate complement expression in rabbit isolated heart. Am. J. Physiol. Heart Circ. Physiol. 279:2000;H195-H201.
57. Cerra F.B. Hypermetabolism, organ failure, and metabolic support. Surgery. 101:1987;1-14.
58. Klein A., et al. Quantitative discrimination of hepatic reticuloendothelial clearance and phagocytic killing. J. Leukoc. Biol. 55:1994;248-252.
59. Tubaro E., et al. Liver xanthine oxidase increase in mice in three patholgoical models. A possible defence mechanism. Biochem. Pharmacol. 29:1980;1939-1943.
60. Klein A.S., et al. Allopurinol: discrimination of antioxidant from enzyme inhibitory activities. Free Radic. Biol. Med. 21:1996;713-717.
61. Umezawa K., et al. Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice. Infect. Immun. 65:1997;2932-2940.
62. Potoka D.A., et al. Endothelial cells potentiate oxidant-mediated Kupffer cell phagocytic killing. Free Radic. Biol. Med. 24:1998;1217-1227.
63. Chinnaiyan A.M., et al. Molecular signatures of sepsis: multiorgan gene expression profiles of systemic inflammation. Am. J. Pathol. 159:2001;1199-1209.
64. Crosby P.F., et al. Liver xanthine oxidase activity of mice infected with Schistosoma mansoni. J. Parasitol. 55:1969;673.
65. Tubaro E., et al. Xanthine oxidase increase in polymorphonuclear leucocytes and macrophages in mice in three pathological situations. Biochem. Pharmacol. 29:1980;1945-1948.
66. Takao S., et al. Role of reactive oxygen metabolites in murine peritoneal macrophage phagocytosis and phagocytic killing. Am. J. Physiol. 271:1996;C1278-C1284.
67. -/-) mouse model of chronic granulomatous disease. Infect. Immun. 68:2000;2374-2378.
68. Fearon D.T., Locksley R.M. The instructive role of innate immunity in the acquired immune response. Science. 272:1996;50-53.
69. Lavine M.D., Strand M.R. Insect hemocytes and their role in immunity. Insect Biochem. Mol. Biol. 32:2002;1295-1309.
70. Nappi A.J., et al. Superoxide anion generation in Drosophila during melanotic encapsulation of parasites. Eur. J. Cell Biol. 68:1995;450-456.
71. Nappi A.J., et al. Nitric oxide involvement in Drosophila immunity. Nitric Oxide. 4:2000;423-430.
72. Massie H.R., et al. Uric acid content of Drosophila decreases with aging. Exp. Gerontol. 26:1991;609-614.
73. Lee W.J., et al. Molecular cloning and chromosomal localization of a prophenoloxidase cDNA from the malaria vector Anopheles gambiae. Insect Mol. Biol. 7:1998;41-50.
74. Soderhall K., Cerenius L. Role of the prophenoloxidase-activating system in invertebrate immunity. Curr. Opin. Immunol. 10:1998;23-28.
75. Mackintosh J.A. The antimicrobial properties of melanocytes, melanosomes and melanin and the evolution of black skin. J. Theor. Biol. 211:2001;101-113.
76. Ranson H., et al. Evolution of supergene families associated with insecticide resistance. Science. 298:2002;179-181.
77. Coleman M., et al. Molecular characterization of the amplified aldehyde oxidase from insecticide resistant Culex quinquefasciatus. Eur. J. Biochem. 269:2002;768-779.
78. Amaya Y., et al. Proteolytic conversion of xanthine dehydrogenase from the NAD-dependent type to the O2-dependent type. Amino acid sequence of rat liver xanthine dehydrogenase and identification of the cleavage sites of the enzyme protein during irreversible conversion by trypsin. J. Biol. Chem. 265:1990;14170-14175.
79. Wurzinger K.H., Hartenstein R. Phylogeny and correlations of aldehyde oxidase, xanthine oxidase, xanthine dehydrogenase and peroxidase in animal tissues. Comp. Biochem. Physiol. B. 49:1974;171-185.
80. Boman H.G. Innate immunity and the normal microflora. Immunol. Rev. 173:2000;5-16.
81. Kayyali U.S., et al. Phosphorylation of xanthine dehydrogenase/oxidase in hypoxia. J. Biol. Chem. 276:2001;14359-14365.