Prediction of in vivo radiation dose status in radiotherapy patients using ex vivo and in vivo gene expression signatures

Radiation Research

Volumn 175, Issue 3, 2011, Pages 257-265

  Paul, Sunirmal ^a   Barker, Christopher A ^b   Turner, Helen C ^a   McLane, Amanda ^b   Wolden, Suzanne L ^b   Amundson, Sally A ^a  

^a New York Presbyterian Morgan Stanley Children's Hospital   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOCYTIC LEUKEMIA; APLASTIC ANEMIA; ARTICLE; BLOOD SAMPLING; CANCER PATIENT; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; DOSIMETRY; EX VIVO STUDY; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENOME ANALYSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MANTLE CELL LYMPHOMA; MICROARRAY ANALYSIS; MULTIPLE MYELOMA; NONHODGKIN LYMPHOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; T CELL LEUKEMIA; WHOLE BODY RADIATION;

FEMALE; GENE EXPRESSION PROFILING; GENOMICS; HUMANS; MALE; MODELS, BIOLOGICAL; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RADIATION DOSAGE; RADIOMETRY; RADIOTHERAPY DOSAGE; REPRODUCIBILITY OF RESULTS; WHOLE-BODY IRRADIATION;

EID: 79952139326     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR2420.1     Document Type: Article

References (45)

1. T. C. Pellmar and S. Rockwell, Priority list of research areas for radiological nuclear threat countermeasures. Radiat. Res. 163, 115-123 (2005). (Pubitemid 40039952)
2. D. C. Lloyd, Chromosomal analysis to assess radiation dose. Stem Cells 15 (Suppl. 2), 195-201 (1997). (Pubitemid 27494854)
3. A. Vaurijoux, G. Gruel, F. Pouzoulet, E. Gregoire, C. Martin, S. Roch-Lefevre, P. Voisin, P. Voisin and L. Roy, Strategy for population triage based on dicentric analysis. Radiat. Res. 171, 541-548 (2009).
4. F. N. Flegal, Y. Devantier, J. P. McNamee and R. C. Wilkins, Quickscan dicentric chromosome analysis for radiation biodosimetry. Health Phys. 98, 276-281 (2010).
5. H. M. Swartz, A. B. Flood, R. M. Gougelet, M. E. Rea, R. J. Nicolalde and B. B. Williams, A critical assessment of biodosimetry methods for large-scale incidents. Health Phys. 98, 95-108 (2010).
6. G. Garty, Y. Chen, A. Salerno, H. Turner, J. Zhang, O. Lyulko, A. Bertucci, Y. Xu, H. Wang and D. J. Brenner, The RABIT: a rapid automated biodosimetry tool for radiological triage. Health Phys. 98, 209-217 (2010).
7. P. G. Prasanna, M. Moroni and T. C. Pellmar, Triage dose assessment for partial-body exposure: dicentric analysis. Health Phys. 98, 244-251 (2010).
8. F. Trompier, C. Bassinet, A. Wieser, C. De Angelis, D. Viscomi and P. Fattibene, Radiation-induced signals analysed by EPR spectrometry applied to fortuitous dosimetry. Ann. Ist. Super. Sanita 45, 287-296 (2009).
9. D. E. Wilcox, X. He, J. Gui, A. E. Ruuge, H. Li, B. B. Williams and H. M. Swartz, Dosimetry based on EPR spectral analysis of fingernail clippings. Health Phys. 98, 309- 317 (2010).
10. R. G. Ivey, O. Subramanian, T. D. Lorentzen and A. G. Paulovich, Antibody-based screen for ionizing radiationdependent changes in the mammalian proteome for use in biodosimetry. Radiat Res. 171, 549-561 (2009).
11. M. Sharma, B. D. Halligan, B. T. Wakim, V. J. Savin, E. P. Cohen and J. E. Moulder, The urine proteome for radiation biodosimetry: effect of total body vs. local kidney irradiation. Health Phys. 98, 186-195 (2010).
12. A. D. Patterson, C. Lanz, F. J. Gonzalez and J. R. Idle, The role of mass spectrometry-based metabolomics in medical countermeasures against radiation. Mass Spectrom. Rev. 29, 503-521 (2010).
13. S. A. Amundson, S. Shahab, M. Bittner, P. Meltzer, J. Trent and A. J. Fornace, Jr., Identification of potential mRNA markers in peripheral blood lymphocytes for human exposure to ionizing radiation. Radiat. Res. 154, 342-346 (2000).
14. S. Paul and S. A. Amundson, Development of gene expression signatures for practical radiation biodosimetry. Int. J. Radiat. Oncol. Biol. Phys. 71, 1236-1244 (2008).
15. M. Brengues, B. Paap, M. Bittner, S. Amundson, B. Seligmann, R. Korn, R. Lenigk and F. Zenhausern, Biodosimetry on small blood volume using gene expression assay. Health Phys. 98, 179- 185 (2010).
16. S. A. Amundson, M. B. Grace, C. B. McLeland, M. W. Epperly, A. Yeager, Q. Zhan, J. S. Greenberger and A. J. Fornace, Jr., Human in vivo radiation-induced biomarkers: gene expression changes in radiotherapy patients. Cancer Res. 64, 6368-6371 (2004). (Pubitemid 39297886)
17. H. K. Dressman, G. G. Muramoto, N. J. Chao, S. Meadows, D. Marshall, G. S. Ginsburg, J. R. Nevins and J. P. Chute, Gene expression signatures that predict radiation exposure in mice and humans. PLoS Med. 4, e106 (2007).
18. S. K. Meadows, H. K. Dressman, G. G. Muramoto, H. Himburg, A. Salter, Z. Wei, G. S. Ginsburg, N. J. Chao, J. R. Nevins and J. P. Chute, Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS One 3, e1912 (2008).
19. B. Shank, Techniques of magna-field irradiation. Int. J. Radiat. Oncol. Biol. Phys. 9, 1925-1931 (1983). (Pubitemid 14178676)
20. R. Simon, A. Lam, M-C. Li, M. Ngan, S. Menenzes and Y. Zhao, Analysis of gene expression data using BRB-Array Tools. Cancer Inform. 2, 11-17 (2007). (Pubitemid 47075796)
21. Y. Benjamini and Y. Hochberg, Controlling the false discovery rate: A practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B 57, 289-300 (1995).
22. P. D. Thomas, M. J. Campbell, A. Kejariwal, H. Mi, B. Karlak, R. Daverman, K. Diemer, A. Muruganujan and A. Narechania, PANTHER: a library of protein families and subfamilies indexed by function. Genome Res. 13, 2129-2141 (2003). (Pubitemid 37161770)
23. P. D. Thomas, A. Kejariwal, N. Guo, H. Mi, M. J. Campbell, A. Muruganujan and B. Lazareva-Ulitsky, Applications for protein sequence-function evolution data: mRNA/protein expression analysis and coding SNP scoring tools. Nucleic Acids Res. 34, W645-W650 (2006). (Pubitemid 44529850)
24. D. M. Rocke, Z. Goldberg, C. Schweitert and A. Santana, A method for detection of differential gene expression in the presence of inter-individual variability in response. Bioinformatics 21, 3990-3992 (2005). (Pubitemid 41631839)
25. Z. Goldberg, D. M. Rocke, C. Schwietert, S. R. Berglund, A. Santana, A. Jones, J. Lehmann, R. Stern, R. Lu and C. Hartmann Siantar, Human in vivo dose-response to controlled, low-dose low linear energy transfer ionizing radiation exposure. Clin. Cancer Res. 12, 3723-3729 (2006). (Pubitemid 44000253)
26. M. Ringner, S. Veerla, S. Andersson, J. Staaf and J. Hakkinen, ACID: a database for microarray clone information. Bioinformatics 20, 2305-2306 (2004). (Pubitemid 39341619)
27. C. A. Barker, A. Rimner and J. Yahalom, A century of total body irradiation (TBI). Int. J. Radiat. Oncol. Biol. Phys. 75, S434-S435 (2009).
28. S. A. Amundson, K. T. Do, L. C. Vinikoor, R. A. Lee, C. A. Koch-Paiz, J. Ahn, M. Reimers, Y. Chen, D. A. Scudiero and A. J. Fornace, Jr., Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen. Cancer Res. 68, 415-424 (2008). (Pubitemid 351380067)
29. W. F. Blakely, N. I. Ossetrova, M. H. Whitnall, D. J. Sandgren, V. I. Krivokrysenko, A. Shakhov and E. Feinstein, Multiple parameter radiation injury assessment using a nonhuman primate radiation model-biodosimetry applications. Health Phys. 98, 153-159 (2010).
30. V. G. Cheung, L. K. Conlin, T. M. Weber, M. Arcaro, K. Y. Jen, M. Morley and R. S. Spielman, Natural variation in human gene expression assessed in lymphoblastoid cells. Nat. Genet. 33, 422-425 (2003). (Pubitemid 36278862)
31. A. R. Whitney, M. Diehn, S. J. Popper, A. A. Alizadeh, J. C. Boldrick, D. A. Relman and P. O. Brown, Individuality and variation in gene expression patterns in human blood. Proc. Natl. Acad. Sci. USA 100, 1896-1901 (2003). (Pubitemid 36254545)
32. V. Dumeaux, K. S. Olsen, G. Nuel, R. H. Paulssen, A. L. Borresen-Dale and E. Lund, Deciphering normal blood gene expression variation-The NOWAC postgenome study. PLoS Genet. 6, e1000873 (2010).
33. O. Ramilo, W. Allman, W. Chung, A. Mejias, M. Ardura, C. Glaser, K. M. Wittkowski, B. Piqueras, J. Banchereau and D. Chaussabel, Gene expression patterns in blood leukocytes discriminate patients with acute infections. Blood 109, 2066-2077 (2007). (Pubitemid 46348207)
34. T. P. Shanley, N. Cvijanovich, R. Lin, G. L. Allen, N. J. Thomas, A. Doctor, M. Kalyanaraman, N. M. Tofil, S. Penfil and H. R. Wong, Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol. Med. 13, 495-508 (2007). (Pubitemid 47585744)
35. H. R. Wong, T. P. Shanley, B. Sakthivel, N. Cvijanovich, R. Lin, G. L. Allen, N. J. Thomas, A. Doctor, M. Kalyanaraman and B. J. Aronow, Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol. Genomics 30, 146-155 (2007). (Pubitemid 47173278)
36. R. A. Heller, M. Schena, A. Chai, D. Shalon, T. Bedilion, J. Gilmore, D. E. Woolley and R. W. Davis, Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc. Natl. Acad. Sci. USA 94, 2150-2155 (1997). (Pubitemid 27136843)
37. A. E. Baird, Blood genomics in human stroke. Stroke 38, 694-698 (2007). (Pubitemid 46184244)
38. K. J. Martin, E. Graner, Y. Li, L. M. Price, B. M. Kritzman, M. V. Fournier, E. Rhei and A. B. Pardee, High-sensitivity array analysis of gene expression for the early detection of disseminated breast tumor cells in peripheral blood. Proc. Natl. Acad. Sci. USA 98, 2646-2651 (2001). (Pubitemid 32209536)
39. M. Cadeiras, M. Bayern, E. Burke, R. Dedrick, A. Gangadin, F. Latif, K. Shazad, A. Sinha, E. G. Tabak and M. C. Deng, Gene expression profiles of patients with antibody-mediated rejection after cardiac transplantation. J. Heart Lung Transplant. 27, 932-934 (2008).
40. J. A. Lederer, B. H. Brownstein, M. C. Lopez, S. Macmillan, A. J. Delisle, M. P. Macconmara, M. A. Choudhry, W. Xiao, S. Lekousi and I. H. Chaudry, Comparison of longitudinal leukocyte gene expression after burn injury or traumahemorrhage in mice. Physiol. Genomics 32, 299-310 (2008). (Pubitemid 351328553)
41. M. E. Mugavin, Multidimensional scaling: a brief overview. Nurs. Res. 57, 64-68 (2008).
42. E. C. Baechler, F. M. Batliwalla, G. Karypis, P. M. Gaffney, K. Moser, W. A. Ortmann, K. J. Espe, S. Balasubramanian, K. M. Hughes and T. W. Behrens, Expression levels for many genes in human peripheral blood cells are highly sensitive to ex vivo incubation. Genes Immun. 5, 347-353 (2004). (Pubitemid 39139761)
43. J. J. Eady, G. M. Wortley, Y. M. Wormstone, J. C. Hughes, S. B. Astley, R. J. Foxall, J. F. Doleman and R. M. Elliott, Variation in gene expression profiles of peripheral blood mononuclear cells from healthy volunteers. Physiol. Genomics 22, 402-411 (2005). (Pubitemid 41356372)
44. D. A. Smirnov, M. Morley, E. Shin, R. S. Spielman and V. G. Cheung, Genetic analysis of radiation-induced changes in human gene expression. Nature 459, 587-591 (2009).
45. N. I. Ossetrova and W. F. Blakely, Multiple blood-proteins approach for early-response exposure assessment using an in vivo murine radiation model. Int. J. Radiat. Biol. 85, 837-850 (2009).