Age-related changes in the cellular composition and epithelial organization of the mouse trachea

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Wansleeben, Carolien ^a   Bowie, Emily ^a   Hotten, Danielle F ^a   Yu, Yen Rei A ^a   Hogan, Brigid L M ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; KRT5 PROTEIN; PROTEIN P63; UNCLASSIFIED DRUG; CYTOKERATIN 15; KRT1-15 PROTEIN, MOUSE; MYD88 PROTEIN, MOUSE; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHOPROTEIN; TRANSACTIVATOR PROTEIN; TRP63 PROTEIN, MOUSE;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL CELL; BRONCHUS; CELL AGING; CELL COMPOSITION; CELL DAMAGE; CELL STRUCTURE; CILIATED EPITHELIUM; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; MYOEPITHELIUM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; SECRETORY CELL; STEM CELL; SUBMUCOSA; TRACHEA; TRACHEITIS; TRACHEOSPHERE; AGING; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; CELL DIVISION; CHEMISTRY; DEFICIENCY; GENETICS; KNOCKOUT MOUSE; METABOLISM; MULTICELLULAR SPHEROID; PATHOLOGY; RESPIRATORY TRACT MUCOSA;

AGING; ANIMALS; BRONCHI; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION; KERATIN-15; MALE; MICE; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHOPROTEINS; RESPIRATORY MUCOSA; SPHEROIDS, CELLULAR; STEM CELLS; TRACHEA; TRANS-ACTIVATORS;

EID: 84899814099     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093496     Document Type: Article

References (42)

1. Doles J, Storer M, Cozzuto L, Roma G, Keyes WM (2012) Age-associated inflammation inhibits epidermal stem cell function. Genes Dev 26: 2144-2153.
2. Watanabe H, Saito H, Rychahou PG, Uchida T, Evers BM (2005) Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation. Gastroenterology 128: 1391-1404. (Pubitemid 40712188)
3. Zeng N, Yang KT, Bayan JA, He L, Aggarwal R, et al. (2013) PTEN controls beta-cell regeneration in aged mice by regulating cell cycle inhibitor p16. Aging Cell.
4. Biteau B, Hochmuth CE, Jasper H (2008) JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. Cell Stem Cell 3: 442-455.
5. Lucchetta EM, Ohlstein B (2012) The Drosophila midgut: a model for stem cell driven tissue regeneration. Wiley Interdiscip Rev Dev Biol 1: 781-788.
6. Shaykhiev R, Crystal RG (2013) Innate immunity and chronic obstructive pulmonary disease: a mini-review. Gerontology 59: 481-489.
7. Calvi CL, Podowski M, D'Alessio FR, Metzger SL, Misono K, et al. (2011) Critical transition in tissue homeostasis accompanies murine lung senescence. PLoS One 6: e20712.
8. Faner R, Rojas M, Macnee W, Agusti A (2012) Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 186: 306-313.
9. Chilosi M, Carloni A, Rossi A, Poletti V (2013) Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema. Transl Res 162: 156-173.
10. Hernandez JA, Anderson AE Jr., Holmes WL, Morrone N, Foraker AG (1965) The Bronchial Glands in Aging. J Am Geriatr Soc 13: 799-804.
11. Huang J, Li Z, Yao X, Li Y, Reng X, et al. (2013) Altered Th1/Th2 commitment contributes to lung senescence in CXCR3-deficient mice. Exp Gerontol 48: 717-726.
12. Rock JR, Randell SH, Hogan BL (2010) Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling. Dis Model Mech 3: 545-556.
13. Rock JR, Onaitis MW, Rawlins EL, Lu Y, Clark CP, et al. (2009) Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci U S A 106: 12771-12775.
14. Tata PR, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, et al. (2013) Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature 503: 218-223.
15. Driskell RR, Goodheart M, Neff T, Liu X, Luo M, et al. (2007) Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Dev Biol 305: 90-102. (Pubitemid 46589407)
16. Engelhardt JF, Schlossberg H, Yankaskas JR, Dudus L (1995) Progenitor cells of the adult human airway involved in submucosal gland development. Development 121: 2031-2046.
17. Nettesheim P, Martin DH (1970) Appearance of glandlike structures in the tracheobronchial tree of aging mice. J Natl Cancer Inst 44: 687-693.
18. Ferrer-Vaquer A, Piliszek A, Tian G, Aho RJ, Dufort D, et al. (2010) A sensitive and bright single-cell resolution live imaging reporter of Wnt/ss-catenin signaling in the mouse. BMC Dev Biol 10: 121.
19. Giangreco A, Lu L, Mazzatti DJ, Spencer-Dene B, Nye E, et al. (2011) Myd88 deficiency influences murine tracheal epithelial metaplasia and submucosal gland abundance. J Pathol 224: 190-202.
20. Shore SA, Rivera-Sanchez YM, Schwartzman IN, Johnston RA (2003) Responses to ozone are increased in obese mice. J Appl Physiol (1985) 95: 938-945.
21. O'Koren EG, Hogan BL, Gunn MD (2013) Loss of basal cells precedes bronchiolitis obliterans-like pathological changes in a murine model of chlorine gas inhalation. Am J Respir Cell Mol Biol 49: 788-797.
22. Que J, Luo X, Schwartz RJ, Hogan BL (2009) Multiple roles for Sox2 in the developing and adult mouse trachea. Development 136: 1899-1907.
23. Shelton DN, Chang E, Whittier PS, Choi D, Funk WD (1999) Microarray analysis of replicative senescence. Curr Biol 9: 939-945. (Pubitemid 29442477)
24. Coppe JP, Desprez PY, Krtolica A, Campisi J (2010) The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 5: 99-118.
25. Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, et al. (2008) Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6: 2853-2868.
26. Williams AE, Perry MM, Moschos SA, Lindsay MA (2007) microRNA expression in the aging mouse lung. BMC Genomics 8: 172.
27. Mays PK, McAnulty RJ, Laurent GJ (1989) Age-related changes in lung collagen metabolism. A role for degradation in regulating lung collagen production. Am Rev Respir Dis 140: 410-416. (Pubitemid 19218358)
28. Madsen J, Mollenhauer J, Holmskov U (2010) Review: Gp-340/DMBT1 in mucosal innate immunity. Innate Immun 16: 160-167.
29. Madsen J, Sorensen GL, Nielsen O, Tornoe I, Thim L, et al. (2013) A variant form of the human deleted in malignant brain tumor 1 (DMBT1) gene shows increased expression in inflammatory bowel diseases and interacts with dimeric trefoil factor 3 (TFF3). PLoS One 8: e64441.
30. Mollenhauer J, Herbertz S, Holmskov U, Tolnay M, Krebs I, et al. (2000) DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer. Cancer Res 60: 1704-1710. (Pubitemid 30183445)
31. Muller H, End C, Weiss C, Renner M, Bhandiwad A, et al. (2008) Respiratory Deleted in Malignant Brain Tumours 1 (DMBT1) levels increase during lung maturation and infection. Clin Exp Immunol 151: 123-129. (Pubitemid 350230981)
32. Pabst R, Gehrke I (1990) Is the bronchus-associated lymphoid tissue (BALT) an integral structure of the lung in normal mammals, including humans? Am J Respir Cell Mol Biol 3: 131-135.
33. Randall TD (2010) Bronchus-associated lymphoid tissue (BALT) structure and function. Adv Immunol 107: 187-241.
34. Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, et al. (2007) Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 317: 807-810. (Pubitemid 47257918)
35. Wallace KN, Dolan AC, Seiler C, Smith EM, Yusuff S, et al. (2005) Mutation of smooth muscle myosin causes epithelial invasion and cystic expansion of the zebrafish intestine. Dev Cell 8: 717-726. (Pubitemid 40585294)
36. Seiler C, Davuluri G, Abrams J, Byfield FJ, Janmey PA, et al. (2012) Smooth muscle tension induces invasive remodeling of the zebrafish intestine. PLoS Biol 10: e1001386.
37. Paxson JA, Gruntman A, Parkin CD, Mazan MR, Davis A, et al. (2011) Age-dependent decline in mouse lung regeneration with loss of lung fibroblast clonogenicity and increased myofibroblastic differentiation. PLoS One 6: e23232.
38. Mall M, Grubb BR, Harkema JR, O'Neal WK, Boucher RC (2004) Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice. Nat Med 10: 487-493. (Pubitemid 38667907)
39. Ledford JG, Goto H, Potts EN, Degan S, Chu HW, et al. (2009) SP-A preserves airway homeostasis during Mycoplasma pneumoniae infection in mice. J Immunol 182: 7818-7827.
40. Rawlins EL, Okubo T, Xue Y, Brass DM, Auten RL, et al. (2009) The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell 4: 525-534.
41. Wansleeben C, Feitsma H, Montcouquiol M, Kroon C, Cuppen E, et al. (2010) Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Development 137: 1067-1073.
42. You Y, Richer EJ, Huang T, Brody SL (2002) Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative population. American journal of physiology Lung cellular and molecular physiology 283: L1315-1321. (Pubitemid 35379264)