Gp-340/DMBT1 in mucosal innate immunity

Innate Immunity

Volumn 16, Issue 3, 2010, Pages 160-167

  Madsen, Jens ^a   Mollenhauer, Jan ^b   Holmskov, Uffe ^b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Collectin; Deleted in malignant brain tumour 1; DMBT1; Innate immunity; Mucosal; Surfactant protein D

Indexed keywords

AGGLUTININ; COMPLEMENT COMPONENT C1Q; DELETED IN MALIGNANT BRAIN TUMOR 1 PROTEIN; GLYCOPROTEIN; GLYCOPROTEIN GP 340; IMMUNOGLOBULIN A; LACTOFERRIN; MUCIN 5B; PROTEIN DMBT1; SURFACTANT PROTEIN A; SURFACTANT PROTEIN D; TREFOIL FACTOR 2; TREFOIL PEPTIDE; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; COLLECTIN; DMBT1 PROTEIN, HUMAN;

EPITHELIUM CELL; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA VIRUS A; INNATE IMMUNITY; MUCOSAL IMMUNITY; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN SECRETION; REVIEW; SALIVA; STREPTOCOCCUS MUTANS; TRANSCYTOSIS; ANIMAL; ANTIGEN ANTIBODY REACTION; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; INFECTION; METABOLISM; MOUSE; MOUSE MUTANT; ORTHOMYXOVIRUS; PHYSIOLOGY; VIRUS ENTRY; WOUND HEALING;

BACTERIA (MICROORGANISMS); HUMAN IMMUNODEFICIENCY VIRUS 1; INFLUENZA A VIRUS; LOTUS; MUS; NEGIBACTERIA; POSIBACTERIA; STREPTOCOCCUS MUTANS;

AGGLUTINATION; ANIMALS; COLLECTINS; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; INFECTION; MICE; MICE, KNOCKOUT; ORTHOMYXOVIRIDAE; PROTEIN BINDING; RECEPTORS, CELL SURFACE; STREPTOCOCCUS MUTANS; VIRUS INTERNALIZATION; WOUND HEALING;

EID: 77953295344     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425910368447     Document Type: Review

References (64)

1. Holmskov U., Lawson P., Teisner B. et al. Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule. J Biol Chem 1997 ; 272: 13743-13749.
2. Resnick D., Pearson A., Krieger M. The SRCR superfamily: a family reminiscent of the Ig superfamily. Trends Biochem Sci 1994 ; 19: 5-8.
3. Holmskov U., Mollenhauer J., Madsen J. et al. Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D. Proc Natl Acad Sci USA 1999 ; 96: 10794-10799.
4. Mollenhauer J., Wiemann S., Scheurlen W. et al. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. Nat Genet 1997 ; 17: 32-39.
5. Ericson T., Rundegren J. Characterization of a salivary agglutinin reacting with a serotype c strain of Streptococcus mutans. Eur J Biochem 1983 ; 133: 255-261.
6. Ligtenberg TJ, Bikker FJ, Groenink J. et al. Human salivary agglutinin binds to lung surfactant protein-D and is identical with scavenger receptor protein gp-340. Biochem J 2001 ; 359: 243-248.
7. Prakobphol A., Xu F., Hoang VM et al. Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340. J Biol Chem 2000 ; 275: 39860-39866.
8. Mollenhauer J., Holmskov U., Wiemann S. et al. The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability. Oncogene 1999 ; 18: 6233-6240.
9. Oho T., Yu H., Yamashita Y., Koga T. Binding of salivary glycoprotein-secretory immunoglobulin A complex to the surface protein antigen of Streptococcus mutans. Infect Immun 1998 ; 66: 115-121.
10. Rose MC, Voter WA, Sage H., Brown CF, Kaufman B. Effects of deglycosylation on the architecture of ovine submaxillary mucin glycoprotein. J Biol Chem 1984 ; 259: 3167-3172.
11. Schulz BL, Oxley D., Packer NH, Karlsson NG Identification of two highly sialylated human tear-fluid DMBT1 isoforms: the major high-molecular-mass glycoproteins in human tears. Biochem J 2002 ; 366: 511-520.
12. Lauc G., Rudan I., Campbell H., Rudd PM Complex genetic regulation of protein glycosylation. Mol Biosyst 2010 ; 6: 329-335.
13. Eriksson C., Frangsmyr LDanielssonNiemi L. et al. Variant size-and glycoforms of the scavenger receptor cysteine-rich protein gp-340 with differential bacterial aggregation. Glycoconj J 2007 ; 24: 131-142.
14. Ligtenberg AJ, Veerman EC, Amerongen Nieuw, AV A role for Lewis a antigens on salivary agglutinin in binding to Streptococcus mutans. Antonie Van Leeuwenhoek 2000 ; 77: 21-30.
15. Hartshorn KL, Ligtenberg A., White MR et al. Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation. Biochem J 2006 ; 393: 545-553.
16. Teillet F., Gaboriaud C., Lacroix M., Martin L., Arlaud GJ, Thielens NM Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins. J Biol Chem 2008 ; 283: 25715-25724.
17. Jovine L., Qi H., Williams Z., Litscher E., Wassarman PM The ZP domain is a conserved module for polymerization of extracellular proteins. Nat Cell Biol 2002 ; 4: 457-461.
18. Cheng H., Bjerknes M., Chen H. CRP-ductin: a gene expressed in intestinal crypts and in pancreatic and hepatic ducts. Anat Rec 1996 ; 244: 327-343.
19. De Lisle RC Characterization of the major sulfated protein of mouse pancreatic acinar cells: a high molecular weight peripheral membrane glycoprotein of zymogen granules. J Cell Biochem 1994 ; 56: 385-396.
20. Matsushita F., Miyawaki A., Mikoshiba K. Vomeroglandin/ CRP-ductin is strongly expressed in the glands associated with the mouse vomeronasal organ: identification and characterization of mouse vomeroglandin. Biochem Biophys Res Commun 2000 ; 268: 275-281.
21. Li XJ, Snyder SH Molecular cloning of ebnerin, a von Ebners gland protein associated with taste buds. J Biol Chem 1995 ; 270: 17674-17679.
22. Takito J., Yan L., Ma J. et al. Hensin, the polarity reversal protein, is encoded by DMBT1, a gene frequently deleted in malignant gliomas. Am J Physiol 1999 ; 277: F277 - F289.
23. Haase B., Humphray SJ, Lyer S. et al. Molecular characterization of the porcine deleted in malignant brain tumors 1 gene (DMBT1). Gene 2006 ; 376: 184-191.
24. Nunes DP, Keates AC, Afdhal NH, Offner GD Bovine gall-bladder mucin contains two distinct tandem repeating sequences: evidence for scavenger receptor cysteine-rich repeats. Biochem J 1995 ; 310: 41-48.
25. Ace CI, Okulicz WC A progesterone-induced endometrial homolog of a new candidate tumor suppressor, DMBT1. J Clin Endocrinol Metab 1998 ; 83: 3569-3573.
26. Mollenhauer J., Herbertz S., Holmskov U. et al. DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer. Cancer Res 2000 ; 60: 1704-1710.
27. Stoddard E., Cannon G., Ni H. et al. gp340 expressed on human genital epithelia binds HIV-1 envelope protein and facilitates viral transmission. J Immunol 2007 ; 179: 3126-3132.
28. Gronborg M., Bunkenborg J., Kristiansen TZ et al. Comprehensive proteomic analysis of human pancreatic juice. J Proteome Res 2004 ; 3: 1042-1055.
29. Bikker FJ, Ligtenberg AJM, Nazmi K. et al. Identification of the bacteria-binding peptide domain on salivary agglutinin (gp-340/ DMBT1), a member of the scavenger receptor cysteine-rich superfamily. J Biol Chem 2002 ; 277: 32109-32115.
30. Leito JT, Ligtenberg AJ, Nazmi K., de Blieck-Hogervorst JM, Veerman EC, Amerongen Nieuw AV A common binding motif for various bacteria of the bacteria-binding peptide SRCRP2 of DMBT1/gp-340/salivary agglutinin. Biol Chem 2008 ; 389: 1193-1200.
31. Bikker FJ, Ligtenberg AJ, End C. et al. Bacteria binding by DMBT1/SAG/gp-340 is confined to the VEVLXXXXW motif in its scavenger receptor cysteine-rich domains. J Biol Chem 2004 ; 279: 47699-47703.
32. Madsen J., Tornoe I., Nielsen O. et al. CRP-ductin, the mouse homologue of gp-340/deleted in malignant brain tumors 1 (DMBT1), binds Gram-positive and Gram-negative bacteria and interacts with lung surfactant protein D. Eur J Immunol 2003 ; 33: 2327-2336.
33. Rosenstiel P., Sina C., End C. et al. Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion. J Immunol 2007 ; 178: 8203-8211.
34. End C., Bikker F., Renner M. et al. DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands. Eur J Immunol 2009 ; 39: 833-842.
35. Hartshorn KL, White MR, Mogues T., Ligtenberg T., Crouch E., Holmskov U. Lung and salivary scavenger receptor glycoprotein-340 contribute to the host defense against influenza A viruses. Am J Physiol 2003 ; 285: L1066 - L1076.
36. Nagashunmugam T., Malamud D., Davis C., Abrams WR, Friedman HM Human submandibular saliva inhibits human immunodeficiency virus type 1 infection by displacing envelope glycoprotein gp120 from the virus. J Infect Dis 1998 ; 178: 1635-1641.
37. Shugars DC, Sweet SP, Malamud D., Kazmi SH, Page-Shafer K., Challacombe SJ Saliva and inhibition of HIV-1 infection: molecular mechanisms. Oral Dis 2002 ; 8 (Suppl 2). 169-175.
38. Wu Z., Golub E., Abrams WR, Malamud D. gp340 (SAG) binds to the V3 sequence of gp120 important for chemokine receptor interaction. AIDS Res Hum Retroviruses 2004 ; 20: 600-607.
39. Wu Z., Lee S., Abrams W., Weissman D., Malamud D. The N-terminal SRCR-SID domain of gp-340 interacts with HIV type 1 gp120 sequences and inhibits viral infection. AIDS Res Hum Retroviruses 2006 ; 22: 508-515.
40. Wu Z., Van Ryk D., Davis C. et al. Salivary agglutinin inhibits HIV type 1 infectivity through interaction with viral glycoprotein 120. AIDS Res Hum Retroviruses 2003 ; 19: 201-209.
41. Zolla-Pazner S. Identifying epitopes of HIV-1 that induce protective antibodies. Nat Rev Immunol 2004 ; 4: 199-210.
42. Stoddard E., Ni H., Cannon G. et al. gp340 promotes transcytosis of human immunodeficiency virus type 1 in genital tract-derived cell lines and primary endocervical tissue. J Virol 2009 ; 83: 8596-8603.
43. Tino MJ, Wright JR Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner. Am J Respir Cell Mol Biol 1999 ; 20: 759-768.
44. Rundegren J., Arnold RR Differentiation and interaction of secretory immunoglobulin A and a calcium-dependent parotid agglutinin for several bacterial strains. Infect Immun 1987 ; 55: 288-292.
45. Thim L., Mortz E. Isolation and characterization of putative trefoil peptide receptors. Regul Pept 2000 ; 90: 61-68.
46. Thornton DJ, Davies JR, Kirkham S. et al. Identification of a nonmucin glycoprotein (gp-340) from a purified respiratory mucin preparation: evidence for an association involving the MUC5B mucin. Glycobiology 2001 ; 11: 969-977.
47. Boackle RJ, Connor MH, Vesely J. High molecular weight non-immunoglobulin salivary agglutinins (NIA) bind C1Q globular heads and have the potential to activate the first complement component. Mol Immunol 1993 ; 30: 309-319.
48. Oho T., Bikker FJ, Nieuw Amerongen AV, Groenink J. A peptide domain of bovine milk lactoferrin inhibits the interaction between streptococcal surface protein antigen and a salivary agglutinin peptide domain. Infect Immun 2004 ; 72: 6181-6184.
49. Holmskov U. Lung surfactant proteins (SP-A and SP-D) in non-adaptive host responses to infection. J Leukoc Biol 1999 ; 66: 747-752.
50. White MR, Crouch E., van Eijk M. et al. Cooperative anti-influenza activities of respiratory innate immune proteins and neuraminidase inhibitor. Am J Physiol 2005 ; 288: L831 - L840.
51. White MR, Crouch E., Vesona J. et al. Respiratory innate immune proteins differentially modulate the neutrophil respiratory burst response to influenza A virus. Am J Physiol 2005 ; 289: L606 - L616.
52. Rundegren JL, Arnold RR Bacteria-agglutinating characteristics of secretory IgA and a salivary agglutinin. Adv Exp Med Biol 1987 ; 216B: 1005-1013.
53. Ligtenberg AJ, Bikker FJ, De Blieck-Hogervorst JM, Veerman EC, Nieuw Amerongen AV Binding of salivary agglutinin to IgA. Biochem J 2004 ; 383: 159-164.
54. Mitoma M., Oho T., Shimazaki Y., Koga T. Inhibitory effect of bovine milk lactoferrin on the interaction between a streptococcal surface protein antigen and human salivary agglutinin. J Biol Chem 2001 ; 276: 18060-18065.
55. Ward PP, Conneely OM Lactoferrin: role in iron homeostasis and host defense against microbial infection. Biometals 2004 ; 17: 203-208.
56. Kojouharova MS, Tsacheva IG, Tchorbadjieva MI, Reid KB, Kishore U. Localization of ligand-binding sites on human C1q globular head region using recombinant globular head fragments and single-chain antibodies. Biochim Biophys Acta 2003 ; 1652: 64-74.
57. Wickstrom C., Christersson C., Davies JR, Carlstedt I. Macromolecular organization of saliva: identification of insoluble MUC5B assemblies and non-mucin proteins in the gel phase. Biochem J 2000 ; 351: 421-428.
58. Madsen J., Nielsen O., Tornoe I., Thim L., Holmskov U. Tissue localization of human trefoil factors 1, 2, and 3. J Histochem Cytochem 2007 ; 55: 505-513.
59. Taupin D., Podolsky DK Trefoil factors: initiators of mucosal healing. Nat Rev Mol Cell Biol 2003 ; 4: 721-732.
60. Renner M., Bergmann G., Krebs I. et al. DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohns disease. Gastroenterology 2007 ; 133: 1499-1509.
61. Muller H., End C., Renner M. et al. Deleted in Malignant Brain Tumors 1 (DMBT1) is present in hyaline membranes and modulates surface tension of surfactant. Respir Res 2007 ; 8: 69.
62. Ligtenberg AJ, Veerman EC, Nieuw Amerongen AV, Mollenhauer J. Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer. Biol Chem 2007 ; 388: 1275-1289.
63. End C., Lyer S., Renner M. et al. Generation of a vector system facilitating cloning of DMBT1 variants and recombinant expression of functional full-length DMBT1. Protein Expr Purif 2005 ; 41: 275-286.
64. Crouch E., Chang D., Rust K., Persson A., Heuser J. Recombinant pulmonary surfactant protein D. Post-translational modification and molecular assembly. J Biol Chem 1994 ; 269: 15808-15813.