Bladder cancer biomarkers: Review and update

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 6, 2014, Pages 2395-2403

  Ghafouri Fard, Soudeh ^a   Nekoohesh, Leili ^b   Motevaseli, Elahe ^b  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Biomarker; Bladder cancer; Diagnosis; Prognosis

Indexed keywords

TUMOR MARKER;

HUMAN; METABOLISM; PROGNOSIS; URINARY BLADDER NEOPLASMS;

HUMANS; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS;

EID: 84899813702     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.6.2395     Document Type: Review

References (90)

1. Abogunrin F, O'Kane HF, Ruddock MW, et al (2012). The impact of biomarkers in multivariate algorithms for bladder cancer diagnosis in patients with hematuria. Cancer, 118, 2641-50
2. Alvarez A, Lokeshwar VB (2007). Bladder cancer biomarkers: current developments and future implementation. Curr Opin Urol, 17, 341-6
3. Babjuk M, Kostirova M, Mudra K, et al (2002). Qualitative and quantitative detection of urinary human complement factor H-related protein (BTA stat and BTA TRAK) and fragments of cytokeratins 8, 18 (UBC rapid and UBC IRMA) as markers for transitional cell carcinoma of the bladder. Eur Urol, 41, 34-9
4. Bangma CH, Loeb S, Busstra M, et al (2013). Outcomes of a bladder cancer screening program using home hematuria testing and molecular markers. Eur Urol, 64, 41-7
5. Bergeron A, Picard V, LaRue H, et al (2009). High frequency of MAGE-A4 and MAGE-A9 expression in high-risk bladder cancer. Int J Cancer, 125, 1365-71
6. Bhagirath D, Abrol N, Khan R, et al (2012). Expression of CD147, BIGH3 and Stathmin and their potential role as diagnostic marker in patients with urothelial carcinoma of the bladder. Clin Chim Acta, 413, 1641-6
7. Brems-Eskildsen AS, Zieger K, Toldbod H, et al (2010). Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts. BMC Cancer, 10, 646
8. Chen CL, Lai YF, Tang P, et al (2012). Comparative and targeted proteomic analyses of urinary microparticles from bladder cancer and hernia patients. J Proteome Res, 11, 5611-29
9. Chen YT, Chen CL, Chen HW, et al (2010). Discovery of novel bladder cancer biomarkers by comparative urine proteomics using iTRAQ technology. J Proteome Res, 9, 5803-15
10. Cheung G, Sahai A, Billia M, Dasgupta P, Khan MS (2013). Recent advances in the diagnosis and treatment of bladder cancer. BMC Med, 11, 13
11. Chihara Y, Kanai Y, Fujimoto H, et al (2013). Diagnostic markers of urothelial cancer based on DNA methylation analysis. BMC Cancer, 13, 275
12. Dhawan D, Hamdy FC, Rehman I, et al (2006). Evidence for the early onset of aberrant promoter methylation in urothelial carcinoma. J Pathol, 209, 336-43
13. Eissa S, Kassim SK, Labib RA, et al (2005). Detection of bladder carcinoma by combined testing of urine for hyaluronidase and cytokeratin 20 RNAs. Cancer, 103, 1356-62
14. Feldman AS, Banyard J, Wu CL, McDougal WS, Zetter BR (2009). Cystatin B as a tissue and urinary biomarker of bladder cancer recurrence and disease progression. Clin Cancer Res, 15, 1024-31
15. Frantzi M, Makridakis M, Vlahou A (2012). Biomarkers for bladder cancer aggressiveness. Curr Opin Urol, 22, 390-6
16. Ghafouri-Fard S, Ghafouri-Fard S (2012). Immunotherapy in nonmelanoma skin cancer. Immunotherapy, 4, 499-510
17. Ghafouri-Fard S, Abdollahi DZ, Omrani M, Azizi F (2012). shRNA mediated RHOXF1 silencing influences expression of BCL2 but not CASP8 in MCF-7 and MDA-MB-231 cell lines. Asian Pac J Cancer Prev, 13, 5865-9
18. Ghafouri-Fard S, Modarressi MH (2009). Cancer-testis antigens: potential targets for cancer immunotherapy. Arch Iran Med, 12, 395-404
19. Ghafouri-Fard S, Modarressi MH (2012). Expression of cancer-testis genes in brain tumors: implications for cancer immunotherapy. Immunotherapy, 4, 59-75
20. Ghafouri-Fard S, Ousati Ashtiani Z, Sabah Golian B, Hasheminasab SM, Modarressi MH (2010). Expression of two testis-specific genes, SPATA19 and LEMD1, in prostate cancer. Arch Med Res, 41, 195-200
21. Gibanel R, Ribal MJ, Filella X, et al (2002). BTA TRAK urine test increases the efficacy of cytology in the diagnosis of low-grade transitional cell carcinoma of the bladder. Anticancer Res, 22, 1157-60
22. Goodison S, Rosser CJ, Urquidi V (2013). Bladder cancer detection and monitoring: assessment of urine- and blood-based marker tests. Mol Diagn Ther, 17, 71-84.
23. Griffiths TR (2013). Current perspectives in bladder cancer management. Int J Clin Pract, 67, 435-48
24. Guo B, Luo C, Xun C, et al (2009). Quantitative detection of cytokeratin 20 mRNA in urine samples as diagnostic tools for bladder cancer by real-time PCR. Exp Oncol, 31, 43-7
25. Guo Y, Ying L, Tian Y, et al (2013). miR-144 downregulation increases bladder cancer cell proliferation by targeting EZH2 and regulating Wnt signaling. FEBS J, 280, 4531-8
26. Hanke M, Hoefig K, Merz H, et al (2010). A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer. Urol Oncol, 28, 655-61
27. Ho CC, Tan WP, Pathmanathan R, Tan WK, Tan HM (2013). Fluorescence-in-situ-hybridization in the surveillance of urothelial cancers: can use of cystoscopy or ureteroscopy be deferred? Asian Pac J Cancer Prev, 14, 4057-9
28. Holterman DA, Diaz JI, Blackmore PF, et al (2006). Overexpression of alpha-defensin is associated with bladder cancer invasiveness. Urol Oncol, 24, 97-108
29. Hoque MO, Begum S, Topaloglu O, et al (2006). Quantitation of promoter methylation of multiple genes in urine DNA and bladder cancer detection. J Natl Cancer Inst, 98, 996-1004
30. Hu HY, Hu ZL, Wang HQ, Liu C, Yu SJ (2012). Nuclear matrix protein 22 and urinary cytology test in the diagnosis of bladder cancer: a meta-analysis. Zhonghua Wai Ke Za Zhi, 50, 1126-30
31. Irani J, Desgrandchamps F, Millet C, Toubert ME, et al (1999). BTA stat and BTA TRAK: A comparative evaluation of urine testing for the diagnosis of transitional cell carcinoma of the bladder. Eur Urol, 35, 89-92
32. Irmak S, Tilki D, Heukeshoven J, et al (2005). Stage-dependent increase of orosomucoid and zinc-alpha2-glycoprotein in urinary bladder cancer. Proteomics, 5, 4296-304
33. Johnen G, Gawrych K, Bontrup H, et al (2012). Performance of survivin mRNA as a biomarker for bladder cancer in the prospective study UroScreen. PLoS One, 7, 16
34. Karam JA, Lotan Y, Karakiewicz PI, (2007). Use of combined apoptosis biomarkers for prediction of bladder cancer recurrence and mortality after radical cystectomy. Lancet Oncol, 8, 128-36
35. Karbakhsh M, Dabbagh N, Shabani A, Tabibi A, Akhavizadegan H (2013). Age at diagnosis in bladder cancer: does opium addiction play a role? Asian Pac J Cancer Prev, 14, 4723-5
36. Kelly JD, Dudderidge TJ, Wollenschlaeger A (2012). Bladder cancer diagnosis and identification of clinically significant disease by combined urinary detection of Mcm5 and nuclear matrix protein 22. PLoS One, 7, 40305
37. Kohler CU, Bryk O, Meier S, et al (2013). Analyses in human urothelial cells identify methylation of miR-152, miR-200b and miR-10a genes as candidate bladder cancer biomarkers. Biochem Biophys Res Commun, 438, 48-53
38. Kompier LC, Lurkin I, van der Aa MN, et al (2010). FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy. PLoS One, 5, 13821
39. Lai Y, Ye J, Chen J, et al (2010). UPK3A: a promising novel urinary marker for the detection of bladder cancer. Urology, 76, 25
40. Laurberg JR, Brems-Eskildsen AS, Nordentoft I, et al (2012). Expression of TIP60 (tat-interactive protein) and MRE11 (meiotic recombination 11 homolog) predict treatment-specific outcome of localised invasive bladder cancer. BJU Int, 110, 9
41. Lei Y, Yan S, Ming-De L, Na L, Rui-Fa H (2011). Prognostic significance of Aurora-A expression in human bladder cancer. Acta Histochem, 113, 514-8
42. Linden M, Segersten U, Runeson M, et al (2013). Tumour expression of bladder cancer-associated urinary proteins. BJU Int, 112, 407-15
43. Lindgren D, Liedberg F, Andersson A, et al (2006). Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q. Oncogene, 25, 2685-96
44. Lorenzi T, Lorenzi M, Altobelli E, et al (2013). HtrA1 in human urothelial bladder cancer: a secreted protein and a potential novel biomarker. Int J Cancer, 133, 2650-61
45. Matsuda R, Enokida H, Chiyomaru T, et al (2011). LY6K is a novel molecular target in bladder cancer on basis of integrate genome-wide profiling. Br J Cancer, 104, 376-86
46. Mengus C, Schultz-Thater E, Coulot J, et al (2013). MAGE-A10 cancer/testis antigen is highly expressed in high-grade non-muscle-invasive bladder carcinomas. Int J Cancer, 132, 2459-63
47. Miah S, Dudziec E, Drayton RM, et al (2012). An evaluation of urinary microRNA reveals a high sensitivity for bladder cancer. Br J Cancer, 107, 123-8
48. Myers-Irvin JM, Van Le TS, Getzenberg RH (2005). Mechanistic analysis of the role of BLCA-4 in bladder cancer pathobiology. Cancer Res, 65, 7145-50
49. Nana-Sinkam SP, Croce CM (2013). Clinical applications for microRNAs in cancer. Clin Pharmacol Ther, 93, 98-104
50. Nielsen ME, Gonzalgo ML, Schoenberg MP, Getzenberg RH (2006). Toward critical evaluation of the role(s) of molecular biomarkers in the management of bladder cancer. World J Urol, 24, 499-508
51. Nordentoft I, Birkenkamp-Demtroder K, Agerbæk M, et al (2012). miRNAs associated with chemo-sensitivity in cell lines and in advanced bladder cancer. BMC Med Genomics, 5, 40
52. Obara W, Ohsawa R, Kanehira M, et al (2012). Cancer peptide vaccine therapy developed from oncoantigens identified through genome-wide expression profile analysis for bladder cancer. Jpn J Clin Oncol, 42, 591-600
53. Omran OM (2012). CD10 and E-cad expression in urinary bladder urothelial and squamous cell carcinoma. J Environ Pathol Toxicol Oncol, 31, 203-12
54. Orenes-Pinero E, Corton M, Gonzalez-Peramato P, et al (2007). Searching urinary tumor markers for bladder cancer using a two-dimensional differential gel electrophoresis (2D-DIGE) approach. J Proteome Res, 6, 4440-8
55. Pesch B, Taeger D, Johnen G, et al (2013). Screening for bladder cancer with urinary tumor markers in chemical workers with exposure to aromatic amines. Int Arch Occup Environ Health, [Epub ahead of print]
56. Pignot G, Cizeron-Clairac G, Vacher S, et al (2013). microRNA expression profile in a large series of bladder tumors: identification of a 3-miRNA signature associated with aggressiveness of muscle-invasive bladder cancer. Int J Cancer, 132, 2479-91
57. Qin ZK, Yang JA, Ye YL, et al (2009). Expression of Bmi-1 is a prognostic marker in bladder cancer. BMC Cancer, 9, 61
58. Qin ZK, Yang JA, Zeng MS, et al (2008). Expression and clinical significance of Bmi-1 protein in bladder cancer. Ai Zheng, 27, 1327-30
59. Rahmani AH, Alzohairy M, Babiker AY, et al (2013). Implication of androgen receptor in urinary bladder cancer: a critical mini review. Int J Mol Epidemiol Genet, 4, 150-5
60. Rasmussen HH, Orntoft TF, Wolf H, Celis JE (1996). Towards a comprehensive database of proteins from the urine of patients with bladder cancer. J Urol, 155, 2113-9
61. Rosser CJ, Ross S, Chang M, et al (2013). Multiplex protein signature for the detection of bladder cancer in voided urine samples. J Urol, 190, 2257-62
62. Sakaki M, Oka N, Nakanishi R, et al (2008). Serum level of galectin-3 in human bladder cancer. J Med Invest, 55, 127-32
63. Sanchini MA, Gunelli R, Nanni O, et al (2005). Relevance of urine telomerase in the diagnosis of bladder cancer. JAMA, 294, 2052-6
64. Sartini D, Muzzonigro G, Milanese G, et al (2013). Upregulation of tissue and urinary nicotinamide N-methyltransferase in bladder cancer: potential for the development of a urine-based diagnostic test. Cell Biochem Biophys, 65, 473-83
65. Scher MB, Elbaum MB, Mogilevkin Y, et al (2012). Detecting DNA methylation of the BCL2, CDKN2A and NID2 genes in urine using a nested methylation specific polymerase chain reaction assay to predict bladder cancer. J Urol, 188, 2101-7
66. Shariat SF, Savage C, Chromecki TF, et al (2011). Assessing the clinical benefit of nuclear matrix protein 22 in the surveillance of patients with nonmuscle-invasive bladder cancer and negative cytology: a decision-curve analysis. Cancer, 117, 2892-7
67. Sharma P, Gnjatic S, Jungbluth AA, et al (2003). Frequency of NY-ESO-1 and LAGE-1 expression in bladder cancer and evidence of a new NY-ESO-1 T-cell epitope in a patient with bladder cancer. Cancer Immun, 3, 19
68. Siegel R, Naishadham D, Jemal A (2013). Cancer statistics, 2013. CA Cancer J Clin, 63, 11-30
69. Smith ZL, Guzzo TJ (2013). Urinary markers for bladder cancer. F1000Prime Rep, 5, 21
70. Snowdon J, Boag S, Feilotter H, Izard J, Siemens DR (2012). A pilot study of urinary microRNA as a biomarker for urothelial cancer. Can Urol Assoc J, 15, 1-5
71. Srivastava AK, Singh PK, Srivastava K, et al (2013). Diagnostic role of survivin in urinary bladder cancer. Asian Pac J Cancer Prev, 14, 81-5
72. Stoeber K, Swinn R, Prevost AT, et al (2002). Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments. J Natl Cancer Inst, 94, 1071-9
73. Sun YW, Xuan Q, Shu QA, et al (2013). Correlation of tumor relapse and elevated expression of survivin and vascular endothelial growth factor in superficial bladder transitional cell carcinoma. Genet Mol Res, 12, 1045-53
74. Svatek RS, Herman MP, Lotan Y, et al (2006). Soluble Fas-a promising novel urinary marker for the detection of recurrent superficial bladder cancer. Cancer, 106, 1701-7
75. Tabarestani S, Ghafouri-Fard S (2012). Cancer stem cells and response to therapy. Asian Pac J Cancer Prev, 13, 5951-8
76. Tauber S, Brunken C, Vierbuchen M (2011). Expression of the tumormarker p16INK4a in cytology specimens of the urinary bladder. A new means for early recognition and surveillance of urothelial cancer. Urologe A, 50, 1130-3
77. Tyan YC, Yang MH, Chen SC, et al (2011). Urinary protein profiling by liquid chromatography/tandem mass spectrometry: ADAM28 is overexpressed in bladder transitional cell carcinoma. Rapid Commun Mass Spectrom, 25, 2851-62
78. Urquidi V, Goodison S, Kim J, et al (2012a). Vascular endothelial growth factor, carbonic anhydrase 9, and angiogenin as urinary biomarkers for bladder cancer detection. Urology, 79, 1181-6
79. Urquidi V, Goodison S, Ross S, et al (2012b). Diagnostic potential of urinary alpha1-antitrypsin and apolipoprotein E in the detection of bladder cancer. J Urol, 188, 2377-83
80. Urquidi V, Kim J, Chang M, et al (2012c). CCL18 in a multiplex urine-based assay for the detection of bladder cancer. PLoS One, 7, 37797
81. Van Le TS, Myers J, Konety BR, Barder T, Getzenberg RH (2004). Functional characterization of the bladder cancer marker, BLCA-4. Clin Cancer Res, 10, 1384-91
82. Wang DL, Lan JH, Chen L, et al (2012). Integrin-linked kinase functions as a tumor promoter in bladder transitional cell carcinoma. Asian Pac J Cancer Prev, 13, 2799-806
83. Wang, XS, Zhang Z, Wang HC, et al (2006). Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma. Clin Cancer Res, 12, 4851-8
84. Wszolek MF, Rieger-Christ KM, Kenney PA, et al (2011). A MicroRNA expression profile defining the invasive bladder tumor phenotype. Urol Oncol, 29, 794-801
85. Xiong D, Ye YL, Chen MK, et al (2012). Non-muscle myosin II is an independent predictor of overall survival for cystectomy candidates with early-stage bladder cancer. Oncol Rep, 28, 1625-32
86. Yang N, Feng S, Shedden K, et al (2011). Urinary glycoprotein biomarker discovery for bladder cancer detection using LC/MS-MS and label-free quantification. Clin Cancer Res, 17, 3349-59
87. Yin, B, Liu G, Wang XS, et al (2012). Expression profile of cancer-testis genes in transitional cell carcinoma of the bladder. Urol Oncol, 30, 886-92
88. Yoshino H, Seki N, Itesako T, et al (2013). Aberrant expression of microRNAs in bladder cancer. Nat Rev Urol, 10, 396-404
89. Yun SJ, Jeong P, Kim WT, et al (2012). Cell-free microRNAs in urine as diagnostic and prognostic biomarkers of bladder cancer. Int J Oncol, 41, 1871-8
90. Zheng Y, Rodrik V, Toschi A, et al (2006). Phospholipase D couples survival and migration signals in stress response of human cancer cells. J Biol Chem, 281, 15862-8.