Prognostic significance of Aurora-A expression in human bladder cancer

Acta Histochemica

Volumn 113, Issue 5, 2011, Pages 514-518

  Lei, Yu ^a,b   Yan, Sun ^a   Ming De, Lei ^a   Na, Li ^a   Rui Fa, Han ^a  

^a SECOND HOSPITAL OF TIANJIN MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Aurora A; Bladder cancer; Human; Immunohistochemistry; Molecular marker; Prognosis

Indexed keywords

AURORA A KINASE; MESSENGER RNA;

ADULT; AGE; AGED; ARTICLE; BLADDER CANCER; CANCER CELL; CANCER GRADING; CANCER GROWTH; CANCER INVASION; CANCER PATIENT; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CANCER TISSUE; CLINICAL FEATURE; CONFIDENCE INTERVAL; CYTOPLASM; DISEASE FREE SURVIVAL; ENZYME LOCALIZATION; FEMALE; GENDER; GENE EXPRESSION; GENE OVEREXPRESSION; HAZARD RATIO; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; MULTIVARIATE ANALYSIS; OVERALL SURVIVAL; PREDICTION; PROGNOSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; UNIVARIATE ANALYSIS;

ADULT; AGED; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; PROTEIN-SERINE-THREONINE KINASES; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS;

EID: 79955468461     PISSN: 00651281     EISSN: 16180372     Source Type: Journal    
DOI: 10.1016/j.acthis.2010.05.004     Document Type: Article

References (30)

1. Buschhorn H.M., Klein R.R., Chambers S.M., Hardy M.C., Green S., Bearss D., et al. Aurora-A over-expression in high-grade PIN lesions and prostate cancer. Prostate 2005, 64:341-346.
2. Carvajal R.D., Tse A., Schwartz G.K. Aurora kinases: new targets for cancer therapy. Clin Cancer Res 2006, 12:6869-6875.
3. Fu J., Bian M., Jiang Q., Zhang C. Roles of Aurora kinases in mitosis and tumorigenesis. Mol Cancer Res 2007, 5:1-10.
4. Furukawa T., Kanai N., Shiwaku H.O., Soga N., Uehara A., Horii A. AURKA is one of the downstream targets of MAPK1/ERK2 in pancreatic cancer. Oncogene 2006, 25:4831-4839.
5. Gautschi O., Heighway J., Mack P.C., Purnell P.R., Lara P.N., Gandara D.R. Aurora kinases as anticancer drug targets. Clin Cancer Res 2008, 14:1639-1648.
6. Guan Z., Wang X.R., Zhu X.F., Huang X.F., Xu J., Wang L.H., et al. Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells. Cancer Res 2007, 67:10436-10444.
7. Huck J.J., Zhang M., McDonald A., Bowman D., Hoar K.M., Stringer B., et al. MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo. Mol Cancer Res 2010, 8:373-384.
8. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Murray T., et al. Cancer statistics, 2008. CA Cancer J Clin 2008, 58:71-96.
9. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Thun M.J. Cancer statistics, 2009. CA Cancer J Clin 2009, 59:225-249.
10. Jeng Y.M., Peng S.Y., Lin C.Y., Hsu H.C. Overexpression and amplification of Aurora-A in hepatocellular carcinoma. Clin Cancer Res 2004, 10:2065-2071.
11. Katayama H., Brinkley W.R., Sen S. The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev 2003, 22:451-464.
12. Klein A., Flügel D., Kietzmann T. Transcriptional regulation of serine/threonine kinase-15 (STK15) expression by hypoxia and HIF-1. Mol Biol Cell 2008, 19:3667-3675.
13. Kurahashi T., Miyake H., Hara I., Fujisawa M. Significance of Aurora-A expression in renal cell carcinoma. Urol Oncol 2007, 25:128-133.
14. Li D., Zhu J., Firozi P.F., Abbruzzese J.L., Evans D.B., Cleary K., et al. Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. Clin Cancer Res 2003, 9:991-997.
15. Liu L., Guo C., Dammann R., Tommasi S., Pfeifer G.P. RASSF1A interacts with and activates the mitotic kinase Aurora-A. Oncogene 2008, 27:6175-6186.
16. Marumoto T., Zhang D., Saya H. Aurora-A - a guardian of poles. Nat Rev Cancer 2005, 5:42-50.
17. McGrogan B.T., Gilmartin B., Carney D.N., McCann A. Taxanes, microtubules and chemoresistant breast cancer. Biochim Biophys Acta 2008, 1785:96-132.
18. Mountzios G., Terpos E., Dimopoulos M.A. Aurora kinases as targets for cancer therapy. Cancer Treat Rev 2008, 34:175-182.
19. Reiter R., Gais P., Jütting U., Steuer-Vogt M.K., Pickhard A., Bink K., et al. Aurora kinase A messenger RNA overexpression is correlated with tumor progression and shortened survival in head and neck squamous cell carcinoma. Clin Cancer Res 2006, 12:5136-5141.
20. Shimomura T., Hasako S., Nakatsuru Y., Mita T., Ichikawa K., Kodera T., et al. MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel. Mol Cancer Ther 2010, 9:157-166.
21. Stein J.P., Grossfeld G.D., Ginsberg D.A., Esrig D., Freeman J.A., Figueroa A.J., et al. Prognostic markers in bladder cancer: a contemporary review of the literature. J Urol 1998, 160:645-659.
22. Tanaka E., Hashimoto Y., Ito T., Kondo K., Higashiyama M., Tsunoda S., et al. The suppression of aurora-A/STK15/BTAK expression enhances chemosensitivity to docetaxel in human esophageal squamous cell carcinoma. Clin Cancer Res 2007, 13:1331-1340.
23. Tao Y., Zhang P., Frascogna V., Lecluse Y., Auperin A., Bourhis J., et al. Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells. Br J Cancer 2007, 97:1664-1672.
24. Tong T., Zhong Y., Kong J., Dong L., Song Y., Fu M., et al. Overexpression of Aurora-A contributes to malignant development of human esophageal squamous cell carcinoma. Clin Cancer Res 2004, 10:7304-7310.
25. Wang X., Dong L., Xie J., Tong T., Zhan Q. Stable knockdown of Aurora-A by vector-based RNA interference in human esophageal squamous cell carcinoma cell line inhibits tumor cell proliferation, invasion and enhances apoptosis. Cancer Biol Ther 2009, 8:1852-1859.
26. Wang X.X., Liu R., Jin S.Q., Fan F.Y., Zhan Q.M. Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line. Cell Res 2006, 16:356-366.
27. Wan X.B., Long Z.J., Yan M., Xu J., Xia L.P., Liu L., et al. Inhibition of Aurora-A suppresses epithelial-mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells. Carcinogenesis 2008, 29:1930-1937.
28. Zhang W., Wang J., Liu S.J., Hua W., Xin X.Y. Correlation between Aurora-A expression and the prognosis of cervical carcinoma patients. Acta Obstet Gynecol Scand 2009, 88:521-527.
29. Zhao B., Smallwood A., Yang J., Koretke K., Nurse K., Calamari A., et al. Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2. Protein Sci 2008, 17:1791-1797.
30. Yang H., Ou C.C., Feldman R.I., Nicosia S.V., Kruk P.A., Cheng J.Q. Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells. Cancer Res 2004, 64:463-467.