Effect of interferon-gamma on hepatic stellate cells stimulated by acetaldehyde

Hepato-Gastroenterology

Volumn 55, Issue 84, 2008, Pages 1059-1065

  Ha, Ming Hao ^a   Wei, Lai ^a   Rao, Hui Ying ^a   Liu, Feng ^a   Wang, Xue Yan ^a   Feng, Bo ^a   Fei, Ran ^a   Chen, Hong Song ^a   Cong, Xu ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

Acetaldehyde; Hepatic stellate cells; Interferon gamma; Transforming growth factor beta

Indexed keywords

ACETALDEHYDE; ALPHA SMOOTH MUSCLE ACTIN; BROXURIDINE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; RECOMBINANT GAMMA INTERFERON; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG MECHANISM; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STELLATE CELL; UPREGULATION; WESTERN BLOTTING;

ACETALDEHYDE; ACTINS; BLOTTING, WESTERN; CELL DIVISION; CELL LINE; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATIC STELLATE CELLS; HUMANS; INTERFERON-GAMMA; INTERFERON-GAMMA, RECOMBINANT; PEPTIDE FRAGMENTS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 47149096253     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Lieber CS: Alcohol and the liver. Gastroenterology 1994; 106:1085-1105.
2. Greenwel P: Acetaldehyde-mediated collagen regulation in hepatic stellate cells. Alcohol Clin Exp Res 1999; 23:930-933.
3. Nuutinen HU, Salaspuro MP, Valle M, Lindros KO: Blood acetaldehyde concentration gradient between hepatic and antecubital venous blood in ethanol-intoxicated alcoholics and controls. Eur J Clin Invest 1984; 14:306-311.
4. Casini A, Cunningham M, Rojkind M, Lieber CS: Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein- synthesis dependent mechanism. Hepatology 1991; 13:758-765.
5. Casini A, Ceni E, Salzano R, Milani S, Schuppan D: Acetaldehyde regulates the gene expression of matrix-metalloproteinase-1 and -2 in human fat-storing cells. Life Sci 1994; 55:1311-1316.
6. Savolainen ER, Lea MA, Timpl R, Lieber CS: Acetaldehyde and lactate stimulate collagen synthesis of cultured baboon liver myofibroblasts. Gastroenterology 1984; 87:777-787.
7. Brenner DA and Chojkier M: Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. J Biol Chem 1987; 262:17690-17695.
8. Svegliati-Baroni G, Ridolfi F, Di Sario A, Saccomanno S, Bendia E, Benedetti A, Greenwel P: Intracellular signaling pathways involved in acetaldehydeinduced collagen and fibronectin gene expression in human hepatic stellate cells. Hepatology 2001; 33:1130-1140.
9. Santos RM, Norton P, Degli S, Zern MA: TGF-β isoforms in alcoholic liver disease. J Gastroenterol 1998; 33:383-389.
10. Tsukamoto H, Horne W, Kamimura S, Niemela O, Parkkila S, Yla-Herttuala S, Brittenham GM: Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest 1995; 96:620-630.
11. Anania FA, Potter JJ, Rennie-Tankersley L, Mezey E: Activation by acetaldehyde of the promoter of the mouse a2(I) collagen gene when transfected into rat activated stellate cells. Biochem Biophys 1996; 331:187-193.
12. Friedman SL: The cellular basis of hepatic fibrosis. N Engl J Med 1993; 25:1828-1835.
13. Friedman SL, Roll JF, Boyles J, Bissell DM: Hepatic lipocytes: the principal collagen producing cells of normal rat liver. Proc Natl Acad Sci USA 1985; 82:8681-8685.
14. Svegliati-Baroni GD, Ambrosio L, Curto P, Casini A, Mancini R, Jezequel AM, Benedetti A: Interferon gamma decreases hepatic stellate cells activation and extracellular matrix deposition in rat liver fibrosis. Hepatology 1996; 23:1189-1199.
15. Boehm U, Klamp T, Groot M, Howard JC: Cellular responses to interferon-gamma. Annu Rev Immunol 1997; 15:749-795.
16. Darnell JE, Kerr IM, Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994; 264:1415-1419.
17. Horvai AE, Xu L, Korzus E, Brard E, Kalafus D, Mullen TM, Rose DW, Rosenfeld DW, Glass CK: Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300. Proc Natl Acad Sci USA 1997; 94:1074-1079.
18. Xu L, Hui AY, Albanis E, Arthur MJ, O'Byrne SM, Blaner WS, Mukherjee P, Friedman SL, Eng FJ: Human hepatic stellate cell lines. LX-1 and LX-2: new tools for analysis of hepatic fibrosis. Gut 2005; 54:142-151.
19. Sanderson N, Factor V, Nagy P, Kopp J, Kondaiah P, Wakefield L, Roberts AB, Sporn MB, Thorgeirsson SS: Hepatic expression of mature transforming growth factorβ 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci USA 1995; 92:2572-2576.
20. Nakamura T, Sakata R, Ueno T, Sata M, Ueno H: Inhibition of transforming growth factor β prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats. Hepatology 2000; 32:247-255.
21. Moshage H, Casini A, Lieber CS: Acetaldehyde selectively stimulates collagen production in cultured rat liver fat-storing cells but not in hepatocytes. Hepatology 1990; 12:511-518.
22. Gianluca S, Rrancesco R, Patricia G: Intracellular Signaling Pathways Involved in Acetaldehyde-Induced Collagen and Fibronectin Gene Expression in Human Hepatic Stellate Cells. Hepatology 2001; 33:1130-1140.
23. Lieber CS: Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. Alcohol 2004; 34:9-19.
24. Phillips PA, Park S, Apte MV: Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Gut 2003; 52:275-282.
25. Purohit V, Russo D, Coates PM: Role of fatty liver, dietary fatty acid supplements and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium. Alcohol 2004; 34:3-8.
26. Terrence M, Donohue J, Dahn L: Use of Cultured Cells in Assessing Ethanol Toxicity and Ethanol-Related Metabolism. Alcohol Clin Exp Res 2001; 25:87-93S.
27. Atsushi M, Kazuhiro K, Tooru S: Alcohol Activates Activator Protein-1 and Mitogen-Activated Protein Kinases in Rat Pancreatic Stellate Cells. J Pharm Exp Ther 2002; 302:36-42.
28. Dooley S, Delvoux B, Lahme B, Mangasser-Stephan K, Gressner AM: Modulation of transforming growth factor β response and signaling during transdifferentiation of rat hepatic stellate cells to myobroblasts. Hepatology 2000; 31:1094-1106.
29. Friedman SL, Yamasaki G, Wong L: Modulation of transforming growth factor B receptors of rat lipocytes during the hepatic wound healing response. J Biol Chem 1994; 269:10551-10558.
30. Massague J and Chen YG: Controlling TGF-β signaling. Genes Dev 2000; 14:627-644.
31. Damiano M, Anna MB, Giorgio N: Chronic ethanol treatment: dolichol and retinol distribution in isolated rat liver cells. Free Radical Biol Med 2003; 34:337-344, doi:10.1016/S0891-5849(02)01291-1.
32. Rachfal AW and Brigstock DR: Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis. Hepatol Res 2003; 26:1-9.
33. Natalia N, Patricia G, Cederbaum AI: Ethanol and Arachidonic Acid Increase a2(I) Collagen Expression in Rat Hepatic Stellate Cells Overexpressing Cytochrome P450 2E1. J Biological Chemistry 2000; 275:20136-20145.
34. Dharancy S, Malapel M, Desreumaux P: Impaired Expression of the Peroxisome Proliferator-Activated Receptor Alpha During Hepatitis C Virus Infection. Gastroenterology 2005; 128:334-42, doi:10.1053/JGastro2004;11.016.
35. Ueno H, Sakamoto T, Nakamura T, Qi Z, Astuchi N, Takeshita A, Shimizu K, Ohashi H: A soluble transforming growth factor β receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats. Hum Gene Ther 2000; 11:33-42.
36. Bauer M and Schuppan D: TGFβ1 in liver fibrosis: time to change paradigms? FEBS Lett 2001; 502:1-3.
37. Darnell JE, Kerr IM, Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994; 264:1415-1419.
38. Andrew L and David JA: TGF-β signaling and the fibrotic response. FASEB J 2004; 18:816-827.
39. Ulloa L, Doody J, Massague J: Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. Nature 1999; 397:710-713.
40. Hong S, Manna Z, Gerald Y, Yuewen G: Different effects of rat interferon alpha, beta and gamma on rat hepatic stellate cell proliferation and activation. BMC Cell Biology 2002; 3:91471-91479.