Sequential release of autophagy inhibitor and chemotherapeutic drug with polymeric delivery system for oral squamous cell carcinoma therapy

Molecular Pharmaceutics

Volumn 11, Issue 5, 2014, Pages 1662-1675

  Saiyin, Wuliji ^a   Wang, Dali ^b   Li, Lili ^a   Zhu, Lijuan ^b   Liu, Bing ^a   Sheng, Lijian ^c   Li, Yanwu ^a   Zhu, Bangshang ^b   Mao, Limin ^a   Li, Guolin ^a   Zhu, Xinyuan ^b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

autophagy inhibition; chemotherapy; combination therapy; drug delivery; polymeric micelles

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; DOXORUBICIN; HYDRAZONE DERIVATIVE; POLYACYLHYDRAZONE; POLYMER; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DRUG CARRIER; MICELLE;

AQUEOUS SOLUTION; ARTICLE; AUTOPHAGY; CANCER CELL; CANCER CHEMOTHERAPY; CELL PH; CELL PROLIFERATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; MICELLE; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; APOPTOSIS; CHEMISTRY; DRUG EFFECTS; METABOLISM; MOUTH TUMOR; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DOXORUBICIN; DRUG CARRIERS; HUMANS; MICELLES; MOUTH NEOPLASMS; POLYMERS;

EID: 84899787636     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp5000423     Document Type: Article

References (45)

1. Lopes, C. F.; de Angelis, B. B.; Prudente, H. M.; de Souza, B. V.; Cardoso, S. V.; de Azambuja Ribeiro, R. I. Concomitant consumption of marijuana, alcohol and tobacco in oral squamous cell carcinoma development and progression: Recent advances and challenges Arch. Oral Biol. 2012, 57, 1026-1033
2. Chen, S. F.; Nieh, S.; Jao, S. W.; Liu, C. L.; Wu, C. H.; Chang, Y. C.; Yang, C. Y.; Lin, Y. S. Quercetin suppresses drug-resistant spheres via the p38 MAPK-Hsp27 apoptotic pathway in oral cancer cells PLoS One 2012, 7, e49275
3. Zhang, P.; Zhang, Z.; Zhou, X.; Qiu, W.; Chen, F.; Chen, W. Identification of genes associated with cisplatin resistance in human oral squamous cell carcinoma cell line BMC Cancer 2006, 6, 224-234
4. Liu, D.; Yang, Y.; Liu, Q.; Wang, J. Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells Med. Oncol. 2011, 28, 105-111
5. Liu, F.; Liu, D.; Yang, Y.; Zhao, S. Effect of autophagy inhibition on chemotherapy-induced apoptosis in A549 lung cancer cells Oncol. Lett. 2013, 5, 1261-1265
6. Pan, X.; Zhang, X.; Sun, H.; Zhang, J.; Yan, M.; Zhang, H. Autophagy inhibition promotes 5-fluorouraci-induced apoptosis by stimulating ROS formation in human non-small cell lung cancer A549 cells PLoS One 2013, 8, e56679
7. Choi, H. S.; Jeong, E. H.; Lee, T. G.; Kim, S. Y.; Kim, H. R.; Kim, C. H. Autophagy inhibition with monensin enhances cell cycle arrest and apoptosis induced by mTOR or epidermal growth factor receptor inhibitors in lung cancer cells Tuberc. Respir. Dis. 2013, 75, 9-17
8. Altman, B. J.; Rathmell, J. C. Autophagy: not good or bad, but good and bad Autophagy 2009, 5, 569-570
9. Kumar, P.; Zhang, D.-M.; Degenhardt, K.; Chen, Z.-S. Autophagy and transporter-based multi-drug resistance Cell 2012, 1, 558-575
10. Han, W.; Sun, J.; Feng, L.; Wang, K.; Li, D.; Pan, Q.; Chen, Y.; Jin, W.; Wang, X.; Pan, H.; Jin, H. Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells PLoS One 2011, 6, e28491
11. Xi, G.; Hu, X.; Wu, B.; Jiang, H.; Young, C. Y.; Pang, Y.; Yuan, H. Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells Cancer Lett. 2011, 307, 141-148
12. Tu, Y. J.; Fan, X.; Yang, X.; Zhang, C.; Liang, H. P. Evodiamine activates autophagy as a cytoprotective response in murine Lewis lung carcinoma cells Oncol. Rep. 2013, 29, 481-490
13. Sheen, J. H.; Zoncu, R.; Kim, D.; Sabatini, D. M. Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo Cancer Cell 2011, 19, 613-628
14. Hu, M.; Chen, M.; Li, G.; Pang, Y.; Wang, D.; Wu, J.; Qiu, F.; Zhu, X.; Sun, J. Biodegradable hyperbranched polyglycerol with ester linkages for drug delivery Biomacromolecules 2012, 13, 3552-3561
15. Liu, J.; Pang, Y.; Huang, W.; Zhu, Z.; Zhu, X.; Zhou, Y.; Yan, D. Redox-responsive polyphosphate nanosized assemblies: a smart drug delivery platform for cancer therapy Biomacromolecules 2011, 12, 2407-2415
16. Ganta, S.; Devalapally, H.; Shahiwala, A.; Amiji, M. A review of stimuli-responsive nanocarriers for drug and gene delivery J. Controlled Release 2008, 12, 187-204
17. Li, G.; Liu, J.; Pang, Y.; Wang, R.; Mao, L.; Yan, D.; Zhu, X.; Sun, J. Polymeric micelles with water-insoluble drug as hydrophobic moiety for drug delivery Biomacromolecules 2011, 12, 2016-2026
18. Zhou, Y.; Huang, W.; Liu, J.; Zhu, X.; Yan, D. Self-assembly of hyperbranched polymers and its biomedical applications Adv. Mater. 2010, 22, 4567-4590
19. Peer, D.; Karp, J. M.; Hong, S.; Farokhzad, O. C.; Margalit, R.; Langer, R. Nanocarriers as an emerging platform for cancer therapy Nat. Nanotechnol. 2007, 2, 751-760
20. Ge, Z.; Liu, S. Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance Chem. Soc. Rev. 2013, 42, 7289-7325
21. Du, J. Z.; Du, X. J.; Mao, C. Q.; Wang, J. Tailor-made dual pH-sensitive polymer-doxorubicin nanoparticles for efficient anticancer drug delivery J. Am. Chem. Soc. 2011, 133, 17560-17563
22. Gillies, E. R.; Fréchet, J. M. pH-Responsive copolymer assemblies for controlled release of doxorubicin Bioconjugate Chem. 2005, 16, 361-368
23. Li, Y.-Y.; Cheng, H.; Zhu, J.-L.; Yuan, L.; Dai, Y.; Cheng, S.-X.; Zhang, X.-Z.; Zhuo, R.-X. Temperature and pH sensitive multi-colored micellar complexes Adv. Mater. 2009, 21, 2402-2406
24. Wang, D.; Su, Y.; Jin, C.; Zhu, B.; Pang, Y.; Zhu, L.; Liu, J.; Tu, C.; Yan, D.; Zhu, X. Supramolecular copolymer micelles based on the complementary multiple hydrogen bonds of nucleobases for drug delivery Biomacromolecules 2011, 12, 1370-1379
25. Zhu, L.; Wang, D.; Wei, X.; Zhu, X.; Li, J.; Tu, C.; Su, Y.; Wu, J.; Zhu, B.; Yan, D. Multifunctional pH-sensitive superparamagnetic iron-oxide nanocomposites for targeted drug delivery and MR imaging J. Controlled Release 2013, 169, 228-238
26. Zhu, L.; Tu, C.; Zhu, B.; Su, Y.; Pang, Y.; Yan, D.; Wu, J.; Zhu, X. Construction and application of pH-triggered cleavable hyperbranched polyacylhydrazone for drug delivery Polym. Chem. 2011, 2, 1761-1768
27. Hall-Glenn, F.; Aivazi, A.; Akopyan, L.; Ong, J. R.; Baxter, R. R.; Benya, P. D.; Goldschmeding, R.; van Nieuwenhoven, F. A.; Hunziker, E. B.; Lyons, K. M. CCN2/CTGF is required for matrix organization and to protect growth plate chondrocytes from cellular stress Cell Commun. Signal 2013, 7, 219-230
28. Qu, W.; Xiao, J.; Zhang, H.; Chen, Q.; Wang, Z.; Shi, H.; Gong, L.; Chen, J.; Liu, Y.; Cao, R.; Lv, J. B19, a novel monocarbonyl analogue of curcumin, induces human ovarian cancer cell apoptosis via activation of endoplasmic reticulum stress and the autophagy signaling pathway Int. J. Biol. Sci. 2013, 9, 766-777
29. Chen, H.; Luo, Z.; Dong, L.; Tan, Y.; Yang, J.; Feng, G.; Wu, M.; Li, Z.; Wang, H. CD133/prominin-1-mediated autophagy and glucose uptake beneficial for hepatoma cell survival PLoS One 2013, 8, e56878
30. Chen, Y.; Azad, M. B.; Gibson, S. B. Methods for detecting autophagy and determining autophagy-induced cell death Can. J. Physiol. Pharmacol. 2010, 88, 285-295
31. Badaboina, S.; Bai, H. W.; Park, C. H.; Jang, D. M.; Choi, B. Y.; Chung, B. Y. Molecular mechanism of apoptosis induction in skin cancer cells by the centipedegrass extract BMC Complementary Altern. Med. 2013, 13, 350-368
32. Qiu, C.; Jozsef, L.; Yu, B.; Yu, J. Saponin monomer 13 of dwarf lilyturf tuber (DT-13) protects serum withdrawal-induced apoptosis through PI3K/Akt in HUVEC Biochem. Biophys. Res. Commun. 2013, 11, 56-61
33. Blommaart, E. F.; Krause, U.; Schellens, J. P.; Vreeling- Sindelárová, H.; Meijer, A. J. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY 294002 inhibit autophagy in isolated rat hepatocytes Eur. J. Biochem. 1997, 243, 240-246
34. Singh, P.; Godbole, M.; Rao, G.; Annarao, S.; Mitra, K.; Roy, R.; Ingle, A.; Agarwal, G.; Tiwari, S. Inhibition of autophagy stimulate molecular iodine-induced apoptosis in hormone independent breast tumors Biochem. Biophys. Res. Commun. 2011, 415, 181-186
35. Ren, Y.; Huang, F.; Liu, Y.; Yang, Y.; Jiang, Q.; Xu, C. Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells BMB. Rep. 2009, 42, 599-604
36. Garlich, J. R.; De, P.; Dey, N.; Su, J. D.; Peng, X.; Miller, A.; Murali, R.; Lu, Y.; Mills, G. B.; Kundra, V.; Shu, H. K.; Peng, Q.; Durden, D. L. A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity Cancer Res. 2008, 68, 206-215
37. Werzowa, J.; Cejka, D.; Fuereder, T.; Dekrout, B.; Thallinger, C.; Pehamberger, H.; Wacheck, V.; Pratscher, B. Suppression of mTOR complex 2-dependent AKT phosphorylation in melanoma cells by combined treatment with rapamycin and LY294002 Br. J. Dermatol. 2009, 160, 955-964
38. Wang, D.; Chen, H.; Su, Y.; Qiu, F.; Zhu, L.; Huan, X.; Zhu, B.; Yan, D.; Guo, F.; Zhu, X. Supramolecular amphiphilic multiarm hyperbranched copolymer: synthesis, self-assembly and drug delivery applications Polym. Chem. 2013, 4, 85-94
39. Meng, L.; Yang, L.; Zhao, X.; Zhang, L.; Zhu, H.; Liu, C.; Tan, W. Targeted delivery of chemotherapy agents using a liver cancer-specific aptamer PLoS One 2012, 7, e33434
40. Sengupta, S.; Eavarone, D.; Capila, I.; Zhao, G.; Watson, N.; Kiziltepe, T.; Sasisekharan, R. Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system Nature 2005, 436, 568-572
41. 2-and p53-dependent pathways J. Biol. Chem. 2004, 279, 25535-25543
42. Ma, Q.; Li, P.; Xu, M.; Yin, J.; Su, Z.; Li, W.; Zhang, J. Ku80 is highly expressed in lung adenocarcinoma and promotes cisplatin resistance Exp. Clin. Cancer Res. 2012, 31, 99-107
43. Gao, L.; Jiang, T.; Guo, J.; Liu, Y.; Cui, G.; Gu, L.; Su, L.; Zhang, Y. Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats PLoS One 2012, 7, e46092
44. Mohan, N.; Chakrabarti, M.; Banik, N. L.; Ray, S. K. Combination of LC3 shRNA plasmid transfection and genistein treatment inhibited autophagy and increased apoptosis in malignant neuroblastoma in cell culture and animal models PLoS One 2013, 8, e78958
45. Racoma, I. O.; Meisen, W. H.; Wang, Q. E.; Kaur, B.; Wani, A. A. Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells PLoS One 2013, 8, e72882