Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: Implications for PD therapeutics

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Dimant, Hemi ^a   Zhu, Liya ^a   Kibuuka, Laura N ^a   Fan, Zhanyun ^a   Hyman, Bradley T ^a   McLean, Pamela J ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALPHA SYNUCLEIN; CARBOXY TERMINAL HEAT SHOCK PROTEIN 70 INTERACTING PROTEIN; NEUROPROTECTIVE AGENT; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; CHIP PROTEIN, RAT; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; DRUG MECHANISM; IN VIVO STUDY; NERVE CELL; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN POLYMERIZATION; RAT; VIRAL GENE DELIVERY SYSTEM; ANIMAL; CHEMISTRY; METABOLISM; MOLECULAR IMAGING; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; SPRAGUE DAWLEY RAT;

ALPHA-SYNUCLEIN; ANIMALS; MOLECULAR IMAGING; PARKINSON DISEASE; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEOLYSIS; RATS; RATS, SPRAGUE-DAWLEY; TYROSINE 3-MONOOXYGENASE; UBIQUITIN-PROTEIN LIGASES;

EID: 84899736363     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092098     Document Type: Article

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