Vitamin D status and its association with season, hospital and sepsis mortality in critical illness

Critical Care

Volumn 18, Issue 2, 2014, Pages

  Amrein, Karin ^a   Zajic, Paul ^a   Schnedl, Christian ^a   Waltensdorfer, Andreas ^a   Fruhwald, Sonja ^a   Holl, Alexander ^a   Purkart, Tadeja U ^a   Wünsch, Gerit ^a   Valentin, Thomas ^a   Grisold, Andrea ^a   Stojakovic, Tatjana ^a   Amrein, Steven ^a,b   Pieber, Thomas R ^a,c   Dobnig, Harald ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b Private Clinic Kreuzschwestern   (Austria)

^c JOANNEUM RESEARCH   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; C REACTIVE PROTEIN; CALCIUM; PARATHYROID HORMONE; PHOSPHORUS; PROCALCITONIN; VITAMIN D; 25-HYDROXYVITAMIN D; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; AUTUMN; BLOOD CULTURE; CALCIUM BLOOD LEVEL; CAUSE OF DEATH; CORRELATION ANALYSIS; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HOSPITALIZATION; HUMAN; KIDNEY FUNCTION; LENGTH OF STAY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MORTALITY; OBSERVATIONAL STUDY; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEASON; SEASONAL VARIATION; SEPSIS; SPRING; SUMMER; SURVIVAL; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; WINTER; ANALOGS AND DERIVATIVES; BLOOD; MIDDLE AGED; TRENDS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CRITICAL ILLNESS; FEMALE; HOSPITAL MORTALITY; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SEASONS; SEPSIS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84899726223     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc13790     Document Type: Article

References (58)

1. Schaub N, Frei R, Muller C. Addressing unmet clinical needs in the early diagnosis of sepsis. Swiss Med Wkly 2011, 141:w13244.
2. Shimaoka M, Park EJ. Advances in understanding sepsis. Eur J Anaesthesiol Suppl 2008, 42:146-153. 2490719, 18289433.
3. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M, . Early Goal-Directed Therapy Collaborative Group Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345:1368-1377. 10.1056/NEJMoa010307, 11794169, Early Goal-Directed Therapy Collaborative Group.
4. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003, 348:138-150. 10.1056/NEJMra021333, 12519925.
5. To KB, Napolitano LM. Common complications in the critically ill patient. Surg Clin North Am 2012, 92:1519-1557. 10.1016/j.suc.2012.08.018, 23153883.
6. Martin SJ, Yost RJ. Infectious diseases in the critically ill patients. J Pharm Pract 2011, 24:35-43. 10.1177/0897190010388906, 21507873.
7. Lee P, Eisman JA, Center JR. Vitamin D deficiency in critically ill patients. N Engl J Med 2009, 360:1912-1914. 10.1056/NEJMc0809996, 19403914.
8. Van den Berghe G, Van Roosbroeck D, Vanhove P, Wouters PJ, De Pourcq L, Bouillon R. Bone turnover in prolonged critical illness: effect of vitamin D. J Clin Endocrinol Metab 2003, 88:4623-4632. 10.1210/jc.2003-030358, 14557432.
9. Lucidarme O, Messai E, Mazzoni T, Arcade M, du Cheyron D. Incidence and risk factors of vitamin D deficiency in critically ill patients: results from a prospective observational study. Intensive Care Med 2010, 36:1609-1611. 10.1007/s00134-010-1875-8, 20373095.
10. Jeng L, Yamshchikov AV, Judd SE, Blumberg HM, Martin GS, Ziegler TR, Tangpricha V. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J Transl Med 2009, 7:28. 2684740, 19389235.
11. Lee P. Vitamin D metabolism and deficiency in critical illness. Best Pract Res Clin Endocrinol Metab 2011, 25:769-781. 10.1016/j.beem.2011.03.001, 21925077.
12. Holick MF. Vitamin D deficiency. N Engl J Med 2007, 357:266-281. 10.1056/NEJMra070553, 17634462.
13. Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, El-Hajj Fuleihan G, Josse RG, Lips P, Morales-Torres J. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 2009, 20:1807-1820. 10.1007/s00198-009-0954-6, 19543765.
14. Dobnig H, Pilz S, Scharnagl H, Renner W, Seelhorst U, Wellnitz B, Kinkeldei J, Boehm BO, Weihrauch G, Maerz W. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med 2008, 168:1340-1349. 10.1001/archinte.168.12.1340, 18574092.
15. McNally JD, Menon K, Chakraborty P, Fisher L, Williams KA, Al-Dirbashi OY, Doherty DR. The association of vitamin D status with pediatric critical illness. Pediatrics 2012, 130:429-436. 10.1542/peds.2011-3059, 22869837.
16. Madden K, Feldman HA, Smith EM, Gordon CM, Keisling SM, Sullivan RM, Hollis BW, Agan AA, Randolph AG. Vitamin D deficiency in critically ill children. Pediatrics 2012, 130:421-428. 10.1542/peds.2011-3328, 22869836.
17. Braun A, Chang D, Mahadevappa K, Gibbons FK, Liu Y, Giovannucci E, Christopher KB. Association of low serum 25-hydroxyvitamin D levels and mortality in the critically ill. Crit Care Med 2011, 39:671-677. 10.1097/CCM.0b013e318206ccdf, 3448785, 21242800.
18. Braun AB, Gibbons FK, Litonjua AA, Giovannucci E, Christopher KB. Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality. Crit Care Med 2012, 40:63-72. 10.1097/CCM.0b013e31822d74f3, 21926604.
19. McKinney JD, Bailey BA, Garrett LH, Peiris P, Manning T, Peiris AN. Relationship between vitamin D status and ICU outcomes in veterans. J Am Med Dir Assoc 2011, 12:208-211. 10.1016/j.jamda.2010.04.004, 21333923.
20. Venkatram S, Chilimuri S, Adrish M, Salako A, Patel M, Diaz-Fuentes G. Vitamin D deficiency is associated with mortality in the medical intensive care unit. Crit Care 2011, 15:R292. 10.1186/cc10585, 3388639, 22152332.
21. Ginde AA, Camargo CA, Shapiro NI. Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection. Acad Emerg Med 2011, 18:551-554. 10.1111/j.1553-2712.2011.01047.x, 21518095.
22. Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 2008, 29:726-776. 10.1210/er.2008-0004, 2583388, 18694980.
23. Verstuyf A, Carmeliet G, Bouillon R, Mathieu C. Vitamin D: a pleiotropic hormone. Kidney Int 2010, 78:140-145. 10.1038/ki.2010.17, 20182414.
24. Hewison M. Vitamin D and innate and adaptive immunity. Vitam Horm 2011, 86:23-62.
25. Hewison M. Antibacterial effects of vitamin D. Nat Rev Endocrinol 2011, 7:337-345. 10.1038/nrendo.2010.226, 21263449.
26. Cluse ZN, Fudge AN, Whiting MJ, McWhinney B, Parkinson I, O'Loughlin PD. Evaluation of 25-hydroxy vitamin D assay on the immunodiagnostic systems iSYS analyser. Ann Clin Biochem 2012, 49:159-165. 10.1258/acb.2011.011018, 22155920.
27. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Intensive Care Med 2003, 29:530-538. 10.1007/s00134-003-1662-x, 12664219.
28. Amrein K, Schnedl C, Berghold A, Pieber TR, Dobnig H. Correction of vitamin D deficiency in critically ill patients - VITdAL@ICU study protocol of a double-blind, placebo-controlled randomized clinical trial. BMC Endocr Disord 2012, 12:27. 10.1186/1472-6823-12-27, 3534412, 23134762.
29. Grmec S, Gasparovic V. Comparison of APACHE II, MEES and Glasgow coma scale in patients with nontraumatic coma for prediction of mortality. Acute physiology and chronic health evaluation. Mainz emergency evaluation system. Crit Care 2001, 5:19-23. 10.1186/cc973, 29052, 11178221.
30. Youden WJ. Index for rating diagnostic tests. Cancer 1950, 3:32-35. 10.1002/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3, 15405679.
31. Schisterman EF, Perkins NJ, Liu A, Bondell H. Optimal cut-point and its corresponding Youden Index to discriminate individuals using pooled blood samples. Epidemiology 2005, 16:73-81. 10.1097/01.ede.0000147512.81966.ba, 15613948.
32. Heaney RP. Assessing vitamin D status. Curr Opin Clin Nutr Metab Care 2011, 14:440-444. 10.1097/MCO.0b013e328348ed85, 21832900.
33. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Evaluation, treatment, and prevention of vitamin d deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011, 96:1911-1930. 10.1210/jc.2011-0385, 21646368.
34. Amrein K, Sourij H, Wagner G, Holl A, Pieber TR, Smolle KH, Stojakovic T, Schnedl C, Dobnig H. Short-term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients: a randomized, double-blind, placebo-controlled pilot study. Crit Care 2011, 15:R104. 10.1186/cc10120, 3219377, 21443793.
35. Annweiler C, Pochic S, Fantino B, Legrand E, Bataille R, Montero-Odasso M, Beauchet O. Serum vitamin D concentration and short-term mortality among geriatric inpatients in acute care settings. Adv Ther 2010, 27:245-249. 10.1007/s12325-010-0025-6, 20473599.
36. Higgins DM, Wischmeyer PE, Queensland KM, Sillau SH, Sufit AJ, Heyland DK. Relationship of vitamin D deficiency to clinical outcomes in critically ill patients. JPEN J Parenter Enteral Nutr 2012, 36:713-720. 10.1177/0148607112444449, 22523178.
37. Moromizato T, Litonjua AA, Braun AB, Gibbons FK, Giovannucci E, Christopher KB. Association of low serum 25-hydroxyvitamin D levels and sepsis in the critically ill. Crit Care Med 2014, 42:97-107. 10.1097/CCM.0b013e31829eb7af, 23982028.
38. Matthews LR, Ahmed Y, Wilson KL, Griggs DD, Danner OK. Worsening severity of vitamin D deficiency is associated with increased length of stay, surgical intensive care unit cost, and mortality rate in surgical intensive care unit patients. Am J Surg 2012, 204:37-43. 10.1016/j.amjsurg.2011.07.021, 22325335.
39. Krishnan A, Ochola J, Mundy J, Jones M, Kruger P, Duncan E, Venkatesh B. Acute fluid shifts influence the assessment of serum vitamin D status in critically ill patients. Crit Care 2010, 14:R216. 10.1186/cc9341, 3219984, 21110839.
40. Duncan A, Talwar D, McMillan DC, Stefanowicz F, O'Reilly DS. Quantitative data on the magnitude of the systemic inflammatory response and its effect on micronutrient status based on plasma measurements. Am J Clin Nutr 2012, 95:64-71. 10.3945/ajcn.111.023812, 22158726.
41. Heijboer AC, Blankenstein MA, Kema IP, Buijs MM. Accuracy of 6 routine 25-hydroxyvitamin D assays: influence of vitamin D binding protein concentration. Clin Chem 2012, 58:543-548. 10.1373/clinchem.2011.176545, 22247500.
42. Hewison M. An update on vitamin D and human immunity. Clin Endocrinol (Oxf) 2012, 76:315-325. 10.1111/j.1365-2265.2011.04261.x, 21995874.
43. Durr UH, Sudheendra US, Ramamoorthy A. LL-37, the only human member of the cathelicidin family of antimicrobial peptides. Biochim Biophys Acta 2006, 1758:1408-1425. 10.1016/j.bbamem.2006.03.030, 16716248.
44. Leow L, Simpson T, Cursons R, Karalus N, Hancox RJ. Vitamin D, innate immunity and outcomes in community acquired pneumonia. Respirology 2011, 16:611-616. 10.1111/j.1440-1843.2011.01924.x, 21244571.
45. Hertting O, Holm A, Luthje P, Brauner H, Dyrdak R, Jonasson AF, Wiklund P, Chromek M, Brauner A. Vitamin D induction of the human antimicrobial peptide cathelicidin in the urinary bladder. PLoS One 2010, 5:e15580. 10.1371/journal.pone.0015580, 3001888, 21179490.
46. Lee P, Nair P, Eisman JA, Center JR. Vitamin D deficiency in the intensive care unit: an invisible accomplice to morbidity and mortality. Intensive Care Med 2009, 35:2028-2032. 10.1007/s00134-009-1642-x, 19756497.
47. Kempker JA, Tangpricha V, Ziegler TR, Martin GS. Vitamin D in sepsis: from basic science to clinical impact. Crit Care 2012, 16:316. 10.1186/cc11252, 3580673, 22809263.
48. Youssef DA, Ranasinghe T, Grant WB, Peiris AN. Vitamin D's potential to reduce the risk of hospital-acquired infections. Dermatoendocrinol 2012, 4:167-175. 10.4161/derm.20789, 3427196, 22928073.
49. Maxwell JD. Seasonal variation in vitamin D. Proc Nutr Soc 1994, 53:533-543. 10.1079/PNS19940063, 7886053.
50. van der Mei IA, Ponsonby AL, Engelsen O, Pasco JA, McGrath JJ, Eyles DW, Blizzard L, Dwyer T, Lucas R, Jones G. The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude. Environ Health Perspect 2007, 115:1132-1139. 10.1289/ehp.9937, 1940076, 17687438.
51. Andersen R, Brot C, Jakobsen J, Mejborn H, Molgaard C, Skovgaard LT, Trolle E, Tetens I, Ovesen L. Seasonal changes in vitamin D status among Danish adolescent girls and elderly women: the influence of sun exposure and vitamin D intake. Eur J Clin Nutr 2013, 67:270-274. 10.1038/ejcn.2013.3, 23388663.
52. Pittaway JK, Ahuja KD, Beckett JM, Bird ML, Robertson IK, Ball MJ. Make vitamin D while the sun shines, take supplements when it doesn't: a longitudinal, observational study of older adults in Tasmania. Australia. PLoS One 2013, 8:e59063.
53. Danai PA, Sinha S, Moss M, Haber MJ, Martin GS. Seasonal variation in the epidemiology of sepsis. Crit Care Med 2007, 35:410-415. 10.1097/01.CCM.0000253405.17038.43, 17167351.
54. White AN, Ng V, Spain CV, Johnson CC, Kinlin LM, Fisman DN. Let the sun shine in: effects of ultraviolet radiation on invasive pneumococcal disease risk in Philadelphia. Pennsylvania. BMC Infect Dis 2009, 9:196.
55. Zittermann A, Kuhn J, Dreier J, Knabbe C, Gummert JF, Borgermann J. Vitamin D status and the risk of major adverse cardiac and cerebrovascular events in cardiac surgery. Eur Heart J 2013, 34:1358-1364. 10.1093/eurheartj/ehs468, 23315905.
56. Jones G. Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr 2008, 88:582S-586S.
57. Carter GD. Accuracy of 25-hydroxyvitamin D assays: confronting the issues. Curr Drug Targets 2011, 12:19-28. 10.2174/138945011793591608, 20795940.
58. Krishnan A, Venkatesh B. Vitamin D measurement in the intensive care unit: methodology, clinical relevance and interpretation of a random value. Inflamm Allergy Drug Targets 2013, 12:230-238. 10.2174/18715281113129990050, 23782207.