Addressing unmet clinical needs in the early diagnosis of sepsis

Swiss Medical Weekly

Volumn 141, Issue JULY, 2011, Pages

  Schaub, Nora ^a   Frei, Reno ^a   Mueller, Christian ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Blood culture; Calorimetry; Diagnosis; Multiplex real time PCR; Sepsis

Indexed keywords

C REACTIVE PROTEIN; PROCALCITONIN;

ADRENAL INSUFFICIENCY; ANAPHYLAXIS; ANTIBIOTIC THERAPY; AORTA ANEURYSM; BLOOD CULTURE; BURN; CALORIMETRY; DELAYED DIAGNOSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC ERROR; DIAGNOSTIC VALUE; DRUG OVERDOSE; EARLY DIAGNOSIS; FEVER; FUNGUS; HEART INFARCTION; HUMAN; HYPOTENSION; HYPOTHERMIA; INJURY; LABORATORY TEST; LEUKOCYTE; LEUKOCYTOSIS; LEUKOPENIA; LUNG EMBOLISM; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MENTAL HEALTH; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MORBIDITY; MORTALITY; OCCULT BLOOD; PANCREATITIS; REAL TIME POLYMERASE CHAIN REACTION; REVIEW; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TACHYPNEA; THROMBOCYTOPENIA; VANCOMYCIN RESISTANT ENTEROCOCCUS;

EID: 80052243603     PISSN: 14247860     EISSN: None     Source Type: Journal    
DOI: 10.4414/smw.2011.13244     Document Type: Review

References (34)

1. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546-54.
2. Alberti C, Brun-Buisson C, Burchardi H, Martin C, Goodman S, Artigas A, et al. Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study. Intensive Care Med. 2002;28(2):108-21. (Pubitemid 34293822)
3. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29:1303-10. (Pubitemid 32641789)
4. The impact of infections on critically ill acute heart failure patients: an observational study. Rudiger A, Businger F, Schmid ER, Follath F, Maggiorini M. Swiss Med Wkly. 2010;140:w13125.
5. Hotchkiss R, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med. 2003;348:138-50. (Pubitemid 36056721)
6. Russell JA. Management of sepsis. N Engl J Med. 2006;355:1699-713. (Pubitemid 44583960)
7. Wheeler AP, Bernard GR. Treating patients with severe sepsis. N Engl J Med. 1999;340:207-14. (Pubitemid 29063218)
8. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345(19):1368-77.
9. Reier-Nilsen T, Farstad T, Nakstad B, Lauvrak V, Steinbakk M. Comparison of broad range 16S rDNA PCR and conventional blood culture for diagnosis of sepsis in the newborn: a case control study. BMC pediatrics. 2009;9:5.
10. th edition. McGraw Hill. 2004.
11. Dellinger RP, Carlet JM, Masur H, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Intensive Care Med. 2004;30:536-55. (Pubitemid 38541501)
12. Leone M, Bourgoin A, Cambon S, Dubuc M, Albanese J, Martin C. Empirical antimicrobial therapy of septic shock patients: adequacy and impact on the outcome. Crit Care Med. 2003;31:462-7. (Pubitemid 36232941)
13. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368-77.
14. Sprung CL, Annane D, Keh D, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008;358:111-24.
15. Limitations of infrared ear temperature measurement in clinical practice. Twerenbold R, Zehnder A, Breidthardt T, Reichlin T, Reiter M, Schaub N, Bingisser R, Laifer G, Mueller C. Swiss Med Wkly. 2010;140:w13131.
16. Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and therapeutic target. Becker KL, Snider R, Nylen ES. Br J Pharmacol. 2010;159(2):253-64.
17. The stress hormone copeptin: a new prognostic biomarker in acute illness. Katan M, Christ-Cain M. Swiss Med Wkly. 2010;140:w13101.
18. LightCycler SeptiFast Test. Package Insert. Roche Diagnostics GmbH. 2006.
19. Ecker DJ, Sampath R, Li H, et al. New technology for rapid molecular diagnosis of blood stream infections. Expert Rev. Mol. Diag. 2010;10:399-415.
20. Regueiro BJ, Varela-Ledo E, Martinez-Lamas L, et al. Automated extraction improves multiplex molecular detection of infection in septic patients. PLoS One 2010;5:e13387
21. Yanagihara K, Kitagawa Y, Tomonaga M, et al. Evaluation of pathogen detection from clinical samples by real-time polymerase chain reaction using a sepsis pathogen DNA detection kit. Crit Care. 2010;14:R159.
22. Lamoth F, Jaton K, Prod'hom G, Senn L, Bille J, Calandra T, Marchetti O. Multiplex blood PCR in combination with blood cultures for improvement of microbiological documentation of infection in febrile neutropenia. J Clin Microbiol. 2010;48:3510-6.
23. Maubon D, Hamidfar-Roy R, Courby S, et al. Therapeutic impact and diagnostic performance of multiplex PCR in patients with malignancies and suspected sepsis. J Infect. 2010;61:335-42.
24. Avolio M, Diamante P, Zamparo S, et al. Molecular identification of bloodstream pathogens in patients presenting to the emergency department with suspected sepsis. Shock. 2010; 34:27-30.
25. Wallet F, Nseir S, Baumann L, et al. Preliminary clinical study using a multiplex real-time PCR test for the detection of bacterial and fungal DNA directly in blood. Clin Microbiol Infect. 2010;16:774-9.
26. Dierkes C, Ehrenstein B, Siebig S, Linde HJ, Reischl U, Salzberger B. Clinical impact of a commercially available multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis. BMC Infect Dis. 2009;9:126.
27. Lehmann LE, Hunfeld KP, Emrich T, et al. A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples. Med Microbiol Immunol. 2008;197:313-24.
28. Seng P, Drancourt M, Gouriet F, et al. Ongoing revolution in bacteriology: routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clin Infect Dis. 2009;49:543-51.
29. Drancourt M. Detection of microorganisms in blood specimens using matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a review. Clin Microbiol Infect. 2010;16:1620-5.
30. Moussaoui W, Jaulhac B, Hoffmann A-M, Ludes B, Kostrzewa M, Riegel P, Prévost G. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry identifies 90% of bacteria directly from blood culture vials. Cliin Microbiol Infect. 2010;16:1631-8.
31. Baldoni D, Hermann H, Frei R, Trampuz A, Steinhuber A. Performance of microcalorimetry for early detection of methicillin resistance in clinical isolates of Staphylococcus aureus. J Clin Microbiol. 2009;47:774-6.
32. Trampuz A, Steinhuber A, Wittwer M, Leib SL. Rapid diagnosis of experimental meningitis by bacterial heat production in cerebrospinal fluid. BMC Infect Dis. 2007;10;7:116.
33. Trampuz A, Salzmann S, Antheaume J, Daniels AU. Microcalorimetry: a novel method for detection of microbial contamination in platelet products. Transfusion. 2007;47(9):1643-50. (Pubitemid 47300610)
34. Trampuz A, Steinrücken J, Clauss M, Bizzini A, Furustrand U, Uçkay I, Peter R, Bille J, Borens J. Rev Med Suisse. 2010;6(243):731-4.