Vitamin D measurement in the intensive care unit: Methodology, clinical relevance and interpretation of a random value

Inflammation and Allergy - Drug Targets

Volumn 12, Issue 4, 2013, Pages 230-238

  Krishnan, Anand ^a   Venkatesh, Bala ^b,c  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b PRINCESS ALEXANDRA HOSPITAL   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Cardiovascular; Cytokines; Immunity; Infection; Inflammation; Muscle; Sepsis

Indexed keywords

25 HYDROXYVITAMIN D; BETA GALACTOSIDASE; CALCIDIOL 1 MONOOXYGENASE; ERGOCALCIFEROL; FIBROBLAST GROWTH FACTOR 23; OXYGENASE; PARATHYROID HORMONE; VITAMIN D; VITAMIN D BINDING PROTEIN; VITAMIN D RECEPTOR;

ARTICLE; AUTOMATED IMMUNOASSAY; CHEMILUMINESCENCE IMMUNOASSAY; CRITICALLY ILL PATIENT; DRUG DETERMINATION; ENZYME IMMUNOASSAY; EPIMER; FLUID BALANCE; GOOD LABORATORY PRACTICE; HUMAN; INFLAMMATION; INTENSIVE CARE UNIT; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MEASUREMENT; MULTICENTER STUDY (TOPIC); QUALITY CONTROL; RADIOIMMUNOASSAY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY AND SPECIFICITY; STANDARD; TANDEM MASS SPECTROMETRY; THERMOSTABILITY; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY;

BIOLOGICAL ASSAY; CRITICAL ILLNESS; HUMANS; INTENSIVE CARE UNITS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84882768904     PISSN: 18715281     EISSN: None     Source Type: Journal    
DOI: 10.2174/18715281113129990050     Document Type: Article

References (63)

1. M.F. Vitamin, D. Deficiency, N. Eng. J. Med., 2007, 357,266-81.
2. Wang, T.T.; Nestel, F.P.; Bourdeau, V.; Nagai, Y.; Wang, Q.; Liao, J.; Tavera-Mendoza, L.; Lin, R.; Hanrahan, J.W.; Mader, S.; White, J.H. Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J. Immunol., 2004, 173, 2909-2912.
3. Talmor, Y.; Bernheim, J.; Klein, O.; Green, J.; Rashid, G. Calcitriol blunts pro-atherosclerotic parameters through NFand p38 in vitro. Eur. J. Clin. Invest., 2008, 38, 548-554.
4. Cohen-Lahav, M.; Douvdevani, A.; Chaimovitz, C.; Shany, S. The anti-inflammatory activity of 1, 25-dihydroxyvitamin D3 in macrophages. J. Steroid Biochem. Mol. Biol., 2007, 103, 558-562.
5. Pilz, S.; Tomaschitz, A.; März, W.; Drechsler, C.; Ritz, E.; Zittermann, A.; Cavalier, E.; Pieber, T.R.; Lappe, J.M.; Grant, W.B.; Holick, M.F.; Dekker, J.M. Vitamin D, cardiovascular disease and mortality. Clin. Endocrinol. (Oxf), 2011, 75(5), 575-584.
6. Szodoray, P.; Nakken, B.; Gaal, J.; Jonsson, R.; Szegedi, A.; Zold, E.; Szegedi, G.; Brun, J.G.; Gesztelyi, R.; Zeher, M.; Bodolay, E. The complex role of vitamin D in autoimmune diseases. Scand. J. Immunol., 2008, 68, 261-269.
7. Zittermann, A.; Schleithoff, S.S.; Gotting, C.; Fuchs, U.; Kuhn, J.; Kleesiek, K.; Tenderich, G.; Koerfer, R. Calcitriol deficiency and 1-year mortality in cardiac transplant recipients. Transplantation, 2009, 87, 118-124.
8. Melamed, M.L.; Michos, E.D.; Post, W.; Astor, B. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch. Int. Med., 2008, 168, 1629-1637.
9. Braun, A.; Chang, D.; Mahadevappa, K.; Gibbons, F.K.; Liu, Y.; Giovannucci, E.; Christopher, K.B. Association of low serum 25 hydroxyvitamin D levels and mortality in the critically ill. Crit. Care Med., 2011, 39(4), 671-677.
10. Venkatram, S.; Chilimuri, S.; Adrish, M.; Salako, A.; Patel, M.; Diaz-Fuentes, G. Vitamin D deficiency is associated with mortality in the medical intensive care unit. Crit. Care, 2011, 15(6), R 292.
11. Thomas, M.K.; Llyod-Jones, D.M.; Thadhani, R.I.; Shaw, A.C.; Deraska, D.J.; Kitch, B.T.; Vamvakas, E.C.; Dick, I.M.; Prince, R.L.; Finkelstein, J.S. Hypovitaminosis D in medical inpatients. New Eng. J. Med., 1998, 338(12), 777-783.
12. Farrell, C.L.; Martin, S.; McWhinney, B.; Straub, I.; Williams, P.; Herrmann, M. State-of-the-art vitamin D assays: A comparison of Automated Immunoassays with Liquid Chromatography-Tandem Mass Spectrometry methods. Clin. Chem., 2012, 58, 531-542.
13. Carter, G.D.; Carter, C.R.; Gunter, E.; Jones, J.; Jones, G.; Makin, H.L.; Sufi, S. Measurement of vitamin D metabolites: an international perspective on methodology and clinical interpretation. J. Steroid Biochem. Mol. Biol., 2004, 89-90, 467-471.
14. Holick, M.P.; Biancuzzo, R.M.; Chen, T.C.; Klein, E.K.; Young, A.; Bibuld, D.; Reitz, R.; Salameh, W.; Ameri, A.; Tannenbaum, A.D. Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J. Clin. Endocrinol. Metab., 2008, 93(3), 677-681.
15. Adams, J.S.; Hewison, M. Extrarenal expression of 25 hydroxyvitamin D-1-hydroxylase. Arch. Biochem. Biophys., 2012, 523(1), 95-102.
16. Glendenning, P.; Inderjeeth, C.A. Vitamin D: Methods of 25 hydroxyvitamin D analysis, targeting at risk populations and selecting thresholds of treatment. Clin. Biochem., 2012, 45, 901-906.
17. Heaney, R.P.; Armas, L.A.G.; Shary, J.R.; Bell, N.H.; Binkley, N.; Hollis, B.W. 25-hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. Am. J. Clin. Nutr., 2008, 87, 1738-1742
18. Carter, G.D. 25-hdroxyvitamin D: A difficult analyte. Clin. Chem., 2012, 58, 486-488.
19. Binkley, N.; Krueger, D.; Morgan, S.; Wiebe, D. Current status of clinical 25-hydroxyvitamin D measurement: An assessment of between-laboratory agreement. Clin. Chim. Acta, 2010, 411(23-24), 1976-1982.
20. Carter, G.D. Accuracy of 25-hydroxyvitamin D assays: Confronting the issues. Curr. Drug Concepts, 2011, 12, 19-28.
21. Wallace, A.M.; Gibson, S.; de la Hunty, A.; Lamberg-Allardt, C.; Ashwell, M. Measurement of 25-hydroxyvitamin D in the clinical laboratory: Current procedures, performance characteristics and limitations. Steroids, 2010, 75, 477-488.
22. Janssen, M.J.; Wielders, J.P.; Bekker, C.C.; Boesten, L.S.; Buijs, M.M.; Heijboer, A.C.; van der Horst, F.A.; Loupatty, F.J.; van den Ouweland, J.M. Multicenter comparison study of current methods to measure 25-hydroxyvitamin D in serum. Steroids, 2012, 77(13), 1366-1372.
23. de la Hunty, A.; Wallace, A.M.; Gibson, S.; Viljakainen, H.; Lamberg-Allardt, C.; Ashwell, M. UK food standards agency workshop consensus report: the choice of method for measuring 25-hydroxyvitamin D to estimate vitamin D status for the UK national diet and nutrition survey. Br. J. Nutr., 2010, 104, 612-619.
24. Singh, R.J.; Taylor, R.L.; Reddy, S.; Grebe, S.K. C-3 Epimers can account for a significant proportion of total circulating 25 hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status. J. Clin. Endocrinol. Metab., 2006, 91, 3055-3061.
25. Stepman, H.C.M.; Vanderrost, A.; Stockl, D.; Thienpont, L.M. Full-scan mass spectral evidence for 3-epi-25-hydroxyvitamin D3 in serum of infants and adults. Clin. Chem. Lab. Med., 2011, 49, 253-256.
26. Pittas, A.G.; Laskowski, U.; Kos, L.; Saltzman, E. The role of vitamin D in adults requiring nutrition therapy. J. Parent Enteral. Nutr., 2012, 34(1), 70-78
27. Jafri, L.; Khan, A.H.; Siddiqui, A.; Mushtaq, S.; Iqbal, R.; Ghani, F.; Siddiqui, I. Comparison of high performance liquid chromatography, radioimmunoassay and electrochemiluminescence immunoassay for quantification of serum 25 hydroxyvitamin D. Clin. Biochem., 2011, 44, 864-868.
28. Ong, L.; Saw, S.; Sahabdeen, N.; Tey, K.; Ho, C.S.; Sethi, S.K. Current 25-hydroxyvitamin D assays: Do they pass the test? Clin. Chim. Act, 2012, 413, 1127-1134.
29. Roth, H.J.; Schmidt-Gayk, H.; Weber, H.; Niederau, C. Accuracy and clinical implications of seven 25-hydroxyvitamin D methods compared with liquid chromatography-tandem mass spectroscopy as a reference. Ann. Clin. Biochem., 2008, 45, 153-159.
30. Wagner, D.; Hanwell, H.; Vieth, R. An evaluation of automated methods for measurement of serum 25-hydroxyvitamin D. Clin. Biochem., 2009, 42, 1549-1556.
31. Moon, H.W.; Cho, J.H.; Hur, M.; Song, J.; Oh, G.Y.; Park, C.M.; Yun, Y.M.; Kim, J.Q. Comparison of four current 25 hydroxyvitamin D assays. Clin. Biochem., 2012, 45, 326-330.
32. Heijboer, A.C.; Blankenstein, M.A.; Kema, I.P.; Buijs, M.M. Accuracy of 6 routine 25-hydroxyvitamin D assays: Influence of vitamin D binding protein concentrations. Clin. Chem., 2012, 58, 543-548.
33. Mata-Grandos, J.; Vargas-Vasserot, J.; Ferreiro-Vera, C.; de Castro, L.; Guerrero Pavon, R.; Quesada Gomez, J. Evaluation of vitamin D endocrine system (VDES) status and response to treatment of patients in intensive care units (ICUs) using an on-line SPE-LC-MS/MS method. J. Ster. Biochem. Mol. Biol., 2010, 121(1-2), 452-455.
34. Strathmann, F.G.; Laha, T.J.; Hoofnagle, A.N. Quantification of 1,25 dihydroxyvitamin D by immunoextraction and Liquid Chromatography-Tandem Mass Spectrometry. Clin. Chem., 2011, 57(9), 1279-1285.
35. Hollis, B. Measuring 25-hydroxyvitamin D in a clinical environment: challenges and needs. Am J Clin Nutr 2008, 88(Suppl), 507S-10S.
36. Antoniucci, D.M.; Black, D.M.; Sellmeyer, D.E. Serum 25 hydroxyvitamin D is unaffected by multiple free-thaw cycles. Clin. Chem., 2004, 51, 258-260.
37. Shah, I.; James, R.; Barker, J.; Petroczi, A.; Naughton, D.P. Misleading measures in vitamin D analysis: a novel LC-MS/MS assay to account for epimers and isobars. Nutr. J., 2011, 10, 46.
38. Nowson, C.A.; McGrath, J.; Ebeling, P.; Haikerwal, A.; Daly, R.M.; Sanders, K.M.; Seibel, M.J.; Mason, R.S. Vitamin D and health in adults in Australia and New Zealand: a position statement. Med. J. Aust., 2012, 196(11), 686-687.
39. Nair, P.; Lee, P.; Reynolds, C.; Nguyen, N.D.; Myburgh, J.; Eisman J.A.; Significant perturbation of vitamin D parathyroid-calcium axis and adverse clinical outcomes in critically ill patients. Int. Care Med., 2013, 39, 267-274.
40. Amrein, K.; Schnedl, C.; Berghold, A.; Pieber, T.; Dobnig, H. Correction of vitamin D deficiency in critically patients-VITdAL@ICU study protocol of a double-blind, placebocontrolled randomized clinical trial. BMC Endo. Dis., 2012, 12, 27.
41. Rippel, C.; South, M.; Butt, W.; Shekerdemian, L. Vitamin D status in critically ill children. Int. Care Med., 2012, 38, 2055-2062.
42. Flynn, L.; Zimmerman, L.H.; McNorton, K.; Dolman, M.; Tyburski, J.; Baylor, A.; Wilson, R.; Dolman, H. Effects of vitamin D deficiency in critically ill surgical patients. Am. J. Surg., 2012, 203(3), 379-382.
43. Braun, A.B.; Gibbons, F.K.; Litonjua, A.A.; Giovannucci, E.; Christopher, K.B. Low serum 25-hydroxyvitamin D at critical are initiation is associated with increased mortality. Crit. Care Med., 2012, 40(1), 63-72.
44. Higgins, D.M.; Wischmeyer, P.E.; Queensland, K.M.; Sillau, S.H.; Sufit, A.J.; Heyland, D.K. J. Parenter. Enteral. Nut., 2012, 36(6), 713-720.
45. rd.; Pandharipande, P.P.; Ely, E.W.; Ware, L.B. Vitamin D and delirium in critically ill patients: a preliminary investigation. J. Crit. Care, 2013, 28(3), 230-235.
46. Arnson, Y.; Gringauz, I.; Itzhaky, d.; Amital, H. Vitamin D deficiency is associated with poor outcomes and increased mortality in severely ill patients. QJM, 2012, 105(7), 633-639.
47. Ray Matthews, L.; Ahmed, Y.; Wilson, K.L.; Griggs, D.D.; Danner, O.K. Worsening severity of vitamin D deficiency is associated with increased length, surgical intensive care unit cost, and mortality rate in surgical intensive care unit patients. Am. J. Surg., 2012, 204(1), 37-43.
48. McNally, J.D.; Menon, K.; Chakraborty, P.; Fisher, L.; Williams, K.A.; Al-Dirbashi, O.Y.; Doherty, D.R. The association of vitamin D status with pediatric critical illness. Pediatrics, 2012, 130(3), 429-436.
49. Venkatesh, B.; Davidson, B.; Robinson, K.; Pascoe, R.; Appleton, C.; Jones, M. Do random estimations of vitamin D3 and PTH reflect the 24-h profile in the critically ill? Int. Care Med., 2012, 38, 177-179.
50. Madden, K.; Feldman, H.A.; Smith, E.M.; Gordon, C.M.; Keisling, S.M.; Sullivan, R.M.; Hollis, B.W.; Agan, A.A.; Randolph, A.G. Vitamin D deficiency in critically ill children. Pediatrics, 2012, 130(3), 421-428.
51. Cecchi, A.; Bonizzoli, M.; Douar, S.; Mangini, M.; Paladini, S.; Gazzini, B.; Degl'Innocenti, S.; Linden, M.; Zagli, G.; Peris, A. Vitamin D deficiency in septic patients at ICU admission is not a mortality predictor. Minerva Anaesthesiol., 2011, 77(12), 1184-1189.
52. Amrein, K.; Sourij, H.; Wagner, G.; Holl, A.; Pieber, T.R.; Smolle, K.H.; Stojakovic, T.; Schnedl, C.; Dobnig, H. Short-term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients:a randomized, double-blind placebo-controlled pilot study. Crit. Care, 2011, 15, R104.
53. Lucidarme, O.; Messai, E.; Mazzoni, T.; Arcade, M.; du Cheyron, D. Incidence and risk factors of vitamin D deficiency in critically ill patients: results from a prospective observational study. Int. Care Med., 2010, 36(9), 1609-1611.
54. Krishnan, A.; Ochola, J.; Mundy, M.; Jones, M.; Kruger, P.; Duncan, E.; Venkatesh, B. Acute fluid shifts influence the assessment of serum vitamin D status in critically ill patients. Crit. Care, 2010, 14, R 216.
55. Lee, P.; Eisman, J.A.; Vitamin D deficiency in critically ill patients. N. Eng. J. Med., 2009, 360(18), 1912-1914.
56. Jeng, L.; Yamshchikov, A.V.; Judd, S.E.; Blumberg, H.M.; Martin, G.S.; Ziegler, T.R.; Tangpricha, V. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J. Transl. Med., 2009, 7, 28.
57. Van den Berghe, G.; Van Roosbroeck, D.; Vanhove, P.; Wouters, P.J.; De Pourcq, L.; Bouillon, R. Bone turnover in prolonged critical illness: effect of vitamin D. J. Clin. Endocrinol. Metab., 2003, 88(10), 4623-4632.
58. Heaney, R.P. Assessing vitamin D status. Curr. Opin. Clin. Nutr. Metab. Care, 2011, 14, 440-444.
59. Chapuy, MC.; Preziosi, P.; Maamer, M.; Arnaud, S.; Galan, P.; Hercberg, S.; Meunier, P.J. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos. Int., 1997, 7(5), 439-443.
60. Heaney, R.P. Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am. J. Clin. Nutr., 2004, 80(6 suppl), 1706S-1709S.
61. Krishnan, A.; Grosso, A.; Dimeski, G.; Grice, J.; Jones, J.; Venkatesh, B. Evidence for extra-renal production of 1,25(OH)2D3 in critical illness-a preliminary study. Int. Care Med., 2013, (in press).
62. Kazama, J.J.; Yamamoto, T.; Oya, H.; Yamamoto, S.; Sato, Y.; Sakurada, J.; Honda, T.; Endoh, H.; Narita, I. A patient with severe hypercalcemia in multiple organ dysfunction syndrome: role of elevated circulating 1alpha,25(OH)2 vitamin D levels. J. Bone Miner. Res., 2010, 25(6), 1455-1459.
63. Lee, P. Vitamin D metabolism and deficiency in critical illness. Best Prac. Res. Clin. Endocrinol. Metab., 2011, 25, 769-781.