Short-term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients: A randomized, double-blind, placebo-controlled pilot study

Critical Care

Volumn 15, Issue 2, 2011, Pages

  Amrein, Karin ^a   Sourij, Harald ^a   Wagner, Gerit ^a   Holl, Alexander ^a   Pieber, Thomas R ^a   Smolle, Karl Heinz ^a   Stojakovic, Tatjana ^a   Schnedl, Christian ^a   Dobnig, Harald ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; COLECALCIFEROL; OLEOVIT D3; PARATHYROID HORMONE; UNCLASSIFIED DRUG; VITAMIN;

ADULT; ARTICLE; CALCIUM BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; FEMALE; HOSPITALIZATION; HUMAN; HYPERCALCEMIA; HYPERCALCIURIA; INTENSIVE CARE UNIT; MALE; OBSERVATIONAL STUDY; PARATHYROID HORMONE BLOOD LEVEL; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TERTIARY HEALTH CARE; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; AGED; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CRITICAL ILLNESS; DIET SUPPLEMENTATION; DOSE RESPONSE; INTENSIVE CARE; METHODOLOGY; MIDDLE AGED; ORAL DRUG ADMINISTRATION; TIME; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; AGED; CHOLECALCIFEROL; CRITICAL ILLNESS; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INTENSIVE CARE; MALE; MIDDLE AGED; PILOT PROJECTS; TIME FACTORS; TREATMENT OUTCOME; VITAMIN D DEFICIENCY; VITAMINS;

EID: 79953109768     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc10120     Document Type: Article

References (28)

1. Carlstedt F, Lind L, Rastad J, Stjernstrom H, Wide L, Ljunghall S. Parathyroid hormone and ionized calcium levels are related to the severity of illness and survival in critically ill patients. Eur J Clin Invest 1998, 28:898-903. 10.1046/j.1365-2362.1998.00391.x, 9824432.
2. Forsythe RM, Wessel CB, Billiar TR, Angus DC, Rosengart MR. Parenteral calcium for intensive care unit patients. Cochrane Database Syst Rev 2008, 8:CD006163.
3. Hastbacka J, Pettila V. Prevalence and predictive value of ionized hypocalcemia among critically ill patients. Acta Anaesthesiol Scand 2003, 47:1264-1269. 10.1046/j.1399-6576.2003.00236.x, 14616325.
4. Lee P, Milliken S, Center JR. Hypocalcaemic cardiac failure post BMT secondary to unrecognized vitamin D deficiency. Bone Marrow Transplant 2008, 42:363-364. 10.1038/bmt.2008.178, 18574443.
5. Lee P, Samaras K, Glanville AR, Center JR. Transplant recipients on the edge of the hypocalcemia abyss. J Heart Lung Transplant 2009, 28:93-95. 10.1016/j.healun.2008.09.010, 19134537.
6. Lee P, Eisman JA, Center JR. Vitamin D deficiency in critically ill patients. N Engl J Med 2009, 360:1912-1914. 10.1056/NEJMc0809996, 19403914.
7. Van den Berghe G, Van Roosbroeck D, Vanhove P, Wouters PJ, De Pourcq L, Bouillon R. Bone turnover in prolonged critical illness: effect of vitamin D. J Clin Endocrinol Metab 2003, 88:4623-4632. 10.1210/jc.2003-030358, 14557432.
8. Lucidarme O, Messai E, Mazzoni T, Arcade M, du Cheyron D. Incidence and risk factors of vitamin D deficiency in critically ill patients: results from a prospective observational study. Intensive Care Med 2010.
9. Jeng L, Yamshchikov AV, Judd SE, Blumberg HM, Martin GS, Ziegler TR, Tangpricha V. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J Transl Med 2009, 7:28. 10.1186/1479-5876-7-28, 2684740, 19389235.
10. Krishnan A, Ochola J, Mundy J, Jones M, Kruger P, Duncan E, Venkatesh B. Acute fluid shifts influence the assessment of serum vitamin D status in critically ill patients. Crit Care 2009, 14:R216.
11. Louw JA, Werbeck A, Louw ME, Kotze TJ, Cooper R, Labadarios D. Blood vitamin concentrations during the acute-phase response. Crit Care Med 1992, 20:934-941. 10.1097/00003246-199207000-00007, 1617986.
12. Vasilaki AT, Leivaditi D, Talwar D, Kinsella J, Duncan A, O'Reilly DS, McMillan DC. Assessment of vitamin E status in patients with systemic inflammatory response syndrome: plasma, plasma corrected for lipids or red blood cell measurements?. Clin Chim Acta 2009, 409:41-45. 10.1016/j.cca.2009.08.008, 19698706.
13. Galloway P, McMillan DC, Sattar N. Effect of the inflammatory response on trace element and vitamin status. Ann Clin Biochem 2000, 37:289-297. 10.1258/0004563001899429, 10817241.
14. Holick MF. Vitamin D deficiency. N Engl J Med 2007, 357:266-281. 10.1056/NEJMra070553, 17634462.
15. Dobnig H, Pilz S, Scharnagl H, Renner W, Seelhorst U, Wellnitz B, Kinkeldei J, Boehm BO, Weihrauch G, Maerz W. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med 168:1340-1349. 10.1001/archinte.168.12.1340, 18574092.
16. Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 2008, 29:726-776. 10.1210/er.2008-0004, 2583388, 18694980.
17. Verstuyf A, Carmeliet G, Bouillon R, Mathieu C. Vitamin D: a pleiotropic hormone. Kidney Int 2010, 78:140-145. 10.1038/ki.2010.17, 20182414.
18. Lee P, Nair P, Eisman JA, Center JR. Vitamin D deficiency in the intensive care unit: an invisible accomplice to morbidity and mortality?. Intensive Care Med 2009, 35:2028-2032. 10.1007/s00134-009-1642-x, 19756497.
19. Kelly DG. Guidelines and available products for parenteral vitamins and trace elements. JPEN J Parenter Enteral Nutr 2002, 26:S34-36. 10.1177/014860710202600510, 12216718.
20. Kreymann KG, Berger MM, Deutz NE, Hiesmayr M, Jolliet P, Kazandjiev G, Nitenberg G, van den Berghe G, Wernerman J, Ebner C, Hartl W, Heymann C, Spies C. ESPEN Guidelines on Enteral Nutrition: intensive care. Clin Nutr 2006, 25:210-223. 10.1016/j.clnu.2006.01.021, 16697087.
21. Singer P, Berger MM, Van den Berghe G, Biolo G, Calder P, Forbes A, Griffiths R, Kreyman G, Leverve X, Pichard C, . Espen ESPEN Guidelines on Parenteral Nutrition: intensive care. Clin Nutr 2009, 28:387-400. 10.1016/j.clnu.2009.04.024, 19505748, Espen.
22. Vieth R. Critique of the considerations for establishing the tolerable upper intake level for vitamin D: critical need for revision upwards. J Nutr 2006, 136:1117-1122.
23. Bacon CJ, Gamble GD, Horne AM, Scott MA, Reid IRL. High-dose oral vitamin D3 supplementation in the elderly. Osteoporos Int 2009, 20:1407-1415. 10.1007/s00198-008-0814-9, 19101755.
24. von Restorff C, Bischoff-Ferrari HA, Theiler R. High-dose oral vitamin D3 supplementation in rheumatology patients with severe vitamin D3 deficiency. Bone 2009, 45:747-749. 10.1016/j.bone.2009.06.012, 19539796.
25. Mata-Granados JM, Vargas-Vasserot J, Ferreiro-Vera C, Luque de Castro MD, Pavon RG, Quesada Gomez JM. Evaluation of vitamin D endocrine system (VDES) status and response to treatment of patients in intensive care units (ICUs) using an on-line SPE-LC-MS/MS method. J Steroid Biochem Mol Biol 2010.
26. Whyte MP, Haddad JG, Walters DD, Stamp TC. Vitamin D bioavailability: serum 25-hydroxyvitamin D levels in man after oral, subcutaneous, intramuscular, and intravenous vitamin D administration. J Clin Endocrinol Metab 1979, 48:906-911. 10.1210/jcem-48-6-906, 447796.
27. Lawson DE, Sedrani SH, Douglas J. Interrelationships in rats of tissue pools of cholecalciferol and 25-hydroxycholecalciferol formed in u.v. light. Biochem J 1986, 233:535-540. 1153058, 3006671.
28. Witham MD, Crighton LJ, Gillespie ND, Struthers AD, McMurdo ME. The effects of vitamin D supplementation on physical function and quality of life in older patients with heart failure: a randomized controlled trial. Circ Heart Fail 2010, 3:195-201. 10.1161/CIRCHEARTFAILURE.109.907899, 20103775.