Overexpression of Nrf2 protects against microcystin-induced hepatotoxicity in mice

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Lu, Yuan Fu ^a,b   Liu, Jie ^a,b   Wu, Kai Connie ^a   Qu, Qiang ^a   Fan, G ^c   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE 2; GLUTATHIONE TRANSFERASE A1; GLUTATHIONE TRANSFERASE A4; INTERLEUKIN 1BETA; INTERLEUKIN 6; KELCH LIKE ECH ASSOCIATED PROTEIN 1; KERATINOCYTE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; MICROCYSTIN; ORGANIC ANION TRANSPORTER; PROTEIN NQO1; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD SAMPLING; CONJUGATION; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; INFLAMMATION; KNOCKOUT MOUSE; LIPID PEROXIDATION; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; MOUSE; NECROSIS; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; WESTERN BLOTTING; WILD TYPE;

ANIMALS; BIOLOGICAL TRANSPORT; CHEMOKINES; DRUG-INDUCED LIVER INJURY; GLUTATHIONE; LIPID PEROXIDATION; LIVER; MICE; MICROCYSTINS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84899720031     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093013     Document Type: Article

References (26)

1. Oudra B, Dadi-El Andaloussi M, Vasconcelos VM (2009). Identification and quantification of microcystins from a Nostoc muscorum bloom occurring in Oukaïmeden River (High-Atlas mountains of Marrakech, Morocco). Environ Monit Assess 149: 437-444.
2. Vareli K, Jaeger W, Touka A, Frillingos S, Briasoulis E, et al. (2013) Hepatotoxic seafood poisoning (HSP) due to microcystins: A threat from the ocean? Mar Drugs 11: 2751-2768.
3. Bischoff K (2001) The toxicology of microcystin-LR: Occurrence, toxicokinetics, toxicodynamics, diagnosis and treatment. Vet Hum Toxicol 43: 294-297.
4. Svircev Z, Baltić V, Gantar M, Juković M, Stojanović D, et al. (2010) Molecular aspects of microcystin-induced hepatotoxicity and hepatocarcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 28: 39-59.
5. Weng D, Lu Y, Wei Y, Liu Y, Shen P (2007) The role of ROS in microcystin-LR-induced hepatocyte apoptosis and liver injury in mice. Toxicology 232: 15-23. (Pubitemid 46283168)
6. Sun X, Mi L, Liu J, Song L, Chung FL, Gan N (2011) Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice. Toxicol Appl Pharmacol 255: 9-17.
7. Gan N, Mi L, Sun X, Dai G, Chung FL, et al. (2010) Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response. Toxicol Appl Pharmacol 247: 129-137.
8. Kondo F, Ikai Y, Oka H, Okumura M, Ishikawa N, et al. (1992). Formation, characterization, and toxicity of the glutathione and cysteine conjugates of toxic heptapeptide microcystins. Chem Res Toxicol. 5: 591-596.
9. Gehringer MM, Shephard EG, Downing TG, Wiegand C, Neilan BA (2004) An investigation into the detoxification of microcystin-LR by the glutathione pathway in Balb/c mice. Int J Biochem Cell Biol 36: 931-941. (Pubitemid 38299408)
10. Jayaraj R, Anand T, Rao PV (2006) Activity and gene expression profile of certain antioxidant enzymes to microcystin-LR induced oxidative stress in mice. Toxicology 220: 136-146. (Pubitemid 43276403)
11. Buratti FM, Scardala S, Funari E, Testai E (2011) Human glutathione transferases catalyzing the conjugation of the hepatoxin microcystin-LR. Chem Res Toxicol 24: 926-933.
12. Klaassen CD, Reisman SA (2010) Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver. Toxicol Appl Pharmacol 244: 57-65.
13. Kensler TW, Wakabayashi N, Biswal S (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47: 89-116.
14. Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, et al. (2009) Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems. Biochem Biophys Res Commun 389: 431-436.
15. Wu KC, Cui JY, Klaassen CD (2011) Beneficial role of Nrf2 in regulating NADPH generation and consumption. Toxicol Sci 23: 590-600.
16. Wu KC, Liu JJ, Klaassen CD (2012) Nrf2 activation prevents cadmium-induced acute liver injury. Toxicol Appl Pharmacol 263: 14-20.
17. Wu KC, Cui JY, Klaassen CD (2012) Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. PLoS One 7: e39006.
18. Liu J, Wu KC, Lu YF, Ekuase E, Klaassen CD (2013) Nrf2 protection against liver injury produced by various hepatotoxicants. Oxid Med Cell Longev 2013: 305861.
19. Chan K, Lu R, Chang JC, Kan YW (1996) NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci USA 93: 13943-13948. (Pubitemid 26424225)
20. Lu H, Choudhuri S, Ogura K, Csanaky IL, Lei X, et al. (2008) Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicol Sci 103: 35-45. (Pubitemid 351524475)
21. Komatsu M, Furukawa T, Ikeda R, Takumi S, Nong Q, et al. (2007) Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3. Toxicol Sci 97: 407-416. (Pubitemid 47073856)
22. Fischer A, Hoeger SJ, Stemmer K, Feurstein DJ, Knobeloch D, et al. (2010) The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: a comparison of primary human hepatocytes and OATP-transfected HEK293 cells. Toxicol Appl Pharmacol 245: 9-20.
23. Gan N, Sun X, Song L (2010) Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth. Chem Res Toxicol 23: 1477-1484.
24. Konrad FM, Reutershan J (2012) CXCR2 in acute lung injury. Mediators Inflamm 2012: 740987.
25. Lacour S, Gautier JC, Pallardy M, Roberts R (2005) Cytokines as potential biomarkers of liver toxicity. Cancer Biomark 1: 29-39.
26. Sass G, Barikbin R, Tiegs G (2012) The multiple functions of heme oxygenase-1 in the liver. Z Gastroenterol. 50: 34-40.