메뉴 건너뛰기




Volumn 28, Issue 1, 2010, Pages 39-59

Molecular aspects of microcystin-induced hepatotoxicity and hepatocarcinogenesis

Author keywords

Apoptosis; Cyanotoxins; DNA damage; Hepatocarcinogenesis; Hepatotoxicity; Microcystin LR

Indexed keywords

APOPTOSIS; CYANOTOXINS; DNA DAMAGES; HEPATOCARCINOGENESIS; HEPATOTOXICITY; MICROCYSTIN-LR;

EID: 77951248206     PISSN: 10590501     EISSN: 15324095     Source Type: Journal    
DOI: 10.1080/10590500903585382     Document Type: Review
Times cited : (129)

References (111)
  • 3
  • 4
    • 0030006616 scopus 로고    scopus 로고
    • Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay
    • DOI 10.1093/carcin/17.6.1317
    • Ueno Y, Nagatai S, Tsutsumi T, Hasegawa A, Watanabe M, Park H, Chen G, Chen G, Yu S. Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay. Carcinogenesis. 1996; 17(6):1317-1321. (Pubitemid 26196344)
    • (1996) Carcinogenesis , vol.17 , Issue.6 , pp. 1317-1321
    • Ueno, Y.1    Nagata, S.2    Tsutsumi, T.3    Hasegawa, A.4    Watanabe, M.F.5    Park, H.-D.6    Chen, G.-C.7    Chen, G.8    Yu, S.-Z.9
  • 6
    • 0035295956 scopus 로고    scopus 로고
    • The relationship between cyanotoxin (microcystin, MC) in pond-ditch water and primary liver cancer in China
    • Yu S, Zhao N, Zi X. The relationship between cyanotoxin (microcystin, MC) in pond-ditch water and primary liver cancer in China. Zhonghua Zhong Liu Za Zhi 2001; 23(2):96-99.
    • (2001) Zhonghua Zhong Liu Za Zhi , vol.23 , Issue.2 , pp. 96-99
    • Yu, S.1    Zhao, N.2    Zi, X.3
  • 7
    • 0032897110 scopus 로고    scopus 로고
    • 1-initiated rats
    • DOI 10.1093/carcin/20.1.161
    • Sekijima M, Tsutsumi T, Yoshida T, Harada T, Tashiro F, Chen G, Yu SZ, Ueno Y. Enhancement of glutathione S-transferase placental-form positive liver cell foci development by microcystin-LR in aflatoxin B1-initiated rats. Carcinogenesis 1999; 20(1):161-165. (Pubitemid 29033859)
    • (1999) Carcinogenesis , vol.20 , Issue.1 , pp. 161-165
    • Sekijima, M.1    Tsutsumi, T.2    Yoshida, T.3    Harada, T.4    Tashiro, F.5    Chen, G.6    Yu, S.-Z.7    Ueno, Y.8
  • 9
    • 0036654763 scopus 로고    scopus 로고
    • The expression of bcl-2 and bax genes during microcystin induced liver tumorigenesis
    • Hu Z, Chen H, Li Y, Gao L, Sun C. The expression of bcl-2 and bax genes during microcystin induced liver tumorigenesis. Zhonghua Yu Fang Yi Xue Za Zhi 2002; 36(4):239-242.
    • (2002) Zhonghua Yu Fang Yi Xue Za Zhi , vol.36 , Issue.4 , pp. 239-242
    • Hu, Z.1    Chen, H.2    Li, Y.3    Gao, L.4    Sun, C.5
  • 10
    • 33847147603 scopus 로고    scopus 로고
    • The role of ROS in microcystin-LR-induced hepatocyte apoptosis and liver injury in mice
    • DOI 10.1016/j.tox.2006.12.010, PII S0300483X06007372
    • Weng D, Lu Y, Wei Y, Liu Y, Shen P. The role of ROS in microcystin-LR-induced hepatocyte apoptosis and liver injury in mice. Toxicology 2007; 232(1-2):15-23. (Pubitemid 46283168)
    • (2007) Toxicology , vol.232 , Issue.1-2 , pp. 15-23
    • Weng, D.1    Lu, Y.2    Wei, Y.3    Liu, Y.4    Shen, P.5
  • 11
    • 0034644853 scopus 로고    scopus 로고
    • Microcystins (cyanobacterial toxins) in drinking water enhance the growth of aberrant crypt foci in the mouse colon
    • Humpage AR, Hardy SJ, Moore EJ, Froscio SM, Falconer IR. Microcystins (cyanobacterial toxins) in drinking water enhance the growth of aberrant crypt foci in the mouse colon. J. Toxicol. Environ. Health, Part A 2000; 61(3):155-165.
    • (2000) J. Toxicol. Environ. Health, Part A , vol.61 , Issue.3 , pp. 155-165
    • Humpage, A.R.1    Hardy, S.J.2    Moore, E.J.3    Froscio, S.M.4    Falconer, I.R.5
  • 12
    • 50549083214 scopus 로고    scopus 로고
    • Different sensitivities of human colon adenocarcinoma (CaCo-2), astrocytoma (IPDDC-A2) and lymphoblastoid (NCNC) cell lines to microcystin-LR induced reactive oxygen species and DNA damage
    • Žegura B, Volčič M, Lah TT, Filipič M. Different sensitivities of human colon adenocarcinoma (CaCo-2), astrocytoma (IPDDC-A2) and lymphoblastoid (NCNC) cell lines to microcystin-LR induced reactive oxygen species and DNA damage. Toxicon 2008; 52(3):518-525.
    • (2008) Toxicon , vol.52 , Issue.3 , pp. 518-525
    • Žegura, B.1    Volčič, M.2    Lah, T.T.3    Filipič, M.4
  • 14
    • 57749093104 scopus 로고    scopus 로고
    • In vivo study on the effects of microcystin extracts on the expression profiles of proto-oncogenes (c-fos, c-jun and c-myc) in liver, kidney and testis of male Wistar rats injected i.v. with toxins
    • Li H, Xie P, Li G, Hao L, Xiong Q. In vivo study on the effects of microcystin extracts on the expression profiles of proto-oncogenes (c-fos, c-jun and c-myc) in liver, kidney and testis of male Wistar rats injected i.v. with toxins. Toxicon 2009; 53(1):169-175.
    • (2009) Toxicon , vol.53 , Issue.1 , pp. 169-175
    • Li, H.1    Xie, P.2    Li, G.3    Hao, L.4    Xiong, Q.5
  • 16
    • 0026651340 scopus 로고
    • A review: Cyanobacteria secondary metabolites-the cyanotoxins
    • Carmichael WW. A review: cyanobacteria secondary metabolites-the cyanotoxins. J. Applied Bacteriology 1992; 72:445-459.
    • (1992) J. Applied Bacteriology , vol.72 , pp. 445-459
    • Carmichael, W.W.1
  • 18
    • 0343196710 scopus 로고    scopus 로고
    • Neoplastic nodular formation in mouse liver induced by repeated intraperitoneal injections of microcystin-LR
    • DOI 10.1016/S0041-0101(97)00026-3, PII S0041010197000263
    • Ito E, Kondo F, Terao K, Harada K-I. Neoplastic nodular formation in mouse liver induced by repeated intraperitoneal injections of microcystin-LR. Toxicon 1997; 35:1453-1457. (Pubitemid 27478851)
    • (1997) Toxicon , vol.35 , Issue.9 , pp. 1453-1457
    • Emiko, I.1    Kondo, F.2    Terao, K.3    Harada, K.-I.4
  • 19
    • 0033045623 scopus 로고    scopus 로고
    • Genotoxicity of microcystic cyanobacteria extract of a water source in China
    • Ding WX, Shen HM, Zhu HG, Lee BL, Ong CN. Genotoxicity of microcystic cyanobacteria extract of a water source in China. Mutation Research 1999; 442(2):69-77.
    • (1999) Mutation Research , vol.442 , Issue.2 , pp. 69-77
    • Ding, W.X.1    Shen, H.M.2    Zhu, H.G.3    Lee, B.L.4    Ong, C.N.5
  • 20
    • 77951245716 scopus 로고    scopus 로고
    • Update to risk factors for hepatocellular carcinoma
    • Abdel-Hamid N. Update to risk factors for hepatocellular carcinoma. International J. Medicine Medical Sci 2009; 1(3):38-43.
    • (2009) International J. Medicine Medical Sci , vol.1 , Issue.3 , pp. 38-43
    • Abdel-Hamid, N.1
  • 22
    • 14644403686 scopus 로고    scopus 로고
    • Guidance values for microcystins in water and cyanobacterial supplement products (blue-green algal supplements): A reasonable or misguided approach?
    • DOI 10.1016/j.taap.2004.09.005
    • Dietrich D, Hoeger S. Guidance values for microcystins in water and cyanobacterial supplement products (blue-green algal supplements): A reasonable or misguided approach? Toxicol. Applied Pharmacol 2005; 203(3):273-289. (Pubitemid 40311874)
    • (2005) Toxicology and Applied Pharmacology , vol.203 , Issue.SPEC. ISS.3 , pp. 273-289
    • Dietrich, D.1    Hoeger, S.2
  • 23
    • 0003428550 scopus 로고    scopus 로고
    • WHO. Cyanobacterial toxins: Microcystin-LR. Geneva: World Health Organization
    • WHO. Cyanobacterial toxins: Microcystin-LR. In: Guidelines for drinking-water quality, Addendum to Volume2. Geneva: World Health Organization; 1998.
    • (1998) Guidelines for Drinking-water Quality, Addendum to Volume 2
  • 24
    • 0028065199 scopus 로고
    • Molecular structure of the cyanobacterial tumor-promoting microcystins
    • DOI 10.1016/0014-5793(94)00680-6
    • Rudolph-Böhner S, Mierke DF, Moroder L. Molecular structure of cyanobacterial tumour-promoting microcystins. FEBS Letters 1994; 349:319-323. (Pubitemid 24264766)
    • (1994) FEBS Letters , vol.349 , Issue.3 , pp. 319-323
    • Rudolph-Bohner, S.1
  • 26
    • 0027972634 scopus 로고
    • Co-crystallization of the catalytic subunit of the serine/threonine specific protein phosphatase 1 from human in complex with microcystin LR
    • DOI 10.1006/jmbi.1994.1027
    • Barford D, Keller J. Co-crystallization of the catalytic subunit of the serine/ threonine specific protein phosphatase 1 from human in complex with microcystin- LR. J. Molec. Biol 1994; 235:763-766. (Pubitemid 24063593)
    • (1994) Journal of Molecular Biology , vol.235 , Issue.2 , pp. 763-766
    • Barford, D.1    Keller, J.C.2
  • 27
    • 0029094754 scopus 로고
    • Threedimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1
    • Goldberg J, Huang HB, Kwon YG, Greengard P, Nairn AC, Kuriyan J. Threedimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature 1995; 376:745-753.
    • (1995) Nature , vol.376 , pp. 745-753
    • Goldberg, J.1    Huang, H.B.2    Kwon, Y.G.3    Greengard, P.4    Nairn, A.C.5    Kuriyan, J.6
  • 30
    • 4344575960 scopus 로고    scopus 로고
    • Evaluation of analytical methods for detection quantification of cyanotoxins in relation to Australian drinking water guidelines
    • Available at (Oct 10, 2009)
    • Nicholson BC, Burch MD. Evaluation of analytical methods for detection quantification of cyanotoxins in relation to Australian drinking water guidelines. Cooperative Research Centre for Water Quality and Treatment, National Health and Medical Research Council of Australia, Australia, 2001. Available at http://www.nhmrc.gov.au/publications/synopses/ files/eh22.pdf (Oct 10, 2009)
    • (2001) Cooperative Research Centre for Water Quality and Treatment
    • Nicholson, B.C.1    Burch, M.D.2
  • 31
    • 0141543868 scopus 로고    scopus 로고
    • Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR
    • DOI 10.1016/S0041-0101(03)00104-1
    • Li X, Lin Y, Seng L, Lin J. Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of MC-LR. Toxicon 2003; 42(1):85-89. (Pubitemid 37297564)
    • (2003) Toxicon , vol.42 , Issue.1 , pp. 85-89
    • Li, X.1    Liu, Y.2    Song, L.3    Liu, J.4
  • 32
    • 0023160585 scopus 로고
    • Distribution of Microcystis aeruginosa peptide toxin and interactions with hepatic microsomes in mice
    • Brooks WP, Codd GA. Distribution of Microcystis aeruginosa peptide toxin and interactions with hepatic microsomes in mice. Pharmacol. Toxicol 1987; 60(3):187-191.
    • (1987) Pharmacol. Toxicol , vol.60 , Issue.3 , pp. 187-191
    • Brooks, W.P.1    Codd, G.A.2
  • 33
    • 0026217677 scopus 로고
    • Association of microcystin-LR and its biotransformation product with a hepatic-cytosolic protein
    • Robinson NA, Matson CF, Pace JG. Association of microcystin-LR and its biotransformation product with a hepatic-cytosolic protein. J. Biochem. Toxicol 1991; 6:171-180.
    • (1991) J. Biochem. Toxicol , vol.6 , pp. 171-180
    • Robinson, N.A.1    Matson, C.F.2    Pace, J.G.3
  • 36
    • 0025967404 scopus 로고
    • LawrenceWB. Tissue distribution, excretion and hepatic biotransformation of microcystin-LR in mice
    • Robinson NA, Pace JG, Matson CF,Miura GA, LawrenceWB. Tissue distribution, excretion and hepatic biotransformation of microcystin-LR in mice. J. Pharmacol. Exp. Therap 1991; 256(1):176-182.
    • (1991) J. Pharmacol. Exp. Therap , vol.256 , Issue.1 , pp. 176-182
    • Robinson, N.A.1    Pace, J.G.2    Matson Cfmiura, G.A.3
  • 37
    • 0035998334 scopus 로고    scopus 로고
    • Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds
    • DOI 10.1016/S0041-0101(02)00099-5, PII S0041010102000995
    • Ito E, Takai A, Kondo F, Masui H, Imanishi S, Harada KI. Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds. Toxicon 2002; 40(7):1017-1025. (Pubitemid 34663695)
    • (2002) Toxicon , vol.40 , Issue.7 , pp. 1017-1025
    • Ito, E.1    Takai, A.2    Kondo, F.3    Masui, H.4    Imanishi, S.5    Harada, K.-I.6
  • 38
    • 0031754514 scopus 로고    scopus 로고
    • Microtubule-dependent vesicle transport: Modulation of channel and transporter activity in liver and kidney
    • Hamm-Alvarez SF, Sheetz MP. Microtubule-dependent vesicle transport: Modulation of channel and transporter activity in liver and kidney. Physiolog. Reviews 1998; 78:1109-1129.
    • (1998) Physiolog. Reviews , vol.78 , pp. 1109-1129
    • Hamm-Alvarez, S.F.1    Sheetz, M.P.2
  • 40
    • 29144449939 scopus 로고    scopus 로고
    • Proteomic analysis of cellular response to microcystin in human amnion FL cells
    • DOI 10.1021/pr050325k
    • Fu WY, Xu LH, Yu YN. Proteomic analyses of cellular response to microcystin in human amnion FL cells. J. Proteomic Res 2005; 4:2207-2215. (Pubitemid 41814289)
    • (2005) Journal of Proteome Research , vol.4 , Issue.6 , pp. 2207-2215
    • Fu, W.-Y.1    Xu, L.-H.2    Yu, Y.-N.3
  • 41
    • 0034163509 scopus 로고    scopus 로고
    • Protein phosphatase 2A is associated in an inactive state with microtubules through 2A1-specific interaction with tubulin
    • DOI 10.1042/0264-6021:3460433
    • Hiraga A, Tamura S. Protein phosphatase 2A is associated in an inactive state with microtubules through 2A-1- specific interaction with tubuline. Biochem J 2000; 346(2):433-439. (Pubitemid 30148130)
    • (2000) Biochemical Journal , vol.346 , Issue.2 , pp. 433-439
    • Hiraga, A.1    Tamura, S.2
  • 43
    • 0033567183 scopus 로고    scopus 로고
    • Increased protein phosphorylation of cytoplasmic dynein results in impaired motor function
    • DOI 10.1042/0264-6021:3420001
    • Runnegar MT, Wei X, Hamm-Alvarez SF. Increased protein phosphorylation of cytoplasmic dynein results in impaired motor function. Biochem J 1999; 15(342):1-6. (Pubitemid 29410841)
    • (1999) Biochemical Journal , vol.342 , Issue.1 , pp. 1-6
    • Runnegar, M.T.1    Wei, X.2    Hamm-Alvarez, S.F.3
  • 44
    • 0026544023 scopus 로고
    • Cytoskeletal changes in hepatocytes induced by Microcystis toxins and their relation to hyperphosphorylation of cell proteins
    • Falconer IR, Yeung SK. Cytoskeletal changes in hepatocytes induced by Microcystis toxins and their relation to hyperphosphorylation of cell proteins. Chem.-Biol. Interactions 1992; 81:181-196.
    • (1992) Chem.-Biol. Interactions , vol.81 , pp. 181-196
    • Falconer, I.R.1    Yeung, S.K.2
  • 45
    • 34548429270 scopus 로고    scopus 로고
    • Hepatic gene expression changes in mice associated with prolonged sublethal microcystin exposure
    • Clark SP, Davis MA, Ryan TP, Searfoss GH, Hooser SB. Hepatic Gene Expression Changes in Mice Associated with Prolonged Sublethal Microcystin Exposure. Toxicologic Patholology 2007; 35(4):594-605.
    • (2007) Toxicologic Patholology , vol.35 , Issue.4 , pp. 594-605
    • Clark, S.P.1    Davis, M.A.2    Ryan, T.P.3    Searfoss, G.H.4    Hooser, S.B.5
  • 46
    • 0028799190 scopus 로고
    • Effects of microcystin-LR on actin and the actin-associated proteins alpha- actinin and talin in hepatocytes
    • Ghosh S, Khan SA, Wickstrom M, Beasley V. Effects of microcystin-LR on actin and the actin-associated proteins alpha- actinin and talin in hepatocytes. Natural Toxins 1995; 3(6):405-414.
    • (1995) Natural Toxins , vol.3 , Issue.6 , pp. 405-414
    • Ghosh, S.1    Khan, S.A.2    Wickstrom, M.3    Beasley, V.4
  • 47
    • 0032400774 scopus 로고    scopus 로고
    • The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types
    • DOI 10.1016/S0041-0101(98)00128-7, PII S0041010198001287
    • McDermott CM, Nho CW, Howard W, Holton B. The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types. Toxicon 1998; 36:1981-1996. (Pubitemid 28532776)
    • (1998) Toxicon , vol.36 , Issue.12 , pp. 1981-1996
    • McDermott, C.M.1    Nho, C.W.2    Howard, W.3    Holton, B.4
  • 48
    • 24944453273 scopus 로고    scopus 로고
    • Induction of apoptosis in mouse liver by microcystin-LR: A combined transcriptomic, proteomic, and simulation strategy
    • DOI 10.1074/mcp.M400185-MCP200
    • Chen T,Wang Q, Cui J, YangW, Shi Q, Hua Z, Ji J, Shen P. Induction of apoptosis in mouse liver by microcystin-LR: A combined transcriptomic, proteomic, and simulation strategy. Molec Cell Proteomics 2005; 4:958-974. (Pubitemid 41309153)
    • (2005) Molecular and Cellular Proteomics , vol.4 , Issue.7 , pp. 958-974
    • Chen, T.1    Wang, Q.2    Cui, J.3    Yang, W.4    Shi, Q.5    Hua, Z.6    Ji, J.7    Shen, P.8
  • 49
    • 0025811591 scopus 로고
    • Protection against microcystin-LR-induced hepatotoxicity by Silymarin: Biochemistry, histopathology, and lethality
    • Mereish KA, Bunner DL, Ragland DR, Creasia DA. Protection against microcystin-LR-induced hepatotoxicity by Silymarin: biochemistry, histopathology, and lethality. Pharmaceut Res 1991; 8(2):273-277.
    • (1991) Pharmaceut Res , vol.8 , Issue.2 , pp. 273-277
    • Mereish, K.A.1    Bunner, D.L.2    Ragland, D.R.3    Creasia, D.A.4
  • 50
    • 42149136754 scopus 로고    scopus 로고
    • Characterization of organic anion transporting polypeptide 1b2-null Mice: Essential role in hepatic uptake/toxicity of phalloidin and microcystin-lr
    • DOI 10.1093/toxsci/kfn038
    • Lu H, Choudhuri S, Ogura K, Csanaky IL, Lei X, Cheng X, Song PZ, Klaassen CD. Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicol Sci 2008; 103(1):35-45. (Pubitemid 351524475)
    • (2008) Toxicological Sciences , vol.103 , Issue.1 , pp. 35-45
    • Lu, H.1    Choudhuri, S.2    Ogura, K.3    Csanaky, I.L.4    Lei, X.5    Cheng, X.6    Song, P.-Z.7    Klaassen, C.D.8
  • 51
    • 13944255112 scopus 로고    scopus 로고
    • Antioxidant enzyme activity and lipid peroxidation in liver and kidney of rats exposed to microcystin-LR administered intraperitoneally
    • DOI 10.1016/j.toxicon.2004.11.001
    • Moreno I, Pichardo S, Jos A, Ǵomez-Amores L, Mate A, Vazquez CM, Caméan AM. Antioxidant enzyme activity and lipid peroxidation in liver and kidney of rats exposed to microcystin-LR administered intraperitoneally. Toxicon 2005; 45(4):395-402. (Pubitemid 40269929)
    • (2005) Toxicon , vol.45 , Issue.4 , pp. 395-402
    • Moreno, I.1    Pichardo, S.2    Jos, A.3    Gomez-Amores, L.4    Mate, A.5    Vazquez, C.M.6    Camean, A.M.7
  • 53
    • 0033794092 scopus 로고    scopus 로고
    • Fulminant hepatocyte apoptosis in vivo following microcystin-LR administration to rats
    • Hooser SB. Fulminant hepatocyte apoptosis in vivo following microcystin-LR administration to rats. Toxicologic Pathology 2000; 28(5):726-733.
    • (2000) Toxicologic Pathology , vol.28 , Issue.5 , pp. 726-733
    • Hooser, S.B.1
  • 54
    • 42649101990 scopus 로고    scopus 로고
    • Toxic response indicators of microcystin-LR in F344 rats following a single-dose treatment
    • Billam M, Mukhi S, Tanga L, Gaoa W, Wang JS. Toxic response indicators of microcystin-LR in F344 rats following a single-dose treatment. Toxicon 2008; 51:1068-1080.
    • (2008) Toxicon , vol.51 , pp. 1068-1080
    • Billam, M.1    Mukhi, S.2    Tanga, L.3    Gaoa, W.4    Wang, J.S.5
  • 55
    • 0033846898 scopus 로고    scopus 로고
    • Microcystic cyanobacteria extract induces cytoskeletal disruption and intracellular glutathione alteration in hepatocytes
    • Ding WX, Shen HM, Ong CN. Microcystic cyanobacteria extract induces cytoskeletal disruption and intracellular glutathione alteration in hepatocytes. Environ. Health Persp 2000; 108(7):605-609.
    • (2000) Environ. Health Persp , vol.108 , Issue.7 , pp. 605-609
    • Ding, W.X.1    Shen, H.M.2    Ong, C.N.3
  • 56
    • 0036077231 scopus 로고    scopus 로고
    • Co-operative effects in tumorigenicity. The microcystin example
    • Sedmak B, Šuput D. Co-operative effects in tumorigenicity. The microcystin example. Radiology & Oncology 2002; 36(2):162-164. (Pubitemid 34799946)
    • (2002) Radiology and Oncology , vol.36 , Issue.2 , pp. 162-164
    • Sedmak, B.1    Suput, D.2
  • 57
    • 15844390280 scopus 로고    scopus 로고
    • Epidemiology and carcinogenesis of hepatocellular carcinoma
    • Leong TY, Leong AS. Epidemiology and carcinogenesis of hepatocellular carcinoma. HPB (Oxford) 2005; 7(1):5-15.
    • (2005) HPB (Oxford) , vol.7 , Issue.1 , pp. 5-15
    • Leong, T.Y.1    Leong, A.S.2
  • 58
  • 59
    • 32044462755 scopus 로고    scopus 로고
    • Identification of human liver mitochondrial aldehyde dehydrogenase as a potential target for microcystin-LR
    • DOI 10.1016/j.tox.2005.12.001, PII S0300483X05006207
    • Chen T, Cui J , Liang Y, Xin X, Young DO, Chen C, Shen P. Identification of human liver mitochondrial aldehyde dehydrogenase as a potential target for microcystin- LR. Toxicology 2006; 220(1):71-80. (Pubitemid 43197631)
    • (2006) Toxicology , vol.220 , Issue.1 , pp. 71-80
    • Chen, T.1    Cui, J.2    Liang, Y.3    Xin, X.4    Owen Young, D.5    Chen, C.6    Shen, P.7
  • 61
    • 0031040256 scopus 로고    scopus 로고
    • A molecular basis for different interactions of marine toxins with protein phosphatase 1
    • Bagu JR, Sykes B, Craig M, Holmes CFB. A molecular basis for different interactions of marine toxins with protein phosphatase 1. J. Biol. Chem 1997; 272:5087-5097.
    • (1997) J. Biol. Chem , vol.272 , pp. 5087-5097
    • Bagu, J.R.1    Sykes, B.2    Craig, M.3    Holmes, C.F.B.4
  • 62
  • 63
    • 0030924806 scopus 로고    scopus 로고
    • Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin
    • DOI 10.1074/jbc.272.21.13856
    • Favre B, Turowski P, Hemmings BA. Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J. Biol. Chem 1997; 272(21):13856-13863. (Pubitemid 27224826)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.21 , pp. 13856-13863
    • Favre, B.1    Turowski, P.2    Hemmings, B.A.3
  • 64
    • 0002193472 scopus 로고    scopus 로고
    • Protein dephosphorylation and the intracellular control of the cell number
    • Berndt N. Protein dephosphorylation and the intracellular control of the cell number. Frontiries in Bioscience 1999; 4:D22-42.
    • (1999) Frontiries in Bioscience , vol.4
    • Berndt, N.1
  • 66
    • 0038702246 scopus 로고    scopus 로고
    • Phosphatases in apoptosis: To be or not to be, PP2A is in the heart of the question
    • DOI 10.1016/S0167-4889(03)00029-6
    • Van Hoof C, Goris J. Phosphatases in apoptosis: to be or not to be, PP-2A is in the heart of the question. Biochim. Biophys. Acta 2003; 1640(2-3):97-104. (Pubitemid 36555695)
    • (2003) Biochimica et Biophysica Acta - Molecular Cell Research , vol.1640 , Issue.2-3 , pp. 97-104
    • Van Hoof, C.1    Goris, J.2
  • 69
    • 0029129557 scopus 로고
    • Serine/threonine protein phosphatases
    • Wera S, Hemmings BA. Serine/threonine protein phosphatases. Biochem. J 1995; 311(1):17-29
    • (1995) Biochem. J , vol.311 , Issue.1 , pp. 17-29
    • Wera, S.1    Hemmings, B.A.2
  • 70
    • 0028003818 scopus 로고
    • Phosphorylation of dis2 protein phosphatase at the C-terminal cdc2 consensus and its potential role in cell cycle regulation
    • Yamano H, Ishii K, Yanagida M. Phosphorylation of dis2 protein phosphatase at the C-terminal cdc2 consensus and its potential role in cell cycle regulation. EMBO J 1994; 13:5310-5318. (Pubitemid 24351809)
    • (1994) EMBO Journal , vol.13 , Issue.22 , pp. 5310-5318
    • Yamano, H.1    Ishii, K.2    Yanagida, M.3
  • 71
    • 0024397415 scopus 로고
    • The structure and regulation of protein phosphatases
    • Cohen P. The structure and regulation of protein phosphatases. Ann. Rev. Biochem 1989; 58:453-508. (Pubitemid 19172978)
    • (1989) Annual Review of Biochemistry , vol.58 , pp. 453-508
    • Cohen, P.1
  • 72
    • 33846542682 scopus 로고    scopus 로고
    • A specific PP2A regulatory subunit, B56γ, mediates DNA damage-induced dephosphorylation of p53 at Thr55
    • DOI 10.1038/sj.emboj.7601519, PII 7601519
    • Li H-H, Cai X, Shouse GP, Piluso LG, Liu X. A specific PP2A regulatory subunit, B56, mediates DNA damage-induced dephosphorylation of p53 at Thr55. EMBO J 2007; 26:402-411. (Pubitemid 46160941)
    • (2007) EMBO Journal , vol.26 , Issue.2 , pp. 402-411
    • Li, H.-H.1    Cai, X.2    Shouse, G.P.3    Piluso, L.G.4    Liu, X.5
  • 75
    • 18244386206 scopus 로고    scopus 로고
    • Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1) [1]
    • DOI 10.1111/j.1365-2125.2005.02354.x
    • Niemi M, Kvisto KT, Hofmann U, Shwab M, Eichelbaumm M, Fromm MF. Fexofenadine farmacokinetics are associated with a polymorphism of the SLOC1B1 gene (encoding OATP1B1). Br. J. Clin. Pharmacol 2005; 59:602-604. (Pubitemid 40632253)
    • (2005) British Journal of Clinical Pharmacology , vol.59 , Issue.5 , pp. 602-604
    • Niemi, M.1    Kivisto, K.T.2    Hofmann, U.3    Schwab, M.4    Eichelbaum, M.5    Fromm, M.F.6
  • 77
    • 0343183375 scopus 로고    scopus 로고
    • Carcinogenesis of primary liver malignancies
    • Dürr R, Caselmann WH. Carcinogenesis of primary liver malignancies. Langenbeck's Arch Surg 2000; 385:154-161. (Pubitemid 30316916)
    • (2000) Langenbeck's Archives of Surgery , vol.385 , Issue.3 , pp. 154-161
    • Durr, R.1    Caselmann, W.H.2
  • 78
    • 77951223515 scopus 로고    scopus 로고
    • Introduction to the Toxicology of the Liver
    • V Beasley (Ed.). International Veterinary Information Service (Available from
    • Beasley V. Introduction to the Toxicology of the Liver. In: V Beasley (Ed.), Veterinary Toxicology. International Veterinary Information Service (Available from www.ivis.org); 1999.
    • (1999) Veterinary Toxicology
    • Beasley, V.1
  • 79
    • 0037212282 scopus 로고    scopus 로고
    • Microcystin-LR induces oxidative DNA damage in human hepatoma cell line HepG2
    • DOI 10.1016/S0041-0101(02)00207-6, PII S0041010102002076
    • Zegurǎ B, Sedmak, B, Filipič M. Microcystin-LR induces oxidative DNA damage in human hepatoma cell line HepG2. Toxicon 2003; 41:41-48. (Pubitemid 35449159)
    • (2003) Toxicon , vol.41 , Issue.1 , pp. 41-48
    • Zegura, B.1    Sedmak, B.2    Filipic, M.3
  • 80
    • 27744531603 scopus 로고    scopus 로고
    • Cadherins mediate both the association between PS1 and β-catenin and the effects of PS1 on β-catenin stability
    • DOI 10.1074/jbc.M507503200
    • Serban G, Kouchi Z, Baki L, Georgakopoulos A, Litterst CM, Shioi J, Robakis NK. Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability. J. Biol. Chem 2005; 280(43):36007-36012. (Pubitemid 41633870)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.43 , pp. 36007-36012
    • Serban, G.1    Kouchi, Z.2    Baki, L.3    Georgakopoulos, A.4    Litterst, C.M.5    Shioi, J.6    Robakis, N.K.7
  • 82
    • 20444507951 scopus 로고    scopus 로고
    • Genotoxic potential of microcystin-LR and nodularin in vitro in primary cultured rat hepatocytes and in vivo in rat liver
    • DOI 10.1002/tox.20110
    • Bouaicha N, Maatouk I, Plessis MJ, Perin F. Genotoxic potential of Microcystin- LR and nodularin in vitro in primary cultured rat hepatocytes and in vivo in rat liver. Environ. Toxicol 2005; 20(3):341-347. (Pubitemid 40827454)
    • (2005) Environmental Toxicology , vol.20 , Issue.3 , pp. 341-347
    • Bouaicha, N.1    Maatouk, I.2    Plessis, M.-J.3    Perin, F.4
  • 83
    • 0034903919 scopus 로고    scopus 로고
    • Interactions of selenium compounds with other antioxidants in DNA damage and apoptosis in human normal keratinocytes
    • Shen CL, Song W, Pence BC. Interactions of selenium compounds with other antioxidants in DNA damage and apoptosis in human normal keratinocytes. Cancer Epidemiology Biomarkers & Prevention 2001; 10(4):385-390. (Pubitemid 32703224)
    • (2001) Cancer Epidemiology Biomarkers and Prevention , vol.10 , Issue.4 , pp. 385-390
    • Shen, C.-L.1    Song, W.2    Pence, B.C.3
  • 84
    • 0030589161 scopus 로고    scopus 로고
    • The cyanobacterial toxin microcystin-LR induced DNA damage in mouse liver in vivo
    • DOI 10.1016/S0300-483X(96)03413-0, PII S0300483X96034130
    • Rao PVL, Bhattacharya R. The cyanobacterial toxin microcystin-LR induced DNA damage in mouse liver in vivo. Toxicology 1996; 114:29-36. (Pubitemid 26379365)
    • (1996) Toxicology , vol.114 , Issue.1 , pp. 29-36
    • Rao, P.V.L.1    Bhattacharya, R.2
  • 89
    • 0036048536 scopus 로고    scopus 로고
    • Characterization of subletal MC-LR exposure in mice
    • Guzman RE, Solter PF. Characterization of subletal MC-LR exposure in mice. Veterinary Pathology 2002; 39(1):17-26.
    • (2002) Veterinary Pathology , vol.39 , Issue.1 , pp. 17-26
    • Guzman, R.E.1    Solter, P.F.2
  • 90
    • 0012196927 scopus 로고    scopus 로고
    • Cell proliferation, differentiation and apoptosis
    • JF Holland & E Frei (Eds.), 5 ed. London: B.C. Decker Inc, Hamilton
    • Andreeff M, Goodrich DW, Pardee AB. Cell proliferation, differentiation and apoptosis. In: JF Holland & E Frei (Eds.), Cancer Medicine. 5 ed. London: B.C. Decker Inc, Hamilton; 2000:24-32.
    • (2000) Cancer Medicine , pp. 24-32
    • Andreeff, M.1    Goodrich, D.W.2    Pardee, A.B.3
  • 91
    • 67650106882 scopus 로고    scopus 로고
    • Induction of apoptosis in human liver Hep2 cell line by 5-acyl-7-gen-difluoromethilenechrysin
    • Tan XW, Xia H, Xu JH, Cao JG. Induction of apoptosis in human liver Hep2 cell line by 5-acyl-7-gen-difluoromethilenechrysin. World J. Gastroenterology 2009; 15(18):2234-2239.
    • (2009) World J. Gastroenterology , vol.15 , Issue.18 , pp. 2234-2239
    • Tan, X.W.1    Xia, H.2    Xu, J.H.3    Cao, J.G.4
  • 92
    • 22044451505 scopus 로고    scopus 로고
    • Altered expression of p53, Bcl- 2 and Bax induced by microcystin-LR in vivo and in vitro
    • Wen-yu F, Jia-ping C, Xiu-min W, Li-hong X. Altered expression of p53, Bcl- 2 and Bax induced by microcystin-LR in vivo and in vitro. Toxicon 2005; 46(2):171-177.
    • (2005) Toxicon , vol.46 , Issue.2 , pp. 171-177
    • Wen-Yu, F.1    Jia-Ping, C.2    Xiu-Min, W.3    Li-Hong, X.4
  • 94
    • 0033028684 scopus 로고    scopus 로고
    • Microcystin-LR and liver tumor promotion: Effects on cytokinesis, ploidy, and apoptosis in cultured hepatocytes
    • Humpage AR, Falconer IR. Microcystin-LR and liver tumor promotion: effects on cytokinesis, ploidy, and apoptosis in cultured hepatocytes. Environ. Toxicol 1999; 14:61-75. (Pubitemid 129721405)
    • (1999) Environmental Toxicology , vol.14 , Issue.1998 , pp. 61-75
    • Humpage, A.R.1    Falconer, I.R.2
  • 96
    • 0035283087 scopus 로고    scopus 로고
    • Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin-3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation
    • DOI 10.1182/blood.V97.5.1289
    • Chiang, CW, Harris G, Ellig C, Masters SC, Subramanian R, Shenolikar S. Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin-3- dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation. Blood 2001; 97:1289-1297. (Pubitemid 32183751)
    • (2001) Blood , vol.97 , Issue.5 , pp. 1289-1297
    • Chiang, C.-W.1    Harris, G.2    Ellig, C.3    Masters, S.C.4    Subramanian, R.5    Shenolikar, S.6    Wadzinski, B.E.7    Yang, E.8
  • 97
    • 33750620955 scopus 로고    scopus 로고
    • Ceramide induces apoptosis via a peroxisome proliferator-activated receptor γ-dependent pathway
    • DOI 10.1007/s10495-006-0191-9
    • Wang J, Lv X, Shi J, Hu X. Ceramide induces apoptosis via a peroxisome proliferator activated receptor -γ-dependent pathway. Apoptosis 2006; 11:2043-2045. (Pubitemid 44691586)
    • (2006) Apoptosis , vol.11 , Issue.11 , pp. 2043-2052
    • Wang, J.1    Lv, X.2    Shi, J.3    Hu, X.4
  • 98
    • 0028219150 scopus 로고
    • Toxicity of the blue-green alga (Cyanobacterium) Microcystis aeruginosa in drinking water to growing pigs, as an animal model for human injury and risk assessment
    • Falconer IR, Burch MD, Steffensen DA, Choice M, Coverdale OR. Toxicity of the blue-green alga (cyanobacterium) Microcystis aeruginosa in drinking water to growing pigs, as an animal model for human injury and risk assessment. Enviro. Toxicol. Water Quality 1994; 9:131-139. (Pubitemid 24141384)
    • (1994) Environmental Toxicology and Water Quality , vol.9 , Issue.2 , pp. 131-139
    • Falconer, I.R.1    Burch, M.D.2    Steffensen, D.A.3    Choice, M.4    Coverdale, O.R.5
  • 99
    • 1642559254 scopus 로고    scopus 로고
    • Microcystin-LR and okadaic acid-induced cellular effects: A dualistic response
    • Gehringer MM. Microcystin-LR and okadaic acid-induced cellular effects: a dualistic response. FEBS Letters 2004; 557:1-8.
    • (2004) FEBS Letters , vol.557 , pp. 1-8
    • Gehringer, M.M.1
  • 100
    • 0032838940 scopus 로고    scopus 로고
    • Toxins affecting cell signaling alter cytoskeletal structure
    • Toivola DM, Eriksson JE. Toxins affecting cell signaling alter cytoskeletal structure. Toxicology In Vitro 1999; 13:521-530.
    • (1999) Toxicology in Vitro , vol.13 , pp. 521-530
    • Toivola, D.M.1    Eriksson, J.E.2
  • 101
    • 0343457526 scopus 로고    scopus 로고
    • Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A
    • DOI 10.1074/jbc.273.51.34157
    • Deng X, Ito T, Carr B, Mumby M, May WS Jr. Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A. J. Biol. Chem 1998; 273(51):34157-34163. (Pubitemid 29008888)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.51 , pp. 34157-34163
    • Deng, X.1    Ito, T.2    Carr, B.3    Mumby, M.4    May Jr., W.S.5
  • 102
    • 0027857930 scopus 로고
    • Intracellular signalling by phospholipid hydrolysis and protein kinase C activation
    • Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992; 258:607-614. (Pubitemid 24075388)
    • (1993) Biomedical Research , vol.14 , Issue.SUPPL. 2 , pp. 93-98
    • Asaoka, Y.1    Nakamura -i., S.2    Nishizuka, Y.3
  • 103
    • 34447545755 scopus 로고    scopus 로고
    • Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-Induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3
    • DOI 10.1093/toxsci/kfm054
    • Komatsu M, Furukawa T, Ikeda R, Takumi S, Nong Q, Aoyama K, Akiyama S, Keppler D, Takeuchi T. Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3. Toxicol. Sci 2007; 97(2):407-416. (Pubitemid 47073856)
    • (2007) Toxicological Sciences , vol.97 , Issue.2 , pp. 407-416
    • Komatsu, M.1    Furukawa, T.2    Ikeda, R.3    Takumi, S.4    Nong, Q.5    Aoyama, K.6    Akiyama, S.-I.7    Keppler, D.8    Takeuchi, T.9
  • 104
    • 47349101596 scopus 로고    scopus 로고
    • Involvement of JNK regulation in oxidative stress-mediated murine liver in JURY by Microcystine-LR
    • Wei Y, Weng D, Li F, Zou X, Young DO, Ji J, Shen P. Involvement of JNK regulation in oxidative stress-mediated murine liver in JURY by Microcystine-LR. Apoptosis 2008; 13:1031-1042.
    • (2008) Apoptosis , vol.13 , pp. 1031-1042
    • Wei, Y.1    Weng, D.2    Li, F.3    Zou, X.4    Young, D.O.5    Ji, J.6    Shen, P.7
  • 106
    • 42149140039 scopus 로고    scopus 로고
    • Chronic microcystin exposure induces hepatocyte proliferation with increased expression of mitotic and cyclinassociated genes in P53-deficient mice
    • Clark SP, Ryan TP, Searfoss GH, Davis MA, Hooser SB. Chronic microcystin exposure induces hepatocyte proliferation with increased expression of mitotic and cyclinassociated genes in P53-deficient mice. Toxicologic Pathology 2008; 36(2):190-203.
    • (2008) Toxicologic Pathology , vol.36 , Issue.2 , pp. 190-203
    • Clark, S.P.1    Ryan, T.P.2    Searfoss, G.H.3    Davis, M.A.4    Hooser, S.B.5
  • 107
    • 0027272945 scopus 로고
    • Tumor promotion by inhibitors of protein phosphatases 1 and 2A: The okadaic acid class of compounds
    • Fujiki H, Suganuma M. Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds. Adv. Cancer Res 1993; 61:143-194. (Pubitemid 23266387)
    • (1993) Advances in Cancer Research , vol.61 , pp. 143-194
    • Fujiki, H.1    Suganuma, M.2
  • 108
    • 0033018236 scopus 로고    scopus 로고
    • Okadaic acid mediates p53 hyperphosphorylation and growth arrest in cells with wild-type p53 but increases aberrant mitoses in cells with non-functional p53
    • DOI 10.1093/carcin/20.6.1043
    • Milczarek GJ, Chen W, Gupta A, Martinez JD, Bowden T. Okadaic acid mediates p53 hyperphosphorylation and growth arrest in cells with wild-type p53 but increases aberrant mitoses in cells with non-functional p53. Carcinogenesis 1999; 20(6):1043-1048. (Pubitemid 29263749)
    • (1999) Carcinogenesis , vol.20 , Issue.6 , pp. 1043-1048
    • Milczarek, G.J.1    Chen, W.2    Gupta, A.3    Martinez, J.D.4    Bowden, G.T.5
  • 110
    • 58049209250 scopus 로고    scopus 로고
    • The expression of p53 and p16 in the course of microcystin-LR inducing of liver tumor
    • Hu Z, Chen H, Pang C, Lin Q. The expression of p53 and p16 in the course of microcystin-LR inducing of liver tumor. The Chinese-German Journal of Clinical Oncology 2008; 7(12):690-693.
    • (2008) The Chinese-German Journal of Clinical Oncology , vol.7 , Issue.12 , pp. 690-693
    • Hu, Z.1    Chen, H.2    Pang, C.3    Lin, Q.4
  • 111
    • 46349094295 scopus 로고    scopus 로고
    • The role of p53 tumor-suppressor protein in apoptosis and cancerogenesis
    • Maximov GK, Maximov KG. The role of p53 tumor-suppressor protein in apoptosis and cancerogenesis. Biotechnology & Biotechnological Equipment 2008:664-668. (Pubitemid 351920006)
    • (2008) Biotechnology and Biotechnological Equipment , vol.22 , Issue.2 , pp. 664-668
    • Maximov, G.K.1    Maximov, K.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.