A pilot genome-scale profiling of DNA methylation in sporadic pituitary macroadenomas: Association with Tumor invasion and histopathological subtype

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Ling, Chao ^a,b   Pease, Matthew ^b   Shi, Lingling ^b   Punj, Vasu ^b   Shiroishi, Mark S ^b   Commins, Deborah ^b   Weisenberger, Daniel J ^b   Wang, Kai ^b   Zada, Gabriel ^b  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA;

ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENOME ANALYSIS; GROWTH HORMONE SECRETING CELL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; KCNAB2 GENE; MALE; MOLECULAR PATHOLOGY; PROMOTER REGION; SCORING SYSTEM; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TUMOR GENE; TUMOR INVASION;

ADENOMA; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CPG ISLANDS; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; PITUITARY GLAND; PITUITARY NEOPLASMS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROMOTER REGIONS, GENETIC;

EID: 84899707649     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096178     Document Type: Article

References (53)

1. Ezzat S, Asa SL, Couldwell WT, Barr CE, Dodge WE, et al. (2004) The prevalence of pituitary adenomas: a systematic review. Cancer 101: 613-619. (Pubitemid 38970613)
2. Nammour GM, Ybarra J, Naheedy MH, Romeo JH, Aron DC (1997) Incidental pituitary macroadenoma: a population-based study. Am J Med Sci 314: 287-291. (Pubitemid 27481524)
3. Zada G, Woodmansee WW, Ramkissoon S, Amadio J, Nose V, et al. (2011) Atypical pituitary adenomas: incidence, clinical characteristics, and implications. J Neurosurg 114: 336-344.
4. Knosp E, Steiner E, Kitz K, Matula C (1993) Pituitary adenomas with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings. Neurosurgery 33: 610-617; discussion 617-618.
5. Chandrasekharappa SC, Guru SC, Manickam P, Olufemi SE, Collins FS, et al. (1997) Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276: 404-407.
6. Dudley KJ, Revill K, Clayton RN, Farrell WE (2009) Pituitary tumours: all silent on the epigenetics front. J Mol Endocrinol 42: 461-468.
7. Simpson DJ, Bicknell JE, McNicol AM, Clayton RN, Farrell WE (1999) Hypermethylation of the p16/CDKN2A/MTSI gene and loss of protein expression is associated with nonfunctional pituitary adenomas but not somatotrophinomas. Genes Chromosomes Cancer 24: 328-336. (Pubitemid 29115871)
8. Woloschak M, Yu A, Post KD (1997) Frequent inactivation of the p16 gene in human pituitary tumors by gene methylation. Mol Carcinog 19: 221-224. (Pubitemid 27391999)
9. Bahar A, Bicknell JE, Simpson DJ, Clayton RN, Farrell WE (2004) Loss of expression of the growth inhibitory gene GADD45gamma, in human pituitary adenomas, is associated with CpG island methylation. Oncogene 23: 936-944. (Pubitemid 38250939)
10. Farrell WE (2006) A novel apoptosis gene identified in the pituitary gland. Neuroendocrinology 84: 217-221.
11. Qian ZR, Sano T, Yoshimoto K, Asa SL, Yamada S, et al. (2007) Tumor-specific downregulation and methylation of the CDH13 (H-cadherin) and CDH1 (E-cadherin) genes correlate with aggressiveness of human pituitary adenomas. Mod Pathol 20: 1269-1277. (Pubitemid 350126852)
12. Yuan Y, Qian ZR, Sano T, Asa SL, Yamada S, et al. (2008) Reduction of GSTP1 expression by DNA methylation correlates with clinicopathological features in pituitary adenomas. Mod Pathol 21: 856-865. (Pubitemid 351896660)
13. Duong CV, Emes RD, Wessely F, Yacqub-Usman K, Clayton RN, et al. (2012) Quantitative, genome-wide analysis of the DNA methylome in sporadic pituitary adenomas. Endocr Relat Cancer 19: 805-816.
14. Pease M, Ling C, Mack WJ, Wang K, Zada G (2013) The role of epigenetic modification in tumorigenesis and progression of pituitary adenomas: a systematic review of the literature. PLoS One 8: e82619.
15. Triche TJ Jr, Weisenberger DJ, Van Den Berg D, Laird PW, Siegmund KD (2013) Low-level processing of Illumina Infinium DNA Methylation BeadArrays. Nucleic Acids Res 41: e90.
16. Saeed AI, Bhagabati NK, Braisted JC, Liang W, Sharov V, et al. (2006) TM4 microarray software suite. Methods Enzymol 411: 134-193.
17. Weisenberger DJ, Siegmund KD, Campan M, Young J, Long TI, et al. (2006) CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet 38: 787-793. (Pubitemid 43980599)
18. Weisenberger DJ, Campan M, Long TI, Kim M, Woods C, et al. (2005) Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res 33: 6823-6836. (Pubitemid 41830488)
19. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, et al. (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102: 15545-15550. (Pubitemid 41528093)
20. Ebert MP, Tanzer M, Balluff B, Burgermeister E, Kretzschmar AK, et al. (2012) TFAP2E-DKK4 and chemoresistance in colorectal cancer. N Engl J Med 366: 44-53.
21. Payne SR, Serth J, Schostak M, Kamradt J, Strauss A, et al. (2009) DNA methylation biomarkers of prostate cancer: confirmation of candidates and evidence urine is the most sensitive body fluid for non-invasive detection. Prostate 69: 1257-1269.
22. Chambers TJ, Giles A, Brabant G, Davis JR (2013) Wnt signalling in pituitary development and tumorigenesis. Endocr Relat Cancer 20: R101-111.
23. McCormack T, McCormack K, Nadal MS, Vieira E, Ozaita A, et al. (1999) The effects of Shaker beta-subunits on the human lymphocyte K+ channel Kv1.3. J Biol Chem 274: 20123-20126.
24. Yu FH, Yarov-Yarovoy V, Gutman GA, Catterall WA (2005) Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacol Rev 57: 387-395. (Pubitemid 43036430)
25. Herman JG, Merlo A, Mao L, Lapidus RG, Issa JP, et al. (1995) Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55: 4525-4530.
26. Baylin SB, Herman JG (2000) DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 16: 168-174. (Pubitemid 30169152)
27. Garcia L, Fahmi M, Prevarskaya N, Dufy B, Sartor P (1997) Modulation of voltage-dependent Ca2+ conductance by changing Cl- concentration in rat lactotrophs. Am J Physiol 272: C1178-1185.
28. Gonzalez-Iglesias AE, Jiang Y, Tomic M, Kretschmannova K, Andric SA, et al. (2006) Dependence of electrical activity and calcium influx-controlled prolactin release on adenylyl cyclase signaling pathway in pituitary lactotrophs. Mol Endocrinol 20: 2231-2246. (Pubitemid 44286716)
29. Jones PA (2012) Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet 13: 484-492.
30. Selman WR, Laws ER Jr, Scheithauer BW, Carpenter SM (1986) The occurrence of dural invasion in pituitary adenomas. J Neurosurg 64: 402-407. (Pubitemid 16035061)
31. Zada G, Kelly DF, Cohan P, Wang C, Swerdloff R (2003) Endonasal transsphenoidal approach for pituitary adenomas and other sellar lesions: an assessment of efficacy, safety, and patient impressions. J Neurosurg 98: 350-358. (Pubitemid 36151031)
32. Ogino A, Yoshino A, Katayama Y, Watanabe T, Ota T, et al. (2005) The p15(INK4b)/p16(INK4a)/RB1 pathway is frequently deregulated in human pituitary adenomas. J Neuropathol Exp Neurol 64: 398-403. (Pubitemid 40629130)
33. Farrell WE, Simpson DJ, Frost SJ, Clayton RN (1999) Methylation mechanisms in pituitary tumorigenesis. Endocr Relat Cancer 6: 437-447. (Pubitemid 30048455)
34. Jaffrain-Rea ML, Ferretti E, Toniato E, Cannita K, Santoro A, et al. (1999) p16 (INK4a, MTS-1) gene polymorphism and methylation status in human pituitary tumours. Clin Endocrinol (Oxf) 51: 317-325. (Pubitemid 29439051)
35. Mezzomo LC, Gonzales PH, Pesce FG, Kretzmann Filho N, Ferreira NP, et al. (2012) Expression of cell growth negative regulators MEG3 and GADD45-gamma is lost in most sporadic human pituitary adenomas. Pituitary 15: 420-427.
36. Seemann N, Kuhn D, Wrocklage C, Keyvani K, Hackl W, et al. (2001) CDKN2A/p16 inactivation is related to pituitary adenoma type and size. J Pathol 193: 491-497. (Pubitemid 32266818)
37. Zhang B, Dietrich UM, Geng JG, Bicknell R, Esko JD, et al. (2009) Repulsive axon guidance molecule Slit3 is a novel angiogenic factor. Blood 114: 4300-4309.
38. Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, et al. (2005) VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438: 820-827. (Pubitemid 41753060)
39. Melmed S (2003) Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest 112: 1603-1618.
40. Black PM, Hsu DW, Klibanski A, Kliman B, Jameson JL, et al. (1987) Hormone production in clinically nonfunctioning pituitary adenomas. J Neurosurg 66: 244-250. (Pubitemid 17027882)
41. Herman V, Fagin J, Gonsky R, Kovacs K, Melmed S (1990) Clonal origin of pituitary adenomas. J Clin Endocrinol Metab 71: 1427-1433. (Pubitemid 120032755)
42. Dai XQ, Manning Fox JE, Chikvashvili D, Casimir M, Plummer G, et al. (2012) The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function. Diabetologia 55: 1709-1720.
43. Kidokoro Y (1975) Spontaneous calcium action potentials in a clonal pituitary cell line and their relationship to prolactin secretion. Nature 258: 741-742.
44. McCormack K, Connor JX, Zhou L, Ho LL, Ganetzky B, et al. (2002) Genetic analysis of the mammalian K+ channel beta subunit Kvbeta 2 (Kcnab2). J Biol Chem 277: 13219-13228. (Pubitemid 34952693)
45. Weng J, Cao Y, Moss N, Zhou M (2006) Modulation of voltage-dependent Shaker family potassium channels by an aldo-keto reductase. J Biol Chem 281: 15194-15200. (Pubitemid 43862162)
46. Andreoli V, Trecroci F, La Russa A, Di Palma G, Quattrone A, et al. (2008) Gene symbol: PSEN2. Disease: Alzheimer disease. Hum Genet 124: 304.
47. Bassler J, Kallas M, Pertschy B, Ulbrich C, Thoms M, et al. (2010) The AAA-ATPase Rea1 drives removal of biogenesis factors during multiple stages of 60S ribosome assembly. Mol Cell 38: 712-721.
48. Desvignes T, Pontarotti P, Fauvel C, Bobe J (2009) Nme protein family evolutionary history, a vertebrate perspective. BMC Evol Biol 9: 256.
49. Dong W, Marcinkiewicz M, Vieau D, Chretien M, Seidah NG, et al. (1995) Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary. J Neurosci 15: 1778-1796.
50. Piwonska M, Wilczek E, Szewczyk A, Wilczynski GM (2008) Differential distribution of Ca2+-activated potassium channel beta4 subunit in rat brain: immunolocalization in neuronal mitochondria. Neuroscience 153: 446-460.
51. Nishioka M, Shimada T, Bundo M, Ukai W, Hashimoto E, et al. (2013) Neuronal cell-type specific DNA methylation patterns of the Cacna1c gene. Int J Dev Neurosci 31: 89-95.
52. Kestler DP, Foster JS, Macy SD, Murphy CL, Weiss DT, et al. (2008) Expression of odontogenic ameloblast-associated protein (ODAM) in dental and other epithelial neoplasms. Mol Med 14: 318-326. (Pubitemid 351785705)
53. Kekeeva TV, Popova OP, Shegai PV, Alekseev B, Adnreeva I, et al. (2007) [Abberant methylation of p16, HIC1, N33 and GSTP1 genes in tumor epitelium and tumor-associated stromal cells of prostate cancer]. Mol Biol (Mosk) 41: 79-85.