Hypermethylation of the p16/CDKN2A/MTSI gene and loss of protein expression is associated with nonfunctional pituitary adenomas but not somatotrophinomas

Genes Chromosomes and Cancer

Volumn 24, Issue 4, 1999, Pages 328-336

  Simpson, David J ^a   Bicknell, John E ^a   McNicol, Anne Marie ^b   Clayton, Richard N ^a   Farrell, William E ^a  

^a UNIVERSITY HOSPITAL OF NORTH STAFFORDSHIRE   (United Kingdom)

^b GLASGOW ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR;

ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME BAND; CPG ISLAND; DNA METHYLATION; GENE AMPLIFICATION; GENE INACTIVATION; GENE SILENCING; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RESTRICTION MAPPING; SEQUENCE ANALYSIS; TUMOR SUPPRESSOR GENE;

EID: 0033044772     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1098-2264(199904)24:4<328::aid-gcc6>3.0.co;2-p     Document Type: Article

References (32)

1. Alexander JM, Biller BMK, Bikkal H, Zervas NT, Arnold A, Klibanski A. 1990. Clinically non-functioning pituitary tumors are monoclonal in origin. J Clin Invest 86:336-340.
2. Bates AS, Farrell WE, Bicknell EJ, Talbot AJ, Broome JC, Perrett CW, Thakker RV, Clayton RN. 1997. Allelic deletion in pituitary adenomas reflects aggressive biological activity and has potential value as a prognostic marker. J Clin Endocrinol Metab 82:818-824.
3. Boggild MD, Jenkinson S, Pistorello M, Boscaro M. Scanarini M, Mcternan P, Perrett CW, Thakker RV, Clayton RN. 1994. Molecular genetic studies of sporadic pituitary tumors. J Clin Endocrinol Metab 78:387-392.
4. Cairns P, Tokino K, Eby Y, Sidransky D. 1994. Homozygous deletion of 9p21 in primary human bladder tumors detected by comparative multiplex chain reaction. Cancer Res 54:1422-1424.
5. Costello JF, Berger MS, Su Huang H-J, Cavenee WK. 1996. Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res 56:2405-2410.
6. Farrell WE, Simpson DJ, Bicknell EJ, Talbot AJ, Bates AS, Clayton RN. 1997. Chromosome 9p deletions in invasive and non-invasive non-functional pituitary adenomas: the deleted region involves markers outside of the MTS1 and MTS2 genes. Cancer Res 57:2703-2709.
7. Fearon ER, Vogelstein B. 1990. A genetic model for colorectal tumorigenesis. Cell 61:759-767.
8. Gonzalez-Zulueta M, Bender CM, Yang AS, Nguyen T, Beart RW, Van Tornout JM, Jones PA. 1995. Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 55:4531-4535.
9. Hardy J. 1979. Transphenoidal microsurgical treatment of pituitary tumors. In Linfoot J, editor. Recent advances in the diagnosis and treatment of pituitary tumors. New York: Raven Press, p 375-388.
10. Jameson JL, Klibanski A, Black PM, Zervas NT, Lindell CM, Hsu DW, Ridgway EC, Habener JF. 1987. Glycoprotein hormone genes are expressed in clinically nonfunctioning pituitary adenomas. J Clin Invest 80:1472-1478.
11. Jones PA. 1996. DNA methylation errors and cancer. Cancer Res 56:2463-2467.
12. Kamb A. 1995. Cell cycle regulators and cancer. Trends Genetics 11:136-140.
13. Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavigian SV, Stockert E, Day III RS, Johnson BE, Skolnick MH. 1994. A cell cycle regulator potentially involved in genesis of many tumors. Science 265:415-417.
14. Kishimoto Y, Sugio K, Hung JY, Virmani AK, Mcintire DD, Minna JD, Gazdar AF. 1995. Allele specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small cell lung cancers. J Natl Cancer Inst 87:1224-1229.
15. ink4a cyclin-dependent kinase inhibitor in malignant mesothelioma. J Nat Cancer Inst 87:1870-1875.
16. Lo K-W, Cheung S-T, Leung S-F, van Hasselt A, Tsang Y-S, Mak K-F, Chung Y-F, Woo JKS, Lee JCK, Huang DP. 1996. Hypermethylation of the p16 gene in nasopharyngeal carcinoma. Cancer Res 56:2721-2725.
17. Maesawa C, Tamura G, Nishizuka S, Ogasawara S, Ishida K, Terashima M, Sakata K, Sato S, Saito K, Satodate R. 1996. Inactivation of the CDKN2 gene by homozygous deletion and de novo methylation is associated with advanced stage esophageal cell carcinoma. Cancer Res 56:3875-3878.
18. Makos M, Nelkin BD, Reiter RE, Gnarra JR, Brooks J, Isaacs W, Linehan M, Baylin SB. 1993a. Regional DNA hypermethylation at D17S5 preceeds 17p structural changes in the progression of renal tumors. Cancer Res 53:2719-2722.
19. Makos M, Nelkin BD, Chazin VR, Cavenee WK, Brodeur GM, Baylin SB. 1993b. DNA Hypermethylation is associated with 17p allelic loss in neural tumors. Cancer Res 53:2715-2718.
20. Melmed S. 1994. Pituitary neoplasia. Endocrin Metab Clinics North Am 23:81-92.
21. Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D. 1995. 5' CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1:686-692.
22. ink4a alleles in neoplasia. Cancer Res 58:591-593.
23. Ng MHL, Chung YK, Lo KW, Wickham NWR, Lee JCK, Huang DP. 1997. Frequent hypermethylation of p16 and p15 genes in multiple myeloma. Blood 89:2500-2506.
24. Otterson GA, Khleif SN, Chen W, Coxon AB, Kaye FJ. 1995. CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16ink4 protein induction by 5-aza-2'deoxycytidine. Oncogene 11:1211-1216.
25. Pei L, Melmed S, Scheithauser B, Kovaks K, Prager D. 1995. Frequent loss of heterozygosity at the retinoblastoma gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumor supressor gene other than RB. Cancer Res 55:644-646.
26. Schmutte C, Yang AS, Nguyen TT, Beart RW, Jones PA. 1996. Mechanisms for the involvement of DNA methylation in colon carcinogenesis. Cancer Res 56:2375-238.
27. Serrano M, Hannon GJ, Beach D. 1993. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature 366:704-707.
28. Thakker RV. 1993. The molecular genetics of the multiple endocrine neoplasia syndrome. Clin Endo 38:1-14.
29. van dier Riet P, Nawroz H, Hruban RH, Corio R, Tokino K, Sidransky D. 1994. Frequent loss on chromosome 9p21-22 early in head and neck cancer progression. Cancer Res 54:1156-1158.
30. ink4a gene product in pituitary tumors. Cancer Res 56:2493-2496.
31. Woloschak M, Yu A, Post KD. 1997. Frequent inactivation of the p16 gene in human pituitary tumors by gene methylation. Mol Carcinog 19:221-224.
32. Zingg J-M, Jones PA. 1997. Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis 18:869-882.