Modulation of regulatory T-cell subsets in very long-term treated aviremic HIV+ patients and untreated viremic patients

Open AIDS Journal

Volumn 8, Issue 1, 2014, Pages 1-6

  Serana, Federico ^a   Chiarini, Marco ^a   Quiros Roldan, Eugenia ^b   Gotti, Daria ^b   Zanotti, Cinzia ^a   Sottini, Alessandra ^a   Bertoli, Diego ^a   Caimi, Luigi ^a   Imberti, Luisa ^a  

^a Laboratory of Biotechnology   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Combined antiretroviral therapy; HIV; Regulatory T cells

Indexed keywords

EFAVIRENZ; LAMIVUDINE; LOPINAVIR; RITONAVIR; TENOFOVIR; ZIDOVUDINE;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELL COUNT; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 84899703716     PISSN: None     EISSN: 18746136     Source Type: Journal    
DOI: 10.2174/1874613601408010001     Document Type: Article

References (34)

1. Chevalier MF, Weiss L. The split personality of regulatory T cells in HIV infection. Blood 2013; 121: 29-37.
2. Fazekas de St Groth B, Landay AL. Regulatory T cells in HIV infection: pathogenic or protective participants in the immune response? AIDS 2008; 22: 671-83.
3. Epple HJ, Loddenkemper C, Kunkel D, et al. Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART. Blood 2006; 108: 3072-8.
4. Estes JD, Li Q, Reynolds MR, et al. Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection. J Infect Dis 2006; 193: 703-12.
5. Baker CAR, Clark R, Ventura F, et al. Peripheral CD4 loss of regulatory T cells is associated with persistent viraemia in chronic HIV infection. Clin Exp Immunol 2007; 147: 533-9.
6. Eggena MP, Barugahare B, Jones N, et al. Depletion of regulatory T cells in HIV infection is associated with immune activation. J Immunol 2005; 174: 4407-14.
7. Schulze Zur Wiesch J, Thomssen A, Hartjen P, et al. Comprehensive analysis of frequency and phenotype of T regulatory cells in HIV infection: CD39 expression of FoxP3+ T regulatory cells correlates with progressive disease. J Virol 2011; 85: 1287-97.
8. Del Pozo-Balado MDM, Leal M, Méndez-Lagares G, Pacheco YM. CD4(+)CD25(+/hi)CD127(lo) phenotype does not accurately identify regulatory T cells in all populations of HIV-infected persons. J Infect Dis 2010; 201: 331-5.
9. Foxall RB, Albuquerque AS, Soares RS, et al. Memory and naivelike regulatory CD4+ T cells expand during HIV-2 infection in direct association with CD4+ T-cell depletion irrespectively of viremia. AIDS 2011; 25: 1961-70.
10. Aandahl EM, Michaëlsson J, Moretto WJ, Hecht FM, Nixon DF. Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens. J Virol 2004; 78: 2454-9.
11. Weiss L, Donkova-Petrini V, Caccavelli L, et al. Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients. Blood 2004; 104: 3249-56.
12. Montes M, Sanchez C, Lewis DE, et al. Normalization of FoxP3+ Regulatory T cells in response to effective antiretroviral therapy. J Infect Dis 2010; 203: 496-9.
13. Seddiki N, Santner-Nanan B, Tangye SG, et al. Persistence of naive CD45RA+ regulatory T cells in adult life. Blood 2006; 107: 2830-8.
14. Hunt PW, Landay AL, Sinclair E, et al. A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers. PLoS ONE 2011; 6: e15924.
15. Lim A, Tan D, Price P, et al. Proportions of circulating T cells with a regulatory cell phenotype increase with HIV-associated immune activation and remain high on antiretroviral therapy. AIDS 2007; 21: 1525-34.
16. Tenorio AR, Martinson J, Pollard D, Baum L, Landay A. The relationship of T-regulatory cell subsets to disease stage, immune activation, and pathogen-specific immunity in HIV Infection. J Acquir Immune Defic Syndr 2008; 48: 577-80.
17. Simonetta F, Lecuroux C, Girault I, et al. Early and long-lasting alteration of effector CD45RA-Foxp3high regulatory T-cell homeostasis during HIV infection. J Infect Dis 2012; 205: 1510-9.
18. Kimmig S, Przybylski GK, Schmidt CA, et al. Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J Exp Med 2002; 195: 789-94.
19. Haas J, Fritzsching B, Trübswetter P, et al. Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis. J Immunol 2007; 179: 1322-30.
20. Miyara M, Yoshioka Y, Kitoh A, et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 2009; 30: 899-911.
21. Sallusto F, Lenig D, Förster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401: 708-12.
22. Tosello V, Odunsi K, Souleimanian NE, et al. Differential expression of CCR7 defines two distinct subsets of human memory CD4+CD25+ Tregs. Clin Immunol 2008; 126: 291-302.
23. Menning A, Höpken UE, Siegmund K, et al. Distinctive role of CCR7 in migration and functional activity of naive-and effector/memory-like Treg subsets. Eur J Immunol 2007; 37: 1575-83.
24. Zhou H, Zhao H, Hao Y, et al. Excessive conversion and impaired thymic output contribute to disturbed regulatory T-cell homeostasis in AIDS patients with low CD4 cell counts. AIDS 2013; 27: 1059-69.
25. Oswald-Richter K, Grill SM, Shariat N, et al. HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells. PLoS Biol 2004; 2: e198.
26. Deeks SG, Kitchen CMR, Liu L, et al. Immune activation set point during early HIV Infection predicts subsequent CD4+ T-cell changes independent of viral load. Blood 2004; 104: 942-7.
27. Boyman O, Létourneau S, Krieg C, Sprent J. Homeostatic proliferation and survival of naïve and memory T cells. Eur J Immunol 2009; 39: 2088-94.
28. Juffroy O, Bugault F, Lambotte O, et al. Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway. J Virol 2009; 84: 96-108.
29. Santner-Nanan B, Seddiki N, Zhu E, et al. Accelerated agedependent transition of human regulatory T cells to effector memory phenotype. Int Immunol 2008; 20: 375-83.
30. Cellerai C, Harari A, Stauss H, et al. Early and prolonged antiretroviral therapy is associated with an HIV-1-specific T-cell profile comparable to that of long-term non-progressors. PLoS ONE 2011; 6: e18164.
31. Guihot A, Tubiana R, Breton G, et al. Immune and virological benefits of 10 years of permanent viral control with antiretroviral therapy. AIDS 2010; 24: 614-7.
32. Mercier F, Boulassel M-R, Yassine-Diab B, et al. Persistent human immunodeficiency virus-1 antigenaemia affects the expression of interleukin-7Ralpha on central and effector memory CD4+ and CD8+ T cell subsets. Clin Exp Immunol 2008; 152: 72-80.
33. Kiazyk SAK, Fowke KR. Loss of CD127 expression links immune activation and CD4+ T cell loss in HIV infection. Trends Microbiol 2008; 16: 567-73.
34. Allan SE, Crome SQ, Crellin NK, et al. Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol 2007; 19: 345-54.