Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets

European Journal of Immunology

Volumn 37, Issue 6, 2007, Pages 1575-1583

  Menning, Astrid ^a   Höpken, Uta E ^b   Siegmund, Kerstin ^a   Lipp, Martin ^b   Hamann, Alf ^a   Huenn, Jochen ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Cell trafficking; Chemokines; Inflammation; Suppression; T cell

Indexed keywords

CHEMOKINE RECEPTOR CCR7;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; IN VIVO STUDY; INFLAMMATION; LYMPH NODE; LYMPHOCYTE FUNCTION; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ADOPTIVE TRANSFER; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; CELL PROLIFERATION; FORKHEAD TRANSCRIPTION FACTORS; HYPERSENSITIVITY, DELAYED; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, TRANSGENIC; OVALBUMIN; PEPTIDE FRAGMENTS; RECEPTORS, CHEMOKINE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; VACCINATION;

EID: 34250630932     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200737201     Document Type: Article

References (44)

1. + regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 2005. 6: 345-352.
2. Huehn, J. and Hamann, A., Homing to suppress: Address codes for Treg migration. Trends Immunol. 2005. 26: 632-636.
3. + regulatory T cells. J. Exp. Med. 2004. 199: 303-313.
4. Bluestone, J. A. and Abbas, A. K., Natural versus adaptive regulatory Tcells. Nat. Rev. Immunol. 2003. 3: 253-257
5. + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J. Immunol. 2002. 169: 2461-2465.
6. Valmori, D., Merlo, A., Souleimanian, N. E., Hesdorffer, C. S. and Ayyoub, M., A peripheral circulating compartment of natural naive CD4 Tregs. J. Clin. Invest. 2005. 115: 1953-1962.
7. + regulatory T cells. J. Exp. Med. 2001. 194: 847-853.
8. + Tcells represent major subsets of human peripheral blood memory T cells migrating in response to CCL1/I-309. Eur. J. Immunol. 2002. 32: 3506-3514.
9. + T helper cells. Eur. J. Immunol. 2004. 34: 1303-1311.
10. + T-cell subset. Blood 2005. 105: 2877-2886.
11. + regulatory T cells. J. Immunol. 2006. 177: 840-851.
12. Eksteen, B., Miles, A., Curbishley, S. M., Tselepis, C., Grant, A. J., Walker, L. S. and Adams, D. H., Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10. J. Immunol. 2006. 177: 593-603.
13. Siegmund, K., Feuerer, M., Siewert, C., Ghani, S., Haubold, U., Dankof, A., Krenn, V. et al., Migration matters: Regulatory T cell compartmentalization determines suppressive activity in vivo. Blood 2005. 106: 3097-3104.
14. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 2000. 164: 183-190.
15. Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M. et al., Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 2004. 10: 942-949.
16. + regulatory T cells during acute graft-versus-host disease. Blood 2005. 106: 3300-3307.
17. + T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor. J. Exp. Med. 2005. 201: 1037-1044.
18. Sallusto, F., Lenig, D., Forster, R., Lipp, M. and Lanzavecchia, A., Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999. 401: 708-712.
19. + T cells express functional CCR7. J. Immunol. 2002. 168: 5441-5447.
20. Cyster, J. G., Chemokines and cell migration in secondary lymphoid organs. Science 1999. 286: 2098-2102.
21. Foerster, R., Schubel, A., Breitfeld, D., Kremmer, E., Renner-Muller, I., Wolf, E. and Lipp, M., CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 1999. 99: 23-33.
22. Hopken, U. E., Droese, J., Li, J. P., Joergensen, J., Breitfeld, D., Zerwes, H. G. and Lipp, M., The chemokine receptor CCR7 controls lymph node-dependent cytotoxic T cell priming in alloimmune responses. Eur. J. Immunol. 2004. 34: 461-470.
23. Junt, T., Scandella, E., Forster, R., Krebs, P., Krautwald, S., Lipp, M., Hengartner, H. and Ludewig, B., Impact of CCR7 on priming and distribution of antiviral effector and memory CTL. J. Immunol. 2004. 173: 6684-6693.
24. Kursar, M., Hopken, U. E., Koch, M., Kohler, A., Lipp, M., Kaufmann, S. H. and Mittrucker, H. W., Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection. J. Exp. Med. 2005. 201: 1447-1457.
25. Fontenot, J. D., Rasmussen, J. P., Williams, L. M., Dooley, J. L., Farr, A. G. and Rudensky, A. Y., Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 2005. 22: 329-341.
26. Debes, G. F., Arnold, C. N., Young, A. J., Krautwald, S., Lipp, M., Hay, J. B. and Butcher, E. C., Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nat. Immunol. 2005. 6: 889-894.
27. Bromley, S. K., Thomas, S. Y. and Luster, A. D., Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat. Immunol. 2005. 6: 895-901.
28. Höpken, U. E., Wengner, A. M., Loddenkemper, C., Stein, H., Heimesaat, M. M., Rehm, A. and Lipp, M., CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity. Blood 2007. 109: 886-895.
29. + regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J. Exp. Med. 2006. 203: 2451-2460.
30. + regulatory T cells in the hematolymphoid system. Exp. Hematol. 2006. 34: 1033-1040.
31. + suppressor T cells. Eur J. Immunol. 2003. 33: 1488-1496.
32. + regulatory T cells bear functional skin-homing receptors. J. Immunol. 2006. 177: 4488-4494.
33. high Tcells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 2006. 108: 4260-4267.
34. + T cells undergo conventional first switch to lymphoid tissue homing receptors in thymus but accelerated second switch to nonlymphoid tissue homing receptors in secondary lymphoid tissues. J. Immunol. 2007. 178: 301-311.
35. + T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood 2004. 104: 3804-3812.
36. + regulatory T cells protects from lethal acute GVHD. Blood 2005. 105: 2220-2226.
37. Tang, Q., Adams, J. Y., Tooley, A. J., Bi, M., Fife, B. T., Serra, P., Santamaria, P. et al., Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat. Immunol. 2006. 7: 83-92.
38. + regulatory T cell homing. Eur. J. Immunol. 2007. 37: 978-989.
39. Dudda, J. C. and Martin, S. F., Tissue targeting of T cells by DCs and microenvironments. Trends Immunol. 2004. 25: 417-421.
40. Mora, J. R. and von Andrian, U. H., T-cell homing specificity and plasticity: New concepts and future challenges. Trends Immunol. 2006. 27: 235-243.
41. + T reg cells impinge on autoimmune diabetes. J. Exp. Med. 2005. 202: 1387-1397.
42. Clark, R. A. and Kupper, T. S., IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin, Blood 2007. 109: 194-202.
43. + T cells depends on antigen specificity and tissue localization during influenza A virus infection. J. Virol. 2004. 78: 7528-7535.
44. - regulatory T cells. Proc. Natl. Acad. Sci. USA 2002. 99: 13031-13036.