Association of single-nucleotide polymorphisms in TLR7 (Gln11Leu) and TLR9 (1635A/G) with a higher CD4T cell count during HIV infection

Immunology Letters

Volumn 160, Issue 1, 2014, Pages 58-64

  Said, E A ^a   Al Yafei, F ^a   Zadjali, F ^a   Hasson, S S ^a   Al Balushi, M S ^a   Al Mahruqi, S ^a   Koh, C Y ^a   Al Naamani, K ^b   Al Busaidi, J Z ^a   Idris, M A ^a   Balkhair, A ^a   Al Jabri, A A ^a  

^a SULTAN QABOOS UNIVERSITY   (Oman)

^b Armed Forces Hospital   (Oman)

Author keywords

CD4T cells; HIV; Single nucleotide polymorphism (SNP); Toll like receptor; Viremic

Indexed keywords

GLYCINE; LEUCINE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HOMOZYGOSITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TLR7 GENE; TLR9 GENE; VIREMIA; VIRUS GENOME; VIRUS PATHOGENESIS; ALLELE; AMINO ACID SUBSTITUTION; CASE CONTROL STUDY; GENETICS; GENOTYPE; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; MIDDLE AGED; VIROLOGY; VIRUS LOAD;

ADULT; ALLELES; AMINO ACID SUBSTITUTION; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; FEMALE; GENE FREQUENCY; GENOTYPE; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 9; VIRAL LOAD;

EID: 84899699338     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2014.04.005     Document Type: Article

References (33)

1. Fevrier M., Dorgham K., Rebollo A. CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis. Viruses 2011, 3:586-612.
2. Gaardbo J.C., Hartling H.J., Gerstoft J., Nielsen S.D. Incomplete immune recovery in HIV infection: mechanisms, relevance for clinical care, and possible solutions. Clin Dev Immunol 2012, 2012:670957.
3. Poropatich K., Sullivan D.J. Human immunodeficiency virus type 1 long-term non-progressors: the viral, genetic and immunological basis for disease non-progression. J Gen Virol 2011, 92:247-268.
4. Wille-Reece U., Flynn B.J., Lore K., Koup R.A., Kedl R.M., Mattapallil J.J., et al. HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates. Proc Natl Acad Sci U S A 2005, 102:15190-15194.
5. Wille-Reece U., Flynn B.J., Lore K., Koup R.A., Miles A.P., Saul A., et al. Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates. J Exp Med 2006, 203:1249-1258.
6. Wang F.X., Huang J., Zhang H., Ma X. APOBEC3G upregulation by alpha interferon restricts human immunodeficiency virus type 1 infection in human peripheral plasmacytoid dendritic cells. J Gen Virol 2008, 89:722-730.
7. Chen K., Huang J., Zhang C., Huang S., Nunnari G., Wang F.X., et al. Alpha interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4T cells. J Virol 2006, 80:7645-7657.
8. Vieillard V., Jouveshomme S., Leflour N., Jean-Pierre E., Debre P., De Maeyer E., et al. Transfer of human CD4(+) T lymphocytes producing beta interferon in Hu-PBL-SCID mice controls human immunodeficiency virus infection. J Virol 1999, 73:10281-10288.
9. Gendelman H.E., Baca L.M., Turpin J., Kalter D.C., Hansen B., Orenstein J.M., et al. Regulation of HIV replication in infected monocytes by IFN-alpha. Mechanisms for viral restriction. J Immunol 1990, 145:2669-2676.
10. Bednarik D.P., Mosca J.D., Raj N.B., Pitha P.M. Inhibition of human immunodeficiency virus (HIV) replication by HIV-trans-activated alpha 2-interferon. Proc Natl Acad Sci U S A 1989, 86:4958-4962.
11. Poli G., Orenstein J.M., Kinter A., Folks T.M., Fauci A.S. Interferon-alpha but not AZT suppresses HIV expression in chronically infected cell lines. Science 1989, 244:575-577.
12. Brenchley J.M., Price D.A., Schacker T.W., Asher T.E., Silvestri G., Rao S., et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006, 12:1365-1371.
13. Said E.A., Dupuy F.P., Trautmann L., Zhang Y., Shi Y., El-Far M., et al. Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Nat Med 2010, 16:452-459.
14. Oh D.Y., Baumann K., Hamouda O., Eckert J.K., Neumann K., Kucherer C., et al. A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression. AIDS 2009, 23:297-307.
15. Pine S.O., McElrath M.J., Bochud P.Y. Polymorphisms in toll-like receptor 4 and toll-like receptor 9 influence viral load in a seroincident cohort of HIV-1-infected individuals. AIDS 2009, 23:2387-2395.
16. Soriano-Sarabia N., Vallejo A., Ramirez-Lorca R., Rodriguez Mdel M., Salinas A., Pulido I., et al. Influence of the Toll-like receptor 9 1635A/G polymorphism on the CD4 count, HIV viral load, and clinical progression. J Acquir Immune Defic Syndr 2008, 49:128-135.
17. Bochud P.Y., Hersberger M., Taffe P., Bochud M., Stein C.M., Rodrigues S.D., et al. Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection. AIDS 2007, 21:441-446.
18. Beima-Sofie K.M., Bigham A.W., Lingappa J.R., Wamalwa D., Mackelprang R.D., Bamshad M.J., et al. Toll-like receptor variants are associated with infant HIV-1 acquisition and peak plasma HIV-1 RNA level. AIDS 2013, 27:2431-2439.
19. Andersen O., Hansen B.R., Troensegaard W., Flyvbjerg A., Madsbad S., Orskov H., et al. Sustained low-dose growth hormone therapy optimizes bioactive insulin-like growth factor-I level and may enhance CD4 T-cell number in HIV infection. J Med Virol 2010, 82:197-205.
20. Napolitano L.A., Schmidt D., Gotway M.B., Ameli N., Filbert E.L., Ng M.M., et al. Growth hormone enhances thymic function in HIV-1-infected adults. J Clin Invest 2008, 118:1085-1098.
21. Services A-USDoHH Opportunistic infections 2010, AIDS-U.S. Department of Health & Human Services.
22. Viard J.P., Burgard M., Hubert J.B., Aaron L., Rabian C., Pertuiset N., et al. Impact of 5 years of maximally successful highly active antiretroviral therapy on CD4 cell count and HIV-1 DNA level. AIDS 2004, 18:45-49.
23. Cheng P.L., Eng H.L., Chou M.H., You H.L., Lin T.M. Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population. Transl Res 2007, 150:311-318.
24. De Jager P.L., Richardson A., Vyse T.J., Rioux J.D. Genetic variation in toll-like receptor 9 and susceptibility to systemic lupus erythematosus. Arthritis Rheum 2006, 54:1279-1282.
25. Schlaepfer E., Speck R.F. Anti-HIV activity mediated by natural killer and CD8+ cells after toll-like receptor 7/8 triggering. PLoS ONE 2008, 3:e1999.
26. Baenziger S., Heikenwalder M., Johansen P., Schlaepfer E., Hofer U., Miller R.C., et al. Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology. Blood 2009, 113:377-388.
27. Alter G., Suscovich T.J., Teigen N., Meier A., Streeck H., Brander C., et al. Single-stranded RNA derived from HIV-1 serves as a potent activator of NK cells. J Immunol 2007, 178:7658-7666.
28. Brinkmann V., Geiger T., Alkan S., Heusser C.H. Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells. J Exp Med 1993, 178:1655-1663.
29. Tao K., Fujii M., Tsukumo S., Maekawa Y., Kishihara K., Kimoto Y., et al. Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population. Ann Rheum Dis 2007, 66:905-909.
30. Kikuchi K., Lian Z.X., Kimura Y., Selmi C., Yang G.X., Gordon S.C., et al. Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis. J Autoimmun 2005, 24:347-352.
31. Bednarik D.P., Cook J.A., Pitha P.M. Inactivation of the HIV LTR by DNA CpG methylation: evidence for a role in latency. EMBO J 1990, 9:1157-1164.
32. Sandler N.G., Douek D.C. Microbial translocation in HIV infection: causes, consequences and treatment opportunities. Nat Rev Microbiol 2012, 10:655-666.
33. Krug A., Towarowski A., Britsch S., Rothenfusser S., Hornung V., Bals R., et al. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur J Immunol 2001, 31:3026-3037.