Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Yan, Fei ^a   Yu, Yang ^a   Chow, Dar Chone ^a   Palzkill, Timothy ^a   Madoux, Franck ^b   Hodder, Peter ^b   Chase, Peter ^b   Griffin, Patrick R ^b   O'Malley, Bert W ^a   Lonard, David M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARM 1 PROTEIN; CELL PROTEIN; COLLAGENASE 3; E1A ASSOCIATED P300 PROTEIN; GELATINASE A; NUCLEAR RECEPTOR COACTIVATOR 2; STEROID RECEPTOR COACTIVATOR 1; STEROID RECEPTOR COACTIVATOR 3; UNCLASSIFIED DRUG; VERRUCARIN A; ANTINEOPLASTIC AGENT; COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE 1; HISTONE ACETYLTRANSFERASE PCAF; NCOA1 PROTEIN, MOUSE; NCOA2 PROTEIN, HUMAN; NCOA3 PROTEIN, HUMAN; PROTEIN ARGININE METHYLTRANSFERASE; TRICHOTHECENE DERIVATIVE; TUMOR PROTEIN;

ARTICLE; CANCER CELL; CELL MIGRATION; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG PROTEIN BINDING; DRUG SENSITIZATION; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LIVER CELL; PROTEIN DEGRADATION; PROTEIN FUNCTION; TRANSCRIPTION TERMINATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; HELA CELL LINE; METABOLISM; NEOPLASMS; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; HELA CELLS; HUMANS; NEOPLASM PROTEINS; NEOPLASMS; NUCLEAR RECEPTOR COACTIVATOR 1; NUCLEAR RECEPTOR COACTIVATOR 2; NUCLEAR RECEPTOR COACTIVATOR 3; P300-CBP TRANSCRIPTION FACTORS; PROTEIN-ARGININE N-METHYLTRANSFERASES; PROTEOLYSIS; SIGNAL TRANSDUCTION; TRICHOTHECENES;

EID: 84899693076     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0095243     Document Type: Article

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