The downregulation of onzin expression by PKC-ERK2 signaling and its potential role in AML cell differentiation

Leukemia

Volumn 24, Issue 3, 2010, Pages 544-551

  Wu, S F ^a   Huang, Y ^b   Hou, J K ^a   Yuan, T T ^a   Zhou, C X ^b   Zhang, J ^a   Chen, G Q ^a,b  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b Shanghai Universities   (China)

Author keywords

Differentiation; Extracellular signal regulated protein kinase; Onzin; Protein kinase C e; PU.1

Indexed keywords

BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; ONZIN; PROTEIN KINASE C EPSILON; TRANSCRIPTION FACTOR PU 1; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CASE REPORT; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 77949424527     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2009.280     Document Type: Article

References (48)

1. Heidenreich O, Krauter J, Riehle H, Hadwiger P, John M, Heil G, et al. AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells. Blood 2003; 101: 3157-3163.
2. Zhao KW, Li X, Zhao Q, Huang Y, Li D, Peng ZG, et al. Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation. Blood 2004; 104: 3731-3738.
3. Zhang K, Guo QL, You QD, Yang Y, Zhang HW, Yang L, et al. Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. Cancer Sci 2008; 99: 689-695.
4. Galaviz-Hernandez C, Stagg C, de Ridder G, Tanaka TS, Ko MS, Schlessinger D, et al. Plac8 and Plac9, novel placental-enriched genes identified through microarray analysis. Gene 2003; 309: 81-89.
5. Rissoan MC, Duhen T, Bridon JM, Bendriss-Vermare N, Peronne C, de Saint Vis B, et al. Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. Blood 2002; 100: 3295-3303.
6. Li Y, Rogulski K, Zhou Q, Sims PJ, Prochownik EV. The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase 1. Mol Cell Biol 2006; 26: 3401-3413.
7. Rogulski K, Li Y, Rothermund K, Pu L, Watkins S, Yi F, et al. Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway. Oncogene 2005; 24: 7524-7541.
8. Ashendel CL. The phorbol ester receptor: a phospholipid-regulated protein kinase. Biochim Biophys Acta 1985; 822: 219-242.
9. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992; 258: 607-614.
10. Asaoka Y, Nakamura S, Yoshida K, Nishizuka Y. Protein kinase C, calcium and phospholipid degradation. Trends Biochem Sci 1992; 17: 414-417.
11. Zhao KW, Li D, Zhao Q, Huang Y, Silverman RH, Sims PJ, et al. Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK. J Biol Chem 2005; 280: 42707-42714.
12. Wetsel WC, Khan WA, Merchenthaler I, Rivera H, Halpern AE, Phung HM, et al. Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J Cell Biol 1992; 117: 121-133.
13. Cowan KJ, Storey KB. Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress. J Exp Biol 2003; 206: 1107-1115.
14. Nusrat AR, Chapman Jr HA. An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines. J Clin Invest 1991; 87: 1091-1097.
15. Zhang DE, Hohaus S, Voso MT, Chen HM, Smith LT, Hetherington CJ, et al. Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters. Curr Top Microbiol Immunol 1996; 211: 137-147.
16. Zhang DE, Hetherington CJ, Chen HM, Tenen DG. The macro-phage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor. Mol Cell Biol 1994; 14: 373-381.
17. Zhang DE, Hetherington CJ, Meyers S, Rhoades KL, Larson CJ, Chen HM, et al. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol Cell Biol 1996; 16: 1231-1240.
18. Ledford JG, Kovarova M, Koller BH. Impaired host defense in mice lacking ONZIN. J Immunol 2007; 178: 5132-5143.
19. Meng XW, Heldebrant MP, Kaufmann SH. Phorbol 12-myristate 13-acetate inhibits death receptor-mediated apoptosis in Jurkat cells by disrupting recruitment of Fas-associated polypeptide with death domain. J Biol Chem 2002; 277: 3776-3783.
20. Geiger M, Wrulich OA, Jenny M, Schwaiger W, Grunicke HH, Uberall F. Defining the human targets of phorbol ester and diacylglycerol. Curr Opin Mol Ther 2003; 5: 631-641.
21. Silinsky EM, Searl TJ. Phorbol esters and neurotransmitter release: more than just protein kinase C? Br J Pharmacol 2003; 138: 1191-1201.
22. Besson A, Davy A, Robbins SM, Yong VW. Differential activation of ERKs to focal adhesions by PKC epsilon is required for PMA-induced adhesion and migration of human glioma cells. Oncogene 2001; 20: 7398-7407.
23. Chen J, Deng F, Singh SV, Wang QJ. Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2. Cancer Res 2008; 68: 3844-3853.
24. Wang X, Wang Q, Hu W, Evers BM. Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB- dependent pathway. Oncogene 2004; 23: 1885-1895.
25. LeHoux JG, Lefebvre A. Novel protein kinase C-epsilon inhibits human CYP11B2 gene expression through ERK1/2 signalling pathway and JunB. J Mol Endocrinol 2006; 36: 51-64.
26. Petiti JP, De Paul AL, Gutierrez S, Palmeri CM, Mukdsi JH, Torres AI. Activation of PKC epsilon induces lactotroph proliferation through ERK1/2 in response to phorbol ester. Mol Cell Endocrinol 2008; 289: 77-84.
27. Hsu CL, Kikuchi K, Kondo M. Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment. Blood 2007; 110: 1420-1428.
28. Martin-Thouvenin V, Gendron MC, Hogervorst F, Figdor CG, Lanotte M. Phorbol ester-induced promyelocytic leukemia cell adhesion to marrow stromal cells involves fibronectin specific alpha 5 beta 1 integrin receptors. J Cell Physiol 1992; 153: 95-102.
29. Baatout S. Phorbol esters: useful tools to study megakaryocyte differentiation. Hematol Cell Ther 1998; 40: 33-39.
30. Redig AJ, Platanias LC. The protein kinase C (PKC) family of proteins in cytokine signaling in hematopoiesis. J Interferon Cytokine Res 2007; 27: 623-636.
31. Redig AJ, Platanias LC. Protein kinase C signalling in leukemia. Leuk Lymphoma 2008; 49: 1255-1262.
32. Bassini A, Zauli G, Migliaccio G, Migliaccio AR, Pascuccio M, Pierpaoli S, et al. Lineage-restricted expression of protein kinase C isoforms in hematopoiesis. Blood 1999; 93: 1178-1188.
33. Macfarlane DE, Manzel L. Activation of beta-isozyme of protein kinase C (PKC beta) is necessary and sufficient for phorbol ester-induced differentiation of HL-60 promyelocytes. Studies with PKC beta-defective PET mutant. J Biol Chem 1994; 269: 4327-4331.
34. Tonetti DA, Henning-Chubb C, Yamanishi DT, Huberman E. Protein kinase C-beta is required for macrophage differentiation of human HL-60 leukemia cells. J Biol Chem 1994; 269: 23230-23235.
35. Mischak H, Pierce JH, Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF. Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and-delta and not by protein kinase C-beta II,-epsilon,-zeta, and-eta. J Biol Chem 1993; 268: 20110-20115.
36. Kambhampati S, Li Y, Verma A, Sassano A, Majchrzak B, Deb DK, et al. Activation of protein kinase C delta by all-trans-retinoic acid. J Biol Chem 2003; 278: 32544-32551.
37. Huang Y, Zhao Q, Zhou CX, Gu ZM, Li D, Xu HZ, et al. Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells. Oncogene 2006; 25: 6618-6627.
38. Racke FK, Wang D, Zaidi Z, Kelley J, Visvader J, Soh JW, et al. A potential role for protein kinase C-epsilon in regulating megakaryocytic lineage commitment. J Biol Chem 2001; 276: 522-528.
39. Yen A, Roberson MS, Varvayanis S, Lee AT. Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest. Cancer Res 1998; 58: 3163-3172.
40. Miranda MB, Johnson DE. Signal transduction pathways that contribute to myeloid differentiation. Leukemia 2007; 21: 1363-1377.
41. Miranda MB, McGuire TF, Johnson DE. Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines. Leukemia 2002; 16: 683-692.
42. McKercher SR, Torbett BE, Anderson KL, Henkel GW, Vestal DJ, Baribault H, et al. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J 1996; 15: 5647-5658.
43. Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hemato-poietic lineages. Science 1994; 265: 1573-1577.
44. Friedman AD. Transcriptional control of granulocyte and mono-cyte development. Oncogene 2007; 26: 6816-6828.
45. Ueki N, Zhang L, Hayman MJ. Ski can negatively regulates macrophage differentiation through its interaction with PU.1. Oncogene 2008; 27: 300-307.
46. Rosa A, Ballarino M, Sorrentino A, Sthandier O, De Angelis FG, Marchioni M, et al. The interplay between the master transcription factor PU.1 and miR-424 regulates human mono-cyte/macrophage differentiation. Proc Natl Acad Sci USA 2007; 104: 19849-19854.
47. Sugimoto K, Toyoshima H, Sakai R, Miyagawa K, Hagiwara K, Ishikawa F, et al. Frequent mutations in the p53 gene in human myeloid leukemia cell lines. Blood 1992; 79: 2378-2383.
48. Insinga A, Monestiroli S, Ronzoni S, Carbone R, Pearson M, Pruneri G, et al. Impairment of p53 acetylation, stability and function by an oncogenic transcription factor. EMBO J 2004; 23: 1144-1154.