메뉴 건너뛰기




Volumn 34, Issue 3, 2014, Pages 1367-1376

In vitro and in vivo efficacy of a novel quinuclidinone derivative against breast cancer

Author keywords

Anticancer drugs; Bax; Breast cancer; Cell cycle; E Cadherin; P21; P53

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; CYCLIN D; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P53; QUINUCLIDINONE DERIVATIVE 2; UNCLASSIFIED DRUG; UVOMORULIN; METHYLNITROSOUREA; QUINUCLIDINE DERIVATIVE;

EID: 84899689932     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (3)

References (42)
  • 2
    • 84863688143 scopus 로고    scopus 로고
    • The global breast cancer burden
    • Benson JR and Jatoi I: The global breast cancer burden. Future Oncol 8: 697-702, 2012
    • (2012) Future Oncol , vol.8 , pp. 697-702
    • Benson, J.R.1    Jatoi, I.2
  • 3
    • 33745594629 scopus 로고    scopus 로고
    • The rising burden of cancer in the developing world
    • Kanavos P: The rising burden of cancer in the developing world. Ann Oncol 17(Suppl 8): viii15-viii23, 2006.
    • (2006) Ann Oncol , vol.17 , pp. viii15-viii23
    • Kanavos, P.1
  • 4
    • 0027170826 scopus 로고
    • Clinical chemoprevention: Developing a cancer prevention strategy
    • Benner SE and Hong WK: Clinical chemoprevention: developing a cancer prevention strategy. J Nat Cancer Inst (Bethesda) 85: 1446-1447, 1993.
    • (1993) J Nat Cancer Inst (Bethesda) , vol.85 , pp. 1446-1447
    • Benner, S.E.1    Hong, W.K.2
  • 5
    • 84881251590 scopus 로고    scopus 로고
    • Novel quinuclidinone derivatives induce apoptosis in lung cancer via sphingomyelinase pathways
    • Malki A, Fathy L and El Ashry E: Novel Quinuclidinone derivatives induce apoptosis in lung cancer via sphingomyelinase pathways. Drug Res 63: 1-8, 2013.
    • (2013) Drug Res , vol.63 , pp. 1-8
    • Malki, A.1    Fathy, L.2    El Ashry, E.3
  • 6
    • 0141864377 scopus 로고    scopus 로고
    • Apoptosis, chemoresistance and breast cancer: Insights from the mcf-7 cell model system
    • Simstein R, Burow M and Parker A: Apoptosis, Chemoresistance and Breast Cancer: Insights from the MCF-7 Cell Model System. Exp Biol Med 228: 995-1003, 2003.
    • (2003) Exp Biol Med , vol.228 , pp. 995-1003
    • Simstein, R.1    Burow, M.2    Parker, A.3
  • 8
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors signaling and modulation
    • Ashkenazi A and Dixit VM: Death receptors signaling and modulation. Science 281: 1305-1308, 1998.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 9
    • 0034163385 scopus 로고    scopus 로고
    • CD95 (fas/apo-1) and p53 signal apoptosis independently in diverse cell types
    • O'Connor L, Harris AW and Strasser A: CD95 (FAS/APO-1) and p53 signal apoptosis independently in diverse cell types. Cancer Res 60: 1217-1222, 2000.
    • (2000) Cancer Res , vol.60 , pp. 1217-1222
    • O'Connor, L.1    Harris, A.W.2    Strasser, A.3
  • 10
    • 0036716281 scopus 로고    scopus 로고
    • The bcl2 family regulators of the cellular life-or-death switch
    • Cory S and Adams JM: The Bcl2 family regulators of the cellular life-or-death switch. Nat Rev Cancer 9: 247-656, 2002.
    • (2002) Nat Rev Cancer , vol.9 , pp. 247-656
    • Cory, S.1    Adams, J.M.2
  • 12
    • 0028568315 scopus 로고
    • Cell cycle control and cancer
    • Hartwell LH and Kastan MB: Cell cycle control and cancer. Science 266: 1821-1828, 1994.
    • (1994) Science , vol.266 , pp. 1821-1828
    • Hartwell, L.H.1    Kastan, M.B.2
  • 13
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden KH and Lu X Live or let die: The cell's response to p53. Nat Rev Cancer 2: 594-604, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 14
    • 0035797473 scopus 로고    scopus 로고
    • Tissue specific expression of p53 target genes suggests a key role for killer/dr5 in p53-dependent apoptosis in vivo
    • Burns TF, Bernhard EJ and El-Deiry WS: Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo. Oncogene 20: 4601-4612, 2001.
    • (2001) Oncogene , vol.20 , pp. 4601-4612
    • Burns, T.F.1    Bernhard, E.J.2    El-Deiry, W.S.3
  • 15
    • 0036716281 scopus 로고    scopus 로고
    • The bcl2 family: Regulators of the cellular life-or-death switch
    • Cory S and Adams JM: The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2: 645-656, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 645-656
    • Cory, S.1    Adams, J.M.2
  • 16
    • 8444220527 scopus 로고    scopus 로고
    • Molecular mechanisms of caspase regulation during apoptosis
    • Riedl SJ and Shi YG: Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 5: 897-907, 2004.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 897-907
    • Riedl, S.J.1    Shi, Y.G.2
  • 19
    • 85007758538 scopus 로고    scopus 로고
    • ABC of breast diseases. Breast cancer-epidemiology, risk factors, and genetics
    • McPherson K, Steel CM and Dixon JM: ABC of breast diseases. Breast cancer-epidemiology, risk factors, and genetics. BMJ 321: 624-628, 2000.
    • (2000) BMJ , vol.321 , pp. 624-628
    • McPherson, K.1    Steel, C.M.2    Dixon, J.M.3
  • 20
    • 84862744539 scopus 로고    scopus 로고
    • Inflammatory breast carcinoma incidence and survival - The surveillance epidemiology and end results program of the national cancer institute 1975-1992
    • Chang S, Parker SL, Pham T, Buzdar AU and Hursting SD: Inflammatory breast carcinoma incidence and survival - The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute, 1975-1992 Breast Can Res Treat 46: 40-7, 1997.
    • (1997) Breast Can Res Treat , vol.46 , pp. 40-47
    • Chang, S.1    Parker, S.L.2    Pham, T.3    Buzdar, A.U.4    Hursting, S.D.5
  • 21
    • 84863606865 scopus 로고    scopus 로고
    • Quantitative expression analysis of the apoptosis-related genes bcl2, bax and bcl2l12 in gastric adenocarcinoma cells following treatment with the anticancer drugs cisplatin, etoposide and taxol
    • Korbakis D and Scorilas A: Quantitative expression analysis of the apoptosis-related genes BCL2, BAX and BCL2L12 in gastric adenocarcinoma cells following treatment with the anticancer drugs cisplatin, etoposide and taxol. Tumour Biol 33: 865-875, 2012
    • (2012) Tumour Biol , vol.33 , pp. 865-875
    • Korbakis, D.1    Scorilas, A.2
  • 22
    • 0028927607 scopus 로고
    • The fas death factor
    • Nagata S and Golstein P: The Fas death factor. Science 267: 1449-1456, 1995.
    • (1995) Science , vol.267 , pp. 1449-1456
    • Nagata, S.1    Golstein, P.2
  • 24
    • 0034212656 scopus 로고    scopus 로고
    • Cyclin e induction by genotoxic stress leads to apoptosis of hematopoietic cells
    • Mazumder S, Gong B and Almasan A: Cyclin E Induction by genotoxic stress leads to apoptosis of hematopoietic cells. Oncogene 19: 2828-2835, 2000.
    • (2000) Oncogene , vol.19 , pp. 2828-2835
    • Mazumder, S.1    Gong, B.2    Almasan, A.3
  • 25
    • 0031961995 scopus 로고    scopus 로고
    • Effects of p21 (cip1/waf1) at both the g1/s and the g2/m cell cycle transitions: Prb is a critical determinant in blocking dna replication and in preventing endoreduplication
    • Niculescu AB III, Chen X, Smeets M, Hengst L and Prives C: Effects of p21 (Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol 18: 629-643, 1998.
    • (1998) Mol Cell Biol , vol.18 , pp. 629-643
    • Niculescu, A.B.1    Chen, X.2    Smeets, M.3    Hengst, L.4    Prives, C.5
  • 26
    • 84858055716 scopus 로고    scopus 로고
    • The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle
    • Henley SA and Dick FA: The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle. Cell Division 7: 10-14, 2012.
    • (2012) Cell Division , vol.7 , pp. 10-14
    • Henley, S.A.1    Dick, F.A.2
  • 28
    • 0029038135 scopus 로고
    • Apoptosis, cancer and the p53 tumour suppressor gene
    • Lee JM and Bernstein A: Apoptosis, cancer and the p53 tumour suppressor gene. Cancer Metastasis Rev 14: 149-61, 1995.
    • (1995) Cancer Metastasis Rev , vol.14 , pp. 149-161
    • Lee, J.M.1    Bernstein, A.2
  • 29
    • 0029097316 scopus 로고
    • Molecular controls of growth arrest and apoptosis:p53-dependent and independent pathways
    • Liebermann DA, Hoffman B and Steinman RA: Molecular controls of growth arrest and apoptosis:p53-dependent and independent pathways. Oncogene 11: 199-210, 1995.
    • (1995) Oncogene , vol.11 , pp. 199-210
    • Liebermann, D.A.1    Hoffman, B.2    Steinman, R.A.3
  • 31
    • 0026669469 scopus 로고
    • P53 function and dysfunction
    • Vogelstein B and Kinzler KW: p53 function and dysfunction. Cell 70: 523-526, 1992.
    • (1992) Cell , vol.70 , pp. 523-526
    • Vogelstein, B.1    Kinzler, K.W.2
  • 33
    • 0027496935 scopus 로고
    • The p21 cdk-interacting protein cip1 is a potent inhibitor of g1 cyclin-dependent kinases
    • Harper J, Adami W and Guy R: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases Cell 75(4): 805-816, 1993.
    • (1993) Cell , vol.75 , Issue.4 , pp. 805-816
    • Harper, J.1    Adami, W.2    Guy, R.3
  • 34
    • 0036863609 scopus 로고    scopus 로고
    • Mitochondrial outer membrane proteins assist bid in bax-mediated lipidic pore formation
    • Hardwick JM and Polster BM: Mitochondrial Outer Membrane Proteins Assist Bid in Bax-mediated Lipidic Pore Formation. Mol Cell 2002 10: 963-965, 2002.
    • (2002) Mol Cell , vol.10 , pp. 963-965
    • Hardwick, J.M.1    Polster, B.M.2
  • 35
    • 0022004418 scopus 로고
    • Host factors affecting the growth of carcinogen induced rat mammary carcinomas: A review and tribute to charles brenton huggins
    • Welsch CW: Host factors affecting the growth of carcinogen induced rat mammary carcinomas: A review and tribute to Charles Brenton Huggins. Cancer Res 45: 3415-3443, 1985.
    • (1985) Cancer Res , vol.45 , pp. 3415-3443
    • Welsch, C.W.1
  • 37
    • 0028785824 scopus 로고
    • Rapid induction of mammary intra ductal proliferation, ductal carcinoma in situ and carcinomas by the injection of sexually immature female rats with 1-methyl-1-nitrourea
    • Thompson HJ, Mc Ginley JN, Rothhammer K and Singh M: Rapid induction of mammary intra ductal proliferation, ductal carcinoma in situ and carcinomas by the injection of sexually immature female rats with 1-methyl-1-nitrourea. Carcinogenesis 16: 2407-2411, 1995.
    • (1995) Carcinogenesis , vol.16 , pp. 2407-2411
    • Thompson, H.J.1    Mc Ginley, J.N.2    Rothhammer, K.3    Singh, M.4
  • 38
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling in development and disease
    • Clevers H: Wnt/β-Catenin signaling in development and disease. Cell 13: 469-480, 2006.
    • (2006) Cell , vol.13 , pp. 469-480
    • Clevers, H.1
  • 39
    • 84863352083 scopus 로고    scopus 로고
    • Activation status of wnt/β-catenin signaling in normal and neoplastic breast tissurs: Relationship to her2/neu expression in human and mouse
    • Khalil S, Tan GA, Gurl DD, Zhou XK and Howe LR: Activation status of Wnt/β-catenin signaling in normal and neoplastic breast tissurs: Relationship to her2/neu expression in human and mouse. PLOS 13: e3342, 2012.
    • (2012) PLOS , vol.13
    • Khalil, S.1    Tan, G.A.2    Gurl, D.D.3    Zhou, X.K.4    Howe, L.R.5
  • 40
    • 84055222706 scopus 로고    scopus 로고
    • Inhibition of wnt signaling by cucurbitacin b in breast cancer cells: Reduction of wnt-associated proteins and reduced translocation of galectin-3-mediated β-catenin
    • Dakeng S, Duangmano S, Jiratchariyahul W, U-Pratya Y, Bogler O and Patmasriwat P: Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: Reduction of Wnt-associated proteins and reduced translocation of Galectin-3-mediated β-Catenin. J Cell Biochem 13: 49-60, 2012.
    • (2012) J Cell Biochem , vol.13 , pp. 49-60
    • Dakeng, S.1    Duangmano, S.2    Jiratchariyahul, W.3    U-Pratya, Y.4    Bogler, O.5    Patmasriwat, P.6
  • 41
    • 84873534116 scopus 로고    scopus 로고
    • Lycopene synergistically enhances quinacrine actin to inhibit wnt-tcf signaling in breast cancer cells through apc
    • Preet R, Mohapatra P, Das D, Satapathy S, Choudhuri T, Wyatt MD et al: Lycopene synergistically enhances quinacrine actin to inhibit Wnt-TCF signaling in breast cancer cells through APC. Carcinogenesis 34(2): 277-286, 2012.
    • (2012) Carcinogenesis , vol.34 , Issue.2 , pp. 277-286
    • Preet, R.1    Mohapatra, P.2    Das, D.3    Satapathy, S.4    Choudhuri, T.5    Wyatt, M.D.6
  • 42
    • 0034053069 scopus 로고    scopus 로고
    • Wnt signaling in oncogensis and embryogenesis: A look outside the nucleus
    • Peifer M and Polokis P: Wnt signaling in oncogensis and embryogenesis: a look outside the nucleus. Science 13: 1606-1609, 2000.
    • (2000) Science , vol.13 , pp. 1606-1609
    • Peifer, M.1    Polokis, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.