Stimulation of autophagy prevents amyloid-β peptide-induced neuritic degeneration in PC12 cells

Journal of Alzheimer's Disease

Volumn 40, Issue 4, 2014, Pages 929-939

  Yang, Yi ^a,b,c   Chen, Sicong ^c   Zhang, Jiafeng ^a   Li, Chentan ^a   Sun, Yonghong ^c   Zhang, Lihui ^a   Zheng, Xiaoxiang ^b,c  

^a HANGZHOU NORMAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Alzheimer's disease; amyloid peptide; autophagy; neuritic degeneration

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 METHYLADENINE; AMYLOID BETA PROTEIN[25-35]; CHLOROQUINE; RAPAMYCIN; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (25-35); ENZYME INHIBITOR; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CELL PROLIFERATION; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; DENDRITE; DISEASE COURSE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NERVE CELL DEGENERATION; NERVE FIBER; NERVE FIBER DEGENERATION; NONHUMAN; PATHOGENESIS; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; SUPERIOR CERVICAL GANGLION; SYMPATHETIC NERVE CELL; UPREGULATION; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; MITOCHONDRION; NERVE CELL; NERVE DEGENERATION; NEURITE; NEWBORN; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PC12 CELL LINE; PHYSIOLOGY; RAT; TOXICITY; ULTRASTRUCTURE;

AMYLOID BETA-PEPTIDES; ANIMALS; ANIMALS, NEWBORN; AUTOPHAGY; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NERVE DEGENERATION; NEURITES; NEURONS; ORGAN CULTURE TECHNIQUES; PC12 CELLS; PEPTIDE FRAGMENTS; RATS; SUPERIOR CERVICAL GANGLION;

EID: 84899688008     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-132270     Document Type: Article

References (27)

1. Price DL, Sisodia SS (1998) Mutant genes in familial Alzheimer's disease and transgenic models. Annu Rev Neurosci 21, 479-505.
2. Hardy J (1997) Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci 20, 154-159.
3. LaFerla FM, Green KN, Oddo S (2007) Intracellular amyloidbeta in Alzheimer's disease. Nat Rev Neurosci 8, 499-509.
4. Kaminsky YG, Marlatt MW, Smith MA, Kosenko EA (2010) Subcellular and metabolic examination of amyloidbeta peptides in Alzheimer disease pathogenesis: Evidence for Abeta(25-35). Exp Neurol 221, 26-37.
5. Wong E, Cuervo AM (2010) Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 13, 805-811.
6. Yang Y, Coleman M, Zhang L, Zheng X, Yue Z (2013) Autophagy in axonal and dendritic degeneration. Trends Neurosci 36, 418-428.
7. Nixon RA, Yang DS (2011) Autophagy failure in Alzheimer's disease-locating the primary defect. Neurobiol Dis 43, 38-45.
8. Lee S, Sato Y, Nixon RA (2011) Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. J Neurosci 31, 7817-7830.
9. Yang Y, Fukui K, Koike T, Zheng X (2007) Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons. Eur J Neurosci 26, 2979-2988.
10. Tomiyama T, Asano S, SuwaY, Morita T, Kataoka K, Mori H, Endo N (1994) Rifampicin prevents the aggregation and neurotoxicity of amyloid beta protein in vitro. Biochem Biophys Res Commun 204, 76-83.
11. Kimura S, Noda T, Yoshimori T (2007) Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 3, 452-460.
12. Gao M, Yeh PY, Lu YS, Hsu CH, Chen KF, Lee WC, Feng WC, Chen CS, Kuo ML, Cheng AL (2008) OSU-03012, a novel celecoxib derivative, induces reactive oxygen speciesrelated autophagy in hepatocellular carcinoma. Cancer Res 68, 9348-9357.
13. Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, CuervoAM(2005) Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study. J Neuropathol Exp Neurol 64, 113-122.
14. Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA (2008) Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease. J Neurosci 28, 6926-6937.
15. Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Naslund J, Mathews PM, Cataldo AM, Nixon RA (2005) Macroautophagy-a novel beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol 171, 87-98.
16. Liu X, Xu K, Yan M, Wang Y, Zheng X (2010) Protective effects of galantamine against Abeta-induced PC12 cell apoptosis by preventing mitochondrial dysfunction and endoplasmic reticulum stress. Neurochem Int 57, 588-599.
17. Liu X, Feng L, YanM, XuK, YuY, ZhengX(2010) Changes in mitochondrial dynamics during amyloid beta-induced PC12 cell apoptosis. Mol Cell Biochem 344, 277-284.
18. Lee S, Sato Y, Nixon RA (2011) Primary lysosomal dysfunction causes cargo-specific deficits of axonal transport leading to Alzheimer-like neuritic dystrophy. Autophagy 7, 1562-1563.
19. Shintani T, Klionsky DJ (2004) Autophagy in health and disease: A double-edged sword. Science 306, 990-995.
20. Knoferle J, Koch JC, Ostendorf T, Michel U, Planchamp V, Vutova P, Tonges L, Stadelmann C, BruckW, Bahr M, Lingor P (2010) Mechanisms of acute axonal degeneration in the optic nerve in vivo. Proc Natl Acad Sci U S A 107, 6064-6069.
21. Cheng HC, Kim SR, Oo TF, Kareva T, Yarygina O, Rzhetskaya M, Wang C, During M, Talloczy Z, Tanaka K, Komatsu M, Kobayashi K, Okano H, Kholodilov N, Burke RE (2011) Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy. J Neurosci 31, 2125-2135.
22. Sadasivan S, Zhang Z, Larner SF, Liu MC, ZhengW, Kobeissy FH, Hayes RL, Wang KK (2010) Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype. BMC Neurosci 11, 21.
23. Yang Y, Kawataki T, Fukui K, Koike T (2007) Cellular Zn2+chelators cause "dying-back" neurite degeneration associated with energy impairment. J Neurosci Res 85, 2844-2855.
24. Sanchez-Varo R, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, De Castro V, Jimenez S, Ruano D, Vizuete M, Davila JC, Garcia-Verdugo JM, Jimenez AJ, Vitorica J, Gutierrez A (2012) Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus. Acta Neuropathol 123, 53-70.
25. Yang DS, Kumar A, Stavrides P, Peterson J, Peterhoff CM, Pawlik M, Levy E, Cataldo AM, Nixon RA (2008) Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease. Am J Pathol 173, 665-681.
26. Kim I, Rodriguez-Enriquez S, Lemasters JJ (2007) Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys 462, 245-253.
27. Tatsuta T, Langer T (2008) Quality control of mitochondria: Protection against neurodegeneration and ageing. EMBO J 27, 306-314.