Effect of D23N mutation on the dimer conformation of amyloid β-proteins: Ab initio molecular simulations in water

Journal of Molecular Graphics and Modelling

Volumn 50, Issue , 2014, Pages 113-124

  Okamoto, Akisumi ^a   Yano, Atsushi ^a   Nomura, Kazuya ^a   Higai, Shin'Ichi ^b   Kurita, Noriyuki ^a  

^a TOYOHASHI UNIVERSITY OF TECHNOLOGY   (Japan)

^b MURATA MANUFACTURING CO LTD   (Japan)

Author keywords

Aggregation; Alzheimer's disease; Amyloid protein; Iowa mutation; Molecular orbital; Specific interaction

Indexed keywords

AGGLOMERATION; GLYCOPROTEINS; MOLECULAR ORBITALS; NEURODEGENERATIVE DISEASES; PROTEINS;

AB INITIO FRAGMENT MOLECULAR ORBITAL METHODS; AGGREGATION MECHANISM; ALZHEIMER'S DISEASE; CEREBRAL AMYLOID ANGIOPATHY; CLASSICAL MOLECULAR MECHANICS; IOWA MUTATION; MOLECULAR PATHOGENESIS; SPECIFIC INTERACTION;

DIMERS;

AMYLOID BETA PROTEIN; MONOMER; WATER;

AB INITIO CALCULATION; ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DIMERIZATION; FRAGMENT MOLECULAR ORBITAL; HUMAN; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOLECULAR PATHOLOGY; MUTATION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; SIMULATION; STATIC ELECTRICITY; VASCULAR AMYLOIDOSIS; WILD TYPE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; PROTEIN MULTIMERIZATION;

AMYLOID BETA-PEPTIDES; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN MULTIMERIZATION;

EID: 84899668552     PISSN: 10933263     EISSN: 18734243     Source Type: Journal    
DOI: 10.1016/j.jmgm.2014.03.004     Document Type: Article

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