In vivo evaluation of the potency and bladder-vascular selectivity of the ATP-sensitive potassium channel openers (-)-cromakalim, ZD6169 and WAY-133537 in rats

BJU International

Volumn 91, Issue 3, 2003, Pages 284-290

  Fabiyi, A C ^a   Gopalakrishnan, M ^a   Lynch III, J J ^a   Brioni, J D ^a   Coghlan, M J ^a   Brune, M E ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

ATP sensitive potassium channel; Detrusor instability; Glyburide; Overactive bladder; Partial outlet obstruction; Smooth muscle; Tolterodine

Indexed keywords

4 [3,4 DIOXO 2 (1,2,2 TRIMETHYLPROPYLAMINO) 1 CYCLOBUTENYLAMINO] 3 ETHYLBENZONITRILE; ADENOSINE TRIPHOSPHATE; CROMAKALIM; MUSCARINIC RECEPTOR BLOCKING AGENT; N (4 BENZOYLPHENYL) 3,3,3 TRIFLUORO 2 HYDROXY 2 METHYLPROPIONAMIDE; POTASSIUM CHANNEL STIMULATING AGENT; TOLTERODINE; UNCLASSIFIED DRUG; URETHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTERIAL PRESSURE; ARTICLE; BLADDER FUNCTION; BLADDER NECK STENOSIS; BLADDER PRESSURE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; FEMALE; HEART RATE; HEMODYNAMIC MONITORING; IN VIVO STUDY; MALE; MICTURITION; NEUROGENIC BLADDER; NONHUMAN; PRIORITY JOURNAL; RAT;

AMIDES; ANIMALS; BENZOPHENONES; CALCIUM CHANNELS; CROMAKALIM; CYCLOBUTANES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FEMALE; MALE; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; NITRILES; RATS; RATS, SPRAGUE-DAWLEY; REFLEX, ABNORMAL; URINARY BLADDER; URINARY BLADDER NECK OBSTRUCTION; URINARY BLADDER, NEUROGENIC; VASODILATOR AGENTS;

EID: 0037326487     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410X.2003.03069.x     Document Type: Article

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