SK channel-selective opening by SKA-31 induces hyperpolarization and decreases contractility in human urinary bladder smooth muscle

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 304, Issue 2, 2013, Pages

  Soder, Rupal P ^a   Parajuli, Shankar P ^a   Hristov, Kiril L ^a   Rovner, Eric S ^b   Petkov, Georgi V ^a,b  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Detrusor; Patch clamp; SK channels

Indexed keywords

APAMIN; CARBACHOL; NAPHTHO[1,2 D]THIAZOL 2 YLAMINE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHLORIDE; SKA 31; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; CELL ISOLATION; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; DETRUSOR MUSCLE; DETRUSOR SMOOTH MUSCLE; DRUG EFFECT; DRUG INHIBITION; DRUG POTENCY; ELECTROSTIMULATION; FREQUENCY MODULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERPOLARIZATION; ISOMETRICS; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SMOOTH MUSCLE CONTRACTILITY;

ADULT; AGED; APAMIN; BENZOTHIAZOLES; CARBACHOL; ELECTRIC STIMULATION; FEMALE; HUMANS; MALE; MEMBRANE POTENTIALS; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOGRAPHY; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; URINARY BLADDER; URINARY BLADDER, OVERACTIVE;

EID: 84872413929     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00363.2012     Document Type: Article

References (34)

1. Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, Van Kerrebroeck P, Victor A, Wein A. The standardisation of terminology in lower urinary tract function: report from the standardisation subcommittee of the International Continence Society. Urology 61: 37-49, 2003
2. Afeli SA, Rovner ES, Petkov GV. SK but not IK channels regulate human detrusor smooth muscle spontaneous and nerve-evoked contractions. Am J Physiol Renal Physiol 303: F559-F568, 2012
3. Andersson KE. Pharmacotherapy of the overactive bladder. Discov Med 8: 118-124, 2009
4. Brading AF. Spontaneous activity of lower urinary tract smooth muscles: correlation between ion channels and tissue function. J Physiol 570: 13-22, 2006
5. Brading AF, Williams JH. Contractile responses of smooth muscle strips from rat and guinea-pig urinary bladder to transmural stimulation: effects of atropine and alpha, beta-methylene ATP. Br J Pharmacol 99: 493-498, 1990
6. + channel. Am J Physiol Renal Physiol 295: F1149-F1157, 2008
7. de Groat WC. A neurologic basis for the overactive bladder. Urology 50: 36-52. discussion 53-36, 1997
8. Fry CH, Ikeda Y, Harvey R, Wu C, Sui GP. Control of bladder function by peripheral nerves: avenues for novel drug targets. Urology 63: 24-31, 2004
9. Hashitani H, Brading AF. Electrical properties of detrusor smooth muscles from the pig and human urinary bladder. Br J Pharmacol 140: 146-158, 2003
10. Hashitani H, Brading AF. Ionic basis for the regulation of spontaneous excitation in detrusor smooth muscle cells of the guinea-pig urinary bladder. Br J Pharmacol 140: 159-169, 2003
11. Hashitani H, Brading AF, Suzuki H. Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder. Br J Pharmacol 141: 183-193, 2004
12. Herrera GM, Heppner TJ, Nelson MT. Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels. Am J Physiol Regul Integr Comp Physiol 279: R60-R68, 2000
13. Herrera GM, Pozo MJ, Zvara P, Petkov GV, Bond CT, Adelman JP, Nelson MT. Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel. J Physiol 551: 893-903, 2003
14. Hristov KL, Chen M, Afeli SAY, Cheng Q, Rovner ES, Petkov GV. Expression and function of KV2-containing channels in human urinary bladder smooth muscle. Am J Physiol Cell Physiol 302: C1599-C1608, 2012
15. + channels regulate human detrusor smooth muscle function. Am J Physiol Cell Physiol 301: C903-C912, 2011
16. Hristov KL, Chen M, Soder RP, Parajuli SP, Cheng Q, Kellett WF, Petkov GV. KV2.1 and electrically silent KV channel subunits control excitability and contractility of guinea pig detrusor smooth muscle. Am J Physiol Cell Physiol 302: C360-C372, 2012
17. 2+-activated K_ channels. Am J Physiol Cell Physiol 295: C1344-C1353, 2008
18. Hristov KL, Parajuli SP, Soder RP, Cheng Q, Rovner E, Petkov GV. Suppression of human detrusor smooth muscle excitability and contractility via pharmacological activation of large-conductance Ca2_-activated potassium channels. Am J Physiol Cell Physiol 302: C1632-C1641, 2012
19. + channel openers in bladder and vascular smooth muscle. Naunyn Schmiedebergs Arch Pharmacol 369: 481-489, 2004
20. Mills IW, Greenland JE, McMurray G, McCoy R, Ho KM, Noble JG, Brading AF. Studies of the pathophysiology of idiopathic detrusor instability: the physiological properties of the detrusor smooth muscle and its pattern of innervation. J Urol 163: 646-651, 2000
21. Nielsen JS, Rode F, Rahbek M, Andersson KE, Ronn LC, Bouchelouche K, Nordling J, Bouchelouche P. Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle. BJU Int 108: 771-777, 2011
22. Oger S, Behr-Roussel D, Gorny D, Bernabe J, Comperat E, Chartier- Kastler E, Denys P, Giuliano F. Effects of potassium channel modulators on myogenic spontaneous phasic contractile activity in human detrusor from neurogenic patients. BJU Int 108: 604-611, 2011
23. + channels in mouse urinary bladder smooth muscle cells. Jpn J Pharmacol 84: 97-100, 2000
24. Parajuli SP, Soder RP, Hristov KL, Petkov GV. Pharmacological activation of small conductance calcium-activated potassium channels with naphtho[1,2-d]thiazol-2-ylamine decreases guinea pig detrusor smooth muscle excitability and contractility. J Pharmacol Exp Ther 340: 114-123, 2012
25. Petkov GV. Role of potassium ion channels in detrusor smooth muscle function and dysfunction. Nat Rev Urol 9: 30-40, 2012
26. + channel regulates contractile activity of mouse urinary bladder smooth muscle. J Physiol 537: 443-452, 2001
27. Petkov GV, Heppner TJ, Bonev AD, Herrera GM, Nelson MT. Low levels of KATP channel activation decrease excitability and contractility of urinary bladder. Am J Physiol Regul Integr Comp Physiol 280: R1427-R1433, 2001
28. Sankaranarayanan A, Raman G, Busch C, Schultz T, Zimin PI, Hoyer J, Kohler R, Wulff H. Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium- derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol 75: 281-295, 2009
29. + channel activation with NS1619 decreases myogenic and neurogenic contractions of rat detrusor smooth muscle. Eur J Pharmacol 670: 252-259, 2011
30. 2+ sensitization in contraction of human bladder smooth muscle. J Urol 172: 748-752, 2004
31. + channel 2 is the key functional component of SK channels in mouse urinary bladder. Am J Physiol Regul Integr Comp Physiol 294: R1737-R1743, 2008
32. Wagner TH, Hu TW, Bentkover J, LeBlanc K, Stewart W, Corey R, Zhou Z, Hunt T. Health-related consequences of overactive bladder. Am J Manag Care 8: S598-S607, 2002
33. Wein AJ. Diagnosis and treatment of the overactive bladder. Urology 62: 20-27, 2003
34. Werner ME, Knorn AM, Meredith AL, Aldrich RW, Nelson MT. Frequency encoding of cholinergic- and purinergic-mediated signaling to mouse urinary bladder smooth muscle: modulation by BK channels. Am J Physiol Regul Integr Comp Physiol 292: R616-R624, 2007.