Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways

Journal of Clinical Investigation

Volumn 97, Issue 7, 1996, Pages 1610-1617

  Voisin, Laure ^a   Breuillé, Denis ^b   Combaret, Lydie ^a   Pouyet, Corinne ^b   Taillandier, Daniel ^a   Aurousseau, Eveline ^a   Obled, Christiane ^a   Attaix, Didier ^a  

^a CEMAGREF   (France)

^b Clintec Technologies   (France)

Author keywords

Calpains; Cathepsins; Infection; Protein breakdown; Ubiquitin dependent proteolysis

Indexed keywords

LYSOSOME ENZYME; PROTEASOME; PROTEINASE; UBIQUITIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; MALE; MUSCLE ATROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; RAT; SEPSIS;

ANIMALS; CALCIUM; CYSTEINE ENDOPEPTIDASES; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; ESCHERICHIA COLI INFECTIONS; HUMANS; LYSOSOMES; MALE; MULTIENZYME COMPLEXES; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCULAR ATROPHY; ORGAN SIZE; PEPTIDE HYDROLASES; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SEPSIS; TIME FACTORS; UBIQUITINS;

EID: 0029883726     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118586     Document Type: Article

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