Unraveling the binding mechanism of asiatic acid with human serum albumin and its biological implications

Journal of Biomolecular Structure and Dynamics

Volumn 32, Issue 8, 2014, Pages 1290-1302

  Gokara, Mahesh ^a   Malavath, Tirupathi ^a   Kalangi, Suresh Kumar ^a   Reddana, Pallu ^a   Subramanyam, Rajagopal ^a  

^a UNIVERSITY OF HYDERABAD   (India)

Author keywords

Asiatic acid; drug binding; fluorescence quenching; human serum albumin; molecular dynamics simulation

Indexed keywords

ASIATIC ACID; HUMAN SERUM ALBUMIN; ANTINEOPLASTIC AGENT; PENTACYCLIC TRITERPENE; PROTEIN BINDING; SERUM ALBUMIN;

ALBUMIN BLOOD LEVEL; ALPHA HELIX; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PH; CELL VIABILITY; CIRCULAR DICHROISM; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; FLUORESCENCE SPECTROSCOPY; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; IC 50; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN UNFOLDING; THERMODYNAMICS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HEPG2 CELL LINE; METABOLISM; PH; PROTEIN SECONDARY STRUCTURE;

CENTELLA ASIATICA;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CIRCULAR DICHROISM; HEP G2 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; PENTACYCLIC TRITERPENES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SERUM ALBUMIN; THERMODYNAMICS;

EID: 84899647230     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2013.817953     Document Type: Article

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