Optogenetic inactivation of the subthalamic nucleus improves forelimb akinesia in a rat model of parkinson disease

Neurosurgery

Volumn 74, Issue 5, 2014, Pages 533-540

  Yoon, Hyung Ho ^a   Park, Jin Hoon ^a,b   Kim, Yong Hwan ^c   Min, Joongkee ^a   Hwang, Eunmi ^d   Lee, C Justin ^d   Francis Suh, Jun Kyo ^d   Hwang, Onyou ^a   Jeon, Sang Ryong ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b University of Ulsan   (South Korea)

^c University of Notre Dame   (United States)

^d Korea Institute of Science and Technology   (South Korea)

Author keywords

Deep brain stimulation; Forelimb akinesia; Halorhodopsin; hSynapsin1; Optogenetics; Parkinson disease; Subthalamic nucleus

Indexed keywords

DOPAMINE RECEPTOR; HALORHODOPSIN; VESICULAR GLUTAMATE TRANSPORTER 2;

AKINESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOMORPHINE TEST; ARTICLE; CONTROLLED STUDY; CYLINDER TEST; FORELIMB; IMMUNOFLUORESCENCE; MALE; MOTOR PERFORMANCE; NEUROMODULATION; NONHUMAN; OPTIC NERVE FIBER; OPTOGENETICS; PARKINSON DISEASE; PHOTOSTIMULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ROTATION; SUBTHALAMIC NUCLEUS; ANIMAL; ANIMAL BEHAVIOR; BEHAVIORAL RESEARCH; CHEMISTRY; COMPLICATION; CYTOLOGY; DISEASE MODEL; DYSKINESIA, DRUG-INDUCED; GENE SILENCING; METABOLISM; MOTONEURON; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; SUBSTANTIA NIGRA; WISTAR RAT;

ANIMALS; BEHAVIOR, ANIMAL; BEHAVIORAL RESEARCH; DISEASE MODELS, ANIMAL; DYSKINESIA, DRUG-INDUCED; FORELIMB; GENE SILENCING; HALORHODOPSINS; MALE; MOTOR NEURONS; OPTOGENETICS; PARKINSON DISEASE; RATS; RATS, WISTAR; SUBSTANTIA NIGRA; SUBTHALAMIC NUCLEUS; VESICULAR GLUTAMATE TRANSPORT PROTEIN 2;

EID: 84899642198     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/NEU.0000000000000297     Document Type: Article

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