메뉴 건너뛰기




Volumn 39, Issue 6, 1996, Pages 367-372

Validation of a rodent model of Parkinson's disease: Evidence of a therapeutic window for oral sinemet

Author keywords

6 OHDA; Animal model; Clinically relevant; Parkinsonian symptoms; Therapeutic window

Indexed keywords

CARBIDOPA; CARBIDOPA PLUS LEVODOPA; LEVODOPA;

EID: 0029962329     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/0361-9230(96)00027-5     Document Type: Article
Times cited : (38)

References (25)
  • 1
    • 0027970324 scopus 로고
    • Ibotenic acid lesions of the striatum reduce drug-induced rotation in the 6-hydroxydopamine-lesioned rat
    • Barker, R.; Dunnett, S.B. Ibotenic acid lesions of the striatum reduce drug-induced rotation in the 6-hydroxydopamine-lesioned rat. Exp. Brain Res. 101:365-374; 1994.
    • (1994) Exp. Brain Res. , vol.101 , pp. 365-374
    • Barker, R.1    Dunnett, S.B.2
  • 2
    • 0015881383 scopus 로고
    • Blockage of amphetamine induced motor stimulation and stereotypy in the adult rat following neonatal treatment with 6-hydroxydopamine
    • Creese, E.; Iversen, S. D. Blockage of amphetamine induced motor stimulation and stereotypy in the adult rat following neonatal treatment with 6-hydroxydopamine. Brain Res. 55:369-382; 1973.
    • (1973) Brain Res. , vol.55 , pp. 369-382
    • Creese, E.1    Iversen, S.D.2
  • 3
    • 0017651245 scopus 로고
    • Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity
    • Creese, I.; Burt, D. R.; Snyder, S. H. Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity. Science 197:596-598; 1977.
    • (1977) Science , vol.197 , pp. 596-598
    • Creese, I.1    Burt, D.R.2    Snyder, S.H.3
  • 4
    • 0016422949 scopus 로고
    • The pharmacological and anatomical substrates of the amphetamine response in the rat
    • Creese, I.; Iversen, S. D. The pharmacological and anatomical substrates of the amphetamine response in the rat. Brain Res. 83:419-436; 1975.
    • (1975) Brain Res. , vol.83 , pp. 419-436
    • Creese, I.1    Iversen, S.D.2
  • 5
    • 0028559601 scopus 로고
    • Longterm behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase
    • During, M. J.; Naegele, J. R.; Omalley, K. L.; Geller, A. I. Longterm behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science 266:1399-1403; 1994.
    • (1994) Science , vol.266 , pp. 1399-1403
    • During, M.J.1    Naegele, J.R.2    Omalley, K.L.3    Geller, A.I.4
  • 7
    • 0029097513 scopus 로고
    • Behavioral effects and gene delivery in a rat model of Parkinson's disease
    • Isacson, O. Behavioral effects and gene delivery in a rat model of Parkinson's disease. Science 269:856; 1995.
    • (1995) Science , vol.269 , pp. 856
    • Isacson, O.1
  • 10
    • 0018678057 scopus 로고
    • Somatosensory inattention after dopamine-depleting intracerebral 6-OHDA injections: Spontaneous recovery and pharmacological control
    • Marshall, J. F. Somatosensory inattention after dopamine-depleting intracerebral 6-OHDA injections: Spontaneous recovery and pharmacological control. Brain Res. 177:311-324; 1979.
    • (1979) Brain Res. , vol.177 , pp. 311-324
    • Marshall, J.F.1
  • 11
    • 0018320167 scopus 로고
    • Sensory inattention in rats with 6-hydroxydopamine-induced degeneration of ascending dopaminergic neurons: Apomorphine-induced reversal of deficits
    • Marshall, J. F.; Gotthelf, T. Sensory inattention in rats with 6-hydroxydopamine-induced degeneration of ascending dopaminergic neurons: Apomorphine-induced reversal of deficits. Exp. Neurol. 65:398-411; 1979.
    • (1979) Exp. Neurol. , vol.65 , pp. 398-411
    • Marshall, J.F.1    Gotthelf, T.2
  • 12
    • 0017717948 scopus 로고
    • Striatal efferent fibers play a role in maintaining rotational behavior in the rat
    • Marshall, J. F.; Ungerstedt, U. Striatal efferent fibers play a role in maintaining rotational behavior in the rat. Science 198:62-64; 1977.
    • (1977) Science , vol.198 , pp. 62-64
    • Marshall, J.F.1    Ungerstedt, U.2
  • 14
    • 0029046161 scopus 로고
    • Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. II. Transplant-induced behavioral recovery
    • Nikkhah, G.; Cunningham, M. G.; Mckay, R.; Bjorklund, A. Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. II. Transplant-induced behavioral recovery. J. Neurosci. 15:3562-3570; 1995.
    • (1995) J. Neurosci. , vol.15 , pp. 3562-3570
    • Nikkhah, G.1    Cunningham, M.G.2    McKay, R.3    Bjorklund, A.4
  • 15
    • 0029079688 scopus 로고
    • Long-duration response to levodopa
    • Nutt, J. G.; Carter, J. H.; Woodward, W. R. Long-duration response to levodopa. Neurology 45:1613-1616; 1995.
    • (1995) Neurology , vol.45 , pp. 1613-1616
    • Nutt, J.G.1    Carter, J.H.2    Woodward, W.R.3
  • 16
    • 0029064091 scopus 로고
    • Forelimb akinesia in the rat Parkinson model: Differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test
    • Olsson, M.; Nikkhah, G.; Bentlage, C.; Bjorklund, A. Forelimb akinesia in the rat Parkinson model: Differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J. Neurosci. 15:3863-3875; 1995.
    • (1995) J. Neurosci. , vol.15 , pp. 3863-3875
    • Olsson, M.1    Nikkhah, G.2    Bentlage, C.3    Bjorklund, A.4
  • 17
    • 0002057279 scopus 로고
    • 6-Hydroxydopamine lesions of nigrostriatal neurons as an animal model of Parkinson's disease
    • Woodruff, M. L.; Nonneman, A. J., eds. New York: Plenum Press
    • Reading, P. J.; Dunnett, S. B. 6-Hydroxydopamine lesions of nigrostriatal neurons as an animal model of Parkinson's disease. In: Woodruff, M. L.; Nonneman, A. J., eds. Toxin-induced models of neurological disorders. New York: Plenum Press; 1994:89-119.
    • (1994) Toxin-induced Models of Neurological Disorders , pp. 89-119
    • Reading, P.J.1    Dunnett, S.B.2
  • 18
    • 0020570675 scopus 로고
    • The rotational behavior model: Asymmetry in the effects of unilateral 6-OHDA lesions of the substantia nigra in rats
    • Robinson, T. E.; Becker, J. B. The rotational behavior model: Asymmetry in the effects of unilateral 6-OHDA lesions of the substantia nigra in rats. Brain Res. 264:127-131; 1983.
    • (1983) Brain Res. , vol.264 , pp. 127-131
    • Robinson, T.E.1    Becker, J.B.2
  • 19
    • 0001921593 scopus 로고
    • Models of neurological defects and defects in neurological models
    • Schallert, T. Models of neurological defects and defects in neurological models. Behav. Brain Sci. 18:68-69; 1995.
    • (1995) Behav. Brain Sci. , vol.18 , pp. 68-69
    • Schallert, T.1
  • 20
    • 0018421663 scopus 로고
    • Excessive bracing reactions and their control by atropine and L-DOPA in an animal analog of parkinsonism
    • Schallert, T.; De Ryck, M.; Whishaw, I. Q.; Ramirez, V. D.; Teitelbaum, P. Excessive bracing reactions and their control by atropine and L-DOPA in an animal analog of parkinsonism. Exp. Neurol. 64:33-43; 1979.
    • (1979) Exp. Neurol. , vol.64 , pp. 33-43
    • Schallert, T.1    De Ryck, M.2    Whishaw, I.Q.3    Ramirez, V.D.4    Teitelbaum, P.5
  • 21
    • 0026969268 scopus 로고
    • A clinically relevant unilateral rat model of parkinsonian akinesia
    • Schallert, T.; Jones, T. A.; Norton, D. A clinically relevant unilateral rat model of parkinsonian akinesia. J. Neural Transplant. Plast. 3:332-333; 1992.
    • (1992) J. Neural Transplant. Plast. , vol.3 , pp. 332-333
    • Schallert, T.1    Jones, T.A.2    Norton, D.3
  • 23
    • 0020538899 scopus 로고
    • Posture-independent sensorimotor analysis of inter-hemispheric receptor asymmetries in neostriatum
    • Schallert, T.; Upchurch, M.; Wilcox, R. E.; Vaughn, D. M. Posture-independent sensorimotor analysis of inter-hemispheric receptor asymmetries in neostriatum. Pharmacol. Biochem. Behav. 18:753-759; 1983.
    • (1983) Pharmacol. Biochem. Behav. , vol.18 , pp. 753-759
    • Schallert, T.1    Upchurch, M.2    Wilcox, R.E.3    Vaughn, D.M.4
  • 24
    • 0017833529 scopus 로고
    • Compulsive, abnormal walking caused by anticholinergics in akinetic, 6-hydroxydopamine-treated rats
    • Schallert, T.; Whishaw, I. Q.; Ramirez, V. D.; Teitelbaum, P. Compulsive, abnormal walking caused by anticholinergics in akinetic, 6-hydroxydopamine-treated rats. Science 199:1461-1463; 1978.
    • (1978) Science , vol.199 , pp. 1461-1463
    • Schallert, T.1    Whishaw, I.Q.2    Ramirez, V.D.3    Teitelbaum, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.